W. E. Uspal

• PhD
• Professor (Assistant) at University of Hawai'i at Manoa

Active colloids are self-propelled particles, powered by energy harvested from the environment. This field of research has been growing over the past 20 years, attracting researchers from multiple disciplines. Biomedical engineers seek to harness the abilities of motile bacteria, materials chemists are fascinated by the concept of synthetic particl...

Patches of catalyst imprinted on supporting walls induce motion of the fluid around them once they are supplied with the chemical species (``fuel'') that are converted by the catalytic chemical reaction. While the functioning of such chemically active micropumps is conceptually well understood, an in-depth characterization of the induced hydrodynam...

Many biological microswimmers are capable of chemotaxis, i.e., they can sense an ambient chemical gradient and adjust their mechanism of motility to move towards or away from the source of...

Ensembles of suspended spinning particles in liquids form a distinct category of active matter systems known as chiral fluids. Recent experimental instances of dense chiral fluids have comprised of spinning colloidal magnets powered by an external rotating magnetic field. These particles interact through both magnetic and hydrodynamic forces, organ...

Many biological microswimmers are capable of chemotaxis, i.e., they can sense an ambient chemical gradient and adjust their mechanism of motility to move towards or away from the source of the gradient. Synthetic active colloids endowed with chemotactic behavior hold considerable promise for targeted drug delivery and the realization of programmabl...

The “squirmer model” is a classical hydrodynamic model for the motion of interfacially driven microswimmers, such as self-phoretic colloids or volvocine green algae. To date, most studies using the squirmer model have considered spherical particles with axisymmetric distribution of surface slip. Here, we develop a general approach to the pairing an...

Efficient exploration of space is a paramount motive for active colloids in practical applications. Yet, introducing activity may lead to surface-bound states, hindering efficient space exploration. Here, we show that...

Micromotors have emerged as promising devices for a wide range of applications e.g., microfluidics, lab-on-a-chip devices, active matter, environmental monitoring, etc. The control over the activity of micromotors with the ability to exhibit multimode swimming is one of the most desirable features for many of the applications. Here, we demonstrate...

The "squirmer model" is a classical hydrodynamic model for the motion of interfacially-driven microswimmers, such as self-phoretic colloids or volvocine green algae. To date, most studies using the squirmer model have considered spherical particles with axisymmetric distribution of surface slip. Here, we develop a general approach to the pairing an...

The emergence of large-scale collective phenomena from simple interactions between individual units is a hallmark of active matter systems. Active colloids with alignment-dominated interparticle interactions tend to develop orientational order and form motile coherent states, such as flocks and swarms. Alternatively, a combination of self-propulsio...

Fluid flow is ubiquitous in many environments that form habitats for microorganisms. The tendency of organisms to navigate towards or away from flow is termed rheotaxis. Therefore, it is not surprising that both biological and artificial microswimmers show responses to flows that are determined by the interplay of chemical and physical factors. In...

Chemically active colloids self-propel by catalysing the decomposition of molecular ‘fuel’ available in the surrounding solution. If the various molecular species involved in the reaction have distinct interactions with the colloid surface, and if the colloid has some intrinsic asymmetry in its surface chemistry or geometry, there will be phoretic...

Chemically active Janus particles sustain non-equilibrium spatial variations in the chemical composition of the suspending solution; these induce hydrodynamic flow and (self-)motility of the particles. Direct mapping of these fields has so far proven to be too challenging. Therefore, indirect methods are needed, e.g., deconvolving the response of "...

Coronavirus disease 2019 (COVID-19), due to infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is now causing a global pandemic. Aerosol transmission of COVID-19, although plausible, has not been confirmed by the World Health Organization (WHO) as a general transmission route. Considering the rapid spread of SARS-CoV-2,...

Comprehensive understanding of particle motion in microfluidic devices is essential to unlock additional technologies for shape-based separation and sorting of microparticles like microplastics, cells, and crystal polymorphs. Such particles interact hydrodynamically with confining surfaces, thus altering their trajectories. These hydrodynamic inter...

Comprehensive understanding of particle motion in microfluidic devices is essential to unlock novel technologies for shape-based separation and sorting of microparticles like microplastics, cells and crystal polymorphs. Such particles interact hydrodynamically with confining surfaces, thus altering their trajectories. These hydrodynamic interaction...

Chemically active particles achieve motility without external forces and torques (``self-propulsion'') due to catalytic chemical reactions at their surfaces, which change the chemical composition of the surrounding solution (called ``chemical field``) and induce hydrodynamic flow of the solution. By coupling the distortions of these fields back to...

