Walter Rhomberg

State Hospital Feldkirch | LKH Feldkirch · Department of Radiation Oncology

Background. Calcifications of the costal cartilages occur, as a rule, not until the age of 30 years. The knowledge of the clinical significance of early and extensive calcifications is still incomplete. Materials and Methods. A search was made to find patients below the age of 30 years who showed distinct calcifications of their lower costal cartil...

Background/aim: The aim of this study was to elucidate why some patients with incurable breast cancer may survive far beyond our expectation. Patients and methods: The analysis is based on two cohorts of patients with unresectable locoregional recurrences or distant metastases. Survival time, tumor characteristics, disease-free interval, metasta...

The Catholic Social Science Review 18 (2013): 63-70 Natural Family Planning as a Family Binding Tool: A Survey Report. Walter Rhomberg, Michaela Rhomberg, Hubert Weissenbach In 2008, on behalf of the marriage- and family centers of the Austrian dioceses Salzburg and Feldkirch a survey concerning the performance of natural regulation of conceptio...

Background. About 70% of patients with incurable cancer will eventually succumb to distant metastasis. Therefore, the development of therapies against metastasis is of considerable interest. In the past, clinical research on the dynamics of metastasis was difficult to perform, but now the advent of modern imaging techniques has made it relatively e...

Dexrazoxane is highly effective in reducing anthracycline-induced cardiotoxicity and extravasation injury and is used clinically for these indications. Dexrazoxane has two potential pharmacological activities: it is a prodrug that is hydrolyzed to an iron chelating EDTA-type structure, and it is also a strong inhibitor of topoisomerase II. The anth...

In Chapter 2, preclinical and clinical data are given for razoxane, the older of the two drugs. The various modes of action of razoxane are briefly summarized, e.g. the block of the cell cycle in the G2/M phase, the antimetastatic and antiinvasive activity, the ability to normalize pathological tumor blood vessels, the inhibition of topoisomerase I...

Razoxane (Rz) and dexrazoxane (DXRz) have several interesting modes of action. They block the cell division at the level of G2/M in the cell cycle, they have shown antiinvasive activity in preclinical experiments, and they are able to normalize pathological tumour blood vessels. In addition, the drugs inhibit topoisomerase II α (the full implicatio...

Razoxane and dexrazoxane are two novel drugs with some uniquely useful features. They block cell division at the G2/M border, but nowhere else, so that they have a low toxicity profile. They suppress tumor metastasis and haemorrhages through normalization of pathological blood vessels. Razoxane potentiates radiotherapy especially in the treatment o...

In previous studies, razoxane and vindesine together with radiotherapy was proved to be effective in soft tissue sarcomas (STS). Because razoxane leads to a redifferentiation of pathological tumor blood vessels, it was of particular interest to study the influence of this drug combination in vascular soft tissue sarcomas. This open multicenter Phas...

Razoxane and vindesine were shown to suppress distant metastasis in animal systems. Both drugs affect main steps of the metastatic cascade. Therefore, a pilot study was performed to study the influence of these drugs on the dynamics of metastasis in advanced soft tissue sarcomas (STS). This study was now updated. Twenty-three patients with unresect...

The treatment options in advanced soft tissue sarcomas (STS) are limited. In a pilot study, an antimetastatic and radiosensitizing treatment concept was explored. Twenty-one patients with unresectable and/or oligometastatic STS received the drugs razoxane and vindesine supported by radiotherapy and surgery. Long-term treatment was intended in metas...

In an earlier phase II study, irradiation together with razoxane was shown to improve local control in recurrent rectal cancer. Therefore, the Austrian Society of Radiooncology (OGRO) initiated a randomized controlled trial in 1992 to compare this combined treatment versus radiation therapy alone. Between 1992 and 1999, 36 patients with localized r...

To determine the patterns of evaluation and treatment in Austrian breast cancer patients treated with surgery and radiotherapy in 1993 (PCS93) and 2001 (PCS01), and to compare these with the results of PCS85. According to the evaluation process of the Austrian PCS85, ten randomly selected patient charts from every Austrian radiotherapy center from...

Chondrosarcomas and chordomas are reported to have low radio-sensitivity. Therefore, a study was undertaken to explore the radioresponsiveness of these tumours using the sensitising agent razoxane. Thirteen chondrosarcomas and five chordomas were irradiated with high-energy photons and razoxane in the period from 1984 to 2003. The median tumour dos...

