Waill Ahmed Elkhateeb

• PhD, Mycology
• Professor (Assistant) at National Research Centre

Throughout old history, mushrooms are considered a rich source of many important phytonutrients such as polysaccharides and other nutrients, in addition to many essential amino acids, which are building blocks of vital proteins. In overall, mushrooms offer a wide range of health benefits with a large spectrum of pharmacological properties, includin...

Background Functional foods and dairy products are gaining global attention due to their nutritional value and health-promoting characteristics. Lactic acid bacteria (LAB) are one of the promising components included in these products, thanks to their probiotic properties and ability to produce bioactive compounds such as bacteriocins. On the other...

Recent medical achievements entered the new healthcare era, accompanying significant advances in the treatment and care of patients. The most groundbreaking achievements among these new tools are artificial intelligence, personalized medicine, and telemedicine-all with a great impact on modern healthcare development. Mushrooms and lichens were desc...

Abstract: The development of multidrug-resistant bacteria (MDRB) and the emergence of new lethal diseases have raised the need for potent anti-infective agents with different killing action mechanisms that contribute to treating and/or supporting the currently used drugs. For this purpose, bacteriocins are considered excellent candidates with promi...

Lichens are a rich source of diverse secondary metabolites, with depsides playing a crucial role in their biological properties. Atranorin, a prominent depside, has been widely studied due to its signifi cant pharmacological effects. This review explores the biosynthesis of atranorin, elucidates its molecular structure, and presents insights from d...

Fungi are a distinguished category of microorganisms that belong to a distinct kingdom. Biotechnological methods have significant contributions in several domains and shown generosity in manufacturing diverse metabolites that belong to distinct chemical classes and possess varying bioactivity and/or industrial applications. The mentioned advantages...

Truffles, esteemed members of the kingdom Fungi, are categorized under the phylum Ascomycota and the class Ascomycetes. They belong to the order Pezizales and the family Tuberaceae, with their most prominent and celebrated genus being Tuber. Truffles provide numerous health benefits due to their bioactive compounds. They have antioxidant, anticance...

Background Enzymes are complex proteins serving as biological catalysts to facilitate reactions in mild and environment-friendly conditions. Saprophytic fungi have long been harnessed for the efficient production of several industrially-significant enzymes whose market is still growing to cope with the increase in demand and natural resources’ depl...

Spreading of new diseases has elevated the need to synthesis novel derivatives from currently used drugs. Corticosteroidal drugs are potent drugs that are involved in treating different diseases, and their market is expected to witness continuous growth due to the emergence of new diseases as COVID-19 and spread of chronic diseases. Therefore, cont...

Functional dairy products are attracting consumers’ attention, as they simultaneously have nutritional and health benefits. Hence, we aimed in this study to fortify a dairy product (yogurt) with phytosomes of extract from Hydnora abyssinica (a holoparasitic plant that has ethnobotanical value) and a potential bacteriocin-producing probiotic lactic...

Mushrooms are substantial source of nutritional, medicinal compounds, and other benefi ts compounds still need to be worked out for their important applications. Mushrooms as higher Basidiomycetes and Ascomycetes contain secondary metabolites in their fruit bodies, cultured mycelium, and cultured broth. These secondary metabolites have been used in...

Background Truffles are ectomycorrhizal wild mushrooms that have ethnomycological importance as a folklore remedy used to treat different skin and eye diseases and they are currently known as expensive food and potential sources of bioactive compounds. Objective This study aims to investigate the in vitro bioactive potential of the ethyl acetate e...

Pharmaceuticals are those chemicals used for diagnosing, treating, or preventing of a disease (Singh et al., 2017). World-wide consumption of pharmaceuticals is continuously increasing due to the spread of chronic diseases, emergence of new diseases, the decreased immunity accompanied with unhealthy life styles, and aging population noticed in many...

Spreading of new diseases has elevated the need to synthesis novel derivatives from currently used drugs. Corticosteroidal drugs are potent drugs that are involved in treating different diseases, and their market is expected to witness continuous growth due to the emergence of new diseases as COVID-19 and spread of chronic diseases. Therefore, cont...

Diabetes is emerging as a pandemic, so it is essential to find new nutraceuticals or drugs to treat or prevent it. Some mushrooms appear to be effective in controlling blood glucose levels and correcting diabetes problems without any negative side effects. Mushrooms with immune-modulating polysaccharides are used in limited areas as palatable food...

