About
64
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252
Citations
Introduction
Additional affiliations
June 2019 - present
August 2016 - June 2019
Position
- PostDoc Position
Description
- Ultrafast cardiohepatic viscoelastography.
Education
September 2010 - June 2016
September 2007 - June 2010
September 2003 - June 2007
Publications
Publications (64)
Purpose:
Owing to acoustic-pressure dependence, amplitudes of backscattered-echoes of encapsulated microbubbles (MBs) are unavoidably regulated by an uneven acoustic field, resulting in the misestimation of hemodynamics in conventional amplitude-coding dynamic contrast-enhanced ultrasound (DCEUS) with focused pulse transmission. This study aimed t...
Background:
Noninvasive vascular strain imaging under conventional line-by-line scanning has a low frame rate and lateral resolution, and depends on the coordinate system. It is thus affected by high deformations due to image decorrelation between frames.
Purpose:
To develop an ultrafast time-ensemble regularized tissue-Doppler optical-flow prin...
Background: Immune checkpoint inhibitors (ICIs) -induced adverse events (AEs) have been reported affecting almost all human organs. However, studies about ocular AEs are few. A meta-analysis was performed to evaluate the risks of ICI-related ophthalmic AEs compare to chemotherapy.
Methods: Eligible studies were selected from phase II/III randomized...
Objective:
Changes in ultrasound backscatter energy (CBE) imaging can monitor thermal therapy. Catheter-based ultrasound (CBUS) can treat deep tumors with precise spatial control of energy deposition and ablation zones, of which CBE estimation can be limited by low contrast and robustness due to small or inconsistent changes in ultrasound data. Th...
Purpose:
Application of the Nakagami statistical model and associated m parameter have the potential to suppress artifacts from adjustable system parameters and operator selections typical in echo amplitude-coded microbubble-enhanced ultrasound (MEUS). However, the feasibility of applying m estimation and determination of the associated Nakagami d...
Background
The corona virus disease 2019 (COVID-19) pandemic poses a severe challenge to public health, especially to those patients with underlying diseases. In this meta-analysis, we studied the prevalence of cancer among patients with COVID-19 infection and their risks of severe events.
Methods
We searched the Pubmed, Embase and MedRxiv database...
Purpose:
Passive acoustic mapping (PAM) has received increasing attention in recent years and has an extremely widespread application prospect in real-time monitoring of ultrasound treatment. When using a diagnostic ultrasound transducer, such as a linear-array transducer, the initially used time exposure acoustics (TEA) algorithm will produce hig...
Purpose:
To evaluate the impact of cap thickness for small incision lenticule extraction (SMILE) on changes in corneal curvature and biomechanics.
Methods:
One hundred eyes (50 patients) were enrolled in this prospective contralateral eye study. The difference in manifest refraction spherical equivalent (MRSE) in the same patient was less than 0...
Background We performed a systematic review and meta-analysis to evaluate the risks of ophthalmic adverse events (AEs) associated with immune checkpoint inhibitors (ICIs) in patients with solid tumors.Methods Eligible studies were selected after a comprehensive search of multiple databases including phase II/III randomized controlled trials (RCTs)...
Purpose:
The Nakagami statistical model and Nakagami shape parameter m have been widely used in linear tissue characterization and preliminarily characterized the envelope distributions of nonlinear encapsulated microbubbles (EMBs). However, the Nakagami distribution of nonlinear scattering EMBs lacked a systematical investigation. Thus, this stud...
Purpose: Angiogenesis in liver cancers can be characterized by hepatic functional perfusion imaging (FPI) on the basis of dynamic contrast-enhanced ultrasound (DCEUS). However, accuracy is limited by breathing motion which results in out-of-plane image artifacts. Current hepatic FPI studies do not correct for these artifacts and lack the evaluation...
Purpose:
Passive acoustic mapping (PAM) has been proposed as a means of monitoring ultrasound therapy, particularly non-thermal cavitation-mediated applications. In PAM, the most common beamforming algorithm is a delay, sum, and integrate (DSAI) approach. But using DSAI leads to low-quality images for the case where a narrow-aperture receiving arr...
