Wei Pang

Wei Pang
Chinese Academy of Sciences | CAS · Kunming Institute of Zoology

About

279
Publications
40,634
Reads
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3,304
Citations
Citations since 2016
180 Research Items
2513 Citations
20162017201820192020202120220100200300400500
20162017201820192020202120220100200300400500
20162017201820192020202120220100200300400500
20162017201820192020202120220100200300400500

Publications

Publications (279)
Article
Full-text available
Eye blinking is closely related to human physiology and psychology. It is an effective method of communication among people and can be used in human–machine interactions. Existing blink monitoring methods include video-oculography, electro-oculograms and infrared oculography. However, these methods suffer from uncomfortable use, safety risks, limit...
Article
Full-text available
At the single-cell level, cellular parameters, gene expression and cellular function are assayed on an individual but not population-average basis. Essential to observing and analyzing the heterogeneity and behavior of these cells/clusters is the ability to prepare and manipulate individuals. Here, we demonstrate a versatile microsystem, a stereo a...
Article
The heartbeat is one of the main human physiological activities and is closely related to psychological and physiological states. Since limited solutions exist for convenient heart rate measurements at the fingertip, such as photoplethysmography, this paper provides an alternative solution enabled by a piezoelectric micromachined ultrasonic transdu...
Article
Full-text available
The emerging SARS-CoV-2 variants, commonly with many mutations in S1 subunit of spike (S) protein are weakening the efficacy of the current vaccines and antibody therapeutics. This calls for the variant-proof SARS-CoV-2 vaccines targeting the more conserved regions in S protein. Here, we designed a recombinant subunit vaccine, HR121, targeting the...
Article
Carbon nanotube (CNT)-based chemiresistors are promising gas detectors for gas chromatography (GC) due to their intrinsic nanoscale porosity and excellent electrical conductivity. However, fabrication reproducibility, long desorption time, limited sensitivity, and low dynamic range limit their usage in real applications. This paper reports a novel...
Article
Interest is growing in the creation of wearable sweat sensors for continuous, low-cost, and noninvasive health diagnosis at the molecular level. The biofouling phenomenon leads to degradation of sweat sensors' performance over time, further limiting the successive monitoring of human health status. However, to date, the mechanism of sweat fouling i...
Article
This letter presents a piezoelectric tuning fork resonator vibrating in in-plane flexural mode with a high quality factor (Q) and low motional impedance. A novel double-sided actuating design is implemented based on unimorph structure with a 2.5- $\mu \text{m}$ -thick AlN film as passive layer. The design significantly improves the Q and motional...
Article
Assessment of the cough severity is essential when dealing with respiratory diseases such as chronic obstructive pulmonary disease and COVID‐19. Although a few wearable devices have been reported for cough detection, they mostly rely on microphones, accelerometers, or throat‐fixed flexible sensors, which suffer from key issues including privacy dis...
Article
Full-text available
Wireless power transfer is one of the enabling technologies for powering implantable biomedical devices. Biocompatibility and CMOS compatibility of wireless power transfer devices are highly desired due to safety and footprint concerns. Toward implantable applications, this paper presents an ultrasound-induced wireless power supply based on AlN pie...
Article
The hydrodynamic method mimics the in vivo environment of the mechanical effect on cell stimulation, which not only modulates cell physiology but also shows excellent intracellular delivery ability. Herein, a hydrodynamic intracellular delivery system based on the gigahertz acoustic streaming (AS) effect is proposed, which presents powerful targete...
Article
Self-contained microfluidic platforms with on-chip integration of flow control units, microreactors, (bio)sensors, etc. are ideal systems for point-of-care (POC) testing. However, current approaches such as micropumps and microvalves, increase the cost and the control system, and it is rather difficult to integrate into a single chip. Herein, we de...
Article
Sensitivity is a key parameter for microspeakers, especially in low-power applications such as consumer electronics, medical devices and Internet of Things. However, the sensitivities of most reported piezoelectric MEMS speakers are inferior to those of commercially available electrodynamic speakers. Design of high-sensitivity piezoelectric MEMS sp...
