Wei Zhen Chow

Wei Zhen Chow
The University of Newcastle, Australia · School of Biomedical Sciences and Pharmacy

PhD (Medical Biochemistry) and MMedSc

About

35
Publications
2,639
Reads
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254
Citations
Citations since 2016
22 Research Items
215 Citations
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20162017201820192020202120220102030405060
20162017201820192020202120220102030405060
20162017201820192020202120220102030405060

Publications

Publications (35)
Article
Full-text available
For many chronic stroke survivors, persisting cognitive dysfunction leads to significantly reduced quality of life. Translation of promising therapeutic strategies aimed at improving cognitive function is hampered by existing, disparate cognitive assessments in animals and humans. In this study, we assessed post-stroke cognitive function using a co...
Article
Full-text available
Background The precise mechanisms underlying the aetiology of post-stroke fatigue remain poorly understood. Inflammation has been associated with clinically significant fatigue across a number of neurological disorders; however, at present there is a lack of evidence regarding the association of fatigue and inflammation in the chronic phase of stro...
Article
Full-text available
Stroke survivors report significant levels of psychological distress post stroke. To date, most studies conducted have focused on the relationship between psychological stress and functional outcomes in the acute phase of stroke. However, no studies had considered the role of stress over the chronic phase, where stress may continue to exert negativ...
Article
Full-text available
In the current study, we were interested in investigating whether Low oxygen post-conditioning (LOPC) was capable of limiting the severity of stroke-induced secondary neurodegeneration (SND). To investigate the effect of LOPC we exposed adult male C57/BL6 mice to photothrombotic occlusion (PTO) of the motor and somatosensory cortex. This is known t...
Article
Background: The unanticipated devastating changes affecting the quality of life post-stroke leads to chronic stress. Elevated stress has been associated with the several worst outcomes of stroke. However, not all stroke survivors with acute stress advances to the stage of severe unfavourable outcomes. Apart from stroke severity, the functional outc...
Article
Two-thirds of stroke survivors experience cognitive impairment which reduces the quality of life by affecting the ability to return to work and social participation. Our understanding of the neuropathology of cognitive impairment post-stroke is limited, hence requires clarification in order to design interventions to improve cognitive function afte...
Article
Full-text available
Background Human metapneumovirus (HMPV) is established as one of the causative agents of respiratory tract infections. To date, there are limited reports that describe the effect of HMPV genotypes and/or viral load on disease pathogenesis in adults. This study aims to determine the role of HMPV genetic diversity and nasopharyngeal viral load on sym...
Article
Background and purpose: Cognitive impairment is a common outcome for stroke survivors. Growth hormone (GH) could represent a potential therapeutic option as this peptide hormone has been shown to improve cognition in various clinical conditions. In this study, we evaluated the effects of peripheral administration of GH at 48 hours poststroke for 2...
Article
Full-text available
We report here the first HIV-1 circulating recombinant form (CRF) complex identified among the blood donors in Malaysia. The CRF77_cpx mosaic genome consists of parental subtypes B′, C, and CRF01_AE and is structurally related to CRF07_BC. The identification of CRF77_cpx underlines the genetic complexity and mobility of HIV-1 among the blood donors...
Article
Full-text available
Transfusion-transmissible infections including HIV-1 continue to pose major risks for unsafe blood transfusions due to both window phase infections and divergent viruses that may not be detected by donor screening assays. Given the recent emergence of several HIV-1 circulating recombinant forms (CRFs) in high-risk populations in the Southeast Asia...
Data
Neighbour-joining tree of partial gag-pol sequences of 13MYNBB034 and other CRFs including CRF33_01B and CRF74_01B, previously characterised in Kuala Lumpur. Phylogenetic tree was constructed in MEGA 5.05 using Kimura 2-parameter method of nucleotide substitutions and the reliability of the branching nodes were assessed by bootstrap analysis of 100...
Data
Phylogenetic reconstruction of partial gag-pol sequences of subtype GMY clade (n = 12) and publicly available subtype GAF reference sequences (n = 75) downloaded from GenBank. Neighbour-joining tree was constructed in MEGA 5.05 using Kimura 2-parameter method of nucleotide substitutions and the reliability of the branching nodes were assessed by bo...
Article
Full-text available
HIV-1 subtypes and drug resistance are routinely tested by many international surveillance groups. However, results from different sites often vary. A systematic comparison of results from multiple sites is needed to determine whether a standardized protocol is required for consistent and accurate data analysis. A panel of well-characterized HIV-1...
Data
Summary of the PCR conditions and sequence analysis methods in all seven international sites. (PDF)
Article