Purpose:
Guided waves generated from bone cortex inevitably act on microbubbles flowing through skeletal muscle capillaries in contrast-enhanced ultrasound (CEUS) and might influence the image quality. However, the action mechanism underlying the guided waves influence is still unknown, especially under contrast pulse-inversion transmission mode....
Purpose:
This study aimed to develop a fast scheme of multiparametric perfusion functional imaging (PFI) based on dynamic contrast-enhanced ultrasound (DCEUS) for assessing renal microvascular hemodynamics.
Method:
The flow process in the DCEUS-based PFI was modified step-by-step to improve its operational efficiency, which was validated through...
Background: We performed a systematic review and meta-analysis to evaluate the risk of pneumonitis and pneumonia associated with immune checkpoint inhibitors (ICIs) for solid tumors.
Methods: The following keywords were used in searching the Embase and PubMed database: pneumonitis, pneumonia, and immune checkpoint inhibitors. The data was analyzed...
Background: Sensitive and specific non-invasive biomarkers are urgently needed in order to improve the survival of patients with pancreatic ductal adenocarcinoma (PDAC), which is the fourth leading cause of cancer-related death. We aim to identify serum hub miRNAs as potential diagnostic and prognostic biomarkers for PDAC. Methods: A total of 2578...
Background
We performed a systematic review and meta-analysis to evaluate the risk of immune-related endocrine disorders associated with PD-1 inhibitors therapy for solid tumors.
Methods
An Embase and PubMed search through December 6, 2017, using the following keywords was performed: immune-related endocrine disorders, and PD-1 inhibitors, etc....
Aim
This study aimed to test the accuracy of a speckle tracking algorithm to assess myocardial deformation in a large range of heart rates and strain magnitudes compared to sonomicrometry.
Methods and results
Using a tissue-mimicking phantom with cyclic radial deformation, radial strain derived from speckle tracking (RS-SpT) of the upper segment w...
Video of the phantom model.
For the purposes of optimizing video quality, the experimental setup was removed from the water.
(MOV)
Example of the speckle tracking software assessing radial strain in short axis view in the phantom model.
The post-processing analysis software was EchoPAC (BT12, GE Medical).
(AVI)
Purpose:
This study aimed to clarify the influences of composite dynamic contrast-enhanced ultrasound (DCEUS) on multi-parametric perfusion imaging (PPI) and to develop a novel PPI scheme through pulse-inversion Bubblet decorrelation (PIBD) to improve its contrast and detailed discriminability.
Method:
In in vivo perfusion experiments on rabbit...
Purpose:
The accuracy of multi-parametric perfusion imaging (PPI) based on dynamic contrast-enhanced ultrasound is disturbed by the respiratory motion in some cases, especially during characterizing hemodynamic features of abdominal tumor angiogenesis. This study aimed to effectively remove those disturbances on PPI and evaluate its accuracy.
Met...
This study aimed to develop a focal microvascular contrast-enhanced ultrasonic parametric perfusion imaging (PPI) scheme to overcome the tradeoff between the resolution, contrast, and accuracy of focal PPI in the tumor. Its resolution was limited by the low signal-to-clutter ratio (SCR) of time-intensity-curves (TICs) induced by multiple limitation...
A contrast imaging method based on a wide beam and a method for extracting a perfusion time-intensity curve (TIC) are provided to increase contrast-to-tissue ratio (CTR) through the contrast imaging method based on the wide beam via a pulse inversion microbubble wavelet transform sum squared differences decorrelation (PIWSSD). An auto adaptive anal...
Parametric perfusion imaging (PPI) based on dynamic contrast-enhanced ultrasound (DCEUS) is a multi-parametric functional method that is increasingly used to characterize the hemodynamic features of abdominal tumors. Periodic respiratory kinetics adversely affects the signal-to-clutter ratio (SCR) and accuracy of abdominal PPI. This study proposed...
