Walter Luyten

Walter Luyten
KU Leuven | ku leuven · Department of Biology

MD MSc PhD

About

202
Publications
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Publications

Publications (202)
Article
Full-text available
This study evaluated the effect of the extract and fractions of Bauhinia holophylla on Candida albicans planktonic growth, biofilm formation, mature biofilm, and hyphae growth. Three C. albicans strains (SC5314, ATCC 18804, and ATCC 10231) were tested. The crude extract and the fractions were obtained by exhaustive percolation and liquid–liquid par...
Article
Background Locomotor assays in zebrafish have emerged as a screening test in early drug discovery for antiseizure compounds. However, parameters differ considerably between published studies, which may explain some discrepant results with (candidate) antiseizure medications. New method We optimized a locomotor-based seizure assay in zebrafish with...
Article
Full-text available
Tetradenia riparia Hochsteter codd. (Lamiaceae) in its native African continent, is considered one of the most popular aromatic medicinal plants. In folk medicine it may be used as an infusion to treat respiratory problems, cough, headache, stomach pain, diarrhea, fever, malaria, and dengue; and in the form of compresses it is applied for the relie...
Article
Calamintha species are frequently used in traditional medicine in Algeria as a stimulant, a tonic, an antiseptic, but also to treat digestive disorders and intestinal infections that cause diarrhea as well as pneumonia. Bioassay- guided fractionation led to the isolation of highly effective antistaphylococcal molecules from the aerial parts of Cala...
Article
Background Plants are an abundant natural source of potential chemical compounds; they have been widely used in various industries, such as pharmaceuticals, cosmetics and food. This work aims to study two Saharan medicinal plants by evaluating the activity of plant extract against bacterial and fungal plant pathogens as well as against the model ne...
Article
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The stem of Picrasma quassioides (PQ) was recorded as a prominent traditional Chinese medicine, Kumu, which was effective for microbial infection, inflammation, fever, and dysentery, etc. At present, Kumu is widely used in China to develop different medicines, even as injection (Kumu zhusheye), for combating infections. However, the chemical basis...
Article
Disease epidemics in shrimp aquaculture increase apace with the development of aquaculture systems throughout the world. The disease caused by Vibrio spp. (vibriosis) is considered the most devastating, which has made it the most feared bacterial disease in the shrimp sector. In aquaculture, several strategies have already been applied to control V...
Article
Properties of chemically synthesized Zn1-xGdxO (x = 0.01, 0.03 and 0.05) nanorods were explored through microstructural, morphological, toxicity and magnetic characterizations. Hexagonal wurtzite structure of all the samples without any impurity phases was confirmed by X-ray diffraction characterization. The micrographs of transmission electron mic...
Article
Antimicrobial resistance and cancer are two important problems affecting human health. Actively developing novel antibiotics and anticancer medicines is a priority. Natural pentacyclic triterpenoids have attracted wide attention due to their significant biological activities. In this study, a series of 1,2,3-triazolo fused triterpenoids (betulin, o...
Article
Recently, nine Caenorhabditis elegans genes, grouped into two pathways/clusters, were found to be implicated in healthspan in C. elegans and their homologues in humans, based on literature curation, WormBase data mining and bioinformatics analyses. Here, we further validated these genes experimentally in C. elegans . We downregulated the nine genes...
Article
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Polygodial is a “hot” peppery-tasting sesquiterpenoid that was first described for its anti-feedant activity against African armyworms. Using the haploid deletion mutant library of Saccharomyces cerevisiae, a genome-wide mutant screen was performed to shed more light on polygodial’s antifungal mechanism of action. We identified 66 deletion strains...
Article
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A biologically guided isolation of secondary metabolites from Cousinia alata Schrenk wild plant growing in Akmola region, Kazakhstan, led to the isolation of the bioactive diterpene grindelic acid (1). Six flavonoids were also isolated and identified as retusine (2), pachipodol (3), jaranol (4), penduletin (5), casticin (6), and 5, 7, 3′-trihydroxy...
Article
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Several biogerontology databases exist that focus on genetic or gene expression data linked to health as well as survival, subsequent to compound treatments or genetic manipulations in animal models. However, none of these has yet collected experimental results of compound-related health changes. Since quality of life is often regarded as more valu...
Article
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To uncover potential anti-aging capacities of Traditional Chinese Medicine (TCM), the nematode Caenorhabditis elegans was used to investigate the effects of Eucommia ulmoides and Cuscuta chinensis extracts, selected by screening seven TCM extracts, on different healthspan parameters. Nematodes exposed to E. ulmoides and C. chinensis extracts, start...
