Waseem Jerjes

Waseem Jerjes
NHS · HFP Medical

BDS MBBS MSc MDres PhD MRCGP FHEA FAcadMed

About

307
Publications
56,164
Reads
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4,294
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Introduction
Waseem has an interest in medical education, which he has been pursuing for over a decade. Waseem co-leads the maxillofacial surgery module of the MBBS program at UCL Medical School. Waseem has an extensive research portfolio including over 150 publications, 12 book chapters, and over 120 presentations in national and international meetings. Waseem has interest in research integrity, publication ethics, governance, management, and leadership, as well as the legal side of medicine; he has co-authored nineteen sets of guidelines in these fields. He has also co-authored a book titled “the Power of Research: Best Practices and Principles in Research Integrity and Publication Ethics”.

Publications

Publications (307)
Article
Introduction Healthcare related quality of life (QoL) is defined as the impact one's level of health and wellbeing has on a number of domains, including physical, mental, spiritual and social functions. Photodynamic therapy (PDT), a cancer treatment modality, is increasingly used to treat or palliate head and neck pathologies. Due to the complex na...
Article
Background: Dental implant placement carries a risk of iatrogenic damage to adjacent root surfaces. Purpose: To classify and understand different types of trauma to the tooth root body by dental implants. Materials and methods: This prospective case series included 43 implants placed between February 2017 and June 2020 that had primary stabili...
Article
Full-text available
Head and neck cancers are largely squamous cell carcinomas derived from the epithelial lining of the structures in the region, and are often classified anatomically into oral, oropharyngeal, nasopharyngeal and laryngeal carcinomas. The region’s component structures serve complex and intricate functions, such as speaking, swallowing and breathing, w...
Article
Background The primary aim of this prospective study is to demonstrate the technical feasibility of OCT to map real tumor margins and to monitor skin changes that occurred post- PDT. Moreover, to optimize PDT efficacy based on the relationship between measured OCT features and treatment outcome. Material and Methods A series of 12 patients with ov...
Article
A 77-year-old Caucasian male was diagnosed with squamous cell cancer of the right ear. The patient elected to take part in the first-in-man phase I TPCS2a based bleomycin photochemical internalization (PCI). On Day 0, The patient received the photosensitiser [Amphinex (TPCS2a)], by slow intravenous injection. Four days later, surface illumination b...
Article
Background Skin cancer continues to be the most common cancer in the Caucasian population. Over the past two decades, researchers around the world started assessing the possibility of diagnosing tissue pathologies by using optical systems. In this study, we aimed to use in vivo optical coherence tomography (OCT) technology to describe the morpholog...
Article
Full-text available
Dental implant surgery on atrophied maxilla has many risks; in some patients, simultaneous sinus lifting with implant placement must be performed to increase the chances of successful implantation; this procedure can cause implant migration. Eleven patients were diagnosed with implant migration into the maxillary sinus in four anatomical areas: the...
Article
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Resuming regular clinical activities at dental premises after the COVID‐19 lockdown period or post COVID‐19 is likely to be a challenge for all dental institutes. When returning to the dental practice or training, staff and students alike should abide by the new rules and regulations. In the process of controlling viral spread, clinical dental faci...
Article
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Photochemical internalisation (PCI) is a unique intervention which involves the release of endocytosed macromolecules into the cytoplasmic matrix. PCI is based on the use of photosensitizers placed in endocytic vesicles that, following light activation, lead to rupture of the endocytic vesicles and the release of the macromolecules into the cytopla...
Article
Photochemical internalisation (PCI) depends on the delivery of sub‐lethal photodynamic reaction to facilitate the work of a chemotherapeutic agent. We discuss our experience in managing a patient with extensive squamous cell carcinoma of the right face and scalp under the TPCS2a‐based bleomycin PCI treatment protocol. In this case, an 84‐year‐old C...
Article
Full-text available
Background: The assessment of cutaneous cancer margins intra-operatively or in the immediate postoperative phase can guide the operator into achieving clearer margins. Achieving a clear (tumour-free) margins following surgery is an essential factor that can reduce morbidity and disfigurement. The aim of present study was to determine the accuracy...
Article
Introduction: Photodynamic therapy (PDT) is a relatively new method of treating skin cancers. This prospective study highlights the use of PDT in the management of basal cell carcinomas (BCCs) and T1N0 cutaneous squamous cell carcinomas (SCCs) involving the periorbital area. Materials and methods: Surface illumination PDT was offered under local...
Article
