Wade Thompson

Wade Thompson
University of British Columbia - Vancouver | UBC · Department of Anesthesiology, Pharmacology and Therapeutics

PharmD PhD

About

54
Publications
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1,584
Citations

Publications

Publications (54)
Article
Full-text available
Background Deprescribing literature has been increasing rapidly. Our aim was to develop and validate search filters to identify articles on deprescribing in Medline via PubMed and in Embase via Embase.com . Methods Articles published from 2011 to 2020 in a core set of eight journals (covering fields of interest for deprescribing, such as geriatric...
Article
Background Contemporary guidelines suggest relaxed glycemic targets in populations with type 2 diabetes mellitus (T2DM) at risk of hypoglycemia, including people experiencing multimorbidity, limited life expectancy, or frailty. However, overtreatment remains common. To inform safe deprescribing, a previous systematic review investigated the benefit...
Chapter
Deprescribing is defined as “the planned and supervised process of dose reduction or stopping of medication that might be causing harm, or no longer be of benefit.” Barriers to deprescribing include healthcare professional fear and lack of guidance. These may stem from limited available evidence on benefits and harms of deprescribing medications co...
Article
Full-text available
Importance Statin use is common in older persons. Given uncertainties in ongoing benefit, changes in health status, and shifting goals of care and preferences, statin discontinuation may be considered in some older persons, although there is currently little evidence to guide this decision. Objective To evaluate the association between statin disc...
Article
Purpose To examine use of sedating medications around the time of nursing home admission in Denmark. Methods We conducted a register-based drug utilization study, describing patterns of commonly used medications with sedative effects leading up to and after nursing home admission using data from 94 Danish nursing homes between 2015 and 2017. Resu...
Article
Background Discussing life expectancy helps inform decisions related to preventive medication, screening, and personal care planning. Our aim was to systematically review the literature on patient preferences for discussing life expectancy and to identify predictors for these preferences.Methods We searched PubMed, Cochrane Library, Embase, MEDLINE...
Article
Background Deprescribing (planned, supervised discontinuation) of statins may be considered in some older persons. This should be carefully discussed between patients and GPs. Methods We examined GPs’ preferences for discussing statin deprescribing by conducting a discrete choice experiment (DCE) sent to a stratified random sample of 500 Danish GP...
Article
Deprescribing is defined as “the planned and supervised process of dose reduction or stopping of medication that might be causing harm, or no longer be of benefit”. Barriers to deprescribing include healthcare professional fear and lack of guidance. These may stem from limited available evidence on benefits and harms of deprescribing medications co...
Article
Unnecessary polypharmacy continues to be a problem among older adults. The field of deprescribing (planned, supervised process of medication discontinuation) aims to address this problem. Deprescribing is a relatively new field despite having grown substantially in recent years. Much of the early research in this area focused on identifying barrier...
Article
Thirteen systematic reviews (SRs) were identified. Two of these SRs addressed delayed antibiotic prescribing and 12 of these SRs investigated family medicine interventions. Delayed antibiotic prescribing reduced antibiotic use for upper respiratory tract infections (URTIs) compared to immediate prescribing and did not appear to impact patient satis...
Article
Full-text available
Objective Proton pump inhibitor (PPI) use has risen substantially, primarily driven by ongoing use over months to years. However, there is no consensus on how to define long-term PPI use. Our objectives were to review and compare definitions of long-term PPI use in existing literature and describe the rationale for each definition. Moreover, we aim...
Article
Background and objective: There is limited evidence on the clinical effects of statins in older persons. We aimed to explore statin use and discontinuation patterns in Danes age 70 and older. Design: Register-based drug utilisation study. Setting: Danish nationwide health registries. Subjects: All Danish persons aged ≥70 years between 2011 a...
Article
Full-text available
Background: Deprescribing of proton pump inhibitors (PPIs) can be considered in situations where the drug may no longer be necessary; however, this requires a careful discussion between patients and healthcare providers, often general practitioners (GPs). The aim of our study was to explore how GPs discuss PPI deprescribing with patients and compa...
Article
Full-text available
Background: Hypertension is an important risk factor for subsequent cardiovascular events, including ischaemic and haemorrhagic stroke, myocardial infarction, heart failure, chronic kidney disease, cognitive decline and premature death. Overall, the use of antihypertensive medications has led to reduction in cardiovascular disease, morbidity rates...
