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Waranuch Pitiphat

Waranuch Pitiphat
Faculty of Dentistry, Khon Kaen University, Khon Kaen, Thailand · Preventive Dentistry (Dental Public Health Division)

DDS, MPHM, MS, ScD (Epidemiology), FRCDT (Dental Public Health)

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104
Publications
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Publications

Publications (104)
Article
Full-text available
Background Polymorphisms at positions 49, 262, and 296 in the TAS2R38 bitter taste receptor gene result in two common genetic haplotypes, PAV and AVI, named for the resulting amino acid substitutions. TAS2R38 genotype has been previously associated with caries risk in children. This study aimed to identify TAS2R38 polymorphisms among Thais and to e...
Article
Objective This study aimed to review all research evidence of presurgical cleft size and related factors to success of secondary alveolar bone grafting (SABG). Design and Setting The systematic review searched the OVID-Medline®, PubMed®, Embase®, and Cochrane Central Register of Controlled Trials (CENTRAL) up to August 2020. Two reviewers independ...
Article
Full-text available
Although oral diseases are largely preventable, they are among the most non-communicable diseases globally, and they disproportionately burden disadvantaged communities, specially within low- and middle-income nations. The COVID-19 pandemic has highlighted the social, economic, and health inequalities in our society, including the existing global o...
Article
Birth cohorts are those among observational studies that provide understanding of the natural history and causality of diseases since early in life. Discussions during an International Association for Dental Research symposium in London, United Kingdom, in 2018, followed by a workshop in Bangkok, Thailand, in 2019, concluded that there are few birt...
Research
Full-text available
Health-related quality of life has been crucial for the assessment of treatment outcomes in term of patient's perspective. This study aimed to evaluate the effect of three different types of fluoride treatment on Oral Health-Related Quality of Life (OHRQoL) of children. A randomized control trial was conducted in primary schools in Khon Kaen, Thail...
Article
Full-text available
Guided bone regeneration (GBR) is an effective alveolar ridge reconstruction technique used before or at implant placement. The combination of various barrier membranes and bone substitutes has been employed. This study aimed to perform a preliminarily evaluation of the safety and performance of a new nonabsorbable bi-layered porous polyethylene (P...
Article
Full-text available
Background : Spontaneous abortion, or miscarriage, is a complication of pregnancy which can severely affect women both physically and psychologically. We investigated the associations of periodontitis and periodontopathic bacteria with spontaneous abortion. Methods : We conducted a matched case‐control study in two tertiary hospitals in Khon Kaen,...
Article
Fast eating has been shown to increase the risk of overweight in both children and adults. The objectives of the present study were to investigate the correlation between chewing rate and the number of chews per mouthful and to evaluate if they were associated with the weight of meal intake. Thirty healthy subjects, aged 18–24 yr, ate a test lunch...
Article
Full-text available
In this study, we report a unique dominantly inherited disorganized supernumerary cusp and single root phenotype presented by 11 affected individuals belonging to 5 north-eastern Thai families. Using whole exome sequencing (WES) we identified a common single missense mutation that segregates with the phenotype in exon 6 of CACNA1S (Cav1.1) (NM_0000...
Data
Tooth cusp patterning defects found in affected families. The intraoral photographs and panoramic radiograph of affected daughter from family 1 (1_III.11) showed tooth morphology alteration especially multiple accessory cusps in both premolars (A–D) or upper (C) and lower (D) molars. Panoramic radiograph (B) showed root branching anomalies, with si...
Data
Sanger sequencing of CACNA1S exon 6 from 18 unaffected and unrelated Thai-patient controls originating from the same region as our index cases. None of the control samples presented the mutation, excluding a SNPs carried by individuals from this region.
Data
Estimation of family relationship inference for family 1, 2, and 3 by KING program. N_SNP: The number of SNPs that do not have missing genotypes in either of the individual, HetHet: Proportion of SNPs with double heterozygotes (e.g., AG and AG), IBS0: Proportion of SNPs with zero IBS (identical-by-state) (e.g., AA and GG), Kinship: Estimated kinshi...
Data
CACNA1S mutations and associated pathologies reported in the literature. The 43 CACNA1S known mutations according to HGMD are shown in this table.