Background: In this immediate ex vivo study, we aimed to identify the structures of normal and pathological facial skin using optical coherence tomography (OCT) and compared them to the gold standard histopathology. Material and methods: A total of 53 patients, with 57 suspicious facial lesions, participated in this study. A set of variables hav...
Article
INTRODUCTION: Photodynamic therapy (PDT) is a relatively new method of treating various pathologies. In this retrospective study with prospective intent, a total of 22 patients with T1/T2 N0 cutaneous squamous cell carcinoma (SCC) were treated with intravenous mTHPC (meta-tetrahydroxyphenylchlorin) and surface illumination PDT. Comparisons with the...
Article
Full-text available
Background: OCT is a non-invasive imaging technique that enables the measurement of epithelial thickness and architectural changes, which can help in the diagnosis of pre-cancerous and cancerous lesions. The purpose of the study was to assess whether epithelial tissue thickness improves optical coherence tomography's ability in detecting oral canc...
Article
Full-text available
Background Optical coherence tomography (OCT) has been shown to reliably identify skin changes with the combined advantage of resolution and penetration depth. The objective of this study was to assess the accuracy of OCT in diagnosing various skin pathologies, using pre-set diagnostic criteria, by two reviewers blinded to the actual diagnosis. Mat...
Article
Aim: In this review, we look at the factor of the surgical experience and surgical workload in a variety of surgical disciplines and its effect on the intraoperative and postoperative complications rate. Materials and methods: An extensive systematic electronic search was carried out on the relevant databases. Two independent reviewers were enga...
Article
Introduction: Photodynamic therapy (PDT) is a relatively new method of treating various kinds of pathologies. In this retrospective study, a total of 148 patients with basal cell carcinoma (BCC) were treated with surface illumination methyl aminolevulinate - photodynamic therapy (MAL-PDT) or meta-tetrahydroxyphenylchlorin (mTHPC-PDT). Comparisons...
Article
Background: Photochemical internalisation, a novel minimally invasive treatment, has shown promising preclinical results in enhancing and site-directing the effect of anticancer drugs by illumination, which initiates localised chemotherapy release. We assessed the safety and tolerability of a newly developed photosensitiser, disulfonated tetraphen...
Chapter
The use of photodynamic therapy has developed to include the management of advanced head and neck malignancies as well as providing a palliative option. This minimally invasive technology was able to cause significant reduction in tumour size and control growth leading to improvement in patient’s quality of life (i.e. breathing, swallowing and spea...
Chapter
The management of head and neck disease using photodynamic therapy is currently being employed by few centres around the world. The last few years showed an increase in the number of clinicians with interest in this intervention as well as patients seeking this option, especially after failing some or all the conventional therapies (i.e. surgery, r...
Chapter
The use of optical technology in guiding surgical intervention is at its earliest stages at the moment. The potential is to facilitate tumour-specific targeting which can potentially result in margin-free tumour and improved survival. In a case study, we investigated the role of optical coherence tomography (OCT) in lesion (squamous cell carcinoma)...
Article
Introduction: Photodynamic therapy (PDT) is a minimally invasive intervention used in the management of tissue disorders. In this retrospective study, a total of 62 patients with actinic keratosis (AKs) were treated with surface illumination PDT. Comparisons with the clinical features, rate of recurrence as well as malignant transformation and ove...
Conference Paper
The aim of this thesis was to investigate and evaluate the effect of photodynamic therapy (PDT) in the management of tissue pathologies as well as the advances in photodynamic applications. Firstly, 5-ALA-PDT and mTHPC-PDT were applied in the management of superficial tissue disease. This includes oral dysplasia (147 patients), early stage oral squ...
Article
Incomplete surgical removal of cancer is believed to be the main cause of local recurrence and high mortality. This study assessed the use of optical technology (namely optical coherence tomography [OCT]) in examining oral squamous cell carcinoma (OSCC) resection margins to assess if this modality could guide the surgeon during surgical resections....
Article
Burkitt-like lymphoma, also known as (B-Cell lymphoma, Unclassifiable) is a rare extra-nodal B-cell lymphoma with features intermediate between Burkitt's lymphoma and diffuse large B-cell lymphoma. A 73-year-old Caucasian female presented to our Emergency Department with orbital pain, deterioration of vision, nausea and vomiting. General examinatio...
Article
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Head and Neck Oncology, an open access journal with a closed peer-review system, achieved its first official impact factor on the 2nd of July, 2012. As a result, it achieved the prestigious status of boasting the highest impact factor of any journal in the head and neck discipline in the world. On the 4th of July, 2012 BioMed Central (the former p...
Conference Paper
Full-text available
