Wajid Rehman

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Verified

Wajid verified their affiliation via an institutional email.

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• PhD
• Tenured Professor (Full) at Hazara University

Background: Alzheimer’s disease is a complex and multifactorial brain disorder characterized by gradual memory impairment, cognitive disturbance, and severe dementia, and, ultimately, its progression leads to patient death. This research work presents the design, synthesis, and characterization of novel imidazotriazole-based thiazolidinone derivati...

Pure PbS and Zn-doped thin films have been synthesized with chemical derived spin coating approach. The prepared films were explored by the combination of first principle based investigations and experimental findings. The simulations were executed by Weink2 computational code. The well crystallinized and pure cubic phase thin films were examined b...

The increasing environmental concerns over wastewater contamination have spurred significant interest in developing efficient and sustainable methods for wastewater treatment. In this study, a simple and user-friendly approach was employed to synthesize iron oxide nanoparticles (IO-NPs) using Musa acuminata peel extract as a reducing and stabilizin...

Schiff bases are an important scaffold for designing drug development. They are characterized by having a carbon-nitrogen double bond. This double bond is synthesized by different synthetic schemes by both the aromatic and aliphatic chains. Bases inspired chemists due to their versatile importance in drug discovery and drug development. A large num...

Introduction A series of schiff bases(3-8) were synthesized by the reaction of cefradine with six different aldehydes/ketones. Methods These Schiff bases (3-8) were treated with different bases/salts (NaOH, KOH, Ca(OH)2, Ba(OH)2, Ag(NO)3) to get their metal salts. The structures of the products were as-certained by spectroscopic data. The synthesi...

The second most abundant crop in the world is rice which produces 20–33% rice husk (RH), as biomass of approximately 139.54–230.24 million tons. Its open combustion discharges harmful organic contaminants like polycyclic aromatic hydrocarbons and dioxins along with injurious gases such as CO2, CO, SO2 and NOx. The presence of residual carbon and si...

Edible food packaging has emerged as an innovative solution to address the environmental issues of plastic pollution and excessive packaging. Traditional petroleum-based plastics, commonly used for food packaging due to their availability, strength, and cost-effectiveness, contribute significantly to landfill waste, water pollution, and health prob...

In-vitro and in-silico assessment of thiazole-thiazolidinone derivatives as selective inhibitors of urease and α-glucosidase, Future Medicinal Chemistry, ABSTRACT Aims: Current research work aims to synthesize hybrid compounds with a thiazole-thiazolidinone structure, as potent inhibitors of urease and α-glucosidase enzymes. Materials and methods:...

Background The synthesis of metal-based nanoparticles through conventional methods involves harsh conditions, high costs, and severe environmental threats. To overcome these issues, researchers are nowadays focusing on eco-friendly and low-cost methods for the synthesis of nanoparticles. Finally, several plant-mediated synthesis techniques have bee...

Inflammation is a complex physiological response associated with the onset and progression of various disorders, including diabetes. In this study, we synthesized a series of diclofenac acid derivatives and evaluated their potential anti-diabetic and anti-inflammatory activities. The compounds were specifically assessed for their ability to inhibit...

Diabetes mellitus (DM) is a disorder which is raised at the alarming level and it is characterized by the hyperglycemia results from the impaired action of insulin, production of insulin or both of these simultaneously. Consequently, it causes problems or failure of different body organs such as kidneys, heart, eyes, nerve system. Since this diseas...

Photodynamic Therapy (PDT) has emerged as a highly efficient and non-invasive cancer treatment, which is crucial considering the significant global mortality rates associated with cancer. The effectiveness of PDT primarily relies on the quality of the photosensitizers employed. When exposed to appropriate light irradiation, these photosensitizers a...

Urease enzyme is one of the major causes of severe health issues including urinary catheter encrustation, gastric cancer, duodenal ulcer and peptic ulcer. In search for potent anti-urease compound, we have designed and synthesized indole based 1,3,4-oxadiazole and 1,3,4-thiadiazole hybrid derivatives (1-24) with promising po- tential to inhibit the...

New series of benzimidazole incorporating piperazine moieties in single molecular framework has been reported. The structures of the synthesized derivatives were assigned by 1H-NMR, 13C-NMR, and HR-MS techniques. The hybrid derivatives were evaluated for their acetylcholines- terase and butyrylcholinesterase inhibition effect. All the synthesized a...

The current study involves the synthesis of Schiff bases based on 1,2,4-triazoles skeleton and assessing their α-amylase and α-glucosidase profile. Furthermore, the precise structures of the synthesized derivatives were elucidated using various spectroscopic methods such as ¹ H-NMR, ¹³ C-NMR and HREI-MS. Using glimepiride as the reference standard,...