Data
Human permanent teeth nomenclature. Numerotation designing human permanent teeth according to their type and location following the FDI two digits (No Authors, 1988) and ISO 3950:2016 (Dentistry — Designation system for teeth and areas of the oral cavity) recommendations. Ca, Canines; PreM, Premolars. The image is extracted from the D[4]/phenodent...
Data
Homozygosity regions detected in families 1–3. Homozygosity regions for the nine individuals analyzed by whole exome sequencing (1_II.11, 1_III.10, 2_II.5, 2_II.6, 2_III.6, 2_III.7, 3_II.1, 3_II.2) were reported in this table. No homozygosity region was common to all affected individuals (1_III.10, 2_II.5, 2_III.6, 2_III.7, 3_II.1, 3_II.2) suggesti...
Data
Common rare variants shared by affected individuals in the CACNA1S region. Both alleles of each individual are represented, the blue region on one allele of each affected individual corresponds to the region with common rare variants shared by all affected individuals. Affected individuals are in bold. The variant corresponding to the CACNA1S mutat...
Article
Background: The Obstetrics and Periodontal Therapy (OPT) study, a randomized controlled trial, reported no effect of periodontal treatment on preterm birth. Even though there were more spontaneous abortions or stillbirths in the control group, sensitivity analyses using conventional approaches did not change the results. The development of newer e...
Article
Background: Oral clefts are among the most common congenital anomalies. Most studies on risk factors of oral clefts have been carried out in developed countries. We investigated the associations between maternal exposures in the first trimester and oral clefts in South Vietnam. Methods: We conducted a hospital-based case-control study during Oct...
Conference Paper
Full-text available
Besides a bitter taste, black discoloration of dentinal caries is one of the shortcomings of silver diamine fluoride (SDF) application in children and could affect parental cooperation and satisfaction with the outcome. This study aimed to evaluate parent-child satisfaction with outcomes after three different types of fluoride applications and to i...
Article
Purpose: This cluster randomised controlled trial evaluated the effectiveness of a school-based xylitol chewing-gum programme on caries prevention among students with visual or hearing impairment. Materials and methods: The study compared xylitol gum plus oral health education (intervention group, n = 93) with oral health education alone (contro...
Article
Article title and bibliographic information: Unfinished root canal treatments and the risk of cardiovascular disease. Lin PY, Chien KL, Chang HJ, Chi LY. J Endod 2015;41(12):1991-6. Source of funding: The National Science Council in Taiwan (Government) TYPE OF STUDY/DESIGN: Retrospective cohort study.
Article
The objective of this study was to evaluate the relation between alcohol intake and groups of periodontal antibody titers among individuals with normal glucose tolerance (NGT), prediabetes and diabetes. This was a cross-sectional analysis of the National Health and Nutrition Examination Survey III (NHANES III) 1988–1994 data, among individuals 40 y...
Article
Full-text available
Objective: To compare the effectiveness of a motionless ultrasonic toothbrush to a manual toothbrush in reducing dental plaque, gingival inflammation, and mutans streptococci in patients with fixed orthodontic appliances. Materials and methods: Twenty-five orthodontic patients were recruited to this crossover study. The patients were randomized...
Article
Full-text available
This cohort study was conducted in Khon Kaen, Thailand, to test the hypothesis that a longer breastfeeding duration increases the risk for dental caries in primary teeth. We collected information on infant feeding practices and potential confounders using a structured questionnaire to interview mothers or caregivers during the second trimester of p...
Article
Objective: To evaluate the association between oral health and ventilator-associated pneumonia (VAP) among critically ill patients. Methods: A prospective cohort study was conducted among 162 critically ill patients newly intubated and treated with mechanical ventilator in one tertiary hospital in Thailand. Oral health status was assessed using...
Article
Full-text available
Background: One infant in 700 is born with an oral cleft. Prior studies suggest low micronutrient status is associated with an increased risk of oral clefts. Environmental factors such as passive smoke exposure or supplement use may also affect oral cleft risk. We examined nutrition and environmental related risk factors for oral clefts. Methods:...
