Walter Manucha

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Verified

Walter verified their affiliation via an institutional email.

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• Ph.D.
• Professor (Assistant) at National University of Cuyo

Microgreens of the Brassicaceae family have garnered considerable interest due to their higher phytochemical content compared to their mature counterparts. These bioactive compounds include phenolic compounds, glucosinolates, and isothiocyanates. This study evaluated their bioaccessibility and antioxidant capacity in red mizuna microgreens, sodium...

Dysbiosis, which refers to an imbalance in the composition of the gut microbiome, has been associated with a range of metabolic disorders, including type 2 diabetes, obesity, and metabolic syndrome. Although the exact mechanisms connecting gut dysbiosis to these conditions are not fully understood, various lines of evidence strongly suggest a subst...

The excellent manuscript by Rahme M et al, post hoc exploratory analyses of 221 ambulatoryolder overweight individuals supplemented with calcium and oral vitamin D3, shed light on anexisting problem. I mean Vitamin D is clearly associated with hypertension but itssupplementation did not produce positive results. They do find it in older (≥65 years)...

Aging, mitochondria, and neurodegenerative diseases Aging is often viewed as the buildup of changes that lead to the gradual transformations associated with getting older, along with a rising likelihood of disease and mortality. Although organism-wide deterioration is observed during aging, organs with high metabolic demand, such as the brain, are...

Addictive diseases represent chronic and recurring pathologies whose hallmark is the sick search for permanent reward or satisfaction through actions or substances of abuse. This behavior results in the loss of the ability to adequately manage behavior, continuous abstinence, desire for consumption, loss of self-knowledge in the face of everyday si...

In general terms, cannabinoid-type substances have many limitations for their study and clinical implementation, mainly due to adverse effects that cause deterioration at the central nervous system level and other organic systems. Of particular interest, the science of nanomaterials and their biological application, such as the development of nanof...

Introduction Anandamide (AEA) is an endocannabinoid that has recently been recognized as a regulator of various inflammatory diseases as well as cancer. While AEA was thought to predominantly engage cannabinoid (CB) receptors, recent findings suggest that, given its protective anti-inflammatory role in pathological conditions, anandamide may engage...

Hypertension remains a prevalent global health issue, with numerous strategies aimed at mitigating its widespread impact. Recently, there has been growing interest in developing nutraceuticals derived from natural bioactive compounds with cardio-protective properties. Brassica microgreens—young, edible seedlings—are rich sources of phytochemicals,...

Background and purpose Endocannabinoids are lipid mediators, which elicit complex biological effects that extend beyond the central nervous system. Tissue concentrations of endocannabinoids increase in atherosclerosis, and for the endocannabinoid N‐arachidonoyl‐ethanolamine (anandamide, AEA), this has been linked to an anti‐inflammatory function. I...

Cancer therapy has made significant strides, but limitations remain with some conventional approaches. Adjuvants are agents used alongside primary treatments to enhance their efficacy and patient outcomes. Modern lifestyles contribute to deficiencies in melatonin and vitamin D. Limited sun exposure impacts vitamin D synthesis, and artificial light...

The interplay between mitochondria, epigenetics, and the microbiota is intricately linked to both health and disease. Within our cells, a complex molecular dance occurs, where these components intertwine in a mesmerizing ballet that plays a decisive role in our health. Mitochondria, beyond being energy powerhouses, modulate nuclear gene expression...

Mitochondria functionally degrade as neurons age. Degenerative changes cause inefficient oxidative phosphorylation (OXPHOS) and elevated electron leakage from the electron transport chain (ETC) promoting increased intramitochondrial generation of damaging reactive oxygen and reactive nitrogen species (ROS and RNS). The associated progressive accumu...

The COVID-19 pandemic has highlighted the vulnerability of particular patient groups to SARS-CoV-2 infection, including those with cardiovascular diseases, hypertension, and intestinal dysbiosis. COVID-19 affects the gut, suggesting diet and vitamin D3 supplementation may affect disease progression. Aims: To evaluate levels of Ang II and Ang-(1-7),...