Diabetes mellitus (DM) is a chronic disorder and still a challenge throughout the world, and therefore the search for safe and effective inhibitors for α-amylase and α-glucosidase is increasing day by day. In this work, we try to carry out the synthesis, modification, and computer-aided results of and biological research on thiadiazole-based Schiff...

Vinyltriethoxysilane (VTES) was covalently bonded onto graphene oxide. Several methods, including X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, and X-ray diffraction, were used to demonstrate the presence of VTES on the surface of graphene oxide and the creation of this covalent link. Following that, different quantitie...

Water contamination due to organic pollutants is a challenging issue around the globe, and several attempts have been made to deal with this issue. Out of which, the semiconductor-based photocatalytic process had gained much attention and proved to be an efficient, easy, and economical process for the removal of organic dyes from aqueous solutions....

Impact of chitosan/metal oxide-based blends on the rheology, stability, and microstructures of oil-in-water emulsions, Journal of Food Engineering (2024), doi: https:// Running title: Chitosan/metal oxide modulates the rheology and stability of emulsions J o u r n a l P r e-p r o o f 2 Abstract In this study, chitosan and metal oxides, specifically...

Benzimidazole-based pyrrole/piperidine analogs (1-26) were synthesized and then screened for their acetylcholinesterase and butyrylcholinesterase activities. All the analogs showed good to moderate cholinesterase activities. Synthesized compounds (1-13) were screened in cholin-esterase enzyme inhibition assays and showed AChE activities in the rang...

Aim: Recently, thiadiazole-containing drugs have gained greater clinical relevance and are being explored for the development of new antidiabetic, antiurease and antimicrobial agents that target drug resistance. Methods & results: The authors disclose the synthesis of N-(5-[4-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl)methanimine derivatives st...

Diabetes is an emerging disorder in the world and is caused due to the imbalance of insulin production as well as serious effects on the body. In search of a better treatment for diabetes, we designed a novel class of 1,3,4-thiadiazole-bearing Schiff base analogues and assessed them for the α-glucosidase enzyme. In the series (1–12), compounds are...

In search of new α-glucosidase and urease inhibitors, a series of naproxen-derived 1,3,4-oxadiazole-containing ketones 6a-e and their Schiff-base derivatives 7a-o were synthesized. The isolated compounds were identified by HRMS (EI), 1 H NMR and 13 C NMR spectroscopic techniques. Among the series, compounds 7j, 7i, 7e, 7d and 7o were found to be si...

Benzoxazole-based thiazolidinone hybrids derivatives (1–19) were afforded and further subjected to in vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibition studies for the first time. All these analogues were found to display good inhibition against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE)enzymes with I...

MicroRNAs (miRNAs) are typically non-coding RNAs of 18–26 nucleotides (nts) that are produced endogenously and regulated post-transcriptionally through degradation or translational repression. Since miRNAs are evolutionarily conserved, their preservation is essential for important regulatory functions in plant development, growth, and responses to...

A hybrid library of compounds based on indazole-based thiadiazole containing thiazolidinone moieties (1–17) was synthesized. The synthesized compounds were screened in vitro for their inhibition profile against targetedacetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities. All the derivatives demonstrated a varied range of inhibi...

A series of Schiff bases(3-8) were synthesized by the reaction of cefradine with six different aldehydes/ketones. These Schiff bases(3-8) were treated with different bases/salt (NaOH, KOH, Ca(OH)2, Ba(OH)2, Ag(NO)3) to get their metal salts. Structures of the products were ascertained by spectroscopic data. The synthesized compounds were tested for...

In the present work, a concise library of benzothiazole-derived pyrazoline-based thiazole (1–17) was designed and synthesized by employing a multistep reaction strategy. The newly synthesized compounds were screened for their α-glucosidase and urease inhibitory activities. The scaffolds (1–17) were characterized using a combination of several spect...

Designing a multifunctional conducting hydrogel wound dressing of suitable mechanical properties, adhesiveness, self-healing, autolytic debridement, antibacterial properties, and radical scavenging ability, as well as retaining an appropriate level of moisture around the wound is highly desirable in clinical application for treating cutaneous wound...

Thymidine phosphorylase (TP) is an angiogenic enzyme. It is crucial for the development, invasion and metastasis of tumors as well as angiogenesis. In our current research, we examine how structurally changing bis-thiadiazole bearing bis-schiff bases affects their ability to inhibit TP. Through the oxidative cyclization of pyridine-based bis-thiose...

