Wayne B Jonas

Wayne B Jonas
H&S Ventures · Samueli Integrative Health Programs

M.D.

About

155
Publications
80,695
Reads
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5,414
Citations
Introduction
Wayne B. Jonas, MD is the Executive Director of the Samueli Integrative Health Programs at H&S Ventures. He is a widely published scientific investigator, a practicing family physician, Professor of Family Medicine at Georgetown University, and at the Uniformed Services University of the Health Sciences.
Additional affiliations
January 2007 - present
Georgetown University
Position
  • Professor
July 2001 - December 2016
Samueli Institute
Position
  • CEO
Description
  • Samueli Institute is a non-profit research organization dedicated to creating a flourishing society by advancing the science of healing by applying academic rigor to research on healing, well-being and resilience.

Publications

Publications (155)
Article
Full-text available
Background: Cancers are one of the leading causes of mortality worldwide. Cancer patients are increasingly seeking integrative care clinics to promote their health and well-being during and after treatment. Aim: To examine relationships between physical activity (PA) and quality of life (QoL) in a sample of cancer patients enrolling in integrative...
Article
A new, integrative approach to care is changing the way veteran and military health care is practiced.
Article
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The placebo response is a myth. It does not exist in reality, and continuing to name it is hindering the optimal application of science to healing in medicine. On the surface, it is obvious that, when defined as a biological response to an inert pill (like a sugar pill), the idea of a “response” to a placebo is impossible. Inert treatments by defin...
Article
The hypothalamus has emerged as a novel neurogenic niche in the adult brain during the past decade. However, little is known about its regulation and the role hypothalamic neurogenesis might play in body weight and appetite control. High-fat diet (HFD) has been demonstrated to induce an inflammatory response and to alter neurogenesis in the hypotha...
Article
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Objective: To assess the evidence for the safety and efficacy of invasive procedures for reducing chronic pain and improving function and health-related quality of life compared with sham (placebo) procedures. Design: Systematic review with meta-analysis. Methods: Studies were identified by searching multiple electronic databases, examining re...
Technical Report
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The health of a force is crucial to its Military readiness. Decreasing military budgets, global economic stagnation, and increasing medical healthcare cost threaten the sustainability of Military healthcare systems. Furthermore, these conditions risk both the individual’s as well as the organization’s collective health status significantly. Therefo...
Article
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Background: Grounding health claims in an evidence base is essential for determining safety and effectiveness. However, it is not appropriate to evaluate all healthcare claims with the same methods. "Gold standard" randomized controlled trials may skip over important qualitative and observational data about use, benefits, side effects, and prefere...
Article
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Background: Answering the question of "what works" in healthcare can be complex and requires the careful design and sequential application of systematic methodologies. Over the last decade, the Samueli Institute has, along with multiple partners, developed a streamlined, systematic, phased approach to this process called the Scientific Evaluation...
Article
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Background: The evaluation of freestanding integrative cancer clinical programs is challenging and is rarely done. We have developed an approach called the Claim Assessment Profile (CAP) to identify whether evaluation of a practice is justified, feasible, and likely to provide useful information. Objectives: A CAP was performed in order to (1) c...
Article
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Purpose: Nonspecific factors that accompany healthcare treatments, such as patients' attitudes and expectations, are important parts of the experience of care and can influence outcomes. However, no precise, concise, and generalizable instruments to measure these factors exist. We report on the development and calibration of new item banks, titled...
Article
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Objectives: The benefit and potential mechanisms of action of homeopathy have long been debated. Almost entirely neglected has been the study of individualized homeopathy (IH) as a form of psychotherapy, which incorporates factors that are common to most therapies while using processes that are specific to IH. Methods: Recent research into the t...
Article
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Background: Headaches are prevalent among Service members with traumatic brain injury (TBI); 80% report chronic or recurrent headache. Evidence for nonpharmacologic treatments, such as acupuncture, are needed. Objective: The aim of this research was to determine if two types of acupuncture (auricular acupuncture [AA] and traditional Chinese acupunc...
Article
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Conflicts of interest: The views expressed in this article are those of the authors and do not reflect the official policy of the Department of Army/Navy/Air Force, Department of Defense, or United States Government. There are no conflicts of interest to report. Disclosure: The Evidence for Massage Therapy (EMT) Working Group (diverse stake-holder...