Mitochondrial dysfunction is a key driver of cardiovascular disease (CVD) in metabolic syndrome and diabetes. This dysfunction promotes the production of reactive oxygen species (ROS), which cause oxidative stress and inflammation. Angiotensin II, the main mediator of the renin-angiotensin-aldosterone system, also contributes to CVD by promoting RO...

A surprising new paradigm has been established with the advent of "gliflozins". Beyond their antihyperglycemic action, these drugs have significantly impacted the therapeutics of cardio-vascular-renal-metabolic disorders responsible for the most prevalent diseases we address in clinical practice. Sodium-glucose cotransporter type 2 (SGLT-2 i) inhib...

In metabolic syndrome and diabetes, compromised mitochondrial function emerges as a critical driver of cardiovascular disease, fueling its development and persistence, culminating in cardiac remodeling and adverse events. In this context, angiotensin II-the main interlocutor of the renin-angiotensin-aldosterone system-promotes local and systemic ox...

Neuroinflammation represents a critical immune response within the brain, playing a pivotal role in defense against injury and infection. However, when this response becomes chronic, it can contribute to the development of various neurodegenerative and psychiatric disorders. This bibliographic review delves into the role of vitamin D in modulating...

Los efectos pleiotrópicos de los iSGLT-2 sobre las distintas vías de señalización celular y mitocondriales en diferentes órganos y tejidos se evidencian en estudios de metabolómica, y estos podrían acompañarse de cambios epigenéticos que requieren aún mayor evidencia23,24. Conceptualmente se destaca que, sumado a los efectos protectores descritos e...

Neuroinflammation, a complex process involving the activation of microglia, astrocytes, and other immune cells in the brain, plays a role in neurodegeneration and psychiatric disorders. Current therapeutic strategies for neuroinflammation are limited, necessitating the development of improved approaches. Nanopharmacology offers unprecedented opport...

La metabolómica, como herramienta analítica, ofrece una visión holística de gran cantidad de datos biológicos. Así puede utilizarse este tipo de estudios para analizar los cambios producidos en el organismo luego del consumo de alimentos, y a su vez determinar marcadores químicos que nos den un indicio del camino recorrido por los compuestos bioact...

Las evidencias han crecido muy rápido no dejando dudas de que las gliflozinas, más allá de sus beneficios en varias vías metabólicas, reducen los eventos cardiovasculares y renales. Sin embargo, lo más importante para jerarquizar es la reducción de la mortalidad general en alrededor del 30%. Esto adquiere una especial relevancia cuando se produce e...

Inflammation and oxidative stress are critical underlying mechanisms associated with COVID-19 that contribute to thecomplications and clinical deterioration of patients. Additionally, COVID-19 has the potential to alter the composition ofpatients’ gut microbiota, characterized by a decreased abundance of bacteria with probiotic effects. Interesting...

Many pharmacological interventions may provide great health benefits by preventing or attenuating GD, some of them may also be detrimental by inducing it. For this reason, new pharmaceutical strategies of drug administration should be implemented in order to overcome the mentioned drawbacks. In this regard, the use of nanocarriers to transport and...

Inflammation and oxidative stress are critical underlying mechanisms associated with COVID-19 that contribute to the complications and clinical deterioration of patients. Additionally, COVID-19 has the potential to alter the composition of patients' gut microbiota, characterized by a decreased abundance of bacteria with probiotic effects. Interesti...

Dr. Russel J. Reiter was awarded his fifth honorary title by the National University of Cuyo, Argentina, for his exemplary contributions towards unraveling the mysteries of the pineal gland and, importantly, its major secretory product, melatonin. This commentary provides a glimpse of his accomplishments and a summary of his speech during the cerem...

Drug discovery and development are usually very costly and time-consuming. Therefore, drug repurposing is an attractive option for treating multiple diseases due to significantly reducing the time and costs invested in these tasks while using less risky compounds. Moreover, drug repurposing may help to discover new drug targets and signaling pathwa...

The imbalance of cardio-renal homeostasis may lead to the development of multiple cardiovascular and kidney diseases, which are highly prevalent in worldwide population and have elevated morbidity and mortality rates. Currently, the available therapeutic options are not enough to achieve an adequate control of cardio-renal diseases. The pharmacolog...