Purpose. Relatively few results are available in the literature about the radiation response of unresectable sarcomas in relation to their histology. Therefore, an attempt was made to summarize the present situation. Materials and methods. This report is based on a review of the literature and the author's own experience. Adult-type soft tissue sar...

Bereits 1921 wurde von Holthusen die Beobachtung gemacht, daß Sauerstoff die Strahlenempfindlichkeit von Zellen erhöht. Gut oxygenierte Zellen sind — zumindest in vitro — um einen Faktor 2–3 strahlenempfindlicher als hypoxische Zellen, die z.B. in Stickstoffmilieu gehalten wurden. Analog zum O2-Verstärkungsfaktor (OER) wird eine Wirkungsänderung du...

We retrospectively compared the efficacy of razoxane and radiotherapy with radiotherapy alone or in combination with a non-razoxane based medication in patients with melanoma brain metastases. From 19 assessable patients receiving whole brain irradiation with or without a boost (mean total dose 40.5 Gy) for measurable brain metastases, 8 patients u...

Little is known about the radiation sensitivity of bile duct carcinomas. The current study was undertaken to prospectively assess the objective response rates in bile duct carcinomas treated with radiotherapy and razoxane. Twenty-three patients with advanced cancer of the biliary tree were irradiated together with the radiosensitizer razoxane at a...

Little is known concerning the relation of porphyrias to radiation treatment for cancer. The recent literature does not report negative outcomes at least in single cases of breast cancer, bladder cancer or in a patient with lymphoma. Theoretically, there is a risk for radiation treatment in cases of porphyrias. Two patients with porphyria are descr...

Background: Little is known concerning the relation of porphyrias to radiation treatment for cancer. The recent literature does not report negative outcomes at least in single cases of breast cancer, bladder cancer or in a patient with lymphoma. Theoretically, there is a risk for radiation treatment in cases of porphyrias. Case Report: Two patients...

The planned MedAustron hadron therapy facility is designed to compare proton and carbon ion beam therapy under the same technical conditions. For the calculation of the number of potential patients for hadron therapy so far, only epidemiological estimations on cancer incidence are available without inclusion of the percentage of patients routinely...

In Austria a national survey was conducted by Med AUSTRON/Osterreichische Gesellschaft for Radio--Onkologie, Radiobiologie und Medizinische Radiophysik (OGRO) in order to estimate the indications, patient numbers and radiotherapy treatment planning procedures and performances at all Austrian radiotherapy institutes. Results were correlated with inc...

Malignant hemangioendotheliomas of the thyroid are rare tumors predominantly seen in areas with endemic goiter such as the Alpine regions. The estimated incidence of the disease is between 0.15 and 0.25 per 100.000 inhabitants annually for Western Austria. The tumor is regarded as radio-resistant, and its prognosis is reported to be dismal. Between...

In Austria, a Patterns of Care Study (PCS) has been conducted to evaluate the standards of practice for breast cancer patients. The year 1985 was selected in order to establish a base data set. At all nine radiation therapy facilities active in patient treatment in 1985, ten patients charts were randomly selected and reviewed. Evaluation of the rad...

To evaluate the local effect of conventional photon irradiation in chordomas if the radiosensitizing agent razoxane is added. The rationale for this procedure were improved results previously seen in soft tissue and chondrosarcomas with this combination. Between 1988 and 1996, five patients with histologically confirmed chordomas of the skull base...

Aggressive angiomyxoma (AAM) is a tumor of the soft tissues predominately occurring in the genital and pelvic area with a strong propensity to local recurrences. The entity was first described in 1983. The tumor is regarded as low-grade sarcoma by some authors; its cause and pathogenesis are presently unknown. This is a case report on a 27-year-old...

In the past, little attention has been given to the relationship of the histology of a primary tumor to its possible subsequent pattern of metastasis. The knowledge of these relations, however, is of importance for the radio-oncologist for several reasons. A review on the relation between the histology of a primary tumor and the pattern of subseque...

Den Beziehungen zwischen der Histologie eines Primärtumors und der Art seiner späteren Metastasierung ist bisher wenig Aufmerksamkeit geschenkt worden. Für den Radioonkologen haben diese Kenntnisse jedoch praktische Bedeutung. Material und Methoden: Es werden die Beziehungen zwischen der Histologie eines Primärtumors und den Eigenheiten einer pote...

