Wei Wang

• Doctor of Philosophy
• Northwest A&F University

To investigate the cadmium (Cd) uptake mechanism in the roots of Coptis chinensis Franch., we utilized non-invasive micro-test technology (NMT) to analyze Cd²⁺ and H⁺ fluxes, alongside ICP-MS to assess Cd content and fluxes under various inhibitors and ion channel blockers. Results revealed that Cd²⁺ uptake primarily occurs in the root meristematic...

Background Thermogenic adipose tissue, both beige and brown, experiences whitening as animals are exposed to warmth and age, but the potential mechanisms are not fully understood. In this study, we employed single-nucleus RNA-seq to construct a cell atlas during whitening progression and identified the characteristics of thermogenic adipocytes. Re...

DCW008, a synthetic allopolyploid rice (2n = 4X = 48, AABB), was obtained from chromosome doubling of interspecific hybrids between Oryza sativa (2n = 24, AA) and O. punctata (2n = 24, BB). The F1 and backcross (BC1) hybrids were produced by crossing DCW008 as a female parent with a high seed set tetraploid rice Sg99012 - 4X (2n = 4X = 48, AAAA). B...

Four polyhydroxyalkanes were isolated from the CH2Cl2 part of Pachysandra terminalis, including two new ones, (2S,3E)-3-isopropylpent-3-ene-1,2,5-triol (1) and (4R,2E)-4,5-dihydroxy-2,3-dimethylpent-2-enoic acid (2); as well as one new natural product, 3-methylbut-3-ene-1,2-diol (3) and one known compound, 4-methyl-3-methylenepentane-1,2-diol (4)....

Wild rice species are invaluable resources for genetic improvement of cultivated rice. “Breeding super rice using double advantages of wide cross and polyploidization” is a novel pathway in rice breeding. To exploit the favorable genes of wild rice fully, a technical system composed of hormone treatment, repeated pollination, hybrid embryo rescue,...

Rhubarb, the Rhei radix et rhizoma (Da huang) is a member of the Polygonaceae family, included in the 2020 edition of the Chinese Pharmacopoeia, and is mainly distributed in Gansu, Sichuan, Qinghai, northwestern Yunnan, and eastern Tibet. Rhei radix et rhizoma is one of the most commonly used traditional Chinese medicines, processed into drinkable...

A protocol for in vitro induction of autoallododecaploid Echinochloa crus-galli with colchicine treatment was established. Colchicine concentration and exposure time had significant effects on the callus survival rate, shoot differentiation rate, and chromosome doubling rate. With the increase of colchicine concentration and the extension of treatm...

The ruminal microbiota generates biogenic methane in ruminants. However, the role of host genetics in modifying ruminal microbiota‐mediated methane emissions remains mysterious, which has severely hindered the emission control of this notorious greenhouse gas. Here, we uncover the host genetic basis of rumen microorganisms by genome‐ and transcript...

Protein aggregation, which can sometimes spread in a prion-like manner, is a hallmark of neurodegenerative diseases. However, whether prion-like aggregates form during normal brain aging remains unknown. Here, we use quantitative proteomics in the African turquoise killifish to identify protein aggregates that accumulate in old vertebrate brains. T...

It is generally accepted that jasmonate‐ZIM domain (JAZ) repressors act to mediate jasmonate (JA) signaling via CORONATINE‐INSENSITIVE1 (COI1)‐mediated degradation. Here, we report a cryptic signaling cascade where a JAZ repressor, FvJAZ12, mediates multiple signaling inputs via phosphorylation‐modulated subcellular translocation rather than the CO...

Semi-Supervised Relation Extraction aims at learning well-performed RE models with limited labeled and large-scale unlabeled data. Existing methods mainly suffer from semantic drift and insufficient supervision, which severely limit the performance. To address these problems, recent work tends to design dual modules to work cooperatively for mutual...

