Wayne Danter

Wayne Danter
123Genetix · Research and Development

Doctor of Medicine

About

33
Publications
1,651
Reads
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311
Citations
Citations since 2017
20 Research Items
231 Citations
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20172018201920202021202220230102030405060

Publications

Publications (33)
Preprint
Full-text available
The evolving global SARS-CoV-2 pandemic emphasizes how unprepared we are for the emergence of the next lethal viral pathogen. A list of potential candidates was created by the World Health Organization which named Nipah virus infection as the highly lethal prototypic member of that list. Building on our earlier viral pandemic preparedness research...
Preprint
CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR- associated nuclease 9) provides powerful gene-editing tools that are applicable for gene therapy of a variety of diseases including, but not limited to cancer, rare diseases, and heart disease. In the current study, we first examined our artificial stem cell and organoid...
Article
Advanced high grade serous ovarian cancer (HGSOC) continues to be a therapeutic challenge for those affected using the current therapeutic interventions. There is an increasing interest in personalized cancer immunotherapy using activated natural killer cells (NK). NK account for approximately 15% of circulating white blood cells. They are also an...
Preprint
Full-text available
COVID-19 is a disease that results from infection with the SARS-CoV-2 virus. The disease is often complicated by cytokine storm and/or a coagulopathy These two complications appear to be responsible for much of the increased mortality seen in severe COVID-19. While available treatment options including systemic corticosteroids and heparin have been...
Preprint
Full-text available
Optimizing patient care based on precision oncology will inevitably become the standard of care. If we accept the principle that every persons’ cancer is different then the most effective therapies will have to be designed for the individual patient and for their tumors genetic profile. Access to tumor mutational profiling is now widely available b...
Article
Full-text available
Metachromatic leukodystrophy (MLD) is a rare neurodegenerative disease that results from a deficiency of the lysosomal enzyme arylsulfatase A (ARSA). Worldwide, there are between one in 40,000 and one in 160,000 people living with the disease. While there are currently no effective treatments for MLD, induced pluripotent stem cell-derived brain org...
Article
Full-text available
The global pandemic caused by the SARS-CoV-2 virus continues to spread. Infection with SARS- CoV-2 causes COVID-19, a disease of variable severity. Mutation has already altered the SARS-CoV-2 genome from its original reported sequence and continued mutation is highly probable. These mutations can: (1) have no significant impact (they are silent), (...
Article
Full-text available
Alzheimer’s disease (AD) is the most common type of neurodegenerative diseases. There are over 44 million people living with the disease worldwide. While there are currently no effective treatments for AD, induced pluripotent stem cell-derived brain organoids have the potential to provide a better understanding of Alzheimer’s pathogenesis. Neverthe...
Preprint
Full-text available
Alzheimer's disease (AD) is the most common type of neurodegenerative diseases. There are over 44 million people living with the disease worldwide. While there are currently no effective treatments for AD, induced pluripotent stem cell-derived brain organoids have the potential to provide a better understanding of Alzheimer’s pathogenesis. Neverthe...
Article
Full-text available
Infection with the SARS-CoV-2 virus has rapidly become a global pandemic for which we were not prepared. Several clinical trials using previously approved drugs and drug combinations are urgently underway to improve our current situation. Unfortunately, a vaccine option is optimistically at least a year away. It is imperative that for future viral...
Article
Full-text available
Infantile onset Pompe disease (IOPD) is a rare and lethal genetic disorder caused by the deletion of the acid alpha-glucosidase (GAA) gene. This gene encodes an essential lysosomal enzyme that converts glycogen to glucose. While enzyme replacement therapy helps some, our understanding of disease pathophysiology is limited. In this project we develo...
Article
Full-text available
Background Conversion of human somatic cells into induced pluripotent stem cells (iPSCs) is often an inefficient, time consuming and expensive process. Also, the tendency of iPSCs to revert to their original somatic cell type over time continues to be problematic. A computational model of iPSCs identifying genes/molecules necessary for iPSC generat...
Article
Full-text available