Article
Caco-2 cells are increasingly used to study the absorption of drugs and nutrients, including D-glucose, an important nutrient that mainly gets absorbed from the intestine by the sodium/glucose cotransporter 1 (SGLT1). However, disadvantages of Caco-2 cells for such studies have been reported, e.g., D-glucose cannot elicit translocation of the intra...
Article
Ethnopharmacological relevance Tetradenia riparia (commonly known as ginger bush) is frequently used in traditional African medicine to treat foodborne infections including diarrhoea, gastroenteritis, and stomach ache. Aim of the study: The present study aims to identify in Tetradenia riparia the compounds active against foodborne pathogens. Mater...
Article
Nanoparticles of Zn1-xLaxO (x = 0, 0.01, 0.03 and 0.05) were successfully synthesized by a cost-effective chemical method. The influences of La on the microstructural, optical, antimicrobial and magnetic properties of these ZnO nanoparticles were investigated. XRD studies revealed the presence of hexagonal wurtzite phase of ZnO without any impurity...
Article
Full-text available
Over the last decades a decrease in mortality has paved the way for late onset pathologies such as cardiovascular, metabolic or neurodegenerative diseases. This evidence has led many researchers to shift their focus from researching ways to extend lifespan to finding ways to increase the number of years spent in good health; “healthspan” is indeed...
Article
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The newly emerged SARS-CoV-2 strains from the coronavirus (CoV) family is causing one of the most disruptive pandemics of the past century. Developing antiviral drugs is a challenge for the scientific community and pharmaceutical industry. Given the health emergency, repurposing of existing antiviral, antiinflammatory or antimalarial drugs is an at...
Article
Full-text available
Holarrhena pubescens is an important medicinal plant of the Apocynaceae family that is widely distributed over the Indian subcontinent. The plant is extensively used in Ayurveda and other traditional medicinal systems without obvious adverse effects. Beside notable progress in the biological and phytochemical evaluation of this plant over the past...
Article
Full-text available
Evaluation des polyphénols et des capacités antioxydantes des fruits de Musa acuminata Colla subsp. burmannicoïdes De Langhe, un bananier sauvage asiatique acclimaté dans la région de Yangambi, RD Congo Musa acuminata subsp. burmannicoïdes est un bananier sauvage importé de la Birmanie il y a un demi-siècle et bien acclimaté dans la Réserve de Bios...
Article
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Holigarna caustica (Dennst.) Oken is used by the tribes of Northeast India for the treatment of intestinal problems. Therefore, the present study was undertaken to investigate the active principles of this plant responsible for its anthelmintic activity, using bioassay-guided fractionation. An ethanol extract of H. caustica fruit was fractionated o...
Article
Full-text available
The molecular basis of aging and of aging-associated diseases is being unraveled at an increasing pace. An extended healthspan, and not merely an extension of lifespan, has become the aim of medical practice. Here, we define health based on the absence of diseases and dysfunctions. Based on an extensive review of the literature, in particular for h...
Article
Full-text available
SARS‐CoV‐2 causes the potentially fatal COVID-19 disease. Already during the outbreak of SARS‐CoV‐1, the use of vitamin C was suggested. Many patients with severe COVID-19 have elevated levels of the mediators interleukin-6 and endothelin-1. These mediators may explain the age-dependence of COVID-19 pneumonia, the preponderance of male and obese or...
Article
Full-text available
Chikungunya and yellow fever virus cause vector-borne viral diseases in humans. There is currently no specific antiviral drug for either of these diseases. Banana plants are used in traditional medicine for treating viral diseases such as measles and chickenpox. Therefore, we tested selected banana cultivars for their antiviral but also cytotoxic p...
Preprint
Full-text available
SARS-CoV-2 causes the potentially fatal COVID-19 disease. Already during the outbreak of SARS-CoV-1, the use of vitamin C was suggested. Many severe COVID-19 patients have elevated levels of the mediators interleukin-6 and endothelin-1. These mediators may explain the age-dependence of COVID-19 pneumonia, the preponderance of male and obese or hype...
Article
Full-text available
Background. Infections by microbes (viruses, bacteria, and fungi) and parasites can cause serious diseases in both humans and animals. Heavy use of antimicrobials has created selective pressure and caused resistance to currently available antibiotics, hence the need for finding new and better antibiotics. Natural products, especially from plants, a...