Research about the effect of exosomes derived from tumor associated macrophages (TAM-exos) in the distant organ metastasis of breast cancer is limited. In this study, we found that TAM-exos could promote the migration of 4T1 cells. Through comparing the expression of microRNAs in 4T1 cells, TAM-exos, and exosomes from bone marrow derived macrophage...

The muskox and reindeer are the only ruminants that have evolved to survive in harsh Arctic environments. However, the genetic basis of this Arctic adaptation remains largely unclear. Here, we compared a de novo assembled muskox genome with reindeer and other ruminant genomes to identify convergent amino acid substitutions, rapidly evolving genes a...

Introduction Regulation of brain‐derived neurotrophic factor (BDNF) in the basal forebrain ameliorates sleep deprivation‐induced fear memory impairments in rodents. Antisense oligonucleotides (ASOs) targeting ATXN2 was a potential therapy for spinocerebellar ataxia, whose pathogenic mechanism associates with reduced BDNF expression. We tested the h...

Redox catalysts play a vital role in chemical looping oxidative dehydrogenation processes, which have recently been considered to be a promising prospect for propylene production. This work describes the coupling of surface acid catalysis and selective oxidation from lattice oxygen over MoO3-Fe2O3 redox catalysts for promoted propylene production....

Atherosclerosis (AS) is the main cause of cardiovascular diseases. However, the role of AQP9 in AS is not well understood. In the present study, we predicted that miR-330-3p might regulate AQP9 in AS through bioinformatics analysis, and we established AS model using ApoE−/− mouse (C57BL/6) with high-fat diet (HFD). Hematoxylin and eosin (H&E) and O...

Masked Language Modeling (MLM) is widely used to pretrain language models. The standard random masking strategy in MLM causes the pre-trained language models (PLMs) to be biased toward high-frequency tokens. Representation learning of rare tokens is poor and PLMs have limited performance on downstream tasks. To alleviate this frequency bias issue,...

Plant cell walls are essential structures for plant growth and development as well as plant adaptation to environmental stresses. Thus, plants have evolved signaling mechanisms to monitor the changes in the cell wall structure, triggering compensatory changes to sustain cell wall integrity (CWI). CWI signaling can be initiated in response to enviro...

High level of intracellular glutathione (GSH) has been identified as a major barrier for cancer therapy. Therefore, effective regulation of GSH can be regarded as a novel approach for cancer therapy. In this study, an off-on fluorescent probe (NBD-P) is developed for selective and sensitive sensing GSH. NBD-P has a good cell membrane permeability t...

To investigate the effect of paired box protein 5 (PAX5)/integrin subunit alpha X (ITGAX) in atherosclerosis (AS). AS model was established using ApoE-/- mice (C57BL/6). Human vascular smooth muscle cells (HVSMCs) were stimulated with ox-LDL. Quantitative reverse transcription polymerase chain reaction and Western blotting were used to detect the e...

With critical lessons drawn from past major earthquakes, the engineering community is appealing for a fundamental shift in the existing design philosophy for structures in seismic zones. One strategy is to endow structures with self-centering (SC) capability. While the concept of SC structures is not new, many novel technologies have been recently...

Convergent evolution provides powerful opportunities to investigate the genetic basis of complex traits. The Tibetan antelope (Pantholops hodgsonii) and Siberian ibex (Capra sibirica) belong to different subfamilies in Bovidae, but both have evolved similar superfine cashmere characteristics to meet the cold temperature in plateau environments. The...

Atherosclerosis is one of the main causes of cardiovascular diseases. Aquaporin 9 (AQP9), a triglyceride channel is permeable to water, monocarboxylic acids, glycerol and lactic acid. However, the role of AQP9 in atherosclerosis is not clear. In present study, we predicted that miR-330-3p might regulate AQP9 in atherosclerosis through bioinformatic...

Clostridium perfringens beta2 (CPB2) toxin is one of the main pathogenic toxins produced by Clostridium perfringens, which causes intestinal diseases in animals and humans. The N6-methyladenosine (m6A) modification is the most common reversible modification in eukaryotic disease processes. Methyltransferase-like 3 (METTL3) regulates immunity and in...