Colorants have many applications in food, cosmetics, pharmaceutics, textile, paints, plastics, paper, ink and photographic industries. Colorants are classified according to their solubility into dyes and pigments. Those of natural origin have many advantages over synthetic ones, as natural colorants usually do not induce allergies or other health p...

Mushrooms and lichens are plentiful source of nutritional and medicinal compounds. However, medicinal uses of the mushrooms and lichens still need to be worked out for their biological activities. Mushrooms and Lichens have reserved their position centuries ago as food and medicine. They are rich in nutrients and in biologically active compounds th...

The textile industry makes extensive use of synthetic, non-renewable colors. However, using these synthetic pigments causes the release of toxic and hazardous substances into the environment. It is a difficult task to find new pigments made from natural materials, yet doing so opens up safer textile coloring methods. A lot of attention has been pai...

Carbohydrates (saccharides) are the building units for the synthesis of polymers or complex carbohydrates. Nutrition polysaccharides are sources of energy and they also provide dietary fibers. Exopolysaccharides can be used to form strong, flexible films for the packaging industry. Also, in the manufacturing of detergents, adhesives, paper, paint,...

Mushrooms can be highlighted as alternate sources of anti-inflammatory drugs. In recent years, natural resources have come into spotlight due to their enormous potential to be utilized in the discovery/development of novel bioactive chemicals. The anti-inflammatory properties of mushroom extracts and the bioactive metabolites that contribute to thi...

In Asian countries, a variety of medicinal plants are utilized in folk medicine for hemostatic and antiseptic. The methanolic extracts of Jatropha variegata, Acokanthera schimperi, and Ceropegia rupicolawere tested for the following purposes: first, isolation of endophytic fungi, second, antimicrobial and cytotoxicity activity, and third, phytocons...

Mangroves are woody trees or shrubs salt marsh halophytes that encompass over 75% of the tropical coastline on the planet. Mangroves are characterized by their sophisticated morphological and physiological adaptations as well as their rich synthesis of biologically active secondary metabolites. They also contribute in decreasing CO2 levels in the a...

Lichens are found on every landform and have a history of use as food, medicine, dyes, livestock feed and other fields. The pharmaceutical potential of lichens is high and several companies are now attempting to commercialise these unique agents. The secondary metabolites that lichen produces have a wide range of biological functions, including ant...

Due to the harmful impacts of using chemicals in controlling plant pests as nematodes, there is a current trend of employing natural pesticides that show potency together without contaminating the environment or negatively affect human and other creatures. Hence, the name of nematophagous fungi has risen as potent biocontrol tools that attack nemat...

Spreading of new diseases as well as the weakness of some currently used drugs have directed scientists towards screening for new sources of biologically active compounds. Mushrooms are macrofungi that are famous for being rich sources of bioactive and nutritional compounds from different chemical classes. Out of mushrooms genera, the genus Ganoder...

Vitamin D is one of the most important vitamins to human health as it plays a significant role in human's various physiological functions including metabolism of phosphorus and calcium, neuromuscular and skeletal homeostasis and is also effective against various diseases. Although it is found in two major forms, vitamin D 3 (from animal-derived pro...

Understanding the negative impacts of using chemical fertilizers on living organisms and the environment, in general, has encouraged finding natural alternatives. Hence, biofertilizers are applied through soil or seed and are prepared from promising microbial strains (living or dormant cells) that help economically important plants in taking nutrie...

Microbes in general and fungi especially are promising biotechnological tools that are used for green synthesis of numerous products. Fungi in particular are potent producers of many important compounds used in different applications. Hence, this review aims to explore fungi and their potential as a source of various bioactive compounds like mycopr...

This review represents an overview of leather substitutes derived from mushrooms. Mushrooms are raw materials for leather substitutes and provide a cost-effective, socially and environmentally friendly option for natural (bovine) and synthetic leather (Muskin). Companies and consumers (such as the vegan community) are increasingly interested in mus...

The oil palm, an economically important tree, has been one of the world’s major sources of edible oil and a significant precursor of biodiesel fuel. Unfortunately, it now faces the threat of a devastating disease named basal stem rot disease. Many researchers have identified Ganoderma boninense and Ganoderma zonatum as the major pathogens that affe...