Article
Full-text available
Ten banana (Musa spp.) cultivars were studied for their antimicrobial properties. Three plant parts (corm, pseudostem and leaves) were collected separately and extracted with different solvents, viz., hexane, acetone, ethanol and water. The 50% inhibitory concentration (IC 50) was evaluated using a broth microdilution assay. Eight human bacterial a...
Article
Full-text available
Ten banana (Musa spp.) cultivars were studied for their antimicrobial properties. Three plant parts (corm, pseudostem and leaves) were collected separately and extracted with different solvents, viz., hexane, acetone, ethanol and water. The 50% inhibitory concentration (IC 50) was evaluated using a broth microdilution assay. Eight human bacterial a...
Article
Full-text available
Intestinal parasitic nematodes infect approximately two billion people worldwide. In the absence of vaccines for human intestinal nematodes, control of infections currently relies mainly on chemotherapy, but resistance is an increasing problem. Thus, there is an urgent need for the discovery and development of new anthelmintic drugs, especially one...
Article
With the aim to discover interesting lead compounds that could be further developed into compounds active against pharmacoresistant epilepsies, we first collected 14 medicinal plants used in traditional Chinese medicine (TCM) against epilepsy. Of the six extracts that tested positive in a pentylenetetrazole (PTZ) behavioral zebrafish model, only th...
Article
Full-text available
Essential oils (EOs) have been used therapeutically for centuries. In recent decades, randomized controlled (clinical) trials have supported efficacy in specific therapeutic indications for a few of them. Some EOs, their components or derivatives thereof have been approved as drugs. Nevertheless, they are still considered products that are mainly u...
Conference Paper
Introduction and aims: Oncology treatments research aim at identify and develop new anti-cancer drugs with improved efficacy and no cross-resistance to complement the present chemotherapeutics, and chromones and coumarins derivatives have shown such activity [1,2]. In this study, we test a novel series of synthetic chromone and coumarin derivatives...
Poster
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Background: Resistance to known anthelmintics has become a growing concern 1. Based on 2017-2019 ethnomedical and ethnoveterinary surveys carried out in Katanga Province, several species of shrub locally identified as Vitex species (Lamiaceae) are used to treat animal helminthiases. Aim of the study: In this study, 4 Vitex species (including differ...
Article
The objective of this study is to evaluate the in vitro antibacterial effectiveness of select Indian medicinal plants against multidrug-resistant (MDR) and biofilm-forming Staphylococcus. Twenty Indian medicinal plants used traditionally were preselected for testing against 17 different clinical strains (originating from animal or hospital patients...
Article
Ethnopharmacological relevance: Warburgia ugandensis Sprague subspecies ugandensis is a plant widely distributed in Eastern, Central and Southern Africa. In humans, it is used to treat respiratory infections, tooth aches, malaria, skin infections, venereal diseases, diarrhea, fevers and aches. Aim of the study: This study aims to identify the bi...
Article
Dengue virus (DENV) is the most prevalent mosquito-borne viral pathogen and made the disease a major health concern worldwide. However, specific antiviral drugs against this arbovirose or vaccines are not yet available for treatment or prevention. Thus, here we aimed to study the antiviral activity of hydroethanolic extract, fraction ethyl acetate...
Conference Paper
Insects constitute an alternate source of protein with the benefits of lower environmental impacts than conventional livestock. Ruspolia differens is among the favourite insects used to reduce food insecurity across Sub-Saharan Africa. Current indigenous knowledge rumours the utilisation of this insect as traditional medicine for specific ailments,...
Article
The anti-microbial activity of crude extracts (hexane, acetone, ethanol, and aqueous) of 46 edible plants from Odisha, India, was studied using a broth microdilution assay against 8 common food-borne pathogens (Gram-positive: Bacillus cereus, Streptococcus faecalis, Listeria innocua, Micrococcus luteus, and Gram-negative: Escherichia coli, Pseudomo...
Article
G Protein-Coupled Receptors (GPCRs) transduce extracellular signals and activate intracellular pathways, usually through activating associated G proteins. Due to their involvement in many human diseases, they are recognized worldwide as valuable drug targets. Many experimental approaches help identify small molecules that target GPCRs, including in...
Preprint
Full-text available
Different parts of Cnestis ferruginea are used in traditional African medicine for treating infectious diseases such as dysentery, bronchitis, eye troubles, conjunctivitis, sinusitis, gonorrhea, and syphilis. Despite its long traditional use in the treatment of infections, this plant is not well studied for its in vitro antimicrobial properties. Th...
Article
Each year, fruit growers have hundreds of tons of bark and pruning waste. Despite their potential for chemical recycling, residues from this waste are frequently used for applications with low added value. By converting the waste stream into a valuable source, this study emphasizes waste valorisation and engenders re-use strategies for the producti...