The histology of colorectal tumors was correlated with the presence of liver metastases in a retrospective study performed on 179 patients who were autopsied between 1975 and 1990. For the analysis of metastatic patterns, 116 cases with at least one distant metastatic site were selected. A distinct relationship between mucin expression of colorecta...

Angiosarcomas of the heart are rare neoplasms bearing an unfavorable prognosis. In recent series, the median survival is about 5 months. The response to radiation therapy is uncertain. A 65-year-old copper smith with an angiosarcoma of the right atrium and metastases of the liver received a partial resection of the primary tumor in January 1992. Th...

Background Angiosarcomas of the heart are rare neoplasms bearing an unfavorable prognosis. In recent series, the median survival is about 5 months. The response to radiation therapy is uncertain. Case Report A 65-year-old copper smith with an angiosarcoma of the right atrium and metastases of the liver received a partial resection of the primary tu...

Background: Angiosarcomas of the heart are rare neoplasms bearing an unfavorable prognosis. In recent series, the median survival is about 5 months. The response to radiation therapy is uncertain. Case Report: A 65- year-old copper smith with an angiosarcoma of the right atrium and metastases of the liver received a partial resection of the primary...

In the treatment of breast cancer, the indication for adjuvant systemic treatment was extended also to nodal negative tumor stages in the last years. For that reason, the indicator status of axillary dissection lost some of its importance. Therefore, in node negative patients, the necessity of axillary dissection and the use of definitive axillary...

Background In the treatment of breast cancer, the indication for adjuvant systemic treatment was extended also to nodal negative tumor stages in the last years. For that reason, the indicator status of axillary dissection lost some of its importance. Therefore, in node negative patients, the necessity of axillary dissection and the use of definitiv...

Background: In the treatment of breast cancer, the indication for adjuvant systemic treatment was extended also to nodal negative tumor stages in the last years. For that reason, the indicator status of axillary dissection lost some of its importance. Therefore, in node negative patients, the necessity of axillary dissection and the use of definiti...

Known etiologic factors related to endothelial angiosarcomas are exposures to arsenic, thorium dioxide, therapeutic irradiation, and certain congenital diseases. Little is known on the etiology of hemangiopericytomas. Since 1974, several reports have appeared on a distinct relationship between the exposure to vinyl chloride monomers and angiosarcom...

Malignant hemangioendothelioma of the thyroid is a rare tumor predominantly described in areas with endemic goiter like the Alpine regions. The estimated incidence of the disease is between 0.15 and 0.25 per 100,000 inhabitants per year for Western Austria. The prognosis is reported to be dismal. Between 1982 and 1995, 10 cases with immunohistochem...

Onkologische Behandlung berührt auch Bereiche der Sexualität des Patienten. Durch Verbesserungen der Therapie und damit höhere Heilungsraten ist gleichzeitig mit vermehrter Langzeittoxizität und in manchen Fällen mit erhöhten genetischen Risiken zu rechnen. Da das Pflegepersonal oft einen besseren Zugang zu persönlichen Problembereichen des Patient...

Die Strahlentherapie (Radioonkologie) ist eine eigenständige klinische und wissenschaftliche Disziplin, ihre Aufgabe ist es, maligne Tumoren mit Hilfe ionisierender Strahlen allein oder in Kombination mit anderen Modalitäten zu bekämpfen und zu erforschen.

Ziel des Strahlenschutzes für beruflich exponierte Personen ist es, den einzelnen Menschen und seine Nachkommen vor möglichen Schäden durch ionisierende Strahlen zu bewahren. Solche Schäden können sich beim einzelnen Individuum als körperliche Veränderung (somatischer Schaden) oder als Mutation in den Keimzellen (genetischer Schaden) manifestieren....

The effect of the sensitizer razoxane on soft tissue sarcomas (STS) was prospectively evaluated in a randomized, controlled trial. The main purpose of the study was to determine the response rates and local control under the combined treatment compared to irradiation alone. Between 1978 and 1988, 144 patients entered the study; 130 were evaluable f...

In a 68-year-old man with a painful syndrome of the lower extremities which began at the age of 64 years, workup revealed a generalized osteopathy with sclerosis of the axial skeleton and osteopenia at the extremities associated with pathologic fractures. The occupational history showed exposure to several synthetics such as vinyl chloride, polyeth...