Microbes in general and fungi especially are promising biotechnological tools that are used for green synthesis of numerous products. Fungi in particular are potent producers of many important compounds used in different applications. Hence, this review aims to explore fungi and their potential as a source of various bioactive compounds like mycopr...

The oil palm, an economically important tree, has been one of the world’s major sources of edible oil and a significant precursor of biodiesel fuel. Unfortunately, it now faces the threat of a devastating disease named basal stem rot disease. Many researchers have identified Ganoderma boninense and Ganoderma zonatum as the major pathogen that affec...

Microbes in general and fungi especially are promising biotechnological tools that are used for green synthesis of numerous products. Fungi in particular are potent producers of many industrially important compounds. β-Glucans are a group of biologically-active fibres or polysaccharides from natural sources with proven medical significance. β-Gluca...

Microbes in general and fungi especially are promising biotechnological tools that are used for green synthesis of numerous products. Fungi in particular are potent producers of many industrially important compounds. β-Glucans are a group of biologically-active fibres or polysaccharides from natural sources with proven medical significance. β-Gluca...

Mushrooms are generous source of nutritional and medicinal compounds. SpongeBob fungi are a group of mushrooms belonging to Basidiomycota; Class; Agaricomycetes; Order Boletales; Family: Boletaceae. Their name derived from the Nickelodeon cartoon character SpongeBob SquarePants. They are considered from the Basidiomycetes mushrooms all over the wor...

neurodegenerative disease, and renal failure caused 38 million deaths in 2009, more than 62% of all deaths worldwide (WHO, abdominal obesity (waist circumference, >102 cm in men and >88 cm in women), 2) hypertriglyceridemia [≥1.69 mmol/liter Abstract Microbes are promising biotechnological tools that are used for green synthesis of numerous product...

GC‐MS and HPLC analyses of the hydromethanolic extracts of the truffles Tirmania nivea (TN) and Tirmania pinoyi (TP) revealed the presence of 18 metabolites and 11 polyphenols, respectively. In vivo, TP extract protected against subcutaneous pentylenetetrazole (scPTZ) and maximal electric shock (MES)‐induced convulsions faster than TN. TP (100 and...

Background and objective Lactic acid bacteria (LAB) are generous producers of many industrially important products. Of these products, optically pure lactic acid is of great value as it is essential for production of highly crystalline poly-lactic acid, which is the most widely used biodegradable synthetic polymer. Hence, this study aimed to screen...

Marine, endophytic microorganism creatures living in this envi-ronment should be investigated as an exceptional source for severalnew products and knowledge. Microorganisms obtained from suchenvironment can be highly beneficial to science, health, and industry.Searching for novel isolates secreting potent secondary metabolites,and having promising...

Lichens have attracted considerable interest since ancient time due to their medicinal properties. Lichen produce a variety of orcinol-based compounds such as xanthones, anthraquinones, dibenzofurans, depsides, and depsidones. Several related compounds have shown potent bioactivities as antiviral, antioxidant, anti-herbivore, insecticidal, antifung...

Many mushroom genera are famous for their promising therapeutic capabilities. One of the mushrooms genera attracting attention is Cordyceps which has long been used in Asian countries for maintaining long and healthy life. Numerous studies on different metabolic activities of Cordyceps have been performed both in vitro and in vivo. Numerous studies...

The bacteriocins produced by lactic acid bacteria (LAB) are attracting attention due to their promising applications in food and pharmaceuticals fields. Hence, a LAB strain, GCNRC_GA15, was isolated from Egyptian goat cheese, and molecularly identified as Lactiplantibacillus plantarum. This strain showed a wide antimicrobial spectrum, which was fou...

Although celebrating its golden jubilee, rapamycin's importance keeps increasing by the day. Starting as a promising antifungal agent, then as a potent immunosuppressant, strong anticancer drug, and now rapamycin is attracting serious attention as a rejuvenative agent and a possible contributor in treating this era pandemic, COVID-19. Due to its di...

The world of mushroom is rich in species of high interest due to their nutritional and pharmaceutical values. However, this world includes also non edible species, which are not consumed due to being poisonous, of awful smell, or causing some serious gastrointestinal symptoms. Apart from being of no nutritional value, the study of their chemical co...