Article
The transport, enrichment, and purification of nanoparticles are fundamental activities in the fields of biology, chemistry, material science, and medicine. Here, we demonstrate an approach for manipulating nanospecimens in which a virtual channel with a diameter that can be spontaneously self-adjusted from dozens to a few micrometers based on the...
Article
The number of elderly people living with HIV is increasing globally, and the condition of this population is relatively complicated due to the dual effects of aging and HIV infection. However, the impact of HIV infection combined with aging on the immune homeostasis of secondary lymphoid organs remains unclear. Here, we used the simian immunodefici...
Article
Cardiac auscultation is an orthodox method to prevent and diagnose cardiovascular diseases. Traditional stethoscopes cannot offer a highly reliable diagnosis, and electronic stethoscopes suffer from low signal-to-noise ratio (SNR) and high cost. This paper reports an electronic stethoscope based on piezoelectric bimorph MEMS transducers for cardiac...
Article
Contactless acoustic manipulation of micro/nanoscale particles has attracted considerable attention owing to its near independence of the physical and chemical properties of the targets, making it universally applicable to almost all biological systems. Thin-film bulk acoustic wave (BAW) resonators operating at gigahertz (GHz) frequencies have been...
Article
Cell mechanical motion is a key physiological process that relies on the dynamics of actin filaments. Herein, a localized shear-force system based on gigahertz acoustic streaming (AS) is proposed, which can simultaneously realize intracellular delivery and cellular mechanical regulation. The results demonstrate that gold nanorods (AuNRs) can be del...
Article
Currently, researches on nanomaterials have been restricted by slow and multistep synthesis procedures. Herein, we demonstrate an ultrafast, one step method of purification and delivery of quantum dots into living cells, actuated by the acoustic streaming (AS) produced through a gigahertz resonator. Results demonstrate that the impurities in the ca...
Article
Full-text available
Pulmonary microbial invasion frequently occurs during AIDS progression in HIV patients. Inflammatory cytokines and other immunoregulatory factors play important roles in this process. We previously established an AIDS model of SIVmac239 infection in northern pig-tailed macaques (NPMs), which were divided into rapid progressor (RP) and slow progress...
Article
Studies have shown that interferon (IFN)-α has an inhibitory effect on human immunodeficiency virus type 1 (HIV-1) replication in the acute infection stage, but its role in chronic infection is still unclear. We previously established a nonpathogenic HIV-1 and pathogenic simian immunodeficiency virus (SIV) model in northern pig-tailed macaques (NPM...
Article
The presence of chemical warfare agents (CWAs) in the environment is a serious threat to human safety, but there are many problems with the currently available detection methods for CWAs. For example, gas chromatography–mass spectrometry cannot be used for in-field detection owing to the rather large size of the equipment required, while commercial...
Preprint
Full-text available
At the single-cell level, cellular parameters, gene expression and function are assayed on an individual but not population-average basis. Essential to observing and analyzing the heterogeneity and behavior of these cells/clusters is the ability to prepare and manipulate individual. Here, we demonstrate a versatile microsystem, a stereo acoustic st...
Article
The development of Internet of Things (IoT) requires demanding accurate and low-power indoor localization. In this article, a high-precision 3-D ultrasonic indoor localization system with ultralow power is proposed. A new piezoelectric micromachined ultrasonic transducer (PMUT) chip with a slotted membrane is designed and fabricated as a receiver,...
Article
As $a$ common and natural activity of human beings, eye movement has been regarded as an indicator of human physiological and psychological health; eye movement tracking has been applied to $a$ wide range of domains, such as disease diagnostics, drug therapy testing and human-computer interaction. Conventionally, eye movement is captured by thr...
Article
Developing miniature smart electrochemical sweat sensors to perform continuous and noninvasive health diagnosis at molecule level is in the spotlight. Sensor's biofoulings hinder the targets' approaching, decreasing the detection sensitivity over time and further limiting the accurate analysis. Effective cleaning to remove biofoulings on electroche...