Article
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We provide a new perspect ve with which to understand what for a half century has been known as the »placebo effect.« We argue that, as currently used, the concept includes much that has nothing to do with placebos, confusirig the most interesting and important aspects of the phenomenon. We propose a new way to understand those aspects of medical c...
Article
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Background With rising health care costs and the diversity of scientific and clinical information available to health care providers it is essential to have methodologies that synthesize and distill the quality of information and make it practical to clinicians, patients and policy makers. Too often research synthesis results in the statement that...
Article
Full-text available
Person-centered care is a burgeoning social movement and a mission statement for modern healthcare. However, it is not a new idea. Often called the father of modern medicine, William Osler said, “The good physician treats the disease; the great physician treats the patient who has the disease.”1 Social movements typically begin with common issues b...
Article
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Objectives To assess the quantity and quality of randomised, sham-controlled studies of surgery and invasive procedures and estimate the treatment-specific and non-specific effects of those procedures. Design Systematic review and meta-analysis. Data sources We searched PubMed, EMBASE, CINAHL, CENTRAL (Cochrane Library), PILOTS, PsycInfo, DoD Biome...
Article
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In this article, we describe barriers to the entry of biofield healing into mainstream contemporary science and clinical practice. We focus on obstacles that arise from the social nature of the scientific enterprise, an aspect of science highlighted by the influential work of Thomas Kuhn (1922-1996), one of the most important- and controversial-phi...
Article
Full-text available
Systematic reviews (SRs) are widely recognized as the best means of synthesizing clinical research. However, traditional approaches can be costly and time-consuming and can be subject to selection and judgment bias. It can also be difficult to interpret the results of a SR in a meaningful way in order to make research recommendations, clinical or p...
Article
Full-text available
We live in an age of unparalleled technological and scientific progress, juxtaposed with a cascading series of poor social, health, and environmental choices that could bring our species to the brink of catastrophe. Within the past 100 years alone, we have created significant advances in technologies to better control disease outbreaks, extend our...
Article
Background: Post-traumatic stress disorder (PTSD) is a widely recognized consequence of deployment, combat exposure, and trauma. Postdeployment PTSD commonly co-occurs with other medical problems and mood disorders to include depression, suicidality, substance-abuse disorders, anxiety disorders, and chronic pain. These mind and body injuries, and t...
Article
In Reply Advances in medical care depend on well-controlled randomized clinical trials to validate the safety and efficacy of new interventions and to ensure that clinicians understand the active components.¹ Hyperbaric oxygen (HBO) treatment is a very time-consuming and costly procedure that is not without harmful effects. Nevertheless, HBO treatm...
Article
Full-text available
There is universal agreement that a healing environment is desirable for patients and for providers. What constitutes a healing environment is open to discussion and depends on individual perspectives. The Samueli Institute coined the term Optimal Healing Environment (OHE) in 2004 to describe a healthcare system that is designed to stimulate and su...
Article
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We appreciate the effort by Schwarzkopf to examine alternative explanations for predictive anticipatory activity (PAA) or presentiment (for first response, see: Schwarzkopf 2014a; for additional response, see: Schwarzkopf 2014b, for original article, see: Mossbridge et al. 2014). These commentaries are a laudable effort to promote collegial discuss...
Article
Background: Initial posttraumatic stress disorder (PTSD) care is often delayed and many with PTSD go untreated. Acupuncture appears to be a safe, potentially nonstigmatizing treatment that reduces symptoms of anxiety, depression, and chronic pain, but little is known about its effect on PTSD. Methods: Fifty-five service members meeting research...
Article
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Introduction: Previous studies of omega-3 fatty acids report improved outcomes where inflammation is a key factor. The objective of this systematic review is to evaluate effects of omega-3s on inflammatory biomarkers. Methods: Randomized clinical studies that measured the influence of omega-3 fatty acids on inflammatory biomarkers were identifie...
Article
Background: In the recent past, numerous natural disasters and wars have resulted in casualties on site that have been treated successfully by trained personnel using holistic medical techniques, including acupuncture, hypnosis, yoga, biofeedback and other techniques. Adaptations of several of these medical modalities may be taught to first respond...