Article
Full-text available
Background Given uncertainty surrounding benefits and harms, shifts in patient health status, and changing patient goals and preferences, statin deprescribing may be considered in some older people. This decision should be carefully discussed between GPs and patients. Aim To explore how GPs discuss deprescribing of statins with their older patient...
Article
Background Deprescribing of preventive medications may be considered in some nursing home residents. It is important to understand how to effectively communicate around this complex decision, from both a physician and resident perspective. Objective The objective of this study was to explore how nursing home residents would like to discuss depresc...
Preprint
Objective: Preventing or minimising beer loss when opening a can of beer is socially and economically desirable. One theoretically grounded approach is tapping the can prior to opening, although this has never been rigorously evaluated. We aimed to evaluate the effect of tapping a can of beer on beer loss. Methods: Single centre parallel-group rand...
Article
Background and objective: Use of statins is considerable among older persons. We investigated factors associated with statin discontinuation in new statin users aged 70 years or older within the first 4 years of use. Design: Register-based descriptive drug utilization study using data from 2008 to 2016. Population/setting: All Danish persons,...
Article
Full-text available
Purpose A subset of patients with chronic obstructive pulmonary disease (COPD) experience a decrease in exacerbation frequency, leading to a diminished need for treatment with inhaled corticosteroids (ICS). We investigated prescribing and discontinuation patterns of long-acting bronchodilators and ICS in COPD patients according to exacerbation freq...
Article
Introduction Cholinesterase inhibitors (ChEIs) and memantine are medications used to treat the symptoms of specific types of dementia. Their benefits and harms can change over time, particularly during long term use. Therefore, appropriate use of ChEIs and memantine involves both prescribing these medications to individuals who are likely to benefi...
Article
Background Little is known about the roles that allow interprofessional teams to effectively manage older patients experiencing polypharmacy. Objectives To identify and examine the consensus on salient interprofessional roles, responsibilities and competencies required in managing polypharmacy. Methods Four focus groups with 35 team members pract...
Article
In Section 4.3 "Factors Associated with Statin Use in the Oldest Old".
Article
Deprescribing is a clinically important and feasible innovation that ensures medication efficacy, reduces harms, and mitigates polypharmacy. It involves reducing doses or stopping medications that are not useful, no longer needed, or which may be causing harm. It may also involve changing to a safer agent or using non-pharmacological approaches for...
Article
A World Café workshop was held at the Bruyère Evidence-Based Deprescribing Guidelines Symposium in March 2018 with 30 participants (researchers, clinicians, policy makers, stakeholders). This workshop explored priorities for future work in the field of deprescribing and deprescribing guidelines through group discussion. The discussions were guided...
Article
There is a lack of evidence surrounding the efficacy of statins in the oldest old (≥ 80 years of age). As such, there is controversy surrounding use of statins in this population. We sought to evaluate the prevalence of statin use in the oldest old worldwide to understand the scope of this issue. We searched PubMed and grey literature over the last...
Article
Objective: To develop an evidence-based guideline to help clinicians make decisions about when and how to safely taper and stop benzodiazepine receptor agonists (BZRAs); to focus on the highest level of evidence available and seek input from primary care professionals in the guideline development, review, and endorsement processes. Methods: The...
Article
Proton pump inhibitors (PPIs) are widely used, and concerns about overuse have been raised. Therefore, side effects are important to be aware of and several suggested side effects of long‐term use have been studied. In this MiniReview, we sum up the evidence of side effects related to long‐term PPI treatment. Suspected side effects are mainly relat...
Article
Full-text available
Objective: To develop an evidence-based guideline to help clinicians make decisions about when and how to safely taper and stop antipsychotics; to focus on the highest level of evidence available and seek input from primary care professionals in the guideline development, review, and endorsement processes. Methods: The overall team comprised 9 c...
Article
Objective To develop an evidence-based guideline to help clinicians make decisions about when and how to safely taper and stop antipsychotics; to focus on the highest level of evidence available and seek input from primary care professionals in the guideline development, review, and endorsement processes. Methods The overall team comprised 9 clinic...
Article
Full-text available
