Walter Goessler

Walter Goessler
Karl-Franzens-Universität Graz | KFU Graz · Institute of Chemistry

PhD

About

474
Publications
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15,581
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Publications

Publications (474)
Article
Background Epigenetic dysregulation has been proposed as a key mechanism for arsenic-related cardiovascular disease (CVD). We evaluated differentially methylated positions (DMPs) as potential mediators on the association between arsenic and CVD. Methods Blood DNA methylation was measured in 2321 participants (mean age 56.2, 58.6% women) of the Str...
Article
The inductively coupled plasma mass spectrometry (ICPMS) has been attracting increasing attention for many applications as an element-selective chromatographic detector. A major and fundamental limitation in coupling ICPMS with liquid chromatography is the limited compatibility with organic solvents, which has so far been addressed via a tedious ap...
Preprint
Purpose Arsenic exposure and micronutrient deficiencies may alter immune reactivity to influenza vaccination in pregnant women, transplacental transfer of maternal antibodies to the fetus, and maternal and infant acute morbidity. The Pregnancy, Arsenic, and Immune Response (PAIR) Study is a longitudinal pregnancy and birth cohort designed to assess...
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Trace elements in aquatic environments pose a risk to biological communities; this study investigates the total concentrations of arsenic (As), silver (Ag), cadmium (Cd), cobalt (Co), chromium (Cr), copper (Cu), mercury (Hg), nickel (Ni), selenium (Se), lead (Pb), and zinc (Zn) within muscle, carapace, liver, and adipose tissues of diamondback terr...
Article
Increasing evidence suggests that high selenium (Se) exposure is associated with adverse health effects. However, limited evidence exists on the association of Se exposure with cardiovascular disease (CVD), especially in communities affected by high naturally occurring Se in environmental media. We evaluated the prospective association between urin...
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Arsenic can be toxic to living organisms, depending not only on the concentration but also, its chemical form. The aim of this study was to determine arsenic concentrations and perform arsenic speciation analysis for the first time in honeybees, to evaluate their potential as biomonitors. Highest arsenic concentrations were determined in the vicini...
Article
Hydrogen sulfide is endogenously produced in humans and is commonly referred to as the “third gaseous signaling molecule”, but commonly considered as a toxic gas. There is a need to establish reliable biomarkers for exposure to hydrogen sulfide in human matrices not only at toxic levels but also at trace levels. We recently detected trimethylsulfon...
Article
Fruit-bodies of six Thelephora species (Fungi, Basidiomycota, Thelephoraceae) were analyzed for their trace element concentrations. In Thelephora penicillata, extremely high concentrations of Cd and As were found, followed by highly elevated concentrations of Cu and Zn. The highest accumulation ability was found for Cd with a mean concentration of...
Preprint
Iron in the human brain is stored in the cores of ferritin proteins. Excess iron has been implicated in neurological disorders, so a careful balance of the iron concentration is thought to be essential for human health. Though it is known that oligodendrocytes contain most of the brain ferritin, followed by other glial cells and neurons, little is...
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The effect of low-moderate levels of arsenic exposure and of arsenic metabolism on mortality remains uncertain. We used data from a prospective cohort study in 3600 men and women aged 45 to 75 years living in Arizona, Oklahoma, and North and South Dakota. The biomarker of inorganic arsenic exposure was the sum of urine inorganic (iAs), monomethylat...
Article
Background: Chronic exposure to certain metals plays a role in disease development. Integrating untargeted metabolomics with urinary metallome data may contribute to better understanding the pathophysiology of diseases and complex molecular interactions related to environmental metal exposures. To discover novel associations between urinary metal b...
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Magnesium-deficiency is implicated in many metabolic disorders, e.g., type 2 diabetes and metabolic syndrome, representing risk factors for non-alcoholic fatty liver disease (NAFLD). This study aims to investigate the contribution of magnesium-restriction to the development of NAFLD. Magnesium-deficiency was induced in C57BL/6 mice by feeding a mag...
Article
Objectives: In-house developed liquid-chromatography mass spectrometry (LC-MS/MS) methods are used more and more frequently for the simultaneous quantification of vitamin D metabolites. Among these, 24,25-dihydroxyvitamin D3 (24,25(OH)2D3) is of clinical interest. This study assessed the agreement of this metabolite in two validated in-house LC-MS...
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Background Silver nanoparticles (AgNPs) are widely used in biomedicine due to their strong antimicrobial, antifungal, and antiviral activities. Concerns about their possible negative impacts on human and environmental health directed many researchers towards the assessment of the safety and toxicity of AgNPs in both in vitro and in vivo settings. A...
