Weiwei Cui

Weiwei Cui
Tianjin University | tju · State Key Laboratory of Precision Measurement Technology and Instruments

Doctor of Engineering

About

36
Publications
11,586
Reads
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223
Citations
Introduction
WEIWEI CUI received the B.S. and ph.D. degrees from Tianjin University, Tianjin, China, in 2013 and 2019, respectively. His current research interest focuses on GHz acoustofluidics and nanoscale acosutic-MEMS devices. Their most recent publication is "Trapping of Sub-100 nm Nanoparticles Using Gigahertz Acoustofluidic Tweezers for Biosensing Applications".
Additional affiliations
October 2012 - June 2019
Tianjin University
Position
  • PhD

Publications

Publications (36)
Article
Full-text available
A quantitative description of the dynamics of droplet motion has been a long-standing concern in electrowetting research. Although many static and dynamic models focusing on droplet motion induced by electrowetting-on-dielectric (EWOD) already exist, some dynamic features do not fit these models well, especially the dynamic saturation phenomenon. I...
Article
Full-text available
At the single-cell level, cellular parameters, gene expression and cellular function are assayed on an individual but not population-average basis. Essential to observing and analyzing the heterogeneity and behavior of these cells/clusters is the ability to prepare and manipulate individuals. Here, we demonstrate a versatile microsystem, a stereo a...
Preprint
At the single-cell level, cellular parameters, gene expression and function are assayed on an individual but not population-average basis. Essential to observing and analyzing the heterogeneity and behavior of these cells/clusters is the ability to prepare and manipulate individual. Here, we demonstrate a versatile microsystem, a stereo acoustic st...
Article
Addressable trapping and manipulations of micro/nano-scale bioparticles is often necessary and critically important in microfluidic devices for biological and medical applications. While GHz bulk-acoustic-wave (BAW) resonators have shown their excellent performance in trapping, rotating, and focusing particles down to nanometers, arraying them for...
Article
As an acute inflammatory response, sepsis may cause septic shock and multiple organ failure. Rapid and reliable detection of pathogens from blood samples can promote early diagnosis and treatment of sepsis. However, traditional pathogen detection methods rely on bacterial blood culture, which is complex and time-consuming. Although pre-separation o...
Article
Acoustofluidics has emerged as a promising method for submicron particle manipulation. However, ultrahigh‐frequency or focused sound waves are usually required to generate sufficient acoustic radiation force or localized streaming vortex for trapping nanoscale objects, which is more challenging in device fabrication. This work presents a novel meth...
Conference Paper
Full-text available
Ultra-high-speed vortex field generated by GHz bulk-acoustic-wave (BAW) resonator can bring well ability on particle trapping and manipulation in microfluid, but the ability is weakened when high throughput of sample solution is injected. This paper investigates mechanism of this throughput induced performance deterioration to GHz BAW resonator bot...
Conference Paper
Full-text available
This study presents a minimized ultra-centrifugal chip featured with high throughput and precise separation for small nanoparticles (<500 nm). A bulk acoustic wave (BAW) resonator array is developed to merge with microfluidics and work as the actuation component. Benefit from the gigahertz frequency, the BAW resonators can efficiently trigger stron...
Conference Paper
Full-text available
Rapid separation of sub-micron particles based on surface acoustic waves (SAWs) have been remained as challenges as there are lots of demands for such technologies in fundamental biomedical research and frontier developments of diagnosis devices. In this paper, a frequency of 409 MHz SAW actuated digital micro-centrifugal chip is demonstrated for r...
Conference Paper
Full-text available
This paper theoretically and experimentally demonstrates an acoustic-actuated pillar array chip (APAC) for parallel and controllable particle trapping. By altering the size, shape, and the layout of the pillar array, we can precisely program the trapping ability of the APAC system for size-dependent separation of bioparticles. We theoretically reve...
Article
Full-text available
We present a nanoscale acoustofluidic trap (AFT) which manipulates nanoparticles in a microfluidic system actuated by a gigahertz acoustic resonator. The AFT generates independent standing closed vortices with high-speed rotation. By carefully designing and optimizing the geometric confinements, the AFT is able to effectively capture and enrich sub...
Article
Full-text available
a r t i c l e i n f o Even as gigahertz (GHz) acoustic streaming has developed into a multi-functional platform technology for biochemical applications, including ultrafast microfluidic mixing, microparticle operations, and cellar or vesicle surgery , its theoretical principles have yet to be established. This is because few studies have been condu...
Article
In article number 1800068, Xuexin Duan, Wei Pang and co‐workers develop hypersonic‐induced hydrodynamic tweezers (HSHTs) and demonstrate the capability for multifunctional manipulations of micro/nanoparticles including online trapping, on‐situ rotation, queuing, and continuous sorting. Benefitting from the advantages of the hydrodynamic approach, t...
Article