The effect of the radiosensitizer razoxane was prospectively evaluated in advanced and recurrent gastric cancer. Endpoints of the study were mainly palliation, local response rates, and achievement of local control. From 1984 to 1993, razoxane (Rz) was given together with radiation therapy (RT) to 28 patients. Twenty-three patients had inoperable p...

Occupational analyses were conducted between 1971 and 1978 comparing 165 cases of testicular cancer in the Hannover region of Germany with 187 controls without neoplastic diseases admitted to the Hannover University Medical School during the same period. The results showed a significantly higher risk of metal workers developing seminomas and mixed...

Osteogenesis imperfecta (OI) is an inherited disorder of connective tissue with abnormal quality and/or quantity of type 1 collagen. The frequency of the association of OI and breast cancer as well as the frequency of radiation induced side-effects in patients with OI are not known. Certain diseases with widespread collagen alterations such as syst...

The effect of the sensitizer razoxane was prospectively evaluated in recurrent rectal cancer. Endpoints of the study were mainly local response rates and survival. From 1984 to 1990 razoxane was given together with radiation therapy to 40 patients with recurrent inoperable rectal cancer. Loco-regional relapses in the pelvis were isolated in 24 and...

Five new cases of malignant hemangioendothelioma of the thyroid are reported. This rare malignant tumor is described predominantly in regions with endemic goiter such as the Alpine zone. The estimated incidence of the disease is between 0.15 and 0.25 per 100,000 inhabitants per year for Western Austria. Two of the five patients were heavily exposed...

Five new cases of malignant hemangioendothelioma of the thyroid are reported. This rare malignant tumor is described predominantly in regions with endemic goiter such as the Alpine zone. The estimated incidence of the disease is between 0.15 und 0.25 per 100,000 inhabitants per year for Western Austria. Two of the five patients were heavily exposed...

The rate of radiation-induced side-effects is dependent from exogenous technical and endogenous factors. Widespread endogenous factors are arterial hypertension and other cardiovascular diseases. 130 breast cancer patients were retrospectively evaluated for side-effects to estimate the influence of arterial hypertension. All were treated with maste...

Razoxane blocks cell division in the G2/M phase of the cell generation cycle and appears to normalize tumour neovasculature development. These were the principal reasons for the examination and probably for the demonstration of the radiosensitizing activity of Rz. Specially intriguing has been the finding that radiation of primary tumour implants i...

Die Anwendung einer sequentiellen oder gleichzeitigen Radio-Chemotherapie hat in den letzten Jahren breites Interesse gefunden. Dieser Trend wurde unter anderem von der Einsicht in die beschränkten Therapiemöglichkeiten und der Hoffnung auf die Überwindung des Resistenzproblems genährt. Erwünscht sind überadditive lokale Effekte oder komplexe Wirku...

Das Lokalrezidiv des Rektumkarzinoms ist in der Regel mit einer hohen Morbidität und einer schlechten Prognose verbunden. Die bisher einzige Chance für ein Langzeitüberleben bietet die chirurgische Resektion des Rezidivs, welche aber aus technischen Gründen nur 10–30% der Patienten angeboten werden kann. Eine alleinige Strahlentherapie bewirkt zwar...

Zusammenfassung Von 1984 bis Mitte 1990 wurde eine prospektive Phase II Studie mit der Kombination von Strahlentherapie und Razoxan per os bei 30 Patienten mit undifferenzierten Gliomen durchgeführt. Bei 19 Patienten mit einem Gliom Grad IV war die mediane Überlebenszeit 10,5 Monate, 94% der Patienten lebten 6 Monate und länger. Bei 11 Patie...

In der ärztlichen Fortbildung stößt man immer wieder auf Äußerungen, wonach die Strahlentherapie beim malignen Melanom keine Bedeutung habe. Von einer generellen Strahlenresistenz der malignen Melanome kann nicht gesprochen werden. Es gibt eine Reihe unterschiedlicher Krankheitssituationen, in welchen die Strahlentherapie ihren besonderen Stellenwe...

Local recurrences of rectal carcinomas are frequently associated with a considerable morbidity and a dismal prognosis. Surgical resection leads to long term tumor control in about 30 to 40%, but surgery can be offered to only 10 to 30% of the patients. Cytotoxic chemotherapy is able to induce local responses in 15 to 40% of the cases--similar figur...