Tricuspid regurgitation (TR) has become one of the most common valve diseases. Patients with severe TR are often at high surgical mortality risk. Transcatheter tricuspid valve interventions have emerged as a promising alternative to open-heart surgery. The LuX-Valve is a novel radial force-independent transcatheter tricuspid valve replacement syste...

Fourteen phenolic derivatives including two new compounds (1, 2), one new natural product (10) and eleven known ones (3 - 9 and 11–14) were obtained from the roots of Fallopia multiflora var. ciliinervis. The structures were determined using IR, MS, 1D and ²D NMR spectroscopy and the absolute configuration of the new structure (2) was deduced by EC...

The fatigue life of orthotropic steel decks (OSDs) is significantly affected by vehicle loads, and the local stress response of OSDs is sensitive to the transverse position of vehicle loads. However, the presence of autonomous vehicles is likely to change the transverse distribution of vehicles within the lane, thereby affecting vehicle-induced fat...

Due to the absence of explicit connectives, implicit discourse relation recognition (IDRR) remains a challenging task in discourse analysis. The critical step for IDRR is to learn high-quality discourse relation representations between two arguments. Recent methods tend to integrate the whole hierarchical information of senses into discourse relati...

Today, with the increase in the integration of renewable sources, the home energy management system (HEMS) has become a promising approach to improve grid energy efficiency and relieve network stress. Traditionally, complicated thermal models or passive participation of the users prevents HEMS from fully automating the involvement of demand-side en...

The neural network algorithm used to control electronic equipment is an important subject in the field of control and regulation, and its application is becoming increasingly extensive. A neural network algorithm is a very effective learning algorithm that is widely used to control electronic equipment and has the characteristics of good fault tole...

Acetaminophen (APAP), which is widely used for the treatment of analgesic-antipyretic as the first-line drug, can cause extensive hepatic injury and even acute hepatic failure. Oxidative stress and inflammation have been considered as the main mechanism of hepatotoxicity. However, the only antidote available for clinical application is N-acetylcyst...

The intestinal microbial metabolite trimethylamine (TMA), which is activated by flavin monooxygenase (FMO) to produce trimethylamine- N -oxide (TMAO), has been implicated in the pathogenesis of atherosclerosis (AS), leading to the development of therapeutic strategies for AS. This study aimed to investigate whether β-sitosterol can inhibit TMA prod...

This paper presents an experimental and analytical study on the behavior of DSCW loaded in axial compression. Two full-scale tests of DSCW were conducted under the axial compressive load. The effect of the height of DSCW was taken into consideration. Moreover, the failure mode, axial load versus displacement relationship, displacement ductility, an...

Background Patients with long-term tricuspid regurgitation (TR) are mostly accompanied by hepatic, cardiac, and venous remodeling. Transcatheter tricuspid valve replacement (TTVR) device has emerged as a promising alternative to open-heart surgery for TR patients. No study has assessed the impact of TTVR on hepatic, cardiac, and venous remodeling....

Chiral quaternary α-aryl amino acids are biologically valued but synthetically challenging building blocks. Herein, we report a strategy for the synthesis of molecular architectures by unifying a photoredox catalytic asymmetric Giese-type reaction and Clayden rearrangement. A new class of chiral Karady-Beckwith dehydroalanines is designed and serve...

Chinese goldthread (Coptis chinensis Franch.) is an important medicinal plant worldwide. However, its clinical safety is negatively impacted by high cadmium (Cd) and chromium (Cr) levels. Understanding the accumulation pattern and detoxification mechanism of heavy metals, such as Cd and Cr, is important for regulating their transportation and reduc...

The separation of oil-in-water and water-in-oil emulsions with high efficiency and environmental friendly remains a challenge in the past decade. This work describes a new method to improve the trade-off of the poly(acrylonitrile-co-methyl acrylate) (P(AN-MA))-based membrane for water/oil separation. P(AN-MA) microfiltration (MF) membrane was fabri...