Article
Acoustofluidics has emerged as a promising method for submicron particle manipulation. However, ultrahigh‐frequency or focused sound waves are usually required to generate sufficient acoustic radiation force or localized streaming vortex for trapping nanoscale objects, which is more challenging in device fabrication. This work presents a novel meth...
Article
Full-text available
A microfluidic film bulk acoustic wave resonator gas sensor (mFBAR) adapted specifically as an in-line detector in gas chromatography was described. This miniaturized vapor sensor was a non-destructive detector with very low dead volume (0.02 μL). It was prepared by enclosing the resonator in a microfluidic channel on a chip with dimensions of only...
Article
Full-text available
Background As the transmission routes of human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) are similar, previous studies based on separate research on HIV-1 and HCV assumed a similar transmission pattern. However, few studies have focused on the possible correlation of the spatial dynamics of HIV-1 and HCV among HIV-1/HCV coin...
Article
Full-text available
Although spermatogenic dysfunction is widely found in patients with human immunodeficiency virus (HIV), the underlying reasons remain unclear. Thus far, potential hypotheses involving viral reservoirs, testicular inflammation, hormone imbalance, and cachexia show inconsistent correlation with spermatogenic dysfunction. Here, northern pig-tailed mac...
Article
This paper investigates the mechanism of a new acoustic micro-ejector using a Lamb wave transducer array, which can stably generate picoliter (pL) droplet jetting without nozzles. With eight transducers arranged as an octagon array, droplets are ejected based on the mechanism of combined acoustic pressure waves and acoustic streaming. The acoustic...
Article
The development of rapid and efficient tools to modulate neurons is vital for the treatment of nervous system diseases. Here, a novel non-invasive neurite outgrowth modulation method based on a controllable acoustic streaming effect induced by an electromechanical gigahertz resonator microchip is reported. The results demonstrate that the gigahertz...
Article
HIGHLIGHTS • A proposed microsystem system potentially provides accurate and calibration-free measurements based on a combination of front-end particulate matter (PM) separation and back-end PM detection. • Silicon dioxide particles are used to verify the performance of the system’s virtual impactor, and an accurate cutoff diameter of 2 μm in low a...
Article
Full-text available
Hydrodynamic force loading platforms for controllable cell mechanical deformation play an essential role in modern cell technologies. Current systems require assistance from specific microstructures thus limiting the controllability and flexibility in cell shape modulation, and studies on real‐time 3D cell morphology analysis are still absent. This...
Article
Full-text available
Cointegration and coupling a perfect metamaterial absorber (PMA) together with a film bulk acoustic wave resonator (FBAR) in a monolithic fashion is introduced for the purpose of producing ultracompact uncooled infrared sensors of high sensitivity. An optimized ultrathin multilayer stack was implemented to realize the proposed device. It is experim...
Article
Full-text available
Acoustic manipulation of submicron particles in a controlled manner has been challenging to date because of the increased contribution of acoustic streaming which leads to fluid mixing and homogenization. This article describes the patterning of submicron particles and the migration of their patterned locations from pressure nodes to antinodes in n...
Conference Paper
Full-text available
Rapid separation of sub-micron particles based on surface acoustic waves (SAWs) have been remained as challenges as there are lots of demands for such technologies in fundamental biomedical research and frontier developments of diagnosis devices. In this paper, a frequency of 409 MHz SAW actuated digital micro-centrifugal chip is demonstrated for r...
Article
This article proposes a novel structured aluminum nitrate (AlN) thin film based piezoelectric micromachined ultrasonic transducer (PMUT) with superior ultrasonic performances that can directly be applied for pulse-echo imaging. The bottom electrode of the PMUT is thickened and serves both as the electrical layer and supporting layer. Large numbers...
Article
Full-text available
The 2019 novel coronavirus (SARS-CoV-2) outbreak is a major challenge for public health. SARS-CoV-2 infection in human has a broad clinical spectrum ranging from mild to severe cases, with a mortality rate of ~6.4% worldwide (based on World Health Organization daily situation report). However, the dynamics of viral infection, replication and sheddi...
