Wei Wang

University of California, Los Angeles | UCLA · Department of Computer Science

The flux pumps can realize non-contact excitation of high-temperature superconducting (HTS) magnet and eliminate heat leakage caused by current leads. However, earlier proposed flux pump needs to be installed inside the cryostat, which leads to additional heat load to the cryogenic system. Here, we report the successful demonstration of a through-w...

Background: To investigate the clinical significance of preoperative systemic immune-inflammation index (SII) in patients with thymoma who underwent radical resection. Methods: This retrospective study involved 425 patients with thymoma who underwent radical resection at the First Affiliated Hospital of Nanjing Medical University between Septemb...

Background It has been suggested that lactate metabolism (LM) is crucial for the development of cancer. Using integrated single-cell RNA sequencing (scRNA-seq) analysis, we built predictive models based on LM-related genes (LMRGs) to propose novel targets for the treatment of LUAD patients. Methods The most significant genes for LM were identified...

Background: Cell-free DNA (cfDNA) promises to serve as surrogate biomarkers for non-invasive molecular diagnostics. Disease-specific cfDNA, such as circulating tumor DNA (ctDNA), was short and rare, making the detection performance of the current targeted sequencing methods unsatisfying. Methods: Through introducing a linear pre-amplification proce...

Objective: To estimate 30-day hospital readmission rates among persons living with HIV (PLWH) at the Nantong Infectious Disease Hospital in China and analyse the related risk factors. Methods: A single-centre retrospective cohort study was conducted. There were 894 PLWH records obtained from the electronic medical record (EMR) system at the Nant...

Large-scale information systems, such as knowledge graphs (KGs), enterprise system networks, often exhibit dynamic and complex activities. Recent research has shown that formalizing these information systems as graphs can effectively characterize the entities (nodes) and their relationships (edges). Transferring knowledge from existing well-curated...

Magnesium-aluminum (Mg–Al) system alloys have good casting properties, thermal conductivity, and mechanical processing properties; however, hot tearing is one of the most serious defects in the production of Mg alloy castings, which greatly limits its further development and application prospects. Therefore, it is important to study the mechanism o...

Objectives: This study aimed to investigate the potential of complex glandular patterns (CGP) in lymph node micrometastasis (LNMM), and to determine the clinical beneficiaries in stage I lung adenocarcinoma (LUAD) with CGP. Meanwhile, the feasibility of detecting CGP on frozen section was also evaluated. Methods: We retrospectively analyzed the...

Probing binding modes of GDP, GTP and GNP to NRAS are of significance for understanding the regulation mechanism on the activity of RAS proteins. Four separate Gaussian accelerated molecular dynamics (GaMD) simulations were performed on the apo, GDP-, GTP- and GNP-bound NRAS. Dynamics analyses suggest that binding of three ligands highly affects co...

Using Monte Carlo method, the compensation temperature and hysteresis loops of a ferrimagnetic mixed spin-3/2 and spin-5/2 Ising-type graphene-like bilayer are investigated induced by different physical parameters such as crystal field, exchange coupling, external magnetic field and temperature. The variation of magnetization, magnetic susceptibili...

A variety of Poly (ADP-ribose) polymerase inhibitors (PARPi) have been approved for the clinical treatment of breast cancers. However, pre-clinical and clinical evidences indicate that PARPi only benefits patients with homologous recombination (HR)-deficient breast cancers. Besides, the abnormal mechanical microenvironment of breast cancers severel...

Rheumatoid arthritis (RA) is characterized by joint synovitis and bone destruction, the etiology of which remains to be explored. Overactivation of M1 macrophages and osteoclasts has been thought a direct cause of joint inflammation and bone destruction. Glioma-associated oncogene homolog 1 (GLI1) has been revealed to be closely linked to bone meta...

Atmospheric nitrogen deposition has large eco-environmental effects such as ocean acidification, eutrophication in coastal areas. However, knowledge of the source and the pathway of N deposition in coastal areas is limited, especially during tropical storms, hindering the accurate quantification of how anthropogenic activities influence the ocean e...

