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Walther Bild
Grigore T. Popa University of Medicine and Pharmacy | UMF Iasi · Department of Physiology

Professor, MD, PhD

About

96
Publications
20,037
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1,496
Citations
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January 1999 - March 2002
Grigore T. Popa University of Medicine and Pharmacy
Position
  • Professor (Assistant)

Publications

Publications (96)
Article
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Cognitive decline is one of the most important challenges related to the aging process, due to its important impact on individuals. Several studies have reported that physical exercise with a specific intensity and frequency is beneficial for maintaining cognitive health in the ageing population. The present study investigated the impact of general...
Article
Metabolic syndrome (MetS) is not a single disease but a cluster of conditions that significantly increase medical risks. It is typically defined by the presence of five metabolic risk factors: atherogenic dyslipidaemia, high blood pressure, hyperglycaemia, a prothrombotic state, and a proinflammatory state. MetS is a global pandemic that involves c...
Article
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Romania is considered a country with high cardiovascular risk, arterial hypertension and its complications accounting for about 60% of total deaths. The management of high blood pressure often involves a combination of both therapeutic regimens as well as lifestyle changes, to which patients have to be adherent. In order to assess patients adherenc...
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The Renin–Angiotensin System (RAS) has attracted considerable interest beyond its traditional cardiovascular role due to emerging data indicating its potential involvement in neurodegenerative diseases, including Alzheimer’s dementia (AD). This review investigates the therapeutic implications of RAS modulators, specifically focusing on angiotensin-...
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As some of the renin–angiotensin–aldosterone system (RAAS)-dependent mechanisms underlying the cognitive performance modulation could include oxidative balance alterations, in this study we aimed to describe some of the potential interactions between RAAS modulators (Losartan and Ramipril) and oxidative stress in a typical model of memory impairmen...
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The chemical constituents of the Cannabis plant known as cannabinoids have been extensively researched for their potential therapeutic benefits. The use of cannabinoids applied to the skin as a potential method for both skin-related benefits and systemic administration has attracted increasing interest in recent years. This review aims to present a...
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Recently, research has greatly expanded the knowledge of the endocannabinoid system (ECS) and its involvement in several therapeutic applications. Cannabinoid receptors (CBRs) are present in nearly every mammalian tissue, performing a vital role in different physiological processes (neuronal development, immune modulation, energy homeostasis). The...
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One of the most common medical diseases is metabolic syndrome (MetS), which encompasses diabetes and obesity. It has a systemic effect, which has long-lasting consequences on the body that are still not fully understood. The objectives of the study were to investigate the association between the severity of metabolic imbalances, insulin resistance,...
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Brain neurodegenerative diseases (BND) are debilitating conditions that are especially characteristic of a certain period of life and considered major threats to human health. Current treatments are limited, meaning that there is a challenge in developing new options that can efficiently tackle the different components and pathophysiological proces...
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Neurodegenerative diseases are an increasing cause of global morbidity and mortality. They occur in the central nervous system (CNS) and lead to functional and mental impairment due to loss of neurons. Recent evidence highlights the link between neurodegenerative and inflammatory diseases of the CNS. These are typically associated with several neur...
Preprint
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Introduction: The relationship between LH and FSH changes and mental health is not clear yet, but may be independent of a strict diagnosis of infertility. Ongoing research has suggested that testosterone levels may play a role in brain development, which could provide a possible explanation for this association. Healthcare providers caring for wome...
Preprint
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Elevated blood pressure has often been correlated with a higher risk of cognitive dysfuncion, but this association is still not well-defined in the literature. The aim of our study was to to review the possible effects of blood pressure on cognitive functioning. Cognitive disorders are characterized by changes in brain structure and function that a...
Article
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ABSTRACT Elevated blood pressure has often been correlated with a higher risk of cognitive dysfuncion, but this association is still not well-defined in the literature. The aim of our study was to to review the possible effects of blood pressure on cognitive functioning. Cognitive disorders are characterized by changes in brain structure and functi...
Article
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Chronic kidney disease and Alzheimer's disease are chronic conditions highly prevalent in elderly communities and societies, and a diagnosis of them is devastating and life changing. Demanding therapies and changes, such as non-compliance, cognitive impairment, and non-cognitive anomalies, may lead to supplementary symptoms and subsequent worsening...