Article
Full-text available
Despite increasing research efforts, there is a lack of consensus on defining aging or health. To understand the underlying processes, and to foster the development of targeted interventions towards increasing one's health, there is an urgent need to find a broadly acceptable and useful definition of health, based on a list of (molecular) features;...
Article
Parasitic nematodes continue to cause significant economic losses in livestock globally. Given the limited number of anthelmintic drugs on the market and the currently increasing drug resistance, there is an urgent need for novel anthelmintics. Most motility assays of anthelmintic activity for parasitic nematodes are laborious and low throughput, a...
Article
Full-text available
Salvia officinalis is frequently used in traditional Algerian medicine to treat diverse microbial infections, including oral and vaginal candidiasis. The aerial parts of S. officinalis collected in Annaba, Algeria were extracted in parallel by maceration with four solvents viz. hexane, acetone, methanol and water. All the extracts were tested in vi...
Article
Ethnopharmacological relevance Semen Pharbitidis, the seeds of Pharbitis nil (Linn.) Choisy (Convolvulaceae) is a well-known traditional Chinese medicinal plant used for treating helminthiasis and epilepsy in China. Aim of the study This study aims to identify the anti-seizure components from Semen Pharbitidis. Methods A bioassay-guided isolation...
Preprint
Full-text available
A new 6-benzyl-γ-pyrone (1), named aspergyllone was isolated from the culture filtrates of an endolichenic fungus Aspergillus niger Tiegh, obtained from lichen thallus Parmotrema ravum (Krog & Swinscow) Serus, collected in India. 1 was isolated for the first time from an endolichenic fungus together with six other known metabolites identified as au...
Article
Full-text available
EOs are known for their antimicrobial activities against a broad range of microorganisms. It is believed that EOs plants grown by organic farming are more potent than those obtained from conventional farming. Therefore, the aim of this study was to compare pairwise the inhibitory vapor-phase-mediated antimicrobial activity of 66 certified organic E...
Preprint
Full-text available
Despite increasing research efforts, there is a lack of consensus on defining aging or health. To understand the underlying processes, and to foster the development of targeted interventions towards increasing one's health, there is an urgent need: (1) to find a broadly acceptable and useful definition of health, based on a list of features (which...
Article
Full-text available
Ethnopharmacological relevance: Knowledge on the use of plants for different ailments by the tribals of the Chirang Reserve Forest (CRF, Northeast India) was used to assess the potential of these plants for treating viral, bacterial and fungal infections. Materials and methods: Fieldwork in the CRF documented the use of plants for the treatment...
Article
Parasitic helminths continue to pose problems in human and veterinary medicine, as well as in agriculture. Resistance to current anthelmintics has prompted the search for new drugs. Anthelmintic metabolites from medicinal plants could be good anthelmintic drug candidates. However, the compounds active against nematodes have not been identified in m...
Article
Human enterovirus 71 (EV-A71) infections cause a wide array of diseases ranging from diarrhoea and rashes to hand-foot-and-mouth disease and, in rare cases, severe neurological disorders. No specific antiviral drug therapy is currently available. Extracts from seventy-five Chinese medicinal plants selected for antiviral activity based on the Chines...
Preprint
Full-text available
The molecular basis of aging and of aging-related diseases is being unraveled at an increas-ing pace. More recently, a long healthspan is seen as an important goal. However, a precise definition of health and healthspan is not straightforward, and the causal molecular basis of health "per se" is largely unknown. Here, we define health based on dise...
Article
Full-text available
Vancomycin is a glycopeptide antibiotic that inhibits transpeptidation during cell wall synthesis by binding to the D-Ala-D-Ala termini of lipid II. For long, it has been used as a last resort antibiotic. However, since the emergence of the first vancomycin-resistant enterococci in 1987, vancomycin resistance has become widespread, especially in ho...
Article
Full-text available
Ethnopharmacological relevance: Semen Torreyae, the seeds of Torreya grandis Fortune ex Lindley (Cephalotaxaceae) is a well-known traditional Chinese medicinal plant recorded in the Chinese Pharmacopeia (2010 version). It is widely used for treating intestinal parasites in China, owing to its desirable efficacy and safety. However, the anthelminti...
Article
Bio‐active peptides are involved in the regulation of most physiological processes in the body. Classical bio‐active peptides (CBAPs) are cleaved from a larger precursor protein and stored in secretion vesicles from which they are released in the extracellular space. Recently, another non‐classical type of bio‐active peptides (NCBAPs) have gained i...