Article
Background American Indians have a higher burden of chronic lung disease compared to the US average. Several metals are known to induce chronic lung disease at high exposure levels; however, less is known about the role of environmental-level metal exposure. We investigated respiratory effects of exposure to single metals and metal-mixtures in Amer...
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Homogenized or pooled samples of honey bees are used for monitoring of metal pollution in the environment already for a couple of decades. This is the first study that analyzed the elemental composition of individual honey bees. One apiary with 21 hives was used to test in-hive and between-hive differences at the same location. Highest in-hive vari...
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Inspired by the reactivity of (per)chlorate reducing molybdoenzymes and encouraged by the lack of molybdenum-containing functional models thereof, two molybdenum(VI) complexes of the type [MoO2L2] (L = pyrimidine-2-thiolate or 6-methylpyridine-2-thiolate) were found to be active homogeneous catalysts for the reduction of ClO4– to ClO3– in CH2Cl2 us...
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The brain’s supply with vitamin D is poorly understood. Therefore, the present study aimed to determine 25-hydroxy vitamin D3 (25(OH)D) and 24,25-dihydroxy vitamin D (24,25(OH)2D3) in serum and cerebrospinal fluid (CSF) from individuals with intact and disturbed brain-CSF-barrier (BCB) function. In 292 pairs of serum and CSF samples the vitamin D m...
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Deep infection is a serious complication in endoprosthetic surgery. In correlation to the patient local or systemic compromising factors conservative and surgical proceedings has to be evaluated. Systemic antibiotic therapy is the gold standard in infection management. Implanted silver-coated or silver-containing medical devices have been proven to...
Article
With the introduction of tandem mass spectrometry to inductively coupled plasma mass spectrometry (ICPMS/MS), the potential for non-targeted elemental metabolomic analysis has been expanded to many non-metals of pivotal biological importance. Arsenic and selenium are trace elements that share chemical similarity with the non-metals phosphorus and s...
Article
This research explores the possibilities and limitations of WD-XRF, applied as a method for quantification of 20 elements in plant material, using spiked cellulose standards for calibration. Three different analytical methods were investigated: 1) standards created from pure spiked cellulose; 2) spiked cellulose mixed with 20% of binder and 3) spik...
Article
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Background Tattoo inks have been reported to elicit allergic contact dermatitis. Objectives To investigate the labels and the contents of metals and pigments in tattoo inks, considering restrictions within the European Union. Methods 73 tattoo inks currently available on the market, either bought or donated (already used), were investigated for t...
Article
The Cytochrome P450 CYP1A2 is a central enzyme in the metabolism of drugs and xenobiotics. The overall activity of this enzyme is influenced by a complex array of biochemical, dietary, and genetic factors. One of the simplest ways to probe the overall output of CYP1A2 is to measure the ratio between the concentration of a precursor and a product of...
Article
Silver nanoparticles (AgNPs) are among the most commercialized nanomaterials in biomedicine due to their antimicrobial and anti-inflammatory properties. Nevertheless, possible health hazards of exposure to AgNPs are yet to be understood and therefore raise public concern in regards of their safety. In this study, sex-related differences, role of st...
Article
We report the first halogen speciation analysis study by high performance liquid chromatography coupled with inductively coupled plasma tandem mass spectrometry (HPLC-ICPMS/MS) in the fruiting bodies of various mushroom species. Non-targeted speciation analysis revealed the occurrence of dichloroacetic acid (DCAA) in the edible mushroom Russula nig...
Article
Background: Vitamin D is a well-established regulator of calcium and phosphate metabolism that has neurotrophic and neuroprotective properties. Deficiency of vitamin D has been proposed to promote cognitive dysfunction and brain atrophy. However, existing studies provide inconsistent results. Here we aimed to investigate the association between vi...
Article
Background Arsenic has been associated with hypertension, though it is unclear whether associations persist at the exposure concentrations (e.g. <100 μg/L) in drinking water occurring in parts of the Western United States. Methods We assessed associations between arsenic biomarkers and systolic blood pressure (SBP), diastolic blood pressure (DBP),...
Article
Genetic effects are suspected to influence cadmium internal dose. Our objective was to assess genetic determinants of urine cadmium in American Indian adults participating in the Strong Heart Family Study (SHFS). Urine cadmium levels and genotyped short tandem repeat (STR) markers were available on 1936 SHFS participants. We investigated heritabili...
Article
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Boron (B) is a plant nutrient and a limited mineral resource. Therefore, secondary B sources such as end-of-life cellulose fiber insulation (CFI) should be preferred for B fertiliser production over primary borates. In addition, crop B fertilisation is challenging because B is only weakly adsorbed in soils and prone to leaching in particular if the...