Full-text available
On-demand droplet dispensing systems are indispensable tools in bioanalytical fields, such as microarray fabrication. Biomaterial solutions can be very limited and expensive, so minimizing the use of solution per spot produced is highly desirable. Here, we proposed a novel droplet dispensing method which utilizes a gigahertz (GHz) acoustic resonato...
Article
Full-text available
Developing microrobots for precisely manipulating micro/nanoscale objects has triggered tremendous research interest for various applications in biology, chemistry, physics, and engineering. Here, a novel hypersonic‐induced hydrodynamic tweezers (HSHTs), which use gigahertz nano‐electromechanical resonator to create localized 3D vortex streaming ar...
Article
Full-text available
Quantitative biomarker detection methods featured with rapidity, high accuracy, and label-free are demonstrated for the development of point-of-care (POC) technologies or "beside" diagnostics. Microbead aggregation via protein-specific linkage provides an effective approach for selective capture of biomarkers from the samples, and can directly read...
Conference Paper
acoustofluidics. This paper reports a minimized bio-particles manipulation tool utilizing localized ultrahigh frequency acoustic resonators (UHF-AR). The resonator works at frequency of 1540 MHz, which is high enough to break through scale effect and trigger localized acoustofluidic streaming (in formation of 3-D vortices) within microfluidic syste...
Article
We present an acoustic microfluidic mixing approach via acousto-mechanically induced microvortices sustained by localized ultrahigh frequency (UHF) acoustic fields. A micro-fabricated solid-mounted thin-film piezoelectric resonator (SMR) with a frequency of 1.54 GHz has been integrated into microfluidic systems. Experimental and simulation results...
Article
Due to its ability to manipulate droplets flexibly, electrowetting-on-dielectric (EWOD) based digital microfluidics have been widely researched. This paper focuses on the design principles of improved open EWOD based digital microfluidics actuators. EWOD devices of different electrode formation were fabricated and tested. Based on the analysis and...
Conference Paper
Coupling of acoustic disturbance into microfluidics has been widely investigated for micro-mixing, fluid heating, bioparticle manipulations including trapping, sorting, focusing, and cell lysis etc. Here, we demonstrated a microfluidic system which integrated with micro-fabricated bulk acoustic wave resonator (BAW) working at frequency of 1.54 GHz....
Article
Full-text available
Nanopore sensors are expected to be one of the most promising next generation sequencing technologies, with label-free, amplification-free and high-throughput fea‐ tures, as well as rapid detections and low cost. Solid-state nanopores have been widely explored due to their diverse fabrication methods and CMOS compatibility. Here, we highlight the f...
Conference Paper
Full-text available
This paper demonstrates a micro-total-analysis-system (Micro TAS) integrating eletrowetting-on dielectric (EWOD) droplet actuator with solidly mounted resonator (SMR) biosensor array, where biosensors in high spatial density are functionalized with different bioreceptors automatically. The platform is dedicated to high-throughput detection of biolo...
Conference Paper
Full-text available
This work reports our studies on the kinetic issues of local adsorption via experimental investigations and theoretical analysis on hydrophobic surface masked piezoelectric microelectromechanical film bulk acoustic resonator (FBAR) mass sensor. Enhanced limit of detection (LOD) of the hydrophobic masked sensor has been demonstrated with Hg 2+ and I...
Article
Micro/nano scale biosensors integrated with the local adsorption mask have been demonstrated to have a better limit of detection (LOD) and less sample consumptions. However, the molecular diffusions and binding kinetics in such confined droplet have been less studied which limited further development and application of the local adsorption method a...
Article
Full-text available
Although digital microfluidics has shown great potential in a wide range of applications, a lab-on-a-chip with integrated digital droplet actuators and powerful biochemical sensors is still lacking. To address the demand, a fully integrated chip with electrowetting-on-dielectric (EWOD) and a film bulk acoustic resonator (FBAR) sensor is introduced,...
Conference Paper
Although digital microfluidic system has shown great potential in a wide range of applications, a single-chip platform integrating biochemical sensors with digital microfluidic devices is still lacking. In this paper, film bulk acoustic resonator (FBAR) sensors and electrowetting-on-dielectric (EWOD) actuator are integrated on a single silicon chip...
Article
Full-text available
In this paper, we present a single-plate electro-wetting on dielectric (SEWOD) device by integrating an island-ground electrode (IG), which is surrounded by the driving electrodes and looks like an island. Both experiments and theoretical analysis have been conducted to investigate the performance of the IG-SEWOD device. The driving voltage of a fa...
Conference Paper
Full-text available
Film bulk acoustic resonator (FBAR) mass sensor has been widely explored for detection of chemical and biological events. In this paper, an FBAR sensor bounded by hydrophobic Teflon film has been fabricated and tested. Experimental results in Hg2+ detection demonstrate that the Teflon film bordering around the sensor enhances signal of the sensor b...