This study is focused on the effects of annealing temperature and pH on the crystallinity of cobalt oxide (Co3O4) nanoparticles (NPs) synthesized via sol-gel method. X-ray diffraction (XRD) analysis was carried out to investigate the crystalline structure and size of the NPs. The results indicated that increasing the pH from 10 to 14 during NPs syn...

A new series of thiazole derivatives (4a-p) incorporating imidazopyridine moiety was synthesized and assessed for their in vitro potential α-glucosidase potency using acarbose as a reference drug. The obtained results suggested that compounds 4a (docking score = −13.45), 4g (docking score = −12.87), 4o (docking score = −12.15), and 4p (docking scor...

The particle size at the nanometric level allows the manifestation of remarkable properties, chiefly due to changes in surface-to-volume ratio. This study is attributed to the novel green synthesis of nano silver by using essential oils as a capping and reducing agent. Clove oil, cinnamon oil, and cardamom oil were selected for the eco-friendly and...

Alzheimer’s disease (AD) is a progressive neurological illness that is distinguished clinically by cognitive and memory decline and adversely affects the people of old age. The treatments for this disease gained much attention and have prompted increased interest among researchers in this field. As a springboard to explore new anti-Alzheimer’s chem...

The present study is an attempt to improve thermal, mechanical and electrical properties of poly (methyl methacrylate) (PMMA). For this purpose, vinyltriethoxysilane (VTES) was grafted covalently on the surface of graphene oxide (GO). This VTES functionalized graphene oxide (VGO) was dispersed in the PMMA matrix using the solution casting method. T...

Purpose: Ulcer is a serious disease that is caused due to different bacteria and over usage of various NSAIDs which caused to reduce the defensive system of stomach. Therefore, some novel series are needed to overcome these issues. Methods: Oxazole-based imidazopyridine scaffolds (4a-p) were designed and synthesized by two step reaction protocol...

There is an increasing prevalence of diabetes mellitus throughout the world, and new compounds are necessary to combat this. The currently available antidiabetic therapies are long-term complicated and side effect-prone, and this has led to a demand for more affordable and more effective methods of tackling diabetes. Research is focused on finding...

In humans, animals, and agriculture, parasitic nematode infection is a very serious issue. Many drugs are being used to control nematode infections. Owing to toxicity and nematodes' resistance to the available drugs, special attention is required to synthesize new drugs that are environmentally friendly with high-level efficacy. In the present stud...

Diabetes mellitus is a syndrome that is caused due to the imbalance of insulin production in the body. In the present study we have synthesized a class of fifteen compounds (1–15) based on thiadiazole-bearing thiourea that were assessed for in vitro alpha-amylase and alpha-glucosidase inhibitory potentials against standard drug acarbose. In this se...

This study aim to synthesize new 1,3,4-oxadiazole derivatives incorporating mefenamic acid as promising α-glucosidase and urease inhibitors, potentially leading to the treatment of postprandial hyperglycemia as well as H. pylori related disorders. In this regards, we have designed a series of Mefenamic acid derivatives. The synthetic compounds were...

This research work represents a synthetic approach for the development of hybrids derivatives of oxadiazole-based benzothiazole (1–17) and diversity in derivatives was achieved using variety of aryl ring of S-substituted benzothiazole to see the effect on the biological activities. All the synthesized derivatives were evaluated for their in vitro α...

Chitosan (Cs)-based silver-doped titanium dioxide (Cs-AgTiO2) films were synthesized intending their end-use application in food packaging. AgTiO2 NPs were successfully prepared by using electrochemical synthesis. Cs-AgTiO2 films were synthesized by using the solution casting technique. Various advanced instrumental techniques such as scanning elec...

The aim of the current study was to investigate the effects of quality of soil and water on spinach (Spinacia Oleracea) quality, cultivated in district Dera Ismail Khan, Pakistan, with respect to some heavy metals. For this purpose twelve samples each of water, soil and spinach were collected from four different localities of the district. Out of t...

Membrane separation technology is an efficient and high‐performance technique. It is a thin flat sheet and acts like a delicate barrier for the selective transport of substances under the influence of pressure. Low cost and various applications in industry as well as in medical make it more important. The basic property of a dialysis membrane is th...

The present work described the synthetic procedure adopted for the synthesis of bis-indole-based triazine derivatives via a series of reactions. All the compounds were synthesized through a stepwise reaction. After being confirmation through thin-layer chromatography (TLC) these compounds were characterized through various spectroscopic techniques...