bone remodelling in patients with thyroid disease by acting directly or indirectly on bone cells. It has traditionally been known that hyperthyroidism is a risk factor for osteoporosis and fractures. In this study, we investigated the effect of poor thyroxin control on hypothyroid patients with proximal humerus fracture.
Chapter
It is only recently that maxillofacial surgery ceased to be just a dental specialty and now requires formal surgical/medical training for specialist registration. It remains, however, founded in dentistry requiring many of the skills and attributes learned in general dental or oral surgical practice. Medical specialists as a part of emergency treat...
Chapter
Many ENT emergencies are common surgical presentations which can be simply and effectively managed at a junior surgical stage. They are also within the remit of general and emergency surgeons in host institutions where ENT as a specialty is not immediately available.
Article
Optical coherence tomography (OCT) is an evolving optical technology that is capable of delivering real-time, high-resolution signatures of tissue. The purpose of this immediate ex vivo prospective clinical study was: (1) to assess the sensitivity and specificity of OCT on biopsy material in identifying potentially malignant and malignant oral lesi...
Article
Objective: In this prospective comparative study, we looked at the postoperative dental and skeletal relapses in patients undergoing orthognathic surgery for skeletal class III deformity. The surgical interventions were single-jaw versus double-jaw procedures. Study design: Twenty-four adult patients with skeletal class III deformity presented w...
Article
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Introduction This report describes glass displaced into the infratemporal region from submandibular injury. Case Report This report describes an unusual case with foreign body displacement from submandibular region to infratemporal fossa. An appropriate surgical approach to retrieve the object using a trans-oral approach is discussed. Conclusion...
Article
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It is envisaged that we will imagine all the developments that will occur. At no moment in our history is this so far from the truth, there is no status quo and the only real constant is change. Perhaps we will see developments beyond our imagination as something that has happened over the past century. Every time a new scientific and medical journ...
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Introduction This is a review of the evidence on the use of photodynamic therapy in the management of bone lesions in spinal metastasis. Materials and methods The literature was searched for relevant articles and the results were examined. The search included on-going trials that aim to tackle this disease. Results Eight studies were identified i...
Article
Full-text available
Introduction Photodynamic therapy, a minimally invasive oncological modality, has been in use for over 20 years. However, little clinical data is available on its non-oncological efficacy. Several laboratory-based trials on animals have suggested that this technology may be applicable as an antimicrobial therapy. In orthopaedics, where implants and...
Article
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The characteristic of the cells at the leading edge of malignancy may have a deleterious prognostic significance. A 10-year retrospective analysis was performed, data from 282 patients were reviewed and a detailed pathological review was undertaken. The data was entered into a database, which was independently validated for accuracy. Individuals re...
Article
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The aim of this study was to evaluate the findings of elastic scattering spectroscopy co-registered with histopathology in patients with basal cell carcinoma against normal and some common benign skin disorders. Clinically suspicious head and neck skin lesions were included in this study. Those lesions with surrounding innocuous skin were interroga...
Article
Full-text available
Sarcomas developing as primary malignancies of the head and neck are a rare complication after radiation therapy. This kind of sarcoma has variable clinicopathological appearances and behaviour. Radiation-induced spindle cell rhabdomyosarcoma of the sternomastoid muscle is a very rare sarcoma and has very seldom been described in the literature. He...
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Traditionally, in the United Kingdom and Europe, a surgeon is generally not troubled by litigation from patients presenting elective as well as emergency cases, but this aspect of custom has changed. Litigation by patients now significantly affects surgical practice and vicarious liability often affects hospitals. We discuss some fundamental legal...
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As medical editors, we are faced with a host of ethical dilemmas on a daily basis. Most are recognised and dealt with expediently, but the few that remain must be challenged as a cohesive body of editorial opinion.
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The tumour margin is an important surgical concept that significantly affects morbidity and mortality. We describe the clinical application of intraoperative microendoscopy in defining the surgical margins during head and neck surgery. A clinical margin is first marked by the operator followed by microendoscopic assessment of this margin. Biopsies...