Antimicrobial peptides (AMPs) have attracted considerable interest in the past decade due to their advantages for tackling antibiotic resistance. They exhibit potential antimicrobial activity through unique cell membrane destruction mechanism based on their net charge, hydrophobic properties, and α-helix. In this work, a series of HJH peptides was...

In this paper, we are concerned with the team optimal decentralized state estimation problem where the state is transmitted to a remote agent with packet dropouts and is observed by N$$ N $$ local agents with additive noises. In particular, the information of the remote agent is available to all local agents with hierarchical relationships, which l...

Plant height is an important and valuable agronomic trait associated with yield and resistance to abiotic and biotic stresses. Dwarfism has positive effects on plant development and field management, especially for tall monocotyledon banana (Musa spp.). However, several key genes and their regulation mechanism of controlling plant height during ban...

Background: Podocyte infolding glomerulopathy (PIG) is a peculiar and very rare manifestation in renal pathology. Its underlying pathogenesis mechanism and clinical characteristics remain unclear due to sparse reports. Objective: To further elucidate the clinical profile of PIG by carefully reporting our four cases and a comprehensive review of...

Background Lung adenocarcinoma (LUAD) is a heterogeneous disease with a dismal prognosis for advanced tumors. Immune-associated cells in the microenvironment substantially impact LUAD formation and progression, which has gained increased attention in recent decades. Sphingolipids have a profound impact on tumor formation and immune infiltration. Ho...

Background: Lung adenocarcinoma (LUAD) is an extraordinarily malignant tumor, with rapidly increasing morbidity and poor prognosis. Immunotherapy has emerged as a hopeful therapeutic modality for lung adenocarcinoma. Furthermore, a prognostic model (based on immune genes) can fulfill the purpose of early diagnosis and accurate prognostic prediction...

Climate communication scientists search for effective message strategies to engage the ambivalent public in support of climate advocacy. The personal experience of wildfire is expected to render climate change impacts more concretely, pointing to a potential message strategy to engage the public. This study examined Twitter discourse related to cli...

Objective Inflammation and thrombosis are recognized as interrelated biological processes. Both thrombomodulin (TM) and factor XIII-A (FXIII-A) are involved in inflammation and coagulation process. However, their role in the pathogenesis of diabetic nephropathy (DN) remains unclear. In vitro study, the liver X receptor (LXR) agonist T0901317 can up...

The solid solution of a reducible oxide with a (non or) less reducible oxide may open the way to incorporate substantial amounts of hydrogen by the simple exposure to H2...

Chronic kidney disease (CKD) has recently become a serious health and social concern. Vascular calcification, a common complication of CKD, is a risk factor that increases the incidence and mortality of cardiovascular events in patients with CKD. However, there are currently no effective therapeutic targets that can facilitate treatment with fewer...

The solid solution of a reducible oxide with a (non or) less reducible oxide may open the way to incorporate substantial amounts of hydrogen by the simple exposure to H2 at elevated temperatures, as exemplified by the mixture of RuO2 and TiO2. We are able to incorporate 17.6 mol% hydrogen into the mixed oxide Ru0.3Ti0.7O2 by H2 exposure at 250 °C,...

In this work, we propose a new method of particle swarm optimization combined with Monte Carlo simulation (PSO–MC for short) to investigate the magnetic properties of the perovskite LaFeO3 structure described by Ising model. First, we use the particle swarm optimization algorithm to calculate the exchange coupling, and then we use the Monte Carlo m...

Backgroud: SRC-1 works as a transcriptional coactivator for steroid receptors and other transcrip-tional factors. SRC-1 is shown to play oncogenic roles in many cancers, like breast cancer and prostate cancer. Our lab anteriorly accounted that SRC-1 is highly expressed in human HCC spec-imens. SRC-1 accelerates HCC progression via enhancing Wnt/bet...

Banana Fusarium wilt caused by Fusarium oxysporum f. sp. cubense tropical race 4 (Foc TR4) is one of the most destructive banana diseases in the world, which limits the development of the banana industry. Compared with traditional physical and chemical practices, biological control becomes a promising safe and efficient strategy. In this study, str...

Pandemic(epidemic) modeling, aiming at disease spreading analysis, has always been a popular research topic especially following the outbreak of COVID-19 in 2019. Some representative models including SIR-based deep learning prediction models have shown satisfactory performance. However, one major drawback for them is that they fall short in their l...

