Wai Ting Siok

• PhD
• Professor at The Hong Kong Polytechnic University

We used functional magnetic resonance imaging (fMRI) to map the neural systems involved in reading Chinese in 125 participants 6-74 years old to examine two theoretical issues: how brain structure and function are related in the context of the lifetime neural development of human cognition and whether the neural network for reading is universal or...

While phonological skills have been found to be correlated with reading across different writing systems, recent findings have shown that developmental dyslexia in Chinese individuals has multiple deficits, and no single factor has ever been identified as crucial for learning this writing system. To examine whether a deficit in the phonological or...

In the simplest sense, reading acquisition is a process of learning how a writing system represents a spoken language. It requires conscious awareness of how the basic graphic symbol, the grapheme, represents a spoken unit. However, unlike language acquisition, which occurs naturally, rapidly, and automatically in most children, learning to read is...

While neuroimaging studies have identified brain regions associated with single word reading, its three constituents, namely, orthography, phonology, and meaning, and the functional connectivity of their networks remain underexplored. This study examined the neurocognitive underpinnings of these neural activations and functional connectivity of the...

Human learning and cognitive functions change with age and experience, with late-developed complex cognitive functions, particularly those served by the prefrontal cortex, showing more age-dependent variance. Reading as a complex process of constructing meaning from print uses the left prefrontal cortex and may show a similar aging pattern. In this...

In recent years, researchers have studied how nanotechnology could enhance neuroimaging techniques. The application of nanomaterial-based flexible electronics has the potential to advance conventional intracranial electroencephalography (iEEG) by utilising brain-compatible soft nanomaterials. The resultant technique has significantly high spatial a...

The integral capacity of human language together with semantic memory drives the linkage of words and their meaning, which theoretically is subject to cognitive control. However, it remains unknown whether, across different language modalities and input/output formats, there is a shared system in the human brain for word-meaning binding and how thi...

Nowadays, typewriting has become an important mode of written communication. A report that typewriting may hinder Chinese children's reading development has sparked substantial concern about whether typing on electronic devices would increase the rate of reading disorders, wherein children used a pronunciation-based input system that associates alp...

Persistent developmental stuttering is a neurological disorder that commonly manifests as a motor problem. Cognitive theories, however, hold that poorly developed cognitive skills are the origins of stuttering. Working memory (WM), a multicomponent cognitive system that mediates information maintenance and manipulation, is known to play an importan...

Scientific Reports 7 : Article number: 40365 10.1038/srep40365 ; published online: 03 February 2017 ; updated: 11 April 2017 This Article contains errors in Table 2. The correct Table 2 appears below:

Mathematics ability is a complex cognitive trait with polygenic heritability. Genome-wide association study (GWAS) has been an effective approach to investigate genetic components underlying mathematic ability. Although previous studies reported several candidate genetic variants, none of them exceeded genome-wide significant threshold in general p...

Persistent developmental stuttering is a neurologically based speech disorder associated with cognitive-linguistic, motor and emotional abnormalities. Previous studies investigating the relationship between anxiety and stuttering have yielded mixed results, but it has not yet been examined whether anxiety influences brain activity underlying stutte...

Learning to read is thought to involve the recruitment of left hemisphere ventral occipitotemporal cortex (OTC) by a process of "neuronal recycling", whereby object processing mechanisms are co-opted for reading. Under the same theoretical framework, it has been proposed that the visual word form area (VWFA) within the OTC processes orthographic st...

Persistent developmental stuttering (PDS) is a speech disorder that impairs communication skills. Despite extensive research, the core causes of PDS are elusive. Converging evidence from task-induced neuroimaging methods has demonstrated the contributions of the basal ganglia and the cerebellum to PDS, but such task-state neuroimaging findings are...

Background Dyslexia is a polygenic speech and language disorder characterized by an unexpected difficulty in reading in children and adults despite normal intelligence and schooling. Increasing evidence reveals that different speech and language disorders could share common genetic factors. As previous study reported association of GNPTAB, GNPTG an...

Developmental dyslexia (DD) is characterized by difficulties in reading and spelling independent of intelligence, educational backgrounds and neurological injuries. Increasing evidences supported DD as a complex genetic disorder and identified four DD candidate genes namely DYX1C1, DCDC2, KIAA0319 and ROBO1. As such, DCDC2 and KIAA0319 are located...

Background Dyslexia is a polygenic developmental disorder characterized by difficulties in reading and spelling despite normal intelligence, educational backgrounds and perception. Increasing evidences indicated that dyslexia may share similar genetic mechanisms with other speech and language disorders. We proposed that stuttering candidate genes,...

In this study we investigate how the human brain processes small clauses and finite clauses. Small clauses are instances of ‘simpler’ syntax in the sense that they do not involve operations such as Move and Tense, and have been argued to represent an earlier stage of syntactic evolution before the development of fully-fledged syntax (Bickerton, 199...

Developmental dyslexia is a neurological condition characterized by unexpected low reading performance in people with normal intelligence and typical schooling. One prominent theory posits that dyslexic children fail to establish left-hemispheric dominance of visual representations and visual-phonological/meaning integration of printed words and th...