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Traditional plants are largely used in alternative medicine for many disorders treatment. However, some discussions regarding the safety of their usage exist. The present study aims to evaluate the anti-amnesic effect of Datura innoxia leaves aqueous extract, and the possible noxious impact of its use. Thus, there were evaluated the possible protec...
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Pain continues to be a global unmet medical need, and the current recommendations for its management require a constant exploration of new drugs that target multiple pain mechanisms, with an improved safety profile and increased treatment adherence. Currently, the enriched distribution and localization within nociceptors of the selective channel bl...
Article
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Alzheimer’s disease, a major and increasing global health challenge, is an irreversible, progressive form of dementia, associated with an ongoing decline of brain functioning. The etiology of this disease is not completely understood, and no safe and effective anti-Alzheimer’s disease drug to prevent, stop, or reverse its evolution is currently ava...
Preprint
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Backgound : the purpose of the study is to consider the utility of Transcranial Magnetic Stimulation (TMS) in patients with Multiple Sclerosis (MS) and walking impairment, treated with Fampridine, as correlated with the 25-Foot-Walk test (T25-FW). It is known that clinical benefits should be identified within two to four weeks after starting the tr...
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This study was designed to evaluate the spatial working memory (as studied in Y-maze) or short-term and long-term spatial memory (assessed in radial 8 arms-maze task), in a scopolamine-induced memory deficits model in mice, by the oral administration of 2 angiotensin-converting enzyme inhibitors—captopril and ramipril and also the effects of the AT...
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Depression is now one of the most important and prevalent psychiatric disease worldwide. It is believed that depression will represent the second leading cause of disability worldwide by 2020. One of the most important ways to further investigate the pathophysiological mechanisms and possible treatments for this psychiatric disorder (as for most di...
Article
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The brain represents an important site for the action of insulin. Besides the traditionally known importance in glucoregulation, insulin has significant neurotrophic properties and influences the brain activity: insulin influences eating behavior, regulates the storage of energy and several aspects concerning memory and knowledge. Insulin resistanc...
Article
Lately it has been accepted that a complete separate brain renin - angiotensin system (RAS) exists and is being implicated, as our group previously demonstrated, in superior and complex functions such as memory, emotional manifestations related for example to anxiety or pain processing. There is also a lot of controversial data regarding the implic...
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The present study is part of a series of larger investigations concerning combinations of paracetamol with several other drug substances, as a rational modality of pain therapy. By using a nociception model with chemical stimulus (Zymosan A) and the administration of fixed-ratio dose sequences of paracetamol and acetylsalicylic acid we attempt the...
Article
Given the multitude of neuromodulators involved in the generation and transmission of pain, two therapeutic agents with different action mechanisms (an antidepressant - doxepin and an angiotensin-AT1 receptor blocker - candesartan) have been associated in this study. None of the substances is used exclusively as analgesic, but increasingly as adjuv...
Article
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Lately, there is increased evidence that besides the very well known angiotensin (Ang) II, other renin-angiotensin system (RAS) peptides, including Ang III, Ang IV or Ang-(1-7), could mediate important effects at the central level. Thus, very few aspects are known about the central actions of Ang-(1-7), while the effects of its administration alone...
Article
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Deuterium-depleted water (DDW) has a concentration of deuterium 6-7 times lower than naturally occurring water (20-25 ppm vs. 150 ppm). When administered for a longer period, it can reduce the concentration of deuterium throughout the body, activating cellular mechanisms that depend on protons. The aim of the present work was to investigate the inf...
Article
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It has already been demonstrated that a complete brain renin angiotensin system (RAS) exists distinctly separate from the peripheral system and is implicated in complex functions such as memory, emotional responses and pain. Regarding the implications of angiotensin II (the main bioactive peptide of RAS) in pain, although there are many studies in...
Article
While it is now well established that the independent brain renin-angiotensin system (RAS) has some important central functions besides the vascular ones, the relevance of its main bioactive peptide angiotensin II (Ang II) on the memory processes, as well as on oxidative stress status is not completely understood. The purpose of the present work wa...
Article
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Accumulating evidence suggests that the nongenomic cardiovascular actions of aldosterone are produced by varied cellular pathways and mediated by a multitude of messenger systems including the reactive oxygen and nitrogen species. Considering the involvement of the oxidative and nitrosative stress in the pathways leading to the activation of the an...
Article
There is increasing evidence that besides the well-known angiotensin (Ang) II, other renin-angiotensin system (RAS) peptides, including Ang-(1-7), could have important effects at the central level. However, very few things are known about the central actions of Ang-(1-7), while the effects of its administration alone on anxiety have not been tested...