The oxygen distribution and evolution within the oxygen carrier exert significant influence on chemical looping processes. This paper describes the influence of oxygen bulk diffusion within FeVO4 oxygen carrier pellets on the chemical looping oxidative propane dehydrogenation (CL-ODH). During CL-ODH, the oxygen concentration at the pellet surface i...

Transcatheter aortic valve implantation (TAVI) has become a popular treatment for surgical high-risk patients with severe aortic stenosis (AS). Recently, we have applied TAVI to the treatment of aortic regurgitation (AR). Compared with conventional surgical procedures, TAVI is less invasive and considered a useful option for these high-risk patient...

Despite pluripotent stem cells sharing key transcription factors, their maintenance involves distinct genetic inputs. Emerging evidence suggests that super-enhancers (SEs) can function as master regulatory hubs to control cell identity and pluripotency in humans and mice. However, whether pluripotency-associated SEs share an evolutionary origin in...

Pseudorabies virus (PRV) is widely prevalent in China, which can transmit from pigs to other mammals. Moreover, a PRV variant isolated from an acute human encephalitis case was documented recently. It is imperative to investigate PRV epidemiology in pigs, the knowledge regarding pseudorabies (PR) and self-protection behaviors upon working among rel...

Objectives The genus Reynoutria belonging to the family Polygonaceae is widely distributed in the north temperate zone and used in folk medicine. It is administered as a sedative, tonic and digestive, also as a treatment for canities and alopecia. Herein, we reported a review on traditional uses, phytochemistry and pharmacology reported from 1985 u...

Aim Numerous reports have demonstrated the key importance of macrophage-elicited metabolic inflammation in insulin resistance (IR). Our previous studies confirmed that hyperuricemia or high uric acid (HUA) treatment induced an IR state in several peripheral tissues to promote the development of type 2 diabetes mellitus (T2DM). However, the effect o...

Purpose: This research mainly discussed the impacts of epidural anesthesia (EA) and general anesthesia (GA) on perioperative cognitive function (CF) and deep vein thrombosis (DVT) in patients undergoing total knee arthroplasty (TKA). Methods: One hundred and twenty-four patients undergoing TKA in our hospital between July 2015 and October 2021 w...

Oxidative stress and inflammation were considered to be the major mechanisms in liver damage caused by clofibrate (CF). In order to obtain lipid-lowering drugs with less liver damage, the structure of clofibrate was optimized by O-desmethyl anetholtrithione and got the target compound clofibrate-O-desmethyl anetholtrithione (CF-ATT). CF-ATT signifi...

This study presented reduced-order modeling methods for evaluating the structural robustness of steel frame buildings with different composite floor slabs under ground floor column loss scenarios. The adequacy of the reduced-order modeling technique was justified by relatively high-fidelity models, which were verified by a full-scale composite floo...

Design base shear and lateral force distribution are two important aspects of the seismic design process. Different design methods have been proposed to obtain the design base shear of different types of structures. However, the study related to the lateral force distribution is limited, especially for self-centering (SC) structures. The primary ob...

This paper is intended to review advances in the botanical, traditional uses, phytochemical, pharmacological and development and utilization studies of the genus Chloranthus. Chloranthus, a genus of the family Chloranthaceae, which is mainly distributed in the temperate and tropical regions of Asia, has been used as a folk remedy for swollen boils,...

Photocatalytic disinfection is one of the emerging green technologies for pathogenic microorganisms inactivation in water. Herein, a novel step-scheme Ag QDs/MoS2/Bi4O5Br2 heterojunction was successfully synthesized by a facile mechanical assembly route and applied in disinfection under visible light irradiation. Comparing to the pristine Bi4O5Br2,...