Objective: To develop an evidence-based guideline to help clinicians make decisions about when and how to safely taper, stop, or switch antihyperglycemic agents in older adults. Methods: We focused on the highest level of evidence available and sought input from primary care professionals in guideline development, review, and endorsement process...
Article
Background: Proton pump inhibitors (PPIs) treat various upper gastrointestinal (GI) diseases. Around 50% of patients may remain on PPIs long-term without ongoing need. Eligible patients should be offered the choice of continuing their PPI or trying to reduce/stop their PPI (deprescribing), a choice dependent on values and preferences. Objectives:...
Article
Full-text available
Objective: To develop an evidence-based guideline to help clinicians make decisions about when and how to safely taper or stop proton pump inhibitors (PPIs); to focus on the highest level of evidence available and seek input from primary care professionals in the guideline development, review, and endorsement processes. Methods: Five health prof...
Article
Background: Proton pump inhibitors (PPIs) are a class of medications that reduce acid secretion and are used for treating many conditions such as gastroesophageal reflux disease (GERD), dyspepsia, reflux esophagitis, peptic ulcer disease, and hypersecretory conditions (e.g. Zollinger-Ellison syndrome), and as part of the eradication therapy for He...
Article
Deprescribing can be defined as the process of withdrawal or dose reduction of medications which are considered inappropriate in an individual. The aim of this narrative review is to provide an overview of "deprescribing"; firstly discussing the potential benefits and harms followed by the barriers to and enablers of deprescribing. We also provide...
Article
IntroductionIndividualizing glycemic targets to goals of care and time to benefit in persons with type 2 diabetes is good practice, particularly in populations at risk of hypoglycemia and adverse outcomes relating to the use of antihyperglycemics. Guidelines acknowledge the need for relaxed targets in frail older adults, but there is little guidanc...
Article
Full-text available
Background Class specific deprescribing guidelines could help clinicians taper and stop medications no longer needed or which may be causing more harm than benefit. We set out to develop methodology to create such guidelines using evidence-based methods for guideline development, evidence synthesis and recommendation rating. Methods and Findings U...
Data
Sample Medline search strategy for key PICO question of PPI deprescribing guideline. (DOCX)
Article
Objectives: To assess the effect of a proton pump inhibitor (PPI) deprescribing guideline on PPI usage and PPI drug costs in one long-term care home in Ontario, Canada. Design: Interrupted time-series analysis to compare monthly PPI usage and average monthly PPI cost per resident 9 months before guideline implementation to 12 months after. Sett...
Article
Background Observational evidence suggests that atypical antipsychotics such as quetiapine are increasingly being used to manage insomnia. This is concerning given the uncertain efficacy and potential adverse effects associated with these medications. Objectives The objectives of this study are to evaluate the benefits and adverse effects of atypi...
Article
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To determine the effects of deprescribing long-term PPI therapy in adults as compared to continuation of long-term PPI therapy.
Article
This article is one of several prepared as part of a collaboration between the Geriatric Day Hospital of Bruyère Continuing Care, CMAJ, Canadian Family Physician and the Canadian Pharmacists Journal to assist clinicians in the prevention and management of polypharmacy when caring for older patients in their practices.
Article
This article is one of several prepared as part of a collaboration between the Geriatric Day Hospital of Bruyère Continuing Care, CMAJ, Canadian Family Physician and the Canadian Pharmacists Journal to assist clinicians in the prevention and managementof polypharmacy when caring for older patients in their practices.
Article
Full-text available
A method has been developed for the simultaneous analysis of 22 mycotoxins in wheat, barley, oats, rye and maize grain. Analysis is carried out with liquid chromatography-electrospray ionisation tandem mass spectrometry. The compounds included in this analysis are aflatoxins, sterigmatocystin, cyclopiazonic acid, tricothecenes, ochratoxin A, fumoni...
Article
Cyclopiazonic acid (CPA) is an important mycotoxin given its toxicity and prevalence in foods and feeds. There is tremendous interest in developing analytical methods that include CPA as part of a multi-residue mycotoxin routine, but there appears to be considerable difficulty in analysing it using liquid chromatography with electrospray ionisation...

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Projects (3)
Project
A repository for researchers and collaborators to share descriptions of their work and information about ongoing and upcoming deprescribing initiatives. The repository will allow people to see what others are doing in the field of deprescribing and to collaborate more easily. Please take a moment to add any applicable personal information to our research repository hosted through Google Sheets. https://docs.google.com/spreadsheets/d/1WgdgHizQLRSr7tJbAlMxinHIC3jI8XsO5GXrLSEPe7g/edit?usp=sharing