Surface bound catalytic chemical reactions self-propel chemically active Janus particles. In the vicinity of boundaries, these particles exhibit rich behavior, such as the occurrence of wall-bound steady states of "sliding". Most active particles tend to sediment as they are density mismatched with the solution. Moreover Janus spheres, which consis...

We study, by means of an exact analytical solution, the motion of a spheroidal, axisymmetric squirmer in an unbounded fluid, as well as the low Reynolds number hydrodynamic flow associated to it. In contrast to the case of a spherical squirmer --- for which, e.g., the velocity of the squirmer and the magnitude of the stresslet associated with the f...

We study, by means of an exact analytical solution, the motion of a spheroidal, axisymmetric squirmer in an unbounded fluid, as well as the low Reynolds number hydrodynamic flow associated to it. In contrast to the case of a spherical squirmer --- for which, e.g., the velocity of the squirmer and the magnitude of the stresslet associated with the f...

If catalytically active Janus particles are dispersed in certain liquid solutions, they can create a gradient in the chemical composition of this solution along their surfaces, as well as along any nearby confining surfaces. This gradient drives self-propulsion via a self-phoretic mechanism, while the compositional gradient along a wall gives rise...

We study the dynamics of active Janus particles that self-propel in solution by light-activated catalytic decomposition of chemical “fuel.” We develop an analytical model of a photo-active self-phoretic particle that accounts for “self-shadowing” of the light by the opaque catalytic face of the particle. We find that self-shadowing can drive “photo...

Dynamics of chemically active particles moving by self-phoresis near chemically inert walls is studied theoretically by employing various choices for the activity function.

We study the dynamics of active Janus particles that self-propel in solution by light-activated catalytic decomposition of chemical "fuel." We develop an analytical model of a photo-active self-phoretic particle that accounts for "self-shadowing" of the light by the opaque catalytic face of the particle. We find that self-shadowing can drive "photo...

Chemically active colloids can achieve force- and torque-free motility ("self-propulsion") via the promotion, on their surface, of catalytic chemical reactions involving the surrounding solution. Such systems are valuable both from a theoretical perspective, serving as paradigms for nonequilibrium processes, as well as from an application viewpoint...

Over millions of years, Nature has optimized the motion of biological systems at the micro and nanoscales. Motor proteins to motile single cells have managed to overcome Brownian motion and solve several challenges that arise at low Reynolds numbers. In this review, we will briefly describe naturally motile systems and their strategies to move, sta...

While colloids and molecules in solution exhibit passive Brownian motion, particles that are partially covered with a catalyst, which promotes the transformation of a fuel dissolved in the solution, can actively move. These active Janus particles are known as ``chemical nanomotors'' or self-propelling ``swimmers'', and have been realized with a ran...

We combine theory and numerical calculations to accurately predict the motion of anisotropic particles in shallow microfluidic channels, in which the particles are strongly confined in the vertical direction. We formulate an effective quasi-two-dimensional description of the Stokes flow around the particle via the Brinkman equation, which can be so...

Phototactic microorganisms are commonly observed to respond to natural sunlight by swimming upward against gravity. This study demonstrates that synthetic photochemically active microswimmers can also swim against gravity. The particles initially sediment and, when illuminated at low light intensities exhibit wall-bound states of motion near the bo...

In article 1706660, Dhruv P. Singh, William E. Uspal, and co‐workers demonstrate that self‐propelled Janus particles move near a surface or against gravity in response to light. The sedimented colloids swim along the surface when illuminated with low intensity light. When the light intensity is increased above a threshold value, the active colloids...

Various aspects of self-motility of chemically active colloids in Newtonian fluids can be captured by simple models for their chemical activity plus a phoretic-slip hydrodynamic boundary condition on their surface. For particles of simple shapes (e.g., spheres) --as employed in many experimental studies-- which move at very low Reynolds numbers in...

Various aspects of self-motility of chemically active colloids in Newtonian fluids can be captured by simple models for their chemical activity plus a phoretic slip hydrodynamic boundary condition on their surface. For particles of simple shapes (e.g., spheres) -- as employed in many experimental studies -- which move at very low Reynolds numbers i...

Self-phoretic Janus particles move by inducing -- via non-equilibrium chemical reactions occurring on their surfaces -- changes in the chemical composition of the solution in which they are immersed. This process leads to gradients in chemical composition along the surface of the particle, as well as along any nearby boundaries, including solid wal...

Self-phoretic Janus particles move by inducing -- via non-equilibrium chemical reactions occurring on their surfaces -- changes in the chemical composition of the solution in which they are immersed. This process leads to gradients in chemical composition along the surface of the particle, as well as along any nearby boundaries, including solid wal...