Mushrooms are generous source of nutritional, medicinal compounds, and industrial uses of the mushrooms still need to be worked out for their important applications. Mushrooms have signifi cant enzymatic machinery allowing their application in different industries. Capabilities of different members of mushrooms have encouraged researchers to invest...

Concrete is one of the most commonly used materials in buildings construction due to its availability and affordability. However, one of its major disadvantages is crack formation, especially under stress conditions including weather conditions. The crack development greatly affects the durability of concrete through the entrance of various contami...

Mushrooms are the epigeous fruiting bodies of terrestrial fungi and as they lack cellulose and chlorophyll, they have a different lifestyle to other nonmotile life, such as plants. Mushrooms have been documented for centuries as use as food and medicine as they are generous sources of nutrients and biologically active compounds that have various ap...

Since ancient times, several edible mushrooms have been reported as a nutritious food with valuable medicinal properties. The genera Flammulina; Lyophyllum; Agaricus; Boletus; Letinula and Pleurotus are a group of edible mushrooms that are distributed all over the world. The studies on different species of these edible mushrooms have revealed their...

Background There is a pressing need to screen for new sources of potent bioactive compounds to help in treating current widespread diseases. Fungi represent the perfect candidates that can fulfill this need owing to their ability to produce bioactive compounds. Objective To screen for fungi from a novel source, chemically analyze their extracts, a...

Background Root-knot nematodes in general and Meloidogyne incognita , in particular, are pests that cause agricultural losses. Currently, nematode control relies on chemical nematicides, which are hazardous to the environment and human health. The increasing demand for ecofriendly nematicides has prompted researchers to look into biocontrol agents...

Mushrooms are macro fungi that exist everywhere around us. They have significant roles in human health-life as source of nutrition and bioactive compounds. Many edible mushrooms have been reported as promising biotechnological tools for production of secondary metabolites of various biological activities. The genus Macrolepiota; Russula; Amanita; V...

Lichens are composite organisms containing algae (Trebouxia or Trentepohlia), or cyanobacteria (Nostoc), living among fi laments of multiple fungal species in a mutualistic relationship. Lichens dominate vegetation types on about 7% of the planet’s surface; additionally, they are important components of primary producers in a wide range of substrat...

Yeasts are eukaryotic microorganisms that are existing in a wide range of habitats, thanks to their ability to adapt even in extreme locations and conditions. Moreover, the unicellular nature of yeasts makes them better suited for deep liquid substrates or moist and uneven surfaces. Till now, about 1500 species of yeasts are described, and the genu...

The present review focused on production of enzyme cocktail (Cellulases, hemicellulases and pectinases) suitable for perfect biodiesel extraction process from different oil seeds especially Jatropha curcus L. by potent fungal producer utilizing some different abundant Egyptian lignocellulosic wastes. Enzyme cocktails is an eco-friendly process savi...

Research is a deliberate and systematic inquiry or investigation to establish a fact. Research could focus on any desired discipline like science, education, economy, administration, etc. Resources (e.g. humans, funds, equipment etc) are essential in any research, especially impactful research. Research forms an essential part of development for in...

The plant’s oil is most commonly used as helpful in respiratory disorders. To the local community, herbal medicines are standing for low case treatment. Documenting conventional uses are needed for additional investigation of the bioactive compounds in question. Crucial oils having phenol or aldehydes as main components illustrated the maximum anti...

Circinella, Mucor and Rhizopus all these genera belonging to Order: Mucorales. This review is to demonstrate description, ecology, and secondary metabolites from Circinella, Mucor and Rhizopus and some of their reported biological activities. Besides, describing the importance and potentials of those fungi in order to encourage researchers for furt...

Fungal kingdom contains many interesting genera that are available around us and can be isolated commonly from different sources. Humicola and Nigrospora belonging to class Sordariomycetes, are promising fungal genera that produce many important secondary metabolites. Hence, this review describes their morphology and ecology, highlights on secondar...

Fungi are an understudied, biotechnologically valuable group of organisms, due to the huge range of habitats that fungi inhabit; fungi represent great promise for their application in biotechnology and industry. The objective of this review is to highlight on mushroom-substrate combinations that are most suitable for further exploration and develop...

Stachybotrys, Memnoniella, Doratomyces and Graphium all these genera belonging to Class: Sordariomycetes. This review is to demonstrate description, ecology, and secondary metabolites from Stachybotrys, Memnoniella, Doratomyces and Graphium and some of their reported biological activities. Besides, describing the importance and potentials of those...

Botryotrichum and Scopulariopsis are a fungal genera that belongs to Class: Sordariomycetes. This review is to demonstrate secondary metabolites from Botryotrichum and Scopulariopsis and some of their reported biological activities. Moreover, describing the unique chemical diversity of these fungal genera involved in medical, pharmaceutical, agricu...

Background: Hydnora is a subterranean root holoparasitic angiosperm that is strictly parasitic on different species ofEuphorbiaceae, someBurseraceae species, and someFabaceae species. Hydnorais distributed insemi-arid areas of Asian and African continents. Available data about this genus are relatively limited, due to the small number of studies de...

Mushrooms contain secondary metabolites in their fruit bodies, cultured mycelium, and cultured broth which are higher Basidiomycetes and Ascomycetes. Mushrooms have been used in many sides of human activity for many years. Bioluminescence mushrooms gained more attention. Researchers focused on the ecological role of bioluminescence mushrooms as att...

The need to improve the quality life together with the increase in the frequency of threating diseases direct the attention of many scientists to look for potential foods as a source of nutritional and therapeutical agents. Since ancient times, several mushrooms have been reported as a nutritious food with valuable medicinal properties. The genus R...

Symbiosis among microorganisms represents an interesting relationship that takes different shapes. Obligatory, facultative, and endosymbiotic relationships have all been reported between different microorganisms. Whether it is mutualism, commensalism, amensalism, or parasitism, understanding every association is of great importance to science and h...

Background Biological control of insects is the current goal of modern researches to avoid using the harmful chemicals. Some fungi are capable of infecting and killing insects and, hence, are commonly known as entomopathogenic fungi (EPF). On the other hand, some insects can kill harmful fungal strains using their products such as peptides. Hence,...

Fungi have evolved many symbioses including different eukaryotes and prokaryotes. Mutualism is one of the symbioses and here both symbionts benefit from the interaction. The most common mutualistic relationships involving fungi are mycorrhiza and lichens. A mycorrhiza is a symbiotic relationship between a roots of a plant and a fungus while lichen...

Bacteriocins are those ribosomally synthesized peptides secreted by bacteria that were first known in 1925. From this date till now, bacteriocins keep attracting scientists' attention for their potency and their ability to be employed in various human and animal health-improving biotechnological applications. Bacteriocins have started as a safe, na...

Mushrooms and lichens are generous source of nutritional and medicinal compounds, and medicinal uses of the mushrooms and lichens still need to be worked out for their biological activities. This review aims to put ganoderic acid, cordycepin and usnic acid under light spot through representing their important as biological activities exerted by eve...

Insects bodies contain multiple distinctive microbial colonies which play key role in the metabolism, development and health of an insect. In the current study bacterial and fungal microbiota were isolated from larval feces and adult wings of two major insect pests in Egypt, the Cotton leaf worm Spodoptera littoralis and the black cutworm Agrotis i...

Background: Emerging of microbial resistance, spread of life-threatening diseases, and biological control of pathogens destroying economically important crops, are serious problems that encourage scientists to search for unusual sources for novel compounds with biological activities. Fungi are promising sources for such compounds due to their abili...

Metacordyceps neogunnii is an edible mushroom that has been previously known as Cordyceps gunnii. Recently, it has been proven that Metacordyceps neogunnii differs from similar species by having longer asci and wider ascospores and is phylogenetically distinct to related species. Few studies are available to describe bioactivities exerted by Metaco...

The need to improve the life quality together with the increase in the frequency of treating diseases attracted the attention of many researches to view food as a source of nutritional and therapeutical agents. Since earliest times, several mushrooms have been reported as a nutritious food with valuable medicinal properties. The genus Clitocybe and...

This review provides detailed morphological descriptions of some wild mushrooms of the genus Xeromphalina, Cookeina, Gyromitra, Xylaria, Phellodon, Marasmius and Parasola, including common species for each genus.

Truffles are amongst the most highly valued of all fungi within the phylum Ascomycota. Incorporating a number of genera, there is a broad range of current and potential industrial applications, which include cosmetics, food, perfumes, medicinal products as a source of enzymes and in efficient production of silver nanoparticles. However, the supply...

Mushrooms are a rich source of nutritional and bioactive compounds; hence were used as food and medicine centuries ago. Shortage in global materials and resources, besides the increase in world population, has encouraged research in ecofriendly alternatives, which are also relatively cheap. Capabilities of macrofungi in general, and mushrooms in pa...

Contributing in about 38% of the discovered biologically active metabolites, fungi are generous sources of compounds that can be used in drug industry and in saving health of humanity. Fungi exist everywhere around us. However, aquatic fungi represent promising source for novel compounds with potential uses in different biotechnological fields. Man...

Mushrooms are generous source of nutritional and medicinal compounds, and medicinal uses of the mushrooms still need to be worked out for their biological activities. This review aims to put golden mushroom Cantharellus and shaggy ink cap mushroom Coprinus and smoky bracket mushroom Bjerkandera under light spot through describing their morphology a...

Fungi exist everywhere around us. However, edible Mushrooms represent promising source for novel compounds with potential uses in different biotechnological fields. Many mushrooms were sources of novel compounds showing biological actions such as antimicrobial, anticancer, antiinflammatory activities. Likewise, mushrooms are macrofungi that exist e...

Background: Mushrooms are generous source of nutritional and medicinal compounds. Bird's nest fungi are a gasteromyceteous group of mushrooms named for their similarity in shape to small bird's nests. They are considered from the tiniest and most interesting mushrooms all over the world. It is usually found in shady moist environments, and typicall...

The medicinal uses of the mushroom still need to be worked out for their biological activities. Mushrooms are small pharmaceutical factories, manufacturing various promising biologically active chemical compounds. These compounds exist in the mushroom fruit bodies, cultured mycelium, and culture broth. The presence of various phenolic compounds, po...

The genus Trichoderma is multicultural soil-borne fungi found in different ecosystems. They are highly successful colonizers of their habitats. Genus Trichoderma is capable of dealing with various environments such as compost, agricultural soils, rhizosphere, and waste material. Therefore, different strains of Trichoderma have been applied in agric...

Yeasts are widely spread in nature. Fermentation of sugars by yeast is the oldest and largest application of this technology. Many types of yeasts are used for making many foods: baker's yeast in bread production, brewer's yeast in beer fermentation, and yeast in wine. This work describes the prevalence of yeasts in food products.

Yeasts are eukaryotic microorganisms that are existing in a wide range of habitats, thanks to their ability to adapt even in extreme locations and conditions. Moreover, the unicellular nature of yeasts makes them better suited for deep liquid substrates or moist and uneven surfaces. Till now, about 1500 species of yeasts are described, and the genu...

Aspergillus oryzae (A. oryzae) is a ilamentous micro-fungus that is used from centuries in fermentation of diferent foods in many countries all over the world. This valuable fungus is also a rich source of many bioactive secondary metabolites. Moreover, A. oryzae has a prestigious secretory system that allows it to secrete high concentrations of pr...

The development of eco-friendly technologies in material synthesis is of considerable importance to expand their biological applications. Nowadays, a variety of inorganic nanoparticles with well-defined chemical composition, size, and morphology have been synthesized by using different microorganisms. This paper highlights the recent developments o...

Fungi are rich sources of biologically active natural compounds, which are used in the manufacturing of wide range of clinically important drugs. Alternaria is a fungal genus that belongs to family Pleosporaceae, and has been known as a promising secondary metabolites producer. However the same fungus showed harmful pathogenicity against different...

In the field of exploring new natural sources for biologically active products with economic importance, the marine environment draws particular attention due to the noticeable diversity and extreme conditions; it is well known that the marine environment is a valuable source of biological and therapeutic compounds with great value. The marine envi...

Low-cost solutions achieving concrete self-healing are attracting researchers attention. Generally, concrete self-healing mechanism has been so far accomplished by three approaches: autogenous healing, encapsulation of polymeric material, and microbial induced mineralization of calcium carbonate. Microbial approach seems like an attractive potent,...

Screening for bacteriocin-producing lactic acid bacteria (LAB) showing probiotic properties is of high significance due to their applications in food, and health fields. Hence, the aim of the current study was to isolate, identify, and study the in vitro probiotic properties, antimicrobial and antioxidant activities of LAB isolates obtained from Eg...