Walaa Elseady

Tanta University · Department of Anatomy And Embryology

Sofosbuvir is a novel drug candidate for the treatment of hepatitis C viral infection; however, vision loss is one of its growing adverse effects. Saffron is a natural biomolecule with a high antioxidant potential that has been efficiently used in some diseases caused by oxidative stress. This study evaluated Sofosbuvir's neurodegenerative effect o...

Lung diseases such as asthma, chronic obstructive pulmonary diseases, and pneumonia are causing many global health problems. The COVID-19 pandemic has directed the scientific community’s attention toward performing more research to explore novel therapeutic drugs for pulmonary diseases. Herein, gas chromatography coupled with mass spectrometry tent...

Chronic glucocorticoids therapy is commonly complicated by steroid diabetes, while the underlying mechanisms are still elusive. Liraglutide a glucagon like peptide -1 was initially found to induce glycemic control and recently it was found to have many pleotropic effects. However, its role in pancreas remains unknown. So, the present study aims to...

Pregabalin (PGB) is an analog of the inhibitory neurotransmitter gamma-aminobutyric acid. The currently available evidence favors the misuse and abuse potential of PGB. However, its neurotoxicity remains unclear. Therefore, this study assessed the toxic effects of chronic pregabalin dependence as well as withdrawal on the cortical neurons of the fr...

Background: Cisplatin is an alkylating agent that inhibits DNA replication and interferes with proliferation of cancer cells. However, the major limiting factor for its use is the possible development of adverse effects, including ototoxicity. Up till now, the mechanisms of this ototoxicity remain poorly understood. However, induction of oxidative...

Diabetes mellitus (DM) is associated with the increased risk of the central nervous system complications as cerebrovascular disease, impaired cognition, dementia and neurodegeneration. Curcumin is a polyphenol with anti-oxidant, anti-inflammatory, anti-hyperlipidemic, and anti-cancer effects. Therefore, the present study was aimed to focus on the m...

Adequate dietary intake has a crucial effect on brain health. High fat diet (HFD) rich in saturated fatty acids is linked to obesity and its complications as neurodegeneration via inducing oxidative stress and inflammation. The present study aimed to evaluate the effect of HFD on cerebral cortex in addition to shedding the light on the modulatory r...

Liver cirrhosis is a scene profitable to the advance of hepatocellular carcinoma (HCC). The current work was engrossed to weigh the potential role of Cichorium intybus linn against thioacetamide (TAA)‐induced liver cirrhosis and their probable underlying biochemical and molecular mechanisms. farnesoid‐X‐receptor (FXR) expression, proliferating cell...

ABSTRACT Background: Cyclophosphamide (CP) is a widely used chemotherapy because of its significant antitumor activity. It is also used in the treatment of some autoimmune diseases. Lipoic acid (LA) is a multifactorial antioxidant and considered as a potential therapeutic agent in the treatment of different pathological cases. Purpose: The aim of t...