Article
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Benzoic acid decarboxylases have been explored as efficient biocatalysts for the (de)carboxylation of electron‐rich (hetero)aromatics. As members of the amidohydrolase superfamily, these enzymes share considerable structural and mechanistic features including the requirement of a divalent metal ion for catalysis. SEC‐coupled ICPMS/MS measurements a...
Article
Amanita muscaria , also known as the fly agaric mushroom, can accumulate vanadium (V), with up to several hundred mg V kg ⁻¹ dry mass. It is long known that V is...
Article
Inductively coupled plasma mass spectrometry (ICPMS) offers unique possibilities as a chromatographic detector. A major limitation is the difficulty of employing conventional mobile phases in the reversed-phase mode (i.e. containing...
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Carotenoid pigments play a major role in animal body colouration, generating strong interest in the genes involved in the metabolic processes that lead from their dietary uptake to their storage in the integument. Here, we used RNA sequencing (RNA-Seq) to test for differentially expressed genes in a taxonomically replicated design using three pairs...
Article
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Vitamin D status is typically assessed by the measurement of 25-hydroxyvitamin D (25(OH)D). However, in selected patient groups the sole determination of 25(OH)D has been proven insufficient for this purpose. The simultaneous measurement of additional vitamin D metabolites may provide useful information for a better evaluation of the vitamin D stat...
Article
The As concentrations, along with 34 other elements, and the As speciation were investigated in wild-grown samples of the parasitic mushroom Tolypocladium ophioglossoides with inductively coupled plasma mass spectrometry (ICPMS) and high performance liquid chromatography coupled to ICPMS. The As concentrations were 0.070–3.44 mg kg⁻¹ dry mass. More...
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Broad substrate tolerance and excellent regioselectivity, as well as independence from sensitive cofactors established benzoic acid decarboxylases from microbial sources as efficient biocatalysts. Robustness under process conditions makes them particularly attractive for preparative-scale applications. The divalent metal-dependent enzymes are capab...
Article
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Fluorinated carboxylic acids have been in use as ion-pairing reagents for over three decades. It has been observed that ion-pairing reagents not only increase the retention of oppositely charged analytes on reversed-phase HPLC columns but also decrease the retention of similarly charged analytes; these latter effects, however, have not been thoroug...
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Background: Prosthetic joint infection (PJI) is a serious complication of orthopedic implant surgery. Treatment often includes the use of an antibiotic-loaded Polymethyl methacrylate (PMMA) bone cement spacer. Several antibiotics are commonly used for the preparation of these spacers, but due to the increasing number of infections with resistant G...
Article
Metal exposure remains a significant public health problem, particularly in the informal sector. The rise in informal foundries to cast scrap metal into artisanal cookware is widespread in low- and middle-income countries. The main aim of this study was to characterize metal exposure in artisanal cookware makers working in informal foundries in Sou...
Article
Full-text available
3,3-Bis(2,4,6-triisopropylphenyl)-1,1-binaphthyl-2,2-diyl hydrogenphosphate (TRIP) catalyzes the asymmetric allylation of aldehydes with organozinc compounds leading to highly valuable structural motifs, like precursors to lignan natural products. Our mechanistic proposal previously reported relies on two reaction intermediates and requires further...
Article
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A new class of cationic ion-interaction reagents for reversed-phase chromatography is introduced in the present work. Compounds belonging to a homologous series of linear fluoroalkyl chains including trifluoroethylamine (TFEAm), pentafluoropropylamine (PFPAm), heptafluorobutylamine (HFBAm), and nonafluoropentylamine (NFPAm) were tested and compared...
Article
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The HAAs are generally considered as environmental contaminants and are suspected to pose major public health concern. The inductively coupled plasma mass spectrometry (ICPMS) has been improved by coupling with the tandem mass spectrometry technology (ICPMS/MS), enabling ultra-trace determination of heteroatoms. There have been few reports about th...
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A variety of Magnetic Resonance Imaging (MRI) techniques are known to be sensitive to brain iron content. In principle, iron sensitive MRI techniques are based on local magnetic field variations caused by iron particles in tissue. The purpose of this study was to investigate the sensitivity of MR relaxation and magnetization transfer parameters to...
Article
Background: Chronic exposure to arsenic (As), a human toxicant and carcinogen, remains a global public health problem. Health risks persist after As exposure has ended, suggesting epigenetic dysregulation as a mechanistic link between exposure and health outcomes. Objectives: We investigated the association between total urinary As and locus-spe...