Article
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As clinicians and the public move from a pathological (disease-focused) to a salutogenic (health-focused) understanding of the human condition, protective factors contributing to the health of individuals and societies have received more attention. The study of resilience is a foundational aspect of this critical shift and a promising way to unders...
Article
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In the documentary movie Escape Fire,¹ a battle-weary and combat-wounded soldier falls out of his bunk during a medical evacuation flight from Afghanistan to Washington, DC. Disoriented from an overdose of opioid and psychoactive medications previously prescribed for his wounds, pain, and loss, he later embarks on a journey of self-healing in an ef...
Article
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Researchers are increasingly focused on the nanoscale level of organization where biological processes take place in living systems. Nanoparticles (NPs, e.g., 1-100 nm diameter) are small forms of natural or manufactured source material whose properties differ markedly from those of the respective bulk forms of the "same" material. Certain NPs have...
Article
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A decade ago, we published several articles that described our definitions of healing and of healing-oriented practice and environments (HOPE) and how they are organized to create an optimal healing environment (OHE) as they apply to healthcare. We also provided a description of the seven domains and their elements that constitute an OHE.1 In the e...
Article
Chronic pain is a major problem and takes a terrible toll not only on individuals suffering from chronic pain but also on our health care system at large. Addressing it is the responsibility of us all, but we have fallen into a trap. The massive amount of money invested in research, advertising, and delivery of drugs (nearly $30 billion a year in e...
Article
Chronic pain management typically consists of prescription medications or provider-based, behavioral, or interventional procedures which are often ineffective, may be costly, and can be associated with undesirable side effects. Because chronic pain affects the whole person (body, mind, and spirit), patient-centered complementary and integrative med...
Article
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A systematic review was conducted using Samueli Institute's rapid evidence assessment (REAL©) methodology, to rigorously assess both the quality of the research on active, self-care complementary and integrative medicine (ACT-CIM) modalities and the evidence for their efficacy and effectiveness in treating chronic pain symptoms. Each of the followi...
Article
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A recent meta-analysis of experiments from seven independent laboratories (n = 26) indicates that the human body can apparently detect randomly delivered stimuli occurring 1–10 s in the future (Mossbridge etal., 2012). The key observation in these studies is that human physiology appears to be able to distinguish between unpredictable dichotomous f...
Conference Paper
Albert A. de Graaf, Jan van der Greef, John Ives, Wayne Jonas Resilience is a popular construct that continues to be operationalized as either psychological or physiological in nature, with few to no operational definitions that encompass and integrate mental, emotional, social, and physiological components. Understanding and tracking resilience f...
Article
Full-text available
We conducted a systematic review (SR) of the peer reviewed scientific literature on ultraweak photon emissions (UPE) from humans. The question was: Can ultraweak photon emissions from humans be used as a non-invasive health assessment? A systematic search was conducted across eight relevant databases: PubMed/MEDLINE, BIOSIS, CINAHL, PSYCHINFO, All...
Chapter
Management of pain is an essential responsibility in medicine. With the advance of surgical technologies, the use of interventional and other invasive methods to treat pain has become prominent and growing in use. Yet, rarely are these techniques evaluated in a way that can separate their specific impact on pain from expectation and context effects...
Conference Paper
Systematic reviews are widely recognized as the best means of synthesizing clinical research; however traditional approaches can be costly and time-consuming, and the results may be difficult to interpret in a meaningful way in order to make research recommendations or clinical decisions about implementation. In order to bridge this gap, Samueli In...
Conference Paper
The push towards grounding healing claims in an evidence base is underway. It is not appropriate to evaluate all claims of healing with the same methods. The gold standard RCT may skip important qualitative and observational data about use, impacts, and benefits. This gap has prompted a move towards studying treatments in their naturalistic setting...
Conference Paper
Despite widespread use and benefit claims for serious disease, relatively little research has been established regarding the efficacy and safety for the majority of healing practices. Given the diversity of scientific and clinical information available to health care providers, it is essential to have methodologies that synthesize and distill the q...
Conference Paper
A systematic review is the gold standard approach for integrating evidence-based information and assessing gaps in healthcare, which require a specific and precise methodology not always taught in educational institutions or applied in practice. This lack in knowledge on how to properly conduct a systematic review impedes the development of rationa...