This is a report on 14 patients receiving vindesine continuously for between 1 and 7 years. Total vindesine doses ranged from 86 mg to 454 mg and the longest treatment duration was 2564 days. Although there was no patient without a transient acute or subacute toxicity, no unequivocal signs of long-term toxicity have been observed so far. Greater ca...

The case records of 102 patients who had died of gastric cancer between 1975 and 1983 were evaluated. Special emphasis was given to an analysis of the metastatic liver involvement in relation to various histological classifications. The results show a strong preponderance of liver involvement by differentiated adenocarcinomas without intra- or extr...

Two pilot studies on the radiosensitivity of rectum carcinomas have been conducted, during which 42 patients with inoperable primary tumors or recurrences were irradiated with focal doses of about 60 Gy. A rate of 38% of objective remissions was observed under conventional telecobalt irradiation, 20% were progressing in spite of radiotherapy. In ca...

A report is given on three cases of total vaginal necrosis observed between 1980 and 1983 in 156 evaluable patients submitted to primary or postoperative irradiation. Characteristic signs of this disease are the incidence of sudden pains (increased in sitting position), necrosis and ulceration of the complete vaginal area, and a tendency to spontan...

A 21-year-old male patient was treated for idiopathic scoliosis in a general orthopedic practice. Despite treatment a steady increase of lumbar bulging was noted. An extensive soft tissue tumor was found to be the cause of this. The tumor was resected locally at the orthopedic department and was found to be histologically an aggressive fascial fibr...

Es wird über eine 35jährige Patientin mit einem rezidivierenden, inoperablen Astrozytom Grad II-III berichtet, bei welcher unter einer Strahlentherapie (51 Gy HD) und gleichzeitiger Gabe der radiosensibilisierenden Substanz Razoxan eine komplette Remission des Tumors eingetreten ist. Die Remission ist computertomographisch dokumentiert, ihre Entwic...

The radiogenic modifications of the thorax radiography were evaluated in 100 patients irradiated postoperatively for mammary carcinoma between January, 1980 and March, 1983. No adjuvant chemotherapy was given. A telecobalt unit was used for the irradiations. A computer-assisted planning (Evados) was applied in order to obtain an individual optimiza...

Twenty-four patients with recurrent or metastatic cervical cancer were treated with vindesine (VDS) (2 mg/m2) on 2 subsequent days per week. Twenty patients were evaluable for response. There were six partial responses (30%) and no complete responses. The median remission duration was 6.5 months. The results indicate that VDS is active in the treat...

The relationship between the histology of the primary tumour and subsequent metastasization was analysed in 343 patients with disseminated carcinoma of the breast. The metastases were subdivided on clinical criteria into osseous, visceral and localized regional ones. It was found that undifferentiated, infiltrating ductal carcinomas without signifi...

Bei 343 Patientinnen mit disseminiertem Mammakarzinom wurden die Beziehungen zwischen der Histologie des Primärtumors und der nachfolgenden Metastasierung untersucht. Die Metastasen wurden nach klinischen Gesichtspunkten in einen ossären, viszeralen und lokoregionären Typ unterteilt. Es zeigte sich, daß undifferenzierte, infiltrierende duktale Karz...

Among 130 patients with disseminated renal cell carcinomas 29 cases with skeletal involvement have been analyzed. Skeletal metastasis is associated with oligotopic and frequently extraosseous growth of large metastases. Extraosseous growth was noted in 85% of the cases. This phenomenon was less frequent in cases with combined metastatic involvement...

Hundred nine unselected patients with metastatic renal cell carcinoma have been stratified into 3 groups according to their type of metastasis: 17 patients with sceletal involvement only, 67 patients with visceral matastases, and 21 patients with a mixed type of metastasis. Four patients with a locoregional pattern of recurrence were not included i...

From 1971 to 1974 89 patients with advanced ovarian cancer (FIGO-stage III-IV), admitted to seven centers of the Swiss Group for Clinical Cancer Research (SAKK), were randomly allocated to three different treatment schedules: cyclophosphamide (CYT) alone or CYT in combination with either medroxyprogesterone acetate (GEST) or 5-fluorouracil (FU). Re...

The possible toxicities of combined modality therapy in bronchogenic carcinoma are reviewed. Enhancement of local and systemic side effects of each treatment form are the main risks to reduce quality of survival in these patients. Recent studies did not yet resolve the problems of optimal chemotherapy, dose of radiation necessary to obtain complete...