Fleshy fruit ripening involves changes in numerous cellular processes and metabolic pathways, resulting from the coordinated actions of diverse classes of structural and regulatory proteins. These include enzymes, transporters and complex signal transduction systems. Many aspects of the signaling machinery that orchestrates the ripening of climacte...

In the training process of deep learning models, one of the important steps is to choose an appropriate optimizer that directly determines the final performance of the model. Choosing the appropriate direction and step size (i.e. learning rate) of parameter update are decisive factors for optimizers. Previous gradient descent optimizers could be os...

Targeted protein degradation (TPD), represented by proteolysis-targeting chimera (PROTAC), has emerged as a novel therapeutic modality in drug discovery. However, the application of conventional PROTACs is limited to protein targets containing cytosolic domains with ligandable sites. Recently, nucleic-acid-based modalities, such as modified oligonu...

Three new steroidal components hellebogenins A and B (1 – 2) and thibetanoside I (3) together with four know ones (4 – 7) were isolated from the roots and rhizomes of Helleborus thibetanus. Their structures were elucidated by chemical methods and spectroscopic analysis. Among them, compound 1 possessed three double bonds at the positions of 1(2), 5...

A finite strain constitutive model is proposed to represent the cyclic elastoplastic response of structural steels. The model simulates the Lode angle dependence of plastic response, which has been recently observed in experimental studies. The model combines Frederick-Armstrong kinematic hardening rules with an exponential isotropic hardening rule...

Crack images collected from civil infrastructures through unmanned aerial vehicles suffer from motion blur and insufficient resolution, which reduces the accuracy of microcrack detection. Therefore, an automatic microcrack detection method based on super-resolution reconstruction (SRR) and semantic segmentation is proposed. Super-resolution (SR) im...

Background Acute kidney injury (AKI) is a complex disease and can be generally divided into prerenal, intrarenal, and postrenal AKI (PR-AKI). Previous studies have shown that mesenchymal stem cells (MSCs)-derived extracellular vesicles have protective function on prerenal and intrarenal AKI treatment, but whether they have therapeutic efficacy on P...

Ethnopharmacological relevance: The genus Polygonatum Tourn, ex Mill. contains numerous chemical components, such as steroidal saponins, polysaccharides, flavonoids, alkaloids, and others, it possesses diverse pharmacological activities, such as anti-aging, anti-tumor, immunological regulation, as well as blood glucose management and fat reducing...

In situ polymerization has been used to prepare polypyrrole (PPy) supported reduced graphene oxide (RGO). The prepared PPy/RGO composites were characterized by X-ray diffraction, transmission electron microscopy, scanning electron microscopy and X-ray photoelectron spectroscopy. The thermoelectric properties of the PPy/RGO composites were studied b...

Thrombomodulin (TM) is involved in the pathological process of atherosclerosis; however, the underlying mechanism remains unclear. Oxidised low-density lipoprotein (Ox-LDL; 100 μg/mL) was used to induce human vascular smooth muscle cells (HVSMCs) into a stable atherosclerotic cell model. The expression levels of miR-550a-3p and TM were detected by...

Dihydromyricetin (DHM) is a natural flavonoid compound extracted from Ampelopsis grossedentata that has been used for centuries in traditional Chinese medicine. DHM has attracted intensive attention due to its numerous beneficial activities, such as hepatoprotection, cardioprotection, antioxidant, and anti-inflammation. In addition, DHM inhibits th...

Monitoring vehicle axle loads is very important for preventing infrastructure degradation and traffic accidents. However, developing a cost-effective, flexible, and accurate axle load identification technology still remains challenging. In this study, a vehicle axle load identification method based on visual measurement is proposed. The principle o...

In order to predict the ductile fracture of beam-column connections with initial defects, the finite element models of the existing Q460C high-strength steel local connection specimens were established, and J-integral, VGM and SMCS model were used to predict the fracture. Compared with the test results, the predicted results of the J-integral, VGM...