Emerging drug-resistance and drug-associated toxicities are two major factors limiting successful cancer therapy. Combinations of chemotherapeutic drugs have been used in the clinic to improve patient outcome. However, cancer cells can acquire resistance to drugs, alone or in combination. Resistant tumors can also exhibit cross-resistance to other...
Data
COTI-2 in combination with paclitaxel does not induce severe weight loss in animals. AN3-CA human endometrial cells (1 x 107) were injected into the right flanks of athymic nude mice (n = 10 mice per group). Xenografts were grown to an average volume of 170 mm3 before animals received treatment i.v.. Vehicle control and COTI-2 (25 mg/kg) were admin...
Data
Combining treatment of COTI-2 and carboplatin is more effective in delaying OVCAR-3 xenograft growth than either drug alone. OVCAR-3 human ovarian carcinoma cells (5 X 105 cells) were injected into each flank of NIH III nu/nu mice (4–8 weeks old) (n = 6 mice per group). Xenografts were grown to ~100 mm3 before animals received treatment, which cons...
Data
Combining COTI-2 with gemcitabine does not enhance activity against human SCLC cells. DMS-114 (A) and SHP-77 (B) SCLC cells were treated with various concentrations of gemcitabine in combination with or without an IC25 concentration of COTI-2 for 4 days before cell viability was determined. There was no significant difference (p<0.05, Student’s t-t...
Data
Effect of COTI-2 and NAC or BSO treatment on DMS-53 tumor cell proliferation. Cell viability was determined using the alamarBlue assay following COTI-2 or COTI-2 plus NAC (A) or BSO (B) exposure for 4 days. Data points represent the mean of 5 independent replicates. (TIF)
Data
Mortality in mice treated with the vehicle control, carboplatin, and combinations of COTI-2 and carboplatin. (PDF)
Article
Introduction: Identification of novel anti-cancer compounds with high efficacy and low toxicity is critical in drug development. High-throughput screening and other such strategies are generally resource-intensive. Therefore, in silico computer-aided drug design has gained rapid acceptance and popularity. We employed our proprietary computational p...
Article
Introduction TP53 mutations are rare (< 5%) in de novo acute myeloid leukemia (AML) but if present, they are associated with a very poor prognosis (< 1% overall survival at 3 years). p53 mutations have been frequently detected in poor-prognosis patients with complex karyotype or therapy-related AML. COTI-2 is a third generation thiosemicarbazone de...
Article
Full-text available
Identification of novel anti-cancer compounds with high efficacy and low toxicity is critical in drug development. High-throughput screening and other such strategies are generally resource-intensive. Therefore, in silico computer-aided drug design has gained rapid acceptance and popularity. We employed our proprietary computational platform (CHEMS...
Patent
Full-text available
The invention relates to a compound of Formula I: and/or a pharmaceutically-acceptable salt, hydrate, solvate, tautomer, optical isomer, E-isomer, Z-isomer, or combination thereof, wherein the remaining substituents are described herein; and a composition comprising the thiosemicarbazone and/or the semicarbazone. The invention also relates to a me...
Chapter
Artificial Neural Networks (ANN) are pattern recognition and prediction tools modeled on the biologic nervous system. Chemical structures can be decomposed to critical elements that can be used to teach an ANN to relate structure to function. This study was carried out to evaluate a hybrid ANN system for predicting the in vitro anti-HIV1 activity o...
Article
Clinical prediction models for the diagnosis of obstructive sleep apnea (OSA) have lacked the accuracy necessary to confidently replace polysomnography (PSG). Artificial neural networks are computer programs that can be trained to predict outcomes based on experience. This study was conducted to test the hypothesis that a generalized regression neu...
Article
Purpose: Artificial Neural Networks (ANN) are computer programs that can learn to predict outcomes based on experience. This study was carried out to evaluate the impact of ANN predictions of survival and death on the outcome of patients admitted to a tertiary care teaching hospital with community acquired pneumonia (CAP). Methods: Retrospective da...
Article
Purpose: Length of stay (LOS) for hospitalized patients has been one of the most difficult outcomes to predict because the nature and interplay of the factors involved are poorly understood. Artificial neural networks (ANN) are computer programs which can be used to classify outcomes. This study evaluated the accuracy of ANN predictions of LOS for...
Article
Full-text available
The relationship between heart rate (HR) and PR interval (PR) has been investigated to determine inter-subject variability, within-subject variability and potential reference standards. Eight healthy male volunteers underwent upright graded submaximal treadmill exercise during eight separate study sessions. All subjects exhibited statistically sign...

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