Article
Full-text available
Combat-exposed troops and their family members are at risk for stress reactions and related disorders. Multimodal biopsychosocial training programs incorporating complementary and alternative self-management techniques have the potential to reduce stress-related symptoms and dysfunction. Such training can preempt or attenuate the posttraumatic stre...
Article
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Medical practices that reside outside the mainstream medical structures have existed for centuries, often waxing and waning in prominence and use for various reasons. Recently, there has been a resurgence in interest and use of such practices in the USA generally referred to under the label of 'complementary and alternative medicine' (CAM). In this...
Chapter
Understanding the detrimental effects that geochemical processes and environmental pollutants may have on the health of humans and animals has been the subject of extensive study in medical geology and environmental pathology. For example, information obtained from the chemical analysis of mineral deposits in tissues may provide insight into a part...
Data
Appendix 1. SIGN 50 Criteria and Scores.
Article
We all have a good idea of how we want things to go when we visit a physician. We expect to be able to explain why we are there, and we hope the physician will listen and possibly ask questions that help us clarify our thoughts. Most of us hope that the physician will provide some expression of empathy, offer a clear, nontechnical assessment of our...
Article
Full-text available
The long wars in Iraq and Afghanistan have produced extensive and often repeated trauma to United States service members and their families. These injuries occur to the mind, the brain, the body and the soul. The current approach to management of these injuries follows the standard medical model that attempts to isolate the pathophysiological locat...
Article
Full-text available
Background: Exposure to deployment and battle can induce a constellation of physical, cognitive, psycho-logical, and behavioral symptoms, also referred to as war-related Trauma Spectrum Response (wrTSR). One prevalent cause of this response is traumatic brain injury (TBI) and its ensuing sequelae, such as pain and suffering caused by post-traumatic...
Article
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Background: In recent years, both the Department of Defense (DoD) and Department of Veterans Affairs (VA) have begun to turn to complementary and integrative medicine (CIM) therapies to help address chronic physical (pain) and psychological (post-traumatic stress disorder, anxiety, depression) conditions. One of the most prominent CIM therapies for...
Article
Full-text available
The terms 'placebo' and 'placebo effects' cause confusion among patients, practitioners and scientists. This confusion results in both the adoption of practices that have no evidence of specificity yet considerable risk (such as surgery for low back pain) or the elimination of clinical practices proven to facilitate healing because they are not 'be...
Article
To systematically review placebo-controlled randomized trials of homeopathy for psychiatric conditions. Eligible studies were identified using the following databases from database inception to April 2010: PubMed, CINAHL, PsycINFO, Hom-Inform, Cochrane CENTRAL, National Center for Complementary and Alternative Medicine grantee publications database...
Book
Neuroscience, Consciousness and Spirituality presents a variety of perspectives by leading thinkers on contemporary research into the brain, the mind and the spirit. This volumes aims at combining knowledge from neuroscience with approaches from the experiential perspective of the first person singular in order to arrive at an integrated understand...
Article
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BACKGROUND/CONTEXT: There is growing recognition within the field of medicine that healing and healing relationships are important and that developing evidence-based medicine approaches to healing should be an important aspect of this emerging field, including the use of systematic reviews. Health care leaders charged with developing healing initia...
Article
Full-text available
This paper presents the case that certain types of homeopathic medicine may represent a form of hormesis, that is, either pre- or post-conditioning hormesis. An example of a post-conditioning model by van Wijk and colleagues demonstrated successful enhancement of adaptive responses using below-toxic threshold doses (i.e. hormetic doses) of inducing...
Article
The concept of hormesis can provide an evaluation framework for the assessment of homeopathic treatment preparations following a post-conditioning hormesis protocol based on the research of van Wijk and colleagues. This proposal would require that doses of administered drug conform to analytical chemistry requirements for quantification. This devel...
Article
To analyze the solutes leaching from glass containers into aqueous solutions, and to show that these solutes have enzyme activity stabilizing effects in very dilute solutions. Enzyme assays with acetylcholine esterase were used to analyze serially succussed and diluted (SSD) solutions prepared in glass and plastic containers. Aqueous SSD preparatio...