Full-text available
Human metapneumovirus (HMPV) is an important viral respiratory pathogen worldwide. Current knowledge regarding the genetic diversity, seasonality and transmission dynamics of HMPV among adults and children living in tropical climate remains limited. HMPV prevailed at 2.2% (n = 86/3,935) among individuals presented with acute respiratory tract infec...
Article
Co-infections with human immunodeficiency virus type 1 (HIV-1) and human pegivirus (HPgV) are common in hepatitis C virus (HCV)-infected individuals. However, analysis on the evolutionary dynamics and transmission network profiles of these viruses among individuals with multiple infections remains limited. A total of 228 injecting drug users (IDUs)...
Article
Full-text available
Human immunodeficiency virus type 1 (HIV-1) subtypes have been shown to differ in the rate of clinical progression. We studied the association between HIV-1 subtypes and the rate of CD4+ T-cell recovery in a longitudinal cohort of patients on combination antiretroviral therapy (cART). We studied 103 patients infected with CRF01_AE (69%) and subtype...
Article
Full-text available
In many parts of Southeast Asia, the HIV-1 epidemic has been driven by the sharing of needles and equipment among intravenous drug users (IDUs). Over the last few decades, many studies have proven time and again that the diversity of HIV-1 epidemics can often be linked to the route of infection transmission. That said, the diversity and complexity...
Article
Full-text available
A complex HIV-1 unique recombinant form involving subtypes CRF01_AE, B, and B' was recently identified from an injecting drug user in Malaysia. A total of 13 recombination breakpoints were mapped across the near-full-length genome of isolate 10MYPR226, indicating the increasingly diverse molecular epidemiology and frequent linkage among various hig...
Article
Full-text available
The HIV epidemic is primarily characterised by the circulation of HIV-1 group M (main) comprising of 11 subtypes and sub-subtypes (A1, A2, B-D, F1, F2, G, H, J, and K) and to date 55 circulating recombinant forms (CRFs). In Southeast Asia, active inter-subtype recombination involving three main circulating genotypes-subtype B (including subtype B',...
Article
Full-text available
Since the discovery of HIV-1 circulating recombinant form (CRF) 33_01B in Malaysia in the early 2000 s, continuous genetic diversification and active recombination involving CRF33_01B and other circulating genotypes in the region including CRF01_AE and subtype B' of Thai origin, have led to the emergence of novel CRFs and unique recombinant forms....
Data
Bootscan analyses of HIV-1 unique recombinant forms (URFs) constituting three novel clades of circulating recombinant forms (CRFs) isolated from people who inject drugs (PWID) in Malaysia. A, Schematic representation of the full length recombinant structure of CRF33_01B with the four unique recombination breakpoints labelled as 1–4 (HXB2∶2053–2063...
Data
Maximum likelihood analysis of HIV-1 CRF33_01B disseminating among various risk groups and geographical origins in Southeast Asia (Malaysia and Indonesia). The maximum likelihood reconstruction of all available CRF33_01B isolates was estimated by PAUP* v4.0 beta [40]. A total of 242 CRF33_01B sequences (pol region, HXB2∶2253–3260) spanning year 200...
Data
Phylogenetic analysis of the partial gag-PR (HXB2∶1753–2591) and partial RT (HXB2∶2476–3440) HIV-1 sequences amplified among people who inject drugs (PWID) in Kuala Lumpur, Malaysia. The partial gag-PR (n = 16) and partial RT (n = 14) genes were sequenced, codon-aligned and manually adjusted with the HIV-1 reference subtypes and circulating recombi...
Article
Full-text available
A novel HIV-1 genotype designated CRF53_01B was recently characterized from three epidemiologically unrelated persons in Malaysia. Here we announced three recently isolated full-length genomes of CRF53_01B, which is likely to be phylogenetically linked to CRF33_01B, circulating widely in Southeast Asia. The genome sequences may contribute to HIV-1...
Article
Full-text available
There is the inevitable increase in domestic and industrial waste with the increase in world population. The end products from the waste treatment plants are mounting and we are now faced with the inevitable end of one day being surrounded by our waste. Therefore it is crucial for us to find possible applications or uses for this waste. A social pe...
Article
There is the inevitable increase in domestic and industrial waste with the increase in world population. The end products from the waste treatment plants are mounting and we are now faced with the inevitable end of one day being surrounded by our waste. Therefore it is crucial for us to find possible applications or uses for this waste. A social pe...

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Projects

Projects (5)
Project
To investigate the role of growth hormone in stroke recovery - GHD after stroke - GH treatment in experimental stroke
Project
To explore the impact of stress on stroke recovery - Stress assessed by Perceived Stress Scale (PSS), hair cortisol concentrations and blood stress hormones - Resilience assessed by Connor-Davidson Resilience Scale and Brief Resilience Scale To explore changes in cognition - Cognitive functions assessed by CANTAB battery of tests To explore changes in fatigue - Fatigue assessed by Fatigue Assessment Scale - Inflammatory biomarkers