Wei-Min Liu

Wei-Min Liu
Taipei Medical University | TMU · Department of Obstetrics and Gynecology

Doctor of Medicine

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130
Publications
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Introduction
Skills and Expertise

Publications

Publications (130)
Article
Background: Robotic total hysterectomies have been considered contraindicated for patients with intra-abdominal adherences, but the evidence for this is not strong, and we hypothesized that the procedure can be of benefit even in these cases. In our research, we analyzed how the severity of pelvic adhesions affect robotic total hysterectomy, and b...
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Objectives: To compare the survival outcomes between minimally invasive surgery (MIS) and laparotomy radical hysterectomy in patients with early-stage cervical cancer. Methods: We conducted a retrospective study involving women who received a radical hysterectomy for cervical cancer, stage IA1 with lymphovascular invasion, IA2, IB1, IB2, or IIA...
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Background/aim: The purpose of this study was to evaluate the learning curve of robotic hysterectomy and pelvic lymphadenectomy for early-stage endometrial carcinoma. Patients and methods: A retrospective chart review was performed on the first 81 surgeries performed by a single surgeon. The 81 cases were divided into three groups; 4 subgroups o...
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Intrauterine adhesion (IUA), and its severe form Asherman syndrome (Asherman’s syndrome), is a mysterious disease, often accompanied with severe clinical problems contributing to a significant impairment of reproductive function, such as menstrual disturbance (amenorrhea), infertility or recurrent pregnancy loss. Among these, its correlated inferti...
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Objective: To report a case with benign bilateral ovarian tumor during pregnancy mimicking malignancy. Case report: A 32-year-old women at 20 weeks gestation with large bilateral adnexal masses found on prenatal ultrasound. The cysts had been growing gradually over the course of the pregnancy. MRI show huge multiple cysts in both ovaries. CA-125...
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Radical hysterectomy (RH) is the standard treatment for early stage cervical cancer, but the surgical approach for locally bulky-size cervical cancer (LBS-CC) is still unclear. We retrospectively compared the outcomes of women with LBS-CC treated with neoadjuvant chemotherapy (NACT) and subsequent RH between the robotic (R-RH) and abdominal approac...
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Backgrounds: Robotic surgeries have been used frequently for benign diseases in gynecology. However, the advantage of robotic surgery for huge uterus is unclear. Methods: We analyzed surgical outcomes of 527 patients who underwent robotic hysterectomies for benign diseases, separating uterine sizes into five groups by every 250 g. Results: Med...
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Methylene blue is commonly used as a tracer in sentinel lymph node mapping for many malignant diseases or chromopertubation during gynecologic laparoscopy. In contrast with other blue dyes such as patent blue V or isosulfan blue, methylene blue rarely causes an allergy-like reaction in patients undergoing sentinel lymph node mapping. However, in ch...
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Objective Carcinosarcomas also known as malignant mixed mullerian tumors (MMMTs) contain both carcinomatous and sarcomatous elements. Most MMMTs are arising from female genital tract, including ovaries, uterus and fallopian tubes. Extragenital carcinosarcomas are extremely rare, with an estimation less than 40 cases so far. Case report We report t...
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Purpose: To summarize available evidence from randomized-controlled trials which have evaluated triggering of final oocyte maturation with concomitant GnRH agonists and hCG in patients undergoing IVF, and to analyze whether dual triggering is as efficacious as hCG triggering in terms of oocyte and pregnancy outcomes. Methods: A comprehensive lit...
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Objective: A Krukenberg tumor is a malignancy in the ovary that metastasizes from a primary site. Here, we report a very rare case of bilateral Krukenberg tumors of the ovaries arising from a primary adenocarcinoma of the small intestine in a 53-year-old Taiwanese woman. Case report: The patient presented with a 3-month history of abdominal dist...
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Adenomyosis (variant diseases of the endometriosis) is still a biggest challenge for both physicians and patients [1e3]. Common symptoms and signs include an elevated of serum level of CA 125, dysmenorrhea, menorrhagia, and infertility [4,5]. Because of poor understanding of pathophysiology of adenomyosis [6], the current treatment strategy might b...