Conference Paper
This work reports a novel acoustic resonator system integrated dual functions of biological samples capture and amount monitoring on a single chip. The system could capture samples from nano-sized proteins to micro-sized cells on micro-sized chip precisely with controllable concentration, meanwhile the high sensitivity mass sensing was achieved dur...
Conference Paper
Quantitation of protein biomarker featured with portability, rapidity, high sensitivity is critical for the point-of-care testing (POCT) application. Herein, a novel smartphone-enabled microfluidic chemiluminescence platform for the quantitation of prostate specific antigen (PSA) was proposed based on acoustic tweezers approach. The primary antibod...
Article
This paper reports a multi-spectral infrared chemical sensor based on a virtual array of bulk acoustic wave resonators with different frequencies. The plasmonic metasurfaces with different patterns on the top surface of resonators provide high IR absorption without degradation of resonating performance. The metasurfaces enhance the frequency respon...
Article
Full-text available
Background: Estimating the prevalence and characterizing the transmission of HIV-1 drug resistance in treatment-naïve individuals are very important in the prevention and control of HIV/AIDS. As one of the areas most affected by HIV/AIDS, few data are currently available for HIV-1 drug resistance in antiretroviral therapy (ART)-naïve individuals i...
Article
Objectives Infectious Zika viral particles were detected in human milk; however, whether they can be transmitted via breastfeeding remains unknown. Methods Here, in a natural breastfeeding model, wild-type (C57Bl/6; WT) or interferon α/β (IFNα/β) receptor-deficient (A129; KO) murine dams on day 1 post-delivery were infected with Zika virus (ZIKV)...
Article
Gravimetric resonators based on Micro/Nanoelectromechanical System (M/NEMS) are potential candidates in developing smaller, less expensive, and higher performance gas sensors. Metal organic frameworks (MOFs), with high surface areas, recently come into focus as advanced nano-porous sensitive materials in micro gravimetric gas sensors. The surface o...
Article
APOBEC3 family members, particularly APOBEC3F and APOBEC3G, are important cellular antiviral factors. Recently, more attention has been paid to targeting APOBEC3G for AIDS therapy. To appropriately utilize macaque animal models for the study of APOBEC3-related issues, it is important that the differences between human and macaque APOBEC3s are clari...
Article
Performance of electroanalytical lab-on-a-chip devices is often limited by the mass transfer of electroactive species towards the electrode surface, due to the difficulty in applying external convection. This article describes the powerful signal enhancement attained with a 2.54 GHz miniature acoustic resonator integrated with an electrochemical de...
Article
Microbial translocation is a cause of systemic immune activation in HIV/SIV infection. In the present study, we found a lower CD8+ T cell activation level in Macaca leonina (northern pig-tailed macaques, NPMs) than in Macaca mulatta (Chinese rhesus macaques, ChRMs) during SIVmac239 infection. Furthermore, the levels of plasma LPS-binding protein an...
Article
Full-text available
Film bulk acoustic wave resonators have demonstrated great potential in the detection of volatile organic compounds owing to their high sensitivity, miniature size, low power consumption, capacity for integration, and other beneficial characteristics. However, it is necessary to functionalize the surfaces of these resonators to enhance the adsorpti...
Article
This paper presents a 429 MHz flexible Lamb wave resonator based on lithium niobate thin films with a high figure of merit (FoM) of 205, which is about 10 times higher than the FoM of the flexible resonator presented in our previous work. The measured corresponding quality factor (Q) and electromechanical coupling coefficient (Kt²) are 1268 and 16....
Article
Full-text available
Background Controllable and multiple DNA release is critical in modern gene-based therapies. Current approaches require complex assistant molecules for combined release. To overcome the restrictions on the materials and environment, a novel and versatile DNA release method using a nano-electromechanical (NEMS) hypersonic resonator of gigahertz (GHz...
Article
Full-text available
The health effects of suspended particulate matter (PM) in the air are well documented; however, there is a lack of convenient tools to recognize and quantify PM onsite. Here, we design and fabricate a portable PM analysis system to realize onsite aerosol particle analysis. The system contains a micromachined virtual impactor (VI), a thermophoretic...