Waleed Albihlal- PhD
- Postdoctoral Fellow at The Francis Crick Institute
Waleed Albihlal
- PhD
- Postdoctoral Fellow at The Francis Crick Institute
About
12
Publications
16,965
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294
Citations
Introduction
Current institution
Additional affiliations
Position
- Research Associate
February 2022 - present
August 2016 - May 2021
Education
January 2011 - April 2015
University of Essex
Field of study
- Biological Sciences
October 2009 - September 2010
University of Essex
Field of study
- Biotechnology
May 2001 - May 2005
King Saud University
Field of study
- Biochemistry
Publications
Publications (12)
Phosphofructokinase (PFK) is a rate-limiting glycolytic enzyme that also possesses an unexplored RNA binding activity. Here, we show that the α- and β-subunits of yeast PFK, encoded by PFK1 and PFK2 , respectively, bind hundreds of mRNAs in cells, including one’s coding for proteins involved in regulation of mitotic cell cycle. Pkf2p directly binds...
N⁶‐methyladenosine (m6A) is a highly abundant and evolutionarily conserved messenger RNA (mRNA) modification. This modification is installed on RRACH motifs on mRNAs by a hetero‐multimeric holoenzyme known as m6A methyltransferase complex (MTC). The m6A mark is then recognised by a group of conserved proteins known as the YTH domain family proteins...
N6-methyladenosine (m6A), the most abundant mRNA modification, is deposited in mammals/insects/plants by m6A methyltransferase complexes (MTC) comprising a catalytic subunit and at least five additional proteins. The yeast MTC is critical for meiosis and was known to comprise three proteins, of which two were conserved. We uncover three novel MTC c...
Cardiac pathologies are characterized by intense remodeling of the extracellular matrix (ECM) that eventually leads to heart failure. Cardiomyocytes respond to the ensuing biomechanical stress by reexpressing fetal contractile proteins via transcriptional and posttranscriptional processes, such as alternative splicing (AS). Here, we demonstrate tha...
RNA‐binding proteins play essential roles in the post‐transcriptional regulation of gene expression. While hundreds of RNA‐binding proteins can be predicted computationally, the recent introduction of proteome‐wide approaches has dramatically expanded the repertoire of proteins interacting with RNA. Besides canonical RNA‐binding proteins that conta...
In Arabidopsis thaliana, HEAT SHOCK TRANSCRIPTION FACTORA1b (HSFA1b), controls resistance to environmental stress and is a determinant of reproductive fitness by influencing seed yield. To understand how HSFA1b achieves this, we surveyed its genome-wide targets (ChIP-seq) and its impact on the transcriptome (RNA-seq) under non-stress (NS), heat str...
Heat-stressed crops suffer dehydration, depressed growth, and a consequent decline in water productivity, which is the yield
of harvestable product as a function of lifetime water consumption and is a trait associated with plant growth and development.
Heat shock transcription factor (HSF) genes have been implicated not only in thermotolerance but...