Background: Previously, we evaluated angiotensin levels and the cytokine profile in patients with mild COVID-19 and treated with high doses of vitamin D3 (ClinicalTrials.gov NCT04411446). Unfortunately, this treatment did not improve the protective components. Objectives: To perform a sub-study excluding old and obese patients as possible confounde...

Aim: To evaluate angiotensin II (Ang II) and Ang-(1-7) levels and the cytokine profile in patients hospitalized with mild coronavirus disease 2019 (COVID-19) and contrast them with patients with identical clinical conditions but treated with high doses of vitamin D (vitD). Methods: From the 218 patients recruited (ClinicalTrials.gov NCT04411446), 1...

Purpose of Review To address the mechanistic pathways focusing on mitochondria dysfunction, oxidative stress, sirtuins imbalance, and other contributors in patient with metabolic syndrome and cardiovascular disease. Sodium glucose co-transporter type 2 (SGLT-2) inhibitors deeply influence these mechanisms. Recent randomized clinical trials have sho...

Melatonin, a highly functionally diverse, low-molecular-weight antioxidant and anti-inflammatory agent has been sparingly studied relative to its ability to reduce patho-physiological processes common to the peripheral female reproductive system. Currently it is known that melatonin reduction is associated with multiple processes underlying changes...

Aging has a major detrimental effect on the optimal function of the ovary with changes in this organ preceding the age-related deterioration in other tissues, with the middle-aged shutdown leading to infertility. Reduced fertility and consequent inability to conceive by women in pre-sent-day societies who choose to have children later in life leads...

The versatility and wide variety of nanocarriers developed to date allows either the physical encapsulation or chemical conjugation of different drugs with multiple nanomaterials or nanocarrier portions depending on the physical and chemical features of the drugs of interest, making possible the co-formulation of two or more therapeutic compounds s...

Numerous pleiotropic effects have been reported for vitamin D (vit D) since its discovery a century ago. Today it is well known that in addition to its pivotal role in calcium homeostasis and bone metabolism, vit D has antibacterial, anti-proliferative, immunomodulatory, and anti-inflammatory actions, among other beneficial properties. In the conte...

Vitamin D (vit D) is widely known for its role in calcium metabolism and its importance for the bone system. However, various studies have revealed a myriad of extra-skeletal functions, including cell differentiation and proliferation, antibacterial, antioxidant, immunomodulatory, and anti-inflammatory properties in various cells and tissues. Vit D...

We have previously demonstrated significant in vitro natriuretic effects of anandamide (AEA) nanoformulated in polymeric nanoparticles, whose size prevents their accumulation in organs such as the kidneys. Therefore, it is of particular interest to design and test nanostructures that can pharmacologically accumulate in these organs. In this regard,...

Background Most cannabinoids usually present several limitations when evaluating their clinical use, mainly related to the side effects they may cause at the central nervous system and other levels. In this regard, nanotechnology applied to the development of pharmacotherapeutic nanoformulations has become an attractive tool that allows taking adv...

The gut microbiota dysbiosis represents a triggering factor for cardiovascular diseases, including hypertension. In addition to the harmful impact caused by hypertension on different target organs, gut dysbiosis is capable of causing direct damage to critical organs such as the brain, heart, blood vessels, and kidneys. In this sense, it should be n...

Purpose of Review This review summarizes the involvement of inflammaging in vascular damage with focus on the epigenetic mechanisms by which inflammaging-induced hypertension is triggered. Recent findings Inflammaging in hypertension is a complex condition associated with the production of inflammatory mediators by the immune cells, enhancement of...

Oxidative stress and chronic inflammatory conditions contribute as key determinants in the development of vascular and renal diseases. Organosulfur compounds (OSCs) of oil macerated with garlic (OMG) are promissory phytochemicals which could protect from the hyper-inflammation and oxidative stress-induced organ damage. The present work evaluated th...

Background The role of oral vitamin D3 supplementation for hospitalized patients with COVID-19 remains to be determined. The study was aimed to evaluate whether vitamin D3 supplementation could prevent respiratory worsening among hospitalized patients with COVID-19. Methods and findings We designed a multicentre, randomized, double-blind, sequen...