Cavitation is regarded as the primary mechanism in pulsed high-intensity focused ultrasound (pHIFU) therapy. Residual cavitation bubbles can be served as nuclei for the subsequent pHIFU cavitation. Therefore, information on spatial distribution especially concentration distribution of residual cavitation bubbles is important to better control pHIFU...
http://www.medphys.org/PhDAbstracts/diyawangphd.pdf
The aim of the study described here was to develop an ultrasound contrast plane wave imaging (PWI) method based on pulse-inversion bubble wavelet transform imaging (PIWI) to improve the contrast-to-tissue ratio of contrast images. A pair of inverted "bubble wavelets" with plane waves was constructed according to the modified Herring equation. The o...
The aim of this study was to elucidate the linear and non-linear responses of ultrasound contrast agent (UCA) to frequency-dispersive guided waves from the tibia cortex, particularly two individual modes, S0 (1.23 MHz) and A1 (2.06 MHz). The UCA responses to guided waves were illustrated through the Marmottant model derived from measured guided wav...
In microvascular perfusion imaging by contrast-enhanced ultrasound (CEUS), inhibiting the strong tissue backscattering to enhance contrast-to-tissue ratio (CTR) and improving the imaging resolution to distinguish small vessels are two critical aspects. CTR has been greatly enhanced based on the strong nonlinear responses of contrast microbubbles un...
Parametric perfusion imaging (PPI) based on time-intensity-curves (TICs) can quantify and depict the spatial distribution of tumor perfusion information in liver cancer research. However, accurate diagnosis of PPI is seriously disturbed by the fluctuations of TICs and decreases of coded threshold induced by no-microbubble (MB) regions. Such disturb...
The objective of this study was to accurately obtain the transient flow vector distribution (FVD) of microbubbles in arterial stenosis by modified optical flow method based on ultrasound contrast plane wave imaging (UCPI). First, a bolus injection experiment was performed in an arterial stenosis flow phantom using inverted plane waves at 400Hz fram...
http://www2.soopat.com/Patent/201510100876?lx=FMSQ
http://www2.soopat.com/Patent/201510101096?lx=FMSQ
http://www2.soopat.com/Patent/201510567122?lx=FMSQ
http://www2.soopat.com/Patent/201510567968?lx=FMSQ
This work is intended to design an integration sensor for non-invasive blood glucose detection (ISNBGD) with low power consumption, fast detection speed and high accuracy. Based on the modified conservation of energy metabolism theory, the blood glucose level (BGL) is acquired by a multi-linear regression equation of a rate of human metabolism, blo...
Although ultrasound contrast plane wave imaging can avoid the repeated disruption and capture the transient spatial distribution of microbubbles, it is still limited by lower contrast-to-tissue ratio (CTR) due to low negative peak pressure and lacks of transmit focus. The purpose of this paper was to develop an ultrasound contrast plane wave imagin...
http://www2.soopat.com/Patent/201410081743?lx=FMSQ
http://www2.soopat.com/Patent/201410539141?lx=FMSQ
http://www2.soopat.com/Patent/201310139512?lx=FMSQ
Noninvasive blood sugar measuring apparatus is very important for diabetes. Based on the theory that blood sugar is the main energy resource, the method of conservation of energy metabolism ( COEM ) estimates the blood sugar level with the metabolism rate, oxygen saturation, pulse frequency and blood flow of the part of finger. The metabolism rate...
A new non-invasive blood glucose measuring apparatus (NBGMA) made up of MSP430F149 SCM (single chip micyoco) was developed,
which can measure blood glucose level (BGL) frequently, conveniently and painlessly. The hardware and software of this apparatus
were designed, and detecting algorithms based on conservation of energy method (COEM) were presen...
http://www2.soopat.com/Patent/200810143539?lx=FMSQ
Diabetes mellitus is one of the most common diseases. Currently, the main method used for blood glucose measuring is invasive, which has disadvantages. A primary research of non-invasive blood sugar apparatus was present. The correlative hardware, software, sensor module and relevant arithmetic for the calculation of blood glucose level based conve...
A new method is presented to design a transducer for measuring blood sugar level non-invasively, which is based on the energy metabolic conservation law. According to the energy metabolic conservation law that the energy derived by human body equals consumed energy by metabolism, this method establishes the relationship between convection, evaporat...
http://www2.soopat.com/Patent/200710035649?lx=FMSQ
Questions
Questions (2)
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Projects
Projects (7)
Aortic Aneurysm Stiffness Evaluation and Imaging