Article
Full-text available
Objectives: To examine the association between adverse birth outcomes and dental caries in primary teeth. Methods: This study included children in Khon Kaen, Thailand, who participated in the Prospective Cohort Study of Thai Children. Preterm was defined as a birth at <37 weeks gestation, low birthweight (LBW) as birthweight <2500 g, and small-f...
Article
Full-text available
The purpose of this study was to compare the performance of chemomechanical caries removal (CMCR) with that of conventional drilling for efficacy of caries removal, time spent, morphological changes and microhardness of surface dentin, and microleakage of subsequent restorations. Forty-six carious deciduous molars were randomly divided into two gro...
Article
The objective of this study was to analyze salivary lysozyme levels and activities in Thai preschoolers with different dental caries status. Unstimulated saliva samples were collected from 64 preschoolers, divided into a caries free group (n = 32) and a severe early childhood caries (S-ECC) group (n = 32). Both groups were similar regarding gender,...
Article
Full-text available
The aim of this study was to examine levels of salivary mucins in children with deciduous and mixed dentition and to determine correlations between salivary mucins and dental caries status in two dentition stages. Saliva samples were collected from preschool children with deciduous dentition aged between 4 and 6 years (n = 60) and school children w...
Article
Full-text available
The objective of this study was to determine the levels of patient-satisfaction on facial and dental appearance compared with clinician ratings. Participants included 61 patients with repaired unilateral cleft lip and palate (UCLP), aged 14-25 years. Raters comprised three cleft team clinicians. A Likert scale was used to assess the levels of satis...
Article
Paan (betel leaf and betel nut quid) used with or without tobacco has been positively associated with oral cancer. Oral submucous fibrosis (OSMF), a precancerous condition caused by paan, lies on the causal pathway between paan use and oral cancer. The purpose of this analysis was to estimate the effect of paan consumption on oral cancer risk when...
Article
Purpose: This study aimed to determine the prevalence of molar incisor hypomineralization (MIH) in Thai children and evaluate the association between MIH and dental caries in the permanent dentition. Methods: A cross-sectional study was conducted among six- to seven-year-old participants of a birth cohort study in Khon Kaen, Thailand. MIH was ex...
Article
Full-text available
To determine the levels of dental caries, periodontal disease and oral health-related quality of life in children with cleft lip and/or cleft palate compared to non-cleft controls. This cross-sectional study was conducted in Khon Kaen, Thailand. Subjects included 68 oral cleft and 118 non-cleft individuals aged 10-14 years, who were interviewed usi...
Conference Paper
Objective: Oral candidiasis is a common opportunistic infection among HIV-infected individuals, with growing concerns on the emergence of non-albicans species with resistance to antifungal agents. This study aimed to evaluate the factors associated with the presence of oral Candida species in Thai HIV-infected adults. Method: This cross-sectional...
Conference Paper
Objective: Preterm (PT) and low birth weight (LBW) are markers of altered fetal growth which may interrupt calcification and enamel formation of primary teeth. Studies suggest these adverse birth outcomes are correlated with abnormal tooth mineralization that predisposes children to dental caries, however the evidence is inconclusive. We aimed to t...
Conference Paper
Objective: Treatment with mechanical ventilation (MV) increases risk of ventilator-associated pneumonia (VAP) in critically-ill patients. Regardless of convincing evidence as a strong risk factor for VAP, oral health was left out of most VAP-related studies. This prospective cohort study was conducted to evaluate the association between oral health...
Article
Molar incisor hypomineralization (MIH) is a qualitative developmental enamel defect that affects one to four permanent first molars, with or without involvement of permanent incisors. Its etiology is of systemic origin, but is not well understood. Therefore, we conducted this cross-sectional study to examine pre-, peri-, and postnatal risk factors...
Article
Oral candidiasis is a common opportunistic infection among HIV-infected individuals, with growing concerns on the emergence of non-albicans species with resistance to antifungal agents. This cross-sectional study determined the prevalence of oral Candida species in Thai HIV-infected adults, and factors affecting their colonization. Candida species...
Article
Pain reduction from palatal injection was comparatively investigated by using topical anesthetics, 5% lidocaine encapsulated niosomes (LN) and 18%benzocaine/2%tetraciane gel (BZ). The LN was prepared chair-sidedly by an ultrasonic dental scaler with physicochemical evaluation. A pin-prick test on the palatal mucosa of 10 healthy subjects determined...