Background The role of oral vitamin D3 supplementation for hospitalized patients with COVID-19 remains to be determined. The study was aimed to evaluate whether vitamin D3 supplementation could prevent respiratory worsening among hospitalized patients with COVID-19. Methods and findings We designed a multicentre, randomized, double-blind, sequenti...

SARS-CoV-2, the etiological agent of the current COVID-19 pandemic, belongs to a broad family of coronaviruses that also affect humans. SARS-CoV-2 infection usually leads to bilateral atypical pneumonia with significant impairment of respiratory function. However, the infectious capacity of SARS-CoV-2 is not limited to the respiratory system, but m...

The concept of "aging" is defined as the set of gradual and progressive changes in an organism that leads to an increased risk of weakness, disease and death. This process may occur at the cellular and organ level, as well as in the entire organism of any living being. During aging, there is a decrease in biological functions and in the ability to...

No single treatment will eliminate the COVID-19 pandemic. It is imperative that all available tactics and medications be used to overcome this disease, although it will probably never totally disappear. Melatonin is inexpensive so it is affordable throughout the world, it does not require refrigeration and it has a very long shelf-life. Melatonin h...

Numerous pharmaceutical drugs have been repurposed for use as treatments for COVID-19 disease. These drugs have not consistently demonstrated high efficacy in preventing or treating this serious condition and all have side effects to differing degrees. We encourage the continued consideration of the use of the antioxidant and anti-inflammatory agen...

Background Addictions are a group of chronic and recurrent diseases of the brain characterized by a pathological search for reward or relief through the use of a substance or other action. This situation implies an inability to control behavior, difficulty in permanent abstinence, a compelling desire to consume, decreased recognition of significant...

El objetivo fue realizar un estudio de utilización de medicamentos en pacientes mayores de 15 años con enfermedades crónicas no transmisibles prevalentes que asistieron a Centros de Atención Primaria de la Salud de Godoy Cruz, Mendoza, Argentina. Se realizó un estudio descriptivo, observacional y transversal de prescripción-indicación durante dos p...

Background Cardiovascular inflammation and oxidative stress are determining factors in high blood pressure and arrhythmias. Indole-3-carbinol is a cruciferous-derived phytochemical with potential anti-inflammatory and antioxidant effects. However, its implications on the modulation of cardiovascular inflammatory-oxidative markers are unknown. Objec...

Background Cardiovascular disease (CVD), especially heart failure (HF) as its common final pathway, is the leading cause of morbidity and mortality worldwide. Furthermore, oxidative and inflammatory processes represent fundamental underlying mechanisms for the development and progression of HF. Of interest, in recent years the development of marker...

Vascular inflammation is one of the main activating stimuli of cardiovascular disease and its uncontrolled development may worsen the progression and prognosis of these pathologies. Therefore, the search for new therapeutic options to treat this condition is undoubtedly needed. In this regard, it may be better to repurpose endogenous anti-inflammat...

La hipertensión arterial (HTA) como principal factor de riesgo modi cable para las enfermedades cardiovasculares, aumenta su prevalencia constantemente a nivel global. Se estima que alrededor de 1.200 millones personas la padecen y que diariamente mueren cerca de 50.000 por causas cardiovasculares. Los fármacos antihipertensivos disponibles en la a...

Melatonin is synthesized in the pineal gland at night. Since melatonin is produced in the mitochondria of all other cells in a non-circadian manner, the amount synthesized by the pineal gland is less than 5% of the total. Melatonin produced in mitochondria influences glucose metabolism in all cells. Many pathological cells adopt aerobic glycolysis...

A distinctive feature of COVID-19 is its low mortality rate, where the leading cause of decease is related to the development of severe acute respiratory syndrome (SARS). This syndrome involves an exacerbated inflammatory reaction, frequently known as cytokine storm, mainly in the lungs and concomitant over activation of the renin-angiotensin-aldos...