Background Migraine is a common neurovascular disorder that has a severe impact on the individual daily life. Atogepant (AGN-241689) is an orally ingested, small-molecule drugs belonging to calcitonin gene-related peptide receptor antagonist, which has been initiated for the prophylactic treatment of migraine. However, there is no comprehensive lit...

Air quality in Beijing-Tianjin-Hebei and its surrounding regions has been significantly improved during the Three-Year Action Plan for Winning the Battle Against Air Pollution from 2018 to 2020. The PM2.5 concentration can be significantly influenced by meteorological conditions, and the effectiveness of anthropogenic emissions reduction on PM2.5 o...

Ovarian cancer (OC) ranks first among gynecologic malignancies in terms of mortality. The benefits of poly (ADP-ribose) polymerase (PARP) inhibitors appear to be limited to OC with BRCA mutations. Concurrent administration of WEE1 inhibitors (eg, adavosertib (Ada)) and PARP inhibitors (eg, olaparib (Ola)) effectively suppress ovarian tumor growth r...

Tumor-infiltrating lymphocytes (TILs), especially CD8⁺ TILs, represent a favorable prognostic factor in high-grade serous ovarian cancer (HGSOC) and other tumor lineages. Here, we analyze the spatial heterogeneity of different TIL subtypes in HGSOC. We integrated RNA sequencing, whole-genome sequencing, bulk T cell receptor (TCR) sequencing, as wel...

Background: This retrospective study aimed to evaluate the real-world efficacy of neoadjuvant immunochemotherapy in locally advanced stage III non-small cell lung cancer (NSCLC), with a particular focus on analyzing the optimal treatment cycle and peripheral immune markers. Methods: Eligible patients with biopsy-confirmed stage III NSCLC who und...

The mechanism(s) of immune checkpoint inhibitor (ICI)-induced myasthenia gravis (MG), an immune-related adverse event (irAE) that is fatal and limits subsequent ICI use, remain unexplored. Here, through comparative genomic analysis, we identified a pathogenic p.S467C germline variant in SLC22A5 in a thymoma case with ICI-induced MG, which was found...

S-Adenosyl-L-methionine (SAM)-responsive riboswitches play a central role in the regulation of bacterial gene expression at the level of transcription attenuation or translation inhibition. In this study, multiple independent Gaussian-accelerated molecular dynamics simulations were performed to decipher the identification mechanisms of SAM-III (SMK...

Herein, the effect of low-frequency alternating magnetic field (LAMF) of different strengths (Coil current strength of 0, 5, 10, 15 and 20 A) on the hot tear susceptibility (HTS) of AXJ530 (Mg-4.5Al-3Ca-0.17Sr) alloy was systematically investigated by hot tear testing and thermal analysis experiments. The hot tearing mechanism of the alloy under th...

With the development of the GEN-IV nuclear reactors in the 21st Century, as a substitute for the steam cycle, the supercritical carbon dioxide (SCO2) Brayton cycle has been widely used in a variety of power generation scenarios and has attracted widely attention from the scholars. However, the previous research mainly focused on the basic thermodyn...

Recent studies find existing self-supervised speech encoders contain primarily acoustic rather than semantic information. As a result, pipelined supervised automatic speech recognition (ASR) to large language model (LLM) systems achieve state-of-the-art results on semantic spoken language tasks by utilizing rich semantic representations from the LL...

[This corrects the article DOI: 10.3389/fbioe.2022.823933.].

The time-dependent quantum wave packet (TDWP) and quasi-classical trajectory (QCT) are the basic research methods of reaction dynamics. Utilizing these two methods, the total reaction probability ( J = 0), integral cross section (ICS), and rate parameter for the C ⁺ ( ² P ) + SH( X ² Π)( v = 0, 1, 2, 3) → H( ² S ) + CS ⁺ ( X ² Σ ⁺ ) reactions are c...

Objective: Epilepsy is one of the most common and refractory neurological disorders globally. Ganaxolone, a neuroactive steroid that enhances GABAergic inhibition, has been tested in many trials for the resolution of refractory epilepsy. Based on these, our study implemented a meta-analysis to evaluate the general benefit of ganaxolone for refract...