Article
During the last years, special emphasis was directed towards the relation between the molecular and cellular alterations produced by free oxygen radicals and the normal and pathologic implications of nitric oxide. Moreover, lately it is believed that a true radical cascade might exist between the reactive species of oxygen and nitrogen during stres...
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Aspects Regarding the Neurobiology of Psycho-Affective Functions In this mini-review we were interested in analyzing the main achievements concerning the neurobiological substrate of the human psycho-affective functions. The cortico-subcortical areas implicated in the elaboration and the control of the sensorial and psycho-affective reactions of th...
Article
This mini-review tries to summarize the main interdependences between the free radicals of oxygen, nitrogen, and carbon. Also, the main metabolic pathways for these radical species are described, as well as how these affect their interaction and functional implications. Emphasis is made on the metabolic disturbances induced by stressing aggressions...
Article
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The renin-angiotensin system (RAS) is one of the most important neuropeptide systems in the brain and it is known now that in addition to the regulation of blood pressure, RAS is also implicated in the modulation of some superior functions involving the emotional responses, pain or cognitive functions. However, in the last few years various studies...
Article
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In the present study, we were interested in the vascular effects of angiotensin II on perfused rings of the rat thoracic aorta and renal artery. Our results demonstrated different modulator alterations of these preparations induced by ammonium ions. Unlike the aortic rings, which exhibited only a reduction of angiotensin-induced contractility by NH...
Article
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Mild cognitive impairment (MCI) is an early stage of cognitive decline that has a significant risk of converting to dementia. Cardiovascular pathology appears to have a major impact in cognitive decline, and it is clear that early identification and correction of cardiovascular morbidity could have a major impact on cognitive functioning. Our study...
Article
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In addition to its known classical roles, the renin angiotensin system (RAS) has more subtle functions which include the regulation of emotional responses. Previous studies regarding the anxiety related behavior of RAS have showed controversial results. There is also evidence that oxidative stress accompanies angiotensin II infusion, but the role o...
Article
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Inhibition of Central Angiotensin Converting Enzyme Exerts Anxiolytic Effects by Decreasing Brain Oxidative Stress This study investigated the effects of angiotensin II and captopril intracerebroventricular administration on anxiety status and brain oxidative stress. Elevated plus maze was used in order to asses the anxiety-like behavior, while the...
Article
Unlabelled: Pain is an important problem and has been the subject of many studies in recent years. Material and method: The present study has investigated the response of the antioxidant defense systems in contention stress, which mimics nociceptive stress. Contention stress was made by immobilizing the rat, Wistar rats, on an operating table in...
Article
Aims The brain renin-angiotensin system is involved in learning and memory, but the actual role of angiotensin II and its metabolites in this process has been difficult to comprehend. In the present study we assessed the role of the angiotensin AT1 receptors in certain behavioral effects of angiotensin II using their selective antagonist losartan a...
Article
Aims Renin-angiotensin system in the central nervous system participates in the processing of sensory information, learning and memory processes. Inhibitors of renin-angiotensin system, particularly angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists are reported to have potential effects in various learning and memory...
Article
Mild cognitive impairment (MCI) is a nosological entity proposed as an intermediate state between normal aging and dementia. MCI seems to represent an early stage of Alzheimer's disease (AD) and there is a great interest in the relationship between MCI and the progression to AD. Some studies have demonstrated an accumulation of products of free rad...
Article
Biochemical, physiological and functional studies suggest that the brain renin-angiotensin system (RAS) is regulated independently of the peripheral RAS. Also, all enzymes and peptides necessary for the biosynthesis of various angiotensins have been recognized within the central nervous system. There are divergent opinions concerning the localizati...
Article
The classic concept of the renin-angiotensin system being substantially accomplished by the new cognitive and applicative acquisitions, a natural reconsideration and completion is imposed. In consequence, ample referrals are made to the main central and peripheral actions of Angiotensins through specific receptors. Emphasis is given to the effects...
Article
The present work introduces a brief review of the actual knowledge concerning the enzymes involved in the biosynthesis of the active angiotensins, followed by a presentation of their main physio-pharmacological actions. The enzymatic pathways that generate active ang. II (1-8) are complemented with data concerning its transformation into angiotensi...
Article
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The concept of tissue renin-angiotensin systems (RAS) is now well established and it is now usual to think in terms of renal and tissue systems. At the same time it has emerged that angiotensin II (Ang II) is not the only biologically active peptide generated by the RAS. At least three others have been identified: the heptapeptide Ang III, the hexa...