The strain hardening behavior of structural steels is of significant importance for the elastoplastic response prediction and the collapse resistant evaluation of steel components. However, due to the necking occurrence in the uniaxial specimens, only the true stress-strain responses before necking are often obtained and applied for the plasticity...

Pseudobulbus Cremastrae seu Pleiones (PCsP) is a traditional Chinese herbal medicine known as “Shancigu” in China. It has the property of relieving fever, counteracting toxicity, dissipating phlegm and resolving masses. Officially recognized species of PCsP include Pleione bulbocodioides (Franch.) Rolfe (PB), Cremastra appendiculata (D. Don) Makino...

Heterosis and polyploidy have an overwhelming influence on plant evolution. Recently, polyploid rice hybrids have been used to breed new rice varieties because they combine the advantages of both heterosis and polyploidy. In this study, we generated six rice lines: autotetraploid rice hybrids and their autotetraploid parents, diploid donors, and hy...

Generally, humans are more skilled at perceiving differences between high-quality (HQ) and low-quality (LQ) images than directly judging the quality of a single LQ image. This situation also applies to image quality assessment (IQA). Although recent no-reference (NR-IQA) methods have made great progress to predict image quality free from the refere...

N6-methyladenosine (m6A) modification can accommodate mRNA processing, stability, and translation in mammals, and fat mass and obesity associated protein (FTO) is a vital demethylase in the m6A modification pathway. Clostridium perfringens type C (C. perfringens type C) causes diarrhea in piglets and has a serious impact on the pig industry. Howeve...

Recently, an exciting experimental conclusion in Li et al. (Knowl Inf Syst 62(2):611–637, 1) about measures of uncertainty for knowledge bases has attracted great research interest for many scholars. However, these efforts lack solid theoretical interpretations for the experimental conclusion. The main limitation of their research is that the final...

Analyzing and mining of time series have been widely studied in both academia and industry in recent years. Given a set of long time series, data analysts can utilize the window-based similarity search to explore subsequences in arbitrary time windows. Existing techniques are not efficient for window-based query processing. In particular, the whole...

Fleshy fruits have been traditionally categorized into climacteric (CL) and non-climacteric (NC) groups. CL fruits share a common ripening mechanism of hormonal regulation, i.e., the ethylene regulation, whereas whether NC fruits share a common mechanism remains controversial. Abscisic acid (ABA) has been commonly thought to be a key regulator in N...

Two new A-ring contracted triterpenoids, madengaisu A and madengaisu B, and one undescribed ent-kaurane diterpenoid, madengaisu C, along with 20 known compounds were isolated from the roots of Potentilla freyniana Bornm. The structures were elucidated using extensive spectroscopic techniques, including 1D and 2D-NMR, HR-ESI-MS, ECD spectra, IR, and...

Two new iridoids (1 and 2), one new lignan (3) together with one known iridoid (4) and twelve known lignans (5－16) were obtained from the roots of Valeriana officinalis L. (V. officinalis). The structures were determined using IR, MS, ¹D and ²D NMR spectroscopy and the absolute configurations of the new structures were deduced by ECD experiments. A...

Triple-negative breast cancer (TNBC) metastasis is the cause of nearly 90% of breast cancer treatment failures as the side effects of clinical drugs and insufficient efficacy of single-modality therapy. Shikonin (SHK) is a naphthoquinone natural product from the herbal medicine Lithospermum erythrorhizon., which is widely used for cancer therapy as...

Dbscan is a density-based clustering algorithm which is well known for its ability to discover clusters of arbitrary shape as well as to distinguish noise. As it is computationally expensive for large datasets, research studies on the parallelization of Dbscan have been received a considerable amount of attention. In this paper we present an exact,...

Background Resistance to cell death, a protective mechanism for removing damaged cells, is a “Hallmark of Cancer” that is essential for cancer progression. Increasing attention to cancer lipid metabolism has revealed a number of pathways that induce cancer cell death. Scope of review We summarize emerging concepts regarding lipid metabolic reprogr...