The concept of the glial-vascular unit (GVU) was raised recently to emphasize the close associations between brain cells and cerebral vessels, and their coordinated reactions to diverse neurological insults from a “glio-centric” view. GVU is a multicellular structure composed of glial cells, perivascular cells, and perivascular space. Each componen...

Objectives: The latest version of the National Comprehensive Cancer Network recommends neoadjuvant therapy followed by surgical treatment or radical chemoradiotherapy for patients with cT3N0M0. Neoadjuvant therapy can improve the prognosis of patients with locally advanced esophageal cancer. Therefore, the evaluation or prediction of T stage is pa...

Background: Fusarium is a conditional pathogen that can cause invasive infection in patients with hematological diseases under immune function. Methods: A case of recurrent and refractory Philadelphia chromosome-positive acute lymphoblastic leukemia was treated with allogeneic hematopoietic stem cell transplantation after chimeric antigen recept...

Objective: This study focused on investigating relation between biglycan (BGN) and decorin (DCN) expression and prognostic outcome for oral squamous cell carcinoma (OSCC) cases. Material and methods: BGN and DCN mRNA and protein expression was detected by qRT-PCR and Western-blotting (WB) assays from 31 OSCC samples as well as healthy samples. T...

Antisense lncRNAs were endogenous productions from the antisense strand of coding genes and were transcribed in the reverse direction of the sense gene. The purpose of this study was to evaluate the roles and functions of antisense lncRNAs in esophageal squamous cell carcinoma (ESCC). Differentially expressed antisense lncRNAs were initially screen...

Background: Neurostimulations for the post-stroke recovery of upper extremity function has been explored in previous research, but there remains a controversy about the superiority of different neurostimulations. Methods: Randomized controlled trials (RCTs) were searched in MEDLINE, Embase, Cochrane Library and ClinicalTrials.gov, from 1 January...

Using the Monte Carlo method, the ferrimagnetic mixed-spin (3/2, 5/2) Ising model is proposed to research the physical properties of graphene cluster monolayer, such as magnetization, susceptibility, internal energy, specific heat and hysteresis loops. The phase diagrams are also gained to investigate the blocking temperature TB and the discontinuo...

Open Source Software (OSS) is forming the spines of technology infrastructures, attracting millions of talents to contribute. Notably, it is challenging and critical to consider both the developers' interests and the semantic features of the project code to recommend appropriate development tasks to OSS developers. In this paper, we formulate the n...

Background: Although Coprinus is widely known for the phenomenon of deliquescence and production of fungal laccases and extracellular peroxygenases, the genome structure and genetic diversity of Coprinus species have not been extensively studied. To reveal the genomic structure and diversity in Coprinus species, the genomes of five Coprinusspecies...

Although Coprinus is widely known for the phenomenon of deliquescence and production of fungal laccases and extracellular peroxygenases, the genome structure and genetic diversity of Coprinus species have not been extensively studied. To reveal the genomic structure and diversity in Coprinus species, the genomes of five Coprinus species were compar...

Background The optimal positions of different types of nebulizer for aerosol delivery remain unclear. Methods Three ICU ventilators employing three types of nebulizer were separately connected to a simulated lung to simulate nebulization during invasive ventilation. Assist/control-pressure control (A/C-PC) mode was utilized, with inspiratory press...

This paper focuses on a ferrimagnetic mixed-spin (3/2, 5/2) Ising model with an ABA sandwich structure for a graphene-like trilayer. By means of Monte Carlo method, the compensation behaviors and hysteresis characteristics of the system are investigated induced by different parameters. It is found that the negative increase of crystal field of subl...

The uncertainty in the quantitative estimates of long-range transport of pollutants in air quality models is large. In this study, based on the Global Nested Air Quality Prediction Modeling System (GNAQPMS-SM), using Latin hypercube sampling (LHS) method, we conducted a base simulation and an ensemble of 1° × 1° simulations in April 2017 to assess...

It remains challenging to determine the regions of metastasis to lymph nodes during operation for clinical stage I non-small cell lung cancer (NSCLC). This study aimed to establish intraoperative mathematical models with nomograms for predicting the hilar-intrapulmonary node metastasis (HNM) and the mediastinal node metastasis (MNM) in patients wit...