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Objective: We report a rare case of vaginal cuff dehiscence with small bowel evisceration at 7 months post robotic-staging surgery. Case Report: A 41-year-old woman was sent to the emergency room with sudden onset of abdominal pain, vaginal bleeding, and vaginal protruding mass after sexual activity. She had a history of synchronous uterine and ova...
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Objective: To evaluate outcomes after nonobstetric surgical procedures in pregnant patients. Methods: We conducted a retrospective cohort study of 5591 pregnant women who underwent nonobstetric surgical procedures using Taiwan's National Health Insurance Research Database 2008-2012 claims data. Using a propensity score matching procedure, 22,364...
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Objective: To review and evaluate the potential adverse effects of these oral contraceptives (OCP) to overweight women. Case Report: A 19-year-old college student, with a body mass index (BMI) of 35.2 kg/m2, who received 2 months of OCP containing cyproterone and ethinyl estradiol for polycystic ovary syndrome (PCOS)-related menstrual problems was...
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Background: The aim of this study is to evaluate perioperative complications related to robotic-assisted laparoscopic surgery for management of gynaecologic disorders. Materials and methods: Eight hundred and fifty-one women who underwent robotic procedures between December 2011 and April 2015 were retrospectively included for analysis. Patient...
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Based on the significant inhibitory activity toward matrix metalloproteinase-2 and collagenase noticed in preliminary studies, crude extracts of Rhodiola rosea were partitioned and chromatographed sequentially to afford three new compounds, 1,2,3,6-tetra-O-galloyl-4-O-p-hydroxybenzoyl-β-D-glucopyranoside (1), (E)-creoside I (2), and (R,Z)-2-methylh...
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Robotic assisted staging surgery has been increasingly employed for a variety of gynecological malignancies such as ovarian, endometrial, and cervical cancers. Here we demonstrate a hand-assisted robotic approach for managing ovarian cancer with large tumor mass and predominantly solid components, where mini-laparotomy is performed followed by robo...
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A major challenge in personalized cancer medicine is to establish a systematic approach to translate huge oncogenomic datasets to clinical situations and facilitate drug discovery for cancers such as endometrial carcinoma. We performed a genome-wide somatic mutation-expression association study in a total of 219 endometrial cancer patients from TCG...
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The induction of detoxifying enzymes and antioxidant proteins by chemopreventive agents protects cells from oxidizing substances capable of damaging DNA integrity and initiating carcinogenesis. Coniferyl aldehyde, a naturally-occurring substance, was found in many foods and edible plants. We and others previously demonstrated that trans-coniferylal...
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Despite considerable interest in the Nuclear factor-erythroid 2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein-1 (Keap1), p16 and epithelial cadherin (E-cadherin) activation in carcinoma progression, contradictory results regarding association of Nrf2/Keap1/E-cadherin and p16 expression with clinico-pathological features and prognosis ha...
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The purpose of this study was to evaluate the feasibility of robotic surgery and compare its surgical outcomes with those of laparoscopic surgery and laparotomy, with regard to performing staging surgery to manage ovarian cancer. One hundred and thirty-eight women who received surgical staging procedures for treatment of stage IA-IIIC epithelial ov...
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Currently, benefits of robotic surgery in patients with benign gynecological conditions remain unclear. In this study, we compared the surgical outcome of robotic and laparoscopic total hysterectomies and evaluated the feasibility of robotic surgery in cases with pelvic adhesions or large uterus. A total of 216 patients receiving total hysterectomy...
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Robotic surgery has been applied in managing various types of gynecologic cancers. The purpose of this study is to compare the surgical outcomes of robotic surgery, laparoscopy and laparotomy for managing endometrial cancer. A total of 365 patients received surgical staging for treating IA to IIIC endometrial cancer were retrospectively enrolled. P...
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This article reports a rare case of cancer derived from ovarian remnant tissue. A 52-year-old woman, with a history of a total hysterectomy and bilateral salpingo-oophorectomy for uterine myomas and endometriosis 13 years ago, presented with a pelvic mass accompanied by high serum levels of CA125 and CA199. Exploratory laparotomy and pathology repo...
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Objective: The aim of this study was to compare the outcomes of robotic surgery, laparoscopy, and laparotomy for the surgical treatment of stage IA to IIB cervical cancer. Methods: This retrospective study was carried out in a university-affiliated teaching hospital. A total of 100 women with an initial diagnosis of stage IA to IIB cervical canc...