Article
Full-text available
Little is known about oral clefts in developing countries. We aimed to identify micronutrient-related and environmental risk factors for oral clefts in Thailand. We tested hypotheses that maternal exposure during the periconceptional period to multivitamins or liver consumption would decrease cleft lip with or without cleft palate (CL ± P) risk and...
Conference Paper
Molar incisor hypomineralization (MIH) is a qualitative enamel defect of systemic origin of permanent first molars and incisors. MIH molars usually have rapid wear shortly after eruption leading to dental caries and subsequent tooth loss. Etiology of MIH is not yet well-understood. Objective: This cross-sectional study aimed to examine the risk fac...
Article
Background: Toll-like receptors (TLRs) play pivotal roles in host immune responses and have been suggested to be involved in the development of many infectious diseases. In this study, the mRNA expression levels of TLR2, TLR4, and TLR9 and their relationship with periodontopathic bacteria in periodontal tissue are examined. Furthermore, the mechan...
Conference Paper
Objective: The aim of this study was to quantitatively evaluate the thermosensory function of the trigeminal nerve in patients with classical trigeminal neuralgia (TN). Method: Nineteen unilateral classical TN patients (mean age 56.1±12.5 years, 14 women and 5 men) diagnosed according to the diagnostic criteria of the international classifica...
Conference Paper
Objectives: Only a few studies have investigated periodontal disease in the Lao People’s Democratic Republic. This study examined the prevalence of periodontitis and identified risk indicators for severe periodontitis in rural Laotian adults. Methods: A cross-sectional study was conducted among a random sample of 384 adults aged 35-44 years in re...
Article
Background: Chronic inflammation has been implicated in the pathogenesis of gestational diabetes mellitus (GDM). Periodontal disease is associated with increased levels of inflammatory mediators and may be a risk factor for GDM. The authors aimed to examine the association between periodontitis and GDM among non-smoking pregnant females. Methods:...
Conference Paper
Objectives: The objectives of this study were to compare the levels of salivary mucins in school children with and without dental caries and to determine the correlations between salivary mucins and number of decayed teeth. Methods: Subjects included 60 Thai children aged 9-11 years: 30 with caries and 30 without caries. Levels of salivary mucins...
Conference Paper
Objectives: This prospective cohort study aimed to identify the factors related to excessive maxillary overjet (>3.5 mm.) and excessive overbite (>2/3 of lower anterior teeth length) in Thai children. Methods: Subjects included 644 participants of a birth cohort study conducted in Khon Kaen, Thailand, who were followed-up until 8-9 years of age....
Article
Full-text available
Wingless proteins, termed Wnt, are involved in embryonic development, blood cell differentiation, and tumorigenesis. In mammalian hematopoiesis, Wnt signaling is essential for stem-cell homeostasis and lymphocyte differentiation. Recent studies have suggested that these molecules are associated with cardiovascular diseases, rheumatoid arthritis, an...
Article
Full-text available
Candidal infections are often difficult to eradicate due to the resistance of biofilms to antifungal agents. This study aimed at determining the effects of lemongrass (Cymbopogon citratus DC) oil against Candida dubliniensis in both planktonic and biofilms form. The results from broth microdilution method revealed that the minimum inhibitory and mi...
Article
Trefoil factors (TFFs) are secreted molecules that are involved in cytoprotection against tissue damage and the immune response. TFFs have been detected in saliva and oral tissues, but their clinical significance has never been investigated in patients with chronic periodontitis. The objective of this study is to determine whether TFF expression in...
Article
Full-text available
Periodontal treatment is associated with lower hemoglobin A1c in individuals with diabetes, but the relationship between oral hygiene practices and A1c among youth with diabetes is understudied. This study evaluates the cross-sectional relationships among oral health habits, reported oral conditions, and A1c and control of diabetes among a subset o...
Conference Paper
Objective: To examine the correlation between academic achievements in preclinical and clinical courses among dental students of Khon Kaen University, Khon Kaen, Thailand. Methods: Data were collected retrospectively from school records of 310 dental graduates between 2000 and 2005. The samples were categorized into 2 groups: Group I (236 students...