Hundred nine unselected patients with metastatic renal cell carcinoma have been stratified into 3 groups according to their type of metastasis: 17 patients with sceletal involvement only, 67 patients with visceral metastases, and 21 patients with a mixed type of metastasis. Four patients with a locoregional pattern of recurrence were not included i...

Zusammenfassung Es wird eine Übersicht über die unerwünschten Wirkungen bei kombinierter Anwendung von Radio- und Chemotherapie gegeben und auf die Wechselbeziehung bestimmter, beim Bronchuskarzinom wirksamer Zytostatika mit der Bestrahlung eingegangen. Im Vordergrund der Toxizitäten steht eine Verstärkung der lokalen und systemischen Nebenwirkunge...

Radiotherapy combined with ICRF 159 has been given to 63 patients with soft tissue sarcomas and other solid tumors. Analysis of the clinical cases and the data from the localized sarcomas suggest, that ICRF 159 is a potent radiosensitizing agent, at least in sarcomas. This is in accordance with experimental findings and the clinical experience of o...

Combined treatment of lung carcinoma. Report on a prospective randomized study with radiotherapy and ICRF 159 [1,2-(3,5-dioxopiperazines-lyl)propane] In a clinical randomized trial of 40 patients with inoperable lung carcinoma the success of radiotherapy alone (5000 rads) was compared with a combined modality with radiotherapy (5000 rads) and ICRF...

Retrospective evaluation of follow-up series of chestfilms of 30 patients suffering from malignant lympho-reticular processes of the lungs and treated with cytostatic drugs. Among 130 changes of form there were foci of infiltration which could be recognized as due to malignant lymphoreticular deposits. They were large zones of shrinking, stripey sc...

Während der Jahre 1972 und 1973 wurden 130 Patientinnen wegen eines progredienten, metastasierenden Mammakarzinoms mit Hormonen und Zytostatika behandelt. Von ihnen wiesen 30 einen subklinischen oder manifesten Diabetes mellitus auf. Die klinische Analyse dieser Fälle zeigt, daß der metastasierende Brustkrebs bei Frauen mit Diabetes protrahiert ver...

A total of 33 leukaphereses were performed with the IBM continuous flow centrifuge on 28 normal healthy donors for the purpose of obtaining increased yields of granulocytes for infusion into leukopenic recipients. The pretreatment of donors within a 10- to 12-hour period prior to pheresis with a double dose of dexamethasone and the addition of hydr...

Das Anthracyclinderivat Adriamycin wurde bei 25 Patienten mit progredienten, disseminierten Sarkomen eingesetzt. Zwei Patienten waren mit Endoxan und Vincristin, einer durch Telekobaltbestrahlung vorbehandelt worden, die übrigen Patienten erhielten Adriamycin als Ersttherapie.

18 Patienten, die an inoperablen Weichteilsarkomen litten, wurden einer Strahlentherapie in Kombination mit oraler Medikation von ICRF 159 [l,2-(3,5-Dioxopiperazin-l-yl)propan] unterzogen. Von ihnen litten acht an einer lokalisierten, zehn an einer disseminierten Sarkomerkrankung. Das Durchschnittsalter der Patienten war 40 Jahre (13-70). Die appli...

A total of 67 leukaphereses were performed with the IBM blood cell separator (BCS) on 50 healthy donors for the purpose of obtaining a clinically useful number of granulocytes for infusion into patients with acute leukemia and granulocytopenia accompanied by severe infection. The pretreatment of donors with dexamethasone and the addition of hydroxy...

The results of 38 HL-A and other antigen matching studies revealed an inverse relationship between the percent of donor-recipient serologic discordance and increases in recipient granulocyte levels 1 h after infusion of donor cells. Selected unrelated, parent, and sibling donors possessing mean percent serologic discordances of 33, 22, and 16, resp...

The results of 38 HL-A and other antigen matching studies revealed an inverse relationship between the percent of donor-recipient serologic discordance and increases in recipient granulocyte levels 1 h after infusion of donor cells. Selected unrelated, parent, and sibling donors possessing mean percent serologic discordances of 33, 22, and 16, resp...

Mobilization of leukocytes into a serum-filled chamber was quantitatively measured in duplicate in normal subjects during two control periods and while they were receiving prednisone or dexamethasone. The normal mobilization of leukocytes from blood to chamber serum (71.6 X 106 per square centimeter of abrasion surface per 24 hours) was slightly de...