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The Violet Crown Cup, Sarcosphaera coronaria, is a rather inconspicuous mushroom, but with an interesting and unresolved mystery. In earlier days, the mushroom was considered edible, but several poisonings were reported in the early 20th century. The reason for the seemingly sporadic toxicity of S. coronaria is still unknown. One possible explanati...
Article
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Extensive information is available on total arsenic in particulate matter (PM), but little is known about the relative contribution of each individual species. Recent studies often focus on inorganic arsenic as arsenite and arsenate, neglecting the organoarsenicals, i.e., methylarsine, dimethylarsine and trimethylarsine or the corresponding oxidize...
Article
Atmosphere inside caves used for speleotherapy are microenvironments influenced by ventilation and human activities inside. In this context, particulate matter with an aerodynamic diameter from 15 nm to 10 μm was collected with an electrical low-pressure impactor ELPI+ in the Císařská Cave in the northern part of the Moravian Karst (Czech Republic)...
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The original version of this article [1], published on 28 November 2019, contained incorrect title. In this Correction the affected part of the article is shown.
Article
Experimental and prospective epidemiologic evidence suggest that arsenic exposure has diabetogenic effects. However, little is known about how family exposure to arsenic may affect risk for type 2 diabetes (T2D)-related outcomes in adulthood. We evaluated the association of both maternal and offspring arsenic exposure with fasting glucose and incid...
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Background: Carotenoids contribute significantly to animal body coloration, including the spectacular color pattern diversity among fishes. Fish, as other animals, derive carotenoids from their diet. Following uptake, transport and metabolic conversion, carotenoids allocated to body coloration are deposited in the chromatophore cells of the integu...
Article
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Background: Arsenic exposure through drinking water is an established lung carcinogen. Evidence on non-malignant lung outcomes is less conclusive and suggests arsenic is associated with lower lung function. Studies examining low-moderate arsenic (< 50 μg/L), the level relevant for most populations, are limited. We evaluated the association of arse...
Article
Boron is a finite resource, which has been listed as a critical raw material in the EU since 2014. Glass, frits and ceramics production, as well as fertilizers, are among the major uses of B. Moreover, about 50,000 t B have been applied as fire retardant and pest repellent in cellulose fiber insulation (CFI) in Europe since the 1980s. Here we propo...
Article
The recent development of the inductively coupled plasma tandem mass spectrometry (ICPMS/MS) offers exciting opportunities for non-metal speciation analysis. In this work, we report the first sulfur speciation study in wine by HPLC-ICPMS/MS. The major sulfur compounds were found to be sulfate (50-81 mg S L-1) followed by sulfite (18-24 mg S L-1 fre...
Article
Perchlorate is an environmental contaminant that originates from anthropogenic as well as natural sources. The health effects of perchlorate with respect to the thyroid function are well known. The capabilities of the inductively coupled plasma mass spectrometry (ICPMS) has been recently expanded by coupling with tandem mass spectrometry. The advan...
Poster
Full-text available
Arsenic (As) is a toxic metalloid with no known biogenic function. To prevent its toxicity, organisms employ a variety of metabolic processes to transform arsenate (As V), that they obtain from the environment, into less toxic compounds. These compounds are then stored within the cell in specialized compartments or exported out of the cell. In this...
Article
Recycling of scrap metal into artisanal cookware is widespread in poorly resourced countries. The aim of the study was to determine the risk of metal exposure from the use of artisanal cookware available in South Africa. Twenty cookware samples were purchased from local manufacturers and informal traders across South Africa. Aluminum and silicon co...
Article
Background: Chronic exposure to inorganic arsenic (iAs) in the US occurs mainly through drinking water and diet. Although American Indian (AI) populations have elevated urinary arsenic concentrations compared to the general US population, dietary sources of arsenic exposure in AI populations are not well characterized. Methods: We evaluated food...
Article
Full-text available
New Year's Eve fireworks represent one of the most unusual atmospheric pollution events in the course of a year. A majority of particles aerosolized by burning of fireworks consist of metals and their compounds used in firework displays. In this study, ambient particulate matter was sampled using a 14 stage cascade impactor in two European cities d...
Article
Exploitation of silver nanoparticles (AgNPs) in biomedicine represents more than one third of their overall applications. Despite their wide use, detailed toxicokinetic data and information on their action mechanisms in vivo are still scarce. One important obstacle is their fate and transformation patterns in biological environments where AgNPs get...
Article
The concentrations of major and trace elements in Argentinean commercial powdered milk samples were determined with inductively coupled plasma mass spectrometry. Also the daily intake (DI) was calculated for adults and infants. The concentrations of B, Mg, Na, K and Ca were significantly higher in skimmed milk. Cu, Mo, Fe, Mn and Zn were significan...