Diabetes is also known as a critical and noisy disease. Hyperglycemia, that is, increased blood glucose level is a common effect of uncontrolled diabetes, and over a period of time can cause serious effects on health such as blood vessel damage and nervous system damage. However, many attempts have been made to find suitable and beneficial solution...

Here, we discuss the synthesis of thiosemicarbazide derivatives based on benzoxazole. These compounds were obtained via sequence of reactions. The targeted products were confirmed using a number of spectroscopic methods, including NMR (1H and 13C) and EI-MS. After spectral confirmation all the synthesized compounds were evaluated for urease and β-G...

b Physical chemistry laboratory of mineral materials and their application, National center for research in materials sciences, TiO 2 /Co 3 O 4 core-shell nanoparticles were successfully synthesized by the sol-gel method in two steps: the first step is the sol-gel synthesis of Co 3 O 4 nanoparticles, and the second step is the synthesis of TiO 2 /C...

The current study has afforded twelve analogs (4a-l) of pyridine-derived bis-oxadiazole containing bis-schiff base and subsequently evaluated for their potential to inhibit thymidine phosphorylase(in vitro). All the synthesized analogs were structurally elucidated using various spectroscopic tools including NMR and HREIMS. All synthesized scaffolds...

Different research synthetic methods have been developed recently for the synthesis of bis-benzimidazole analogs to investigate various biological significances. In this present study, an attempt was made to synthesize a new series of bis-benzimidazole analogs in a fast and efficient method. A variety of spectroscopic techniques, including 13C NMR,...

Considering foremost global issues instigated by parasitic nematodes, Solanum nigrum (S. nigrum) and Mentha arvensis (M. arvensis) nematicidal potential at the gene level has been explored herein. Methanol, ethyl acetate, chloroform, n-hexane, and distilled water were used for extract preparation. Caenorhabditis elegans (C. elegans) was used as the...

Twenty-one analogs were synthesized based on benzimidazole, incorporating a substituted benzaldehyde moiety (1–21). These were then screened for their acetylcholinesterase and butyrylcholinesterase inhibition profiles. All the derivatives except 13, 14, and 20 showed various inhibitory potentials, ranging from IC50 values of 0.050 ± 0.001 µM to 25....

This study was carried out to synthesize benzotriazole-based bis-Schiff base scaffolds (1–20) and assess them in vitro for α-glucosidase inhibitory potentials. All the synthetics analogs based on benzotriazole-based bis-Schiff base scaffolds were found to display an outstanding inhibition profile on screening against the α-glucosidase enzyme. The s...

Nanotechnology is a recent technology which is developing rapidly and it has a wide range of potential applications. It is the atomic-level tailoring of materials to achieve unique features that may be controlled for the intended purposes. Nanomaterials can be prepared via several physico-chemical methods but bioreduction of bulk to nanomaterials v...

Background: The photocatalytic degradation of toxic organic compounds has received great attention for the past several years. Dyes, such as methyl orange (MO), are one of the major pollutants which create environmental hazards in the hydrosphere, living organisms and human beings. During photocatalytic degradation, NPs are activated in the presenc...

Modern optoelectronic devices are highly dependent upon the electronic and optical characteristics of semiconducting materials. In this work, pure and Al-doped ZrO2 compositions were studied comparatively studied using simulations and experimental investigations. The uniform and well-distributed granular thin films were experimentally deposited. X-...

Acetylcholinesterase and butyrylcholinesterase enzymes are therapeutic target for alzheimer disease and their inhibitors play a vital role for the treatment of this disease. A new series of benzoxazole based 1,3-thiazole hybrid scaffolds (1-20) were synthesized and assessed for acetylcholinesterase and butyrylcholinesterase inhibition profile and t...

A unique series of sulphonamide derivatives was attempted to be synthesized in this study using a new and effective method. All of the synthesized compounds were verified using several spectroscopic methods, including FTIR, ¹H-NMR, ¹³C-NMR, and HREI-MS, and their binding interactions were studied using molecular docking. The enzymes urease and α-gl...

The development of drugs resistance in diabetes mellitus is a growing clinical problem, creates many challenges for patient. To overcome these problems, there is a serious deficiency of antidiabetic agents, may be synthesized that inhibit alpha amylase and alpha glucosidase activity. Here, we have design and synthesized benzoxazole based sulphonami...

Twenty-five analogs were synthesized based on 1,3,4-thiadiazole-fused-[1,2,4]-thiadiazole incorporating 1,4-benzodioxine moiety (1–25) and then tested for the antidiabetic profile. The entire afforded derivatives showed varied inhibition profiles ranging between 0.70 ± 0.01 and 30.80 ± 0.80 μM (against α-amylase) in comparison to standard acarbose...