The Ebola virus (EBOV) was named after the Ebola River in the Democratic Republic of Congo (DRC) (previously Zaire). All afflicted nations reported a total of 27,741 EVD cases and 11,284 deaths as of July 22, 2015. Prior to the 2013-2016 EBOV epidemic, the number of confirmed human cases in EBOV outbreaks was very low, with no more than 425 cases e...

Result exciting to deepen the knowledge on vitamin D (VD) nanoformulations applied to the prevention and treatment of specific inflammatory/oxidative diseases such as neurodegenerative and cardiovascular pathologies instead of continuing to research only on VD nanoformulations implemented in food fortification or bone health (which are so far their...

There is growing evidence that serum vitamin D levels are inversely related to the severity of COVID-19. However, it is not yet known whether this relationship is observed independently of the type of variant of SARS-CoV-2 that has caused the infection or if this is variant-dependent. In this context, we studied a series of clinical cases with a po...

The leading cause of complications or death from COVID-19 is due to the development of acute respiratory distress syndrome (ARDS). This syndrome is characterized by exacerbated inflammation, mainly at the pulmonary level, and an over-activation of the renin-angiotensin-aldosterone system (RAAS), usually culminating in death or permanent respiratory...

Conventional drug delivery systems often have several pharmacodynamic and pharmacokinetic limitations related to their low efficacy and bad safety. It is because these traditional systems cannot always be selectively addressed to their therapeutic target sites. Currently, target-specific and controlled drug delivery is one of the foremost challenge...

Vitamin D supplementation could optimize the ability of the immune system to respond appropriately to COVID-19 vaccination. Routine dosing of vitamin D serum levels is neither usual nor inexpensive practice, and in knowledge of the significant percentage of the population that has shown to present vitamin D deficiency. Thus, awaiting the results of...

Metal ion homeostasis is an essential physiological mechanism necessary for achieving an adequate balance of these ions' concentrations in the different cellular compartments. This fact is of great importance because both an excess or a deficiency of cellular metal ion levels are usually equally harmful due to the exacerbated increase in oxidative...

The use of nanosized particles has emerged to facilitate selective applications in medicine. Drug-delivery systems represent novel opportunities to provide stricter, focused, and fine-tuned therapy, enhancing the therapeutic efficacy of chemical agents at the molecular level while reducing their toxic effects. Melatonin (N-acetyl-5-methoxytriptamin...

Exaggerated oxidative stress and hyper-inflammation are essential features of oxidative/inflammatory diseases. Simultaneously, both processes may be the cause or consequence of mitochondrial dysfunction, thus establishing a vicious cycle among these three factors. However, several natural substances, including melatonin and micronutrients, may prev...

Hypertension and diabetes are two of the leading causes of morbidity and mortality in the current world population, especially in Western societies. These two pathological conditions are key risk factors for the onset and progression of many cardiovascular diseases such as stroke, atherosclerosis, pulmonary hypertension, thrombosis, and heart failu...

Exaggerated oxidative stress and hyper-inflammation are essential features of oxida-tive/inflammatory diseases. Simultaneously, both processes may be the cause or consequence of mitochondrial dysfunction, thus establishing a vicious cycle among these three factors. However, several natural substances, including melatonin and micronutrients, may pre...

COVID-19 is said to be a pandemic that does not distinguish skin color or ethnic origin, but data in many parts of the world, especially in the United States, begins to show that there is a sector of society that is suffering a more significant impact from this pandemic. The black population is being more vulnerable than the white population to inf...

Purpose Hypertensive lesions induce alterations at hemodynamic, peripheral, and central levels. Anandamide (N-arachidonoylethanolamine; AEA) protects neurons from inflammatory damage, but its free administration may cause central adverse effects. AEA controlled release by nanoformulations could reduce/eliminate its side effects. The present study a...

Objectives To evaluate whether a single high dose of oral cholecalciferol improves the respiratory outcomes as compared with placebo among adults COVID-19 patients at moderate risk of clinical complications. Trial design The CARED trial is an investigator-initiated, multicentre, randomized, parallel, two-arm, sequential, double-blind and placebo-c...