For natural microswimmers, the interplay of swimming activity and external flow can promote robust motion, e.g. propulsion against ("upstream rheotaxis") or perpendicular to the direction of flow. These effects are generally attributed to their complex body shapes and flagellar beat patterns. Here, using catalytic Janus particles as a model experim...

For natural microswimmers, the interplay of swimming activity and external flow can promote robust motion, e.g. propulsion against ("upstream rheotaxis") or perpendicular to the direction of flow. These effects are generally attributed to their complex body shapes and flagellar beat patterns. Here, using catalytic Janus particles as a model experim...

Colloids can achieve motility by promoting at their surfaces chemical reactions in the surrounding solution. A well-studied case is that of self-phoresis, in which motility arises due to the spatial inhomogeneities in the chemical composition of the solution and the distinct interactions of the solvent molecules and of the reaction products with th...

Chemically active colloids move by creating gradients in the composition of the surrounding solution and by exploiting the differences in their interactions with the various molecular species in solution. If such particles move near boundaries, e.g., the walls of the container confining the suspension, gradients in the composition of the solution a...

Chemically active colloids locally change the chemical composition of their solvent via catalytic reactions which occur on parts of their surface. They achieve motility by converting the released chemical free energy into mechanical work through various mechanisms, such as phoresis. Here we discuss the theoretical aspects of self-diffusiophoresis,...

The self-motile Janus colloids are important for enabling a wide variety of micro-technology applications as well as for improving our understanding of the mechanisms of motion of artificial micro- and nano-swimmers. We present here a novel type of micro/nano-motors which possess a reversed Janus structure of an internal catalytic "chemical engine"...

Chemically active colloids move by creating gradients in the composition of the surrounding solution and by exploiting the differences in their interactions with the various molecular species in solution. If such particles move near boundaries, e.g., the walls of the container confining the suspension, gradients in the composition of the solution a...

Catalytically active Janus particles suspended in solution create gradients in the chemical composition of the solution along their surfaces, as well as along any nearby container walls. The former leads to self-phoresis, while the latter gives rise to chemi-osmosis, providing an additional contribution to self-motility. Chemi-osmosis strongly depe...

Catalytically active Janus particles suspended in solution create gradients in the chemical composition of the solution along their surfaces, as well as along any nearby container walls. The former leads to self-phoresis, while the latter gives rise to chemi-osmosis, providing an additional contribution to self-motility. Chemi-osmosis strongly depe...

Achieving control over the directionality of active colloids is essential for their use in practical applications such as cargo carriers in microfluidic devices. So far, guidance of spherical Janus colloids was mainly realized using specially engineered magnetic multilayer coatings combined with external magnetic fields. Here, we demonstrate that s...

Achieving control over the directionality of active colloids is essential for their use in practical applications such as cargo carriers in microfluidic devices. So far, guidance of spherical Janus colloids was mainly realized using specially engineered magnetic multilayer coatings combined with external magnetic fields. Here we demonstrate that st...

Two R=2.5 μm microswimmers in 5 vol/vol% H2O2 following a straight step (180 degrees) and one moving nearly parallel to the step for some distance.

R=2.5 μm microswimmer in 5 vol/vol% H2O2 maneuvering a 90° angle.

R=2.5 μm microswimmer in 5 vol/vol% H2O2 detaching from the step feature when it encounters a 270° angle.

R=2.5 μm microswimmer following circular steps with a diameter of approx. 15 μm.

R=1 μm microswimmer in 5 vol/vol% H2O2 following circular steps with a diameter of 15 μm.

R=1 μm microswimmer in 5 vol/vol l% H2O2 following circular steps with a diameter of 40 μm.

Supplementary Figures 1-5, Supplementary Tables 1-2, Supplementary Notes 1-5 and Supplementary References

R=1 μm microswimmer in 5 vol/vol % H2O2 following circular steps with a diameter of 60 μm.

For active particles the interplay between the self-generated hydrodynamic flow and an external shear flow, especially near bounding surfaces, can result in a rich behavior of the particles not easily foreseen from the consideration of the active and external driving mechanisms in isolation. For instance, under certain conditions, the particles exh...

Flow of microparticles through geometrically confined spaces is a core element of most microfluidic technologies. Flowing particles are typically ordered and manipulated with external forces or coflowing streams, but these methods can be limited in generality and scalability. New techniques to control particle trajectories would enable new applicat...

Micron-sized particles moving through solution in response to self-generated chemical gradients serve as model systems for studying active matter. Their far-reaching potential applications will require the particles to sense and respond to their local environment in a robust manner. The self-generated hydrodynamic and chemical fields, which induce...

We consider how to design a microfluidic system in which suspended particles spontaneously order