Twenty-four analogs based on triazinoindole bearing benzimidazole/benzoxazole moieties (1–25) were synthesized. Utilizing a variety of spectroscopic methods, including ¹H-, ¹³C-NMR, and HREI-MS, the newly afforded compounds (1–25) were analyzed. The synthesized analogs were tested against urease enzyme (in vitro) as compared to the standard thioure...

Amylase and glucosidase enzymes are the primary harmful source in the development of the chronic condition known as diabetes mellitus. The main function of these enzymes is to break the macromolecules into simple sugar units which are directly involved in the solubility of blood, hence increasing blood glucose levels. To overcome this effect, there...

In this study, hybrid analogs of benzimidazole containing a thiazole moiety (1–17) were afforded and then tested for their ability to inhibit α-amylase and α-glucosidase when compared to acarbose as a standard drug. The recently available analogs showed a wide variety of inhibitory potentials that ranged between 1.31 ± 0.05 and 38.60 ± 0.70 µM (aga...

Citation: Khan, S.; Iqbal, S.; Khan, M.; Rehman, W.; Shah, M.; Hussain, R.; Rasheed, L.; Khan, Y.; Dera, A.A.; Pashameah, R.A.; et al. Design, Abstract: In this study, a stepwise reaction afforded thiazolidinone-based benzothiazole derivatives 1-15, and the synthesized derivatives were then screened for biological significance and found to be the l...

Twenty-four analogues of benzimidazole-based thiazoles (1–24) were synthesized and assessed for their in vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory potential. All analogues were found to exhibit good inhibitory potential against cholinesterase enzymes, having IC50 values in the ranges of 0.10 ± 0.05 to 11.10 ± 0....

Here, we report the facile route for the synthesis of graphene oxide–functionalized manganese dioxide (GO–MnO2@Tau (GMT) and GO-MnO2@CA) (GMC) nanohybrids and their use as adsorbents for removal of selected dyes from industrial effluents. These nanohybrids were also tested for antibacterial activity in wastewater. Manganese dioxide nanoparticles we...

Herein, a ternary composite of poly(aniline-co-melamine), graphene oxide (GO), and SnO2, (PMGSn) is synthesized by in-situ oxidative polymerization. The morphology, composition, and structure of the composite were analyzed by Scanning electron microscopy (SEM), Energy dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), and Fourier transfo...

A series of fifteen hybrid analogs (1‐15) based on benzimidazole bearing triazole skeleton were synthesized and were evaluated for in vitro AChE and BuChE inhibition profile. All the newly afforded scaffolds showed moderate to good AChE and BuChE activity having IC50 values ranging from 0.40 ± 0.05 μM to 19.60 ± 0.40 μM against AChE and 1.50 ± 0.10...

A series of twenty bis ‐thiazolidinone based chalcone scaffolds (1‐20) were synthesized and characterized by using various spectroscopic tools such as HR‐EI‐MS, 1 HNMR, 13 CNMR and were screened in vitro for their AChE and BuChE inhibition profile. It was noteworthy, that all the synthetic analogues (except analogues 10, 12 and 1 4 , which are foun...

Zinc oxide nanoparticles were synthesized from the leaf extract of Brassica oleracea L. Acephala group (collard green) followed by their characterization using Scanning Electron Microscope (SEM), and Energy Dispersive X-ray (EDX). The antibacterial properties of zinc nanoparticles were tested against Gram-negative bacteria, Pseudomonas aeruginosa (...

In the present study, Co3O4 and graphene oxide (GO) are used as reinforcement materials in a copolymer matrix of poly(aniline-co-melamine) to synthesize ternary composites. The nanocomposite was prepared by oxidative in-situ polymerization and used as an electrode material for energy storage. The SEM images revealed the vertically aligned arrays of...

(1) Background: Nanocomposite films are widely applied in the pharmaceutical industry (e.g., nanodrug delivery systems—NDDS). Indeed, these nanomaterials can be produced at a large industrial scale and display valuable properties (e.g., antibacterial, renewability, biodegradability, bioavailability, safety, tissue-specific targeting, and biocompati...

The physicochemical characteristics of Zinc nanoparticles (ZnO NPs) were investigated using various techniques after they were produced using the sol gel process. The crystalline structure, surface morphology, optical property, elemental and chemical composition of the samples have been studied by X-diffraction (XRD), scanning electron microscopy (...