Under pandemic circumstances, the scientific method used as a dogma does not contribute to the humanitarian help that this critical moment deserves.Researchers and developers made a terrific job giving us the desired protection. More than 90 % of effectivity is a standard of high quality of the vaccine. We are ready to use it, but health authoritie...

Although there is one exception (red blood cells), the lack of energy (ATP) provided by mitochondrial oxidative phosphorylation (OXPHOS) would not be compatible with the long-term survival of normal cells. During conventional metabolism, pyruvate, the cytosolic glycolysis product, enters mitochondria where it is metabolized to acetyl-coenzyme A (ac...

Vitamin D is an essential immune-modulator with receptors widely distributed throughout the body, and its serum levels fluctuate significantly in individuals between winter and summer months. This study examines the association between low vitamin D status and prevalence of COVID-19 cases around the world and proposes a relationship with the season...

Loneliness and social isolation are associated with depression, anxiety and a progressive loss of higher cognitive faculties, mainly in older adults. In the current pandemic situation, with serious restrictions that limit interactions with members of our social circles, these cognitive alterations are becoming progressively more obvious in young ad...

During the current COVID-19 pandemic, the immune defenses of each specific patient play a leading role, since the morbidity and mortality by COVID-19 infection do not only depend on the virus, but also depend on the patient responses against this infection. The immune-inflammatory response is notably involved in the physiopathogenesis of this viral...

Melatonin is an endogenous compound which may reduce morbidity and mortality rates during SARS-CoV-2 infections. Antioxidative actions at the mitochondrial level are likely one of the major beneficial effects. Although this is a molecule with multiple advantages including a very high safety profile, it also has some shortcomings that may limit its...

COVID-19 is said to be a pandemic that does not distinguish between skin color or ethnic origin. However, data in many parts of the world, especially in the United States, begin to show that there is a sector of society suffering a more significant impact from this pandemic. The black population is more vulnerable than the white population to infec...

The COVID-19 pandemic has reached most of the countries worldwide causing death, which often results from an inflammatory storm associated with severe acute respiratory syndrome (SARS). This has prompted researchers to seek specific novel and definitive treatments urgently. In this context, it is interesting to evaluate the preventive and therapeut...

The ancestral cultures have described many therapeutic properties of garlic; therefore it is of central interest to elucidate the molecular basis explaining this millenary empirical knowledge. Indeed it has been demonstrated a neuroprotective effect of allicin-a phytochemical present in garlic-linked to oxidative-inflammatory modulation. Allicin im...

Due to its high degree of contagiousness and like almost no other virus, SARS-CoV-2, has put the health of the world population on alert. COVID-19 can provoke an acute inflammatory process and uncontrolled oxidative stress, which predisposes to respiratory syndrome and -in the worst case- death. Recent evidence suggests the mechanistic role of mito...

Although we lack enough evidence to justify supplementing with vitamin D in the prevention and treatment of COVID-19 infection, it is increasingly feasible that this hypothesis is valid. Two general underlying mechanisms should be considered. One would be the anti-infectious and immunomodulatory action that it exerts by improving intercellular barr...

COVID-19 pandemic has a high mortality rate and is affecting practically the entire world population. The leading cause of death is severe acute respiratory syndrome as a consequence of exacerbated inflammatory response accompanied by uncontrolled oxidative stress as well as the inflammatory reaction at the lung level. Until now, there is not a spe...

The recent inception of the coronavirus SARS-CoV-2, responsible for the coronavirus disease (COVID-19), has caused thousands of deaths globally. The most frequently reported complications among COVID-19 patients are from respiratory involvement. Vitamin D has immunomodulatory effects that could protect against COVID-19 infection. Indeed, there is g...

Background The neuroinflammatory process is associated with the pathogenesis of many cardiovascular disorders, particularly with hypertension. In this regard, the deficiency of vitamin D seems to increase the risk of cardiovascular pathologies related to neuroinflammation. Long-term vitamin D lack leads to over-activation of the renin-angiotensin-...

Vitamin D deficiency is a worldwide pandemic and results in osteoporosis, hypertension, and other cardiovascular diseases. At the cellular level, it produces significant oxidative stress, inflammatory markers, and mitochondrial damage. There is increasing evidence about the role of vitamin D in the regulation of the renin-angiotensin-aldosterone sy...