Questions

Questions (8)
Question
I'm trying to develop a piezoelectric nano-position actuator. My final goal is to get a stable nano scale displacement, which is static, not vibration. If a static voltage is applied on the PZT, ZnO, AlN, or LN film, could it generate a static nano or sub-nano scale displacement? And could you present me some knoeledge or paper about this question? thanks so much!
Question
In my recent project, I needed to separate nanoparticles from the flowing samples. But I found it so difficult to do that. Who has experience on this topic? Any suggestions are welcome! Thanks so much~
Question
I'm trying to develop a microfluidic-based tool to concentrate protein into a target region, and does anyone have experience on this field? Any suggestion would be apprieciated, thanks so much!
Question
I'm trying to control the temperature distribution of the flow in microchannels. While I don't know how to measure the value of the temperature. Do you have any experience in measuring the flow temperature in closed micro channels?
Question
I'm trying to demonstrate the droplet generation process using water in oil system in microfluidic chip, aiming to do cell culture experiments. Generally, surfactant should be added into the oil (here FC-40 is used as the oil) to form a more stable oil-water interface. While, I don't know what kind of surfactant is suitable for my case. Do you have some suggestions? 
Question
We utilize a Au electrode of 200 micrometer wide as working electrode to  generate electric field on solution. The Au electrode is evaporated on SiO2 wafer. Its thickness is 3000A. There is 500A Ti-W between the wafer and Au. For experiment, the AU electrode is merged in tris buffer (PH=8.1, KCl 5mM) and then voltages more than 1.2V  is applied on it. But, after several seconds, the electrode is burned, and becomes black. I have noted that in some publications, votages of several volts are utilized to control the Au electrode in Tris buffer, and no burning occurs.  Is there anyone who has the same experience can tell me how to improve it?Furthermore, Is there any tip to deal with electrolysis happens? 
Question
I want to link a micro-bead of 5 micrometer in diameter to the planar electrode by antibody-to-antigen specific bonding. A few tests have been done but failed. Now I wonder whether this approach is feasible or not. And does anyone have experience to link microbeads to the planar surface in the similar way?

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Projects

Projects (4)
Project
for effective, multifunctional, and portable whole blood process.