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Adenomyosis of the uterus is defined as the presence of endometrial tissue, including glands and stroma, situated at least 2.5 mm below the endometrial-myometrial junction and widely distributed within the myometrium layer of the uterus. There is no consensus on the appropriate treatment for symptomatic uterine adenomyosis in women who want to pres...
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Objectives We sought to evaluate the feasibility of laparoscopic pelvic lymph node dissection (PLND) and para-aortic lymph node dissection (PALND) using a thermal ligating shears (TLS) thermal welding instrument comparing with the conventional laparotomic PLND and PALND in the management of endometrial cancer. Materials and methods The current stu...
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The objective of this study is to present a rare case of pregnancy complicated with ovarian cancer managed by robotic surgery. A 36-year-old woman suffered from sudden onset of lower abdominal pain during her pregnancy at 14 weeks of gestation. As malignancy was highly suspected, left salpingo-oophorectomy, bilateral pelvic lymph node dissection, a...
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Objectives The safety and efficacy of the RevoLix 2-μ continuous wave laser for hysteroscopic myomectomy (HM) was evaluated. Materials and methods A retrospective study was undertaken to evaluate 13 patients with symptomatic submucous myomas, who were treated with HM using a RevoLix laser application. The evaluation items included blood loss from...
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Sexual dysfunction refers to difficulties that occur during the sexual response cycle that prevent the individual from experiencing satisfaction from sexual activity. It is relatively difficult to estimate the prevalence of female sexual dysfunction (FSD), because the definition and diagnostic criteria are still controversial and under development....
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The aim of our study was to assess the long-term efficacy of conservative surgery combined with gonadotropin-releasing hormone agonist therapy for uterine adenomyoma. We carried out an uncontrolled descriptive study of 285 women who had symptomatic uterine adenomyoma. A total of 186 women with pathologically proven adenomyoma underwent ultramini-la...
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The diagnosis and treatment of adnexal mass during pregnancy is a major challenge for obstetricians. A rare case is reported of retroperitoneal cystic lesion during pregnancy. A 31-year-old woman was diagnosed with an adnexal cystic lesion at 8 weeks of gestation and underwent laparoscopic surgery at 14 weeks of gestation. During laparoscopic surge...
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The aim of this study was to evaluate the short-term therapeutic outcome of women with symptomatic uterine myomas treated with laparoscopic uterine vessel occlusion (LUVO) or laparoscopic myomectomy (LM). Ninety-five patients with symptomatic, uncomplicated myomas warranting surgical treatment who expressed a strong desire to retain their uterus we...
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Menopausal experience differs among women with different cultural and ethnic backgrounds and may impact quality of life. Some women with severe menopausal symptoms seek medical help to alleviate menopause-related symptoms. This study examined the demographic characteristics and health-related quality of life (HRQOL) of Taiwanese women experiencing...
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In Taiwan, the establishment of public art or art exhibitions and performances has become a public relations trend of large hospitals. To meet the public's needs, medical facilities provide patients with not only top-quality medical treatment, but also a comfortable and relaxing hospital environment to facilitate recovery from disease and shorten t...
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To assess the feasibility of laparoscopic-guided local injection of etoposide or methotrexate (MTX) in the management of unruptured tubal pregnancy and compare the effectiveness of the two regimens. Retrospective cohort study. Medical center. Thirty-one women with laparoscopically diagnosed unruptured tubal pregnancy. A regimen of etoposide 50 mg v...
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To investigate alterations of integrin α(v), survival and apoptosis signaling pathways in uterine leiomyomas. In a prospective study of 50 women with uterine leiomyomas that had been pathologically confirmed, specimens were obtained laparoscopically from 2007 to 2009. The expressions of integrin α(v) signaling pathways (Ras/Raf/ERK1/2, Akt and clea...
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To assess the effect on FSH of the application of different types of uterine vessel blockage (uterine artery occlusion alone [UAO] or with blockage of vessel anastomosis [UVO]) in the management of women with fibroids.