The International Vitamin D Conference was held in Abu Dhabi on March 14-15, 2019 and was organized by Dr. Fatme Al Anouti. Drs. Pawel Pludowski and John White joined as co-editors of this special issue. It is well documented that vitamin D has pleiotropic physiological actions. Although the most studied function of vitamin D in the regulation of c...

Generally, the development and progression of neurodegenerative diseases are associated with advancing age, so they are usually diagnosed in late adulthood. A primary mechanism underlying the onset of neurodegenerative diseases is neuroinflammation. Based on this background, the concept of "neuroinflammaging" has emerged. In this deregulated neuroi...

COVID-19 has infected hundreds of thousands and killed tens of thousands of people worldwide and it continues to ravage societies as well as fiscal and economic stability of several countries. Currently, several drugs that were designed for other conditions have been repurposed to counter the COVID-19 pandemic. Some have modest efficacy in resistin...

According to investigations in phytomedicine and ethnopharmacology, the therapeutic properties of garlic (Allium sativum) have been described by ancestral cultures. Notwithstanding, it is of particular concern to elucidate the molecular mechanisms underlying this millenary empirical knowledge. Allicin (S-allyl prop-2-ene-1-sulfinothioate), a thioes...

Resumen Si bien carecemos de suficiente evidencia que justifique suplementar con vitamina D en la prevención y/o tratamiento de la infección por COVID-19, a la fecha resulta cada vez más factible que esta hipótesis sea válida. Dos mecanismos básicos generales deberían ser considerados. Uno sería la acción anti-infecciosa e inmuno-moduladora que eje...

Vitamin D deficiency is a worldwide pandemic and results in osteoporosis, hypertension, and other cardiovascular diseases. At the cellular level, it produces significant oxidative stress, inflammatory markers, and mitochondrial damage. There is increasing evidence about the role of vitamin D in the regulation of the renin-angiotensin-aldosterone sy...

This review considers the role of melatonin as an oncostatic agent and particularly as to how it relates to the mechanisms by which melatonin regulates glucose metabolism in cancer cells. Many tumor cells adopt a means of glucose utilization that is different from that of healthy cells. Thus, these cancer cells rapidly take up and metabolize glucos...

La vitamina D tiene un efecto antiinflamatorio conocido en todos los tejidos, incluidos los pulmones. Existen datos clínicos sobre el papel de una posible protección en las infecciones respiratorias virales. También es bien sabido que altas dosis de vitamina D antagonizan el sistema renina-angiotensina, que probablemente tiene una relación importan...

Introduction. Diabetes mellitus (DM) is essential for public health, and Pharmacoepidemiology is a useful tool to control it. Objective: to determine frequency, comorbidities, dispensation, and consumption of medicines in a Primary Health Care Center of Mendoza, Argentina. Methodology. A descriptive, observational, cross-sectional, retrospective s...

From an evolutionary point of view, vitamin D and melatonin appeared very early and share functions related to defense mechanisms. In the current clinical setting, vitamin D is exclusively associated with phosphocalcic metabolism. Meanwhile, melatonin has chronobiological effects and influences the sleep-wake cycle. Scientific evidence, however, ha...

The elevation of blood pressure produces specific organic lesions, including kidney and cardiac damage. On the other hand, cardiovascular disease usually leads to the development of hypertension. Thus, hypertension could be both a cause and a consequence of cardiovascular disease. Previous studies linked the lack of nitric oxide to cardiovascular a...

Purpose of review: Several studies have attributed garlic´s beneficial properties to its high content of organosulfur compounds (OSCs). Here we summarized recent studies published and some own findings regarding OSCs and its effects on Cardiovascular Disease, Inflammation and Obesity. Recent finding: The analysis of the multiple actions produced by...

Drug encapsulation in nanocarriers such as polymeric nanoparticles (Nps) may help to overcome the limitations associated with cannabinoids. In this sense, our work aimed to highlight the use of electrospraying technique for the development of carrier Nps of anandamide (AEA), an endocannabinoid with attractive pharmacological effects but underestima...