Conference Paper
Objectives: Little information is available on the epidemiology of dental erosion among Asian populations. This cross-sectional study aimed to assess the prevalence and risk indicators of dental erosion among 15-year-old adolescents in Khon Kaen, northeast Thailand. Methods: Three hundreds and twenty eight subjects were randomly selected from secon...
Conference Paper
Objectives: The aim of this study was to determine attitudes of disabled students and their teachers towards a school-based xylitol chewing gum program (SXP) for dental caries prevention. Methods: Study population comprised 67 disabled students (aged 8 to 18 years; mean SD, 12.23 2.44 years) and 60 teachers in two special needs schools in Khon Kaen...
Conference Paper
Objectives: In an ongoing case-control study carried out in two tertiary hospitals in Khon Kaen, northeast Thailand, we examined the relationship between periodontal disease and gestational diabetes mellitus (GDM) among non-smoking pregnant women. Methods: As of Feb 1, 2010, there were 29 women who were diagnosed with GDM, and 33 age-matched non-di...
Article
Full-text available
Background of the congress: The International Association for Dental Research (IADR) hosted the 9 th World Congress on Preventive Dentistry (WCPD) in Phuket, Thailand in September, 2009. Previous WCPD’s have been held approximately once every four years and are held in different parts of the world to communicate the latest research findings that ca...
Article
Full-text available
To identify factors associated with monthly breast self-examination (BSE) performance among Thai women living in rural areas, Northeastern Thailand. This present cross-sectional study was conducted during April to July 2008. A random sample of 705 women aged 20 to 64 years living in the rural areas of Northeastern region was interviewed using a str...
Article
Full-text available
Alanine aminopeptidase (ALAP) and dipeptidyl peptidase IV (DPPIV) are ectopeptidases that play a role in collagen degradation and are thought to be involved in the destruction of periodontal tissue. This study compared the activities of salivary ALAP and DPPIV in patients with periodontitis and periodontally healthy subjects. The correlations of en...
Article
The objectives of this study were to determine the survival rate of titanium surgical miniscrews and the clinical parameters that posed the highest risks for failure. Ninety-seven titanium surgical miniscrews (diameter, 1.2 mm; length, 8-12 mm) were placed in the maxilla of 49 patients, at either a high level (nonkeratinized area) or a medium level...
Article
The distribution of periodontal pathogens differs in various geographic locations and racial/ethnic groups. This study investigated the microbiological features of chronic periodontitis (CP) patients in Thailand. Subgingival plaque samples from 20 non-periodontitis subjects, 20 patients with mild CP, and 20 patients with moderate to severe CP were...
Article
Maternal periodontal diseases have been associated with increased risk of preterm birth and restricted fetal growth among relatively low socioeconomic groups. Whether the association can be generalized to middle-class populations remains uncertain. We evaluated periodontitis in relation to preterm birth (<37 weeks' gestation) and small-for-gestatio...
Article
C-reactive protein (CRP) has been implicated as a possible mediator of the association between periodontitis and several systemic diseases. Previous studies suggest an association between increased CRP levels and periodontitis predominantly in Caucasians. This study evaluated the associations of chronic periodontitis and Porphyromonas gingivalis wi...
Article
Aim and Methods: The evidence-based approach, voted in January 2007 as one of the 15 most important medical advances in the last 166 years, has increasingly shaped medical practice and education. In this paper, we apply the evidence-based approach to evaluate the aetiology of periodontitis; for comparison, we provide a brief description of the evid...
Article
Receptor activator of nuclear factor-kappa B (NF-kappaB) ligand (RANKL) and osteoprotegerin (OPG) are critical for homeostatic control of osteoclast activity, suggesting their vital roles in the progression of bone loss in periodontitis. In this study, the expression of RANKL and OPG mRNA and the relationship between these factors and periodontopat...
Article
Full-text available
The aim of this case-control study was to examine the association between periodontitis and preterm birth among non-smoking, non-alcohol drinking women. The cases were 130 women who delivered a live singleton newborn before 37 weeks gestation. A random sample of 260 women who delivered a normal child on the same day as the cases were selected as co...