A novel adsorbent (MTZ-MOFs) was synthesized by a one-step reaction of zinc nitrate hexahydrate and 1-(2-dimethylaminoethyl)-1H-5-mercaptotetrazole to remove mercury from waste water. The results showed that MTZ-MOFs had excellent selectivity and repeatability for Hg(II), the optimum pH was 3.0, the maximum adsorption capacity was 872.8 mg/g, and t...

There is a positive association between air pollution and lung cancer burden. This study aims to identify and examine lung cancer risks and mortality burdens associated with air pollutants, including PM 10 , NO 2 and SO 2 , in seven eastern metropolises of China. The study population comprised a population from seven eastern metropolises of China....

Banana Fusarium wilt caused by Fusarium oxysporum f. sp. cubense (Foc) is the most destructive soil-borne fungal disease. Tropical race 4 (Foc TR4), one of the strains of Foc, can infect many commercial cultivars, which represents a threat to global banana production. Currently, there are hardly any effective chemical fungicides to control the dise...

By establishing Ising model, we investigated the thermodynamic properties and magnetocaloric effect of a diluted Kekulene-like structure with defects. Under the influence of different exchange coupling and the concentration of magnetic atoms, the changes in some magnetic and thermodynamic quantities including the magnetocaloric effect were discusse...

Two-view knowledge graphs (KGs) jointly represent two components: an ontology view for abstract and commonsense concepts, and an instance view for specific entities that are instantiated from ontological concepts. As such, these KGs contain heterogeneous structures that are hierarchical, from the ontology-view, and cyclical, from the instance-view....

Subsequently to the publication of the above paper, the authors have realized that the image chosen to represent the 'Mimic control' experiment in Fig. 4G was inadvertently selected incorrectly; the data originated from the same source as that chosen (correctly) for the 'Inhibitor control' experiment in the same figure. The revised version of Fig....

Objective: There is still an unmet need for a reliable and straightforward biomarker to diagnose and monitor cow's milk protein allergy (CMPA). Fecal calprotectin (FC) has been reported as a biomarker for CMPA. Therefore, the meta-analysis aimed to evaluate the value of FC in the diagnosis and monitoring of CMPA. Methods: PubMed, EMBASE, and the...

Background Proline metabolism is closely related to the occurrence and development of cancer. Δ1-Pyrroline-5-carboxylate reductase (PYCR) is the last enzyme in proline biosynthesis. As one of the enzyme types, PYCR1 takes part in the whole process of the growth, invasion, and drug resistance of cancer cells. This study investigated PYCR1 expression...

This paper investigated the method of using multiple linear-motor flux pumps to increase the central magnetic field of an HTS magnet composed of six stacking insulated YBCO double pancake coils. In this work, we compared two different excitation methods based on linear-motor flux pumps, i.e., in series excitation and in segmented excitations, to in...

This paper proposed and demonstrated a feedback control method for a high temperature superconducting (HTS) dynamo, which was based on an additional DC coil. This method was based on the theory of macroscopic magnetic coupling effects (MMCE) discovered by Wang and Coombs, "Macroscopic magnetic coupling effect: The physical origination of a high-tem...

High temperature superconducting (HTS) magnets conduct DC currents ranging from hundreds to tens of thousands of amperes. To achieve such DC output amplitudes, conventional power supplies are unsuitable, owing to their extreme cost, energy consumption, and bulkiness. The indispensable current leads of conventional power supplies carrying large DC c...

The magnesium-based alloys are excellent hydrogen storage materials due to outstanding physical and chemical properties. In recent years, ternary magnesium-based alloys have attracted extensive attention of scientists and researchers. In this work, the electronic, elastic and thermodynamic properties of the ternary metallic compounds LaMgRe4 (Re =...

Aiming at the problems of the low grade of rubidium (Rb) in biotite, and long leaching time and low leaching efficiency of Rb in mica ore, the chlorination roasting-assisted ultrasonic enhanced water leaching method was employed to extract Rb from biotite ore in this study. During the chlorination roasting process, the optimal conditions were obtai...