Developmental dyslexia (DD) and specific language impairment (SLI) are distinct language disorders. Their phenotypic overlap and co-morbidity are frequently reported. In addition, numerous evidences indicate that genetic factors play an important role in DD and SLI. Therefore, it is worthwhile to identify possible genetic linkage shared by these tw...

Written Chinese as a logographic system was developed over 3,000 y ago. Historically, Chinese children have learned to read by learning to associate the visuo-graphic properties of Chinese characters with lexical meaning, typically through handwriting. In recent years, however, many Chinese children have learned to use electronic communication devi...

How second language (L2) learning is achieved in the human brain remains one of the fundamental questions of neuroscience and linguistics. Previous neuroimaging studies with bilinguals have consistently shown overlapping cortical organization of the native language (L1) and L2, leading to a prediction that a common neurobiological marker may be res...

Developmental dyslexia is a neurological condition that is characterized by severe impairment in reading skill acquisition in people with adequate intelligence and typical schooling. For English readers, reading impairment is critically associated with a phonological processing disorder, which may co-occur with an orthographic (visual word form) pr...

The effect of language on the categorical perception of color is stronger for stimuli in the right visual field (RVF) than in the left visual field, but the neural correlates of the behavioral RVF advantage are unknown. Here we present brain activation maps revealing how language is differentially engaged in the discrimination of colored stimuli pr...

Developmental dyslexia is a neurobiologically based disorder that affects ≈5–17% of school children and is characterized by a severe impairment in reading skill acquisition. For readers of alphabetic (e.g., English) languages, recent neuroimaging studies have demonstrated that dyslexia is associated with weak reading-related activity in left tempor...

In functional neuroimaging studies, individuals with dyslexia frequently exhibit both hypoactivation, often in the left parietotemporal cortex, and hyperactivation, often in the left inferior frontal cortex, but there has been no evidence to suggest how to interpret the differential relations of hypoactivation and hyperactivation to dyslexia. To ad...

Adults and children with developmental dyslexia exhibit reduced parietotemporal activation in functional neuroimaging studies of phonological processing. These studies used age-matched and/or intelligence quotient-matched control groups whose reading ability and scanner task performance were often superior to that of the dyslexic group. It is unkno...

Language development entails four fundamental and interactive abilities: listening, speaking, reading, and writing. Over the past four decades, a large body of evidence has indicated that reading acquisition is strongly associated with a child's listening skills, particularly the child's sensitivity to phonological structures of spoken language. Fu...

We investigated the white matter structure in children (n = 14) with a wide range of reading performance levels using diffusion tensor imaging (DTI), a form of magnetic resonance imaging. White matter structure in a left temporo-parietal region that had been previously described as covarying with reading skill in adult readers also differs between...

Developmental dyslexia is characterized by a severe reading problem in people who have normal intelligence and schooling. Impaired reading of alphabetic scripts is associated with dysfunction of left temporoparietal brain regions. These regions perform phonemic analysis and conversion of written symbols to phonological units of speech (grapheme-to-...

Reading in a second language (L2) is a complex task that entails an interaction between L2 and the native language (L1). To study the underlying mechanisms, we used functional magnetic resonance imaging (fMRI) to visualize Chinese-English bilinguals' brain activity in phonological processing of logographic Chinese and alphabetic English, two writte...

The syllable and the phoneme are two important units in the phonological structure of speech sounds. In the brain mapping literature, it remains unsolved as to whether there are separate brain regions mediating the processing of syllables and phonemes. Using functional magnetic resonance imaging (fMRI), we investigated the neural substrate of these...

This study examined the role of phonological awareness and visual-orthographic skills in Chinese reading acquisition. The subjects were 154 1st, 2nd, 3rd, and 5th graders in Beijing who had learned an alphabetic script known as Hanyu Pinyin to help read Chinese characters. Children's performance on tests of various cognitive skills, reading ability...

This study examined the role of phonological awareness and visual–orthographic skills in Chinese reading acquisition. The subjects were 154 1st, 2nd, 3rd, and 5th graders in Beijing who had learned an alphabetic script known as Hanyu Pinyin to help read Chinese characters. Children's performance on tests of various cognitive skills, reading ability...

In a character decision task, phonetic compound targets (composed of a semantic radical and a phonetic component) followed primes that shared (a) the target's radical and were semantically related (R+S+), (b) the target's radical and were not semantically related (R+S−), (c) no radical but were semantically related (R−S+), and (d) no radical and we...

M. Taft and X. Zhu (1997) reported that character decision latencies to real Chinese characters containing components that entered into many combinations were faster than decision latencies to characters with components that entered into only a small number of combinations. However, this effect was restricted to components that appeared on the righ...

Two experiments examined whether the speed of activating different aspects of a word's meaning influences the time course of accessing phonology and meaning. The authors used a backward masking paradigm with Chinese materials. When targets were exposed at threshold + 14 ms, homophonic masks were observed to facilitate target identification. Semanti...

(Uncorrected OCR) Abstract of thesis entitled �he Role Of Phonological Awareness And Visual-Orthographic Skills In Chinese Reading Acquisition�submitted by Siok Wai Ting for the degree of Doctor of Philosophy at the University of Hong Kong in March 2001 This study examined the role of phonological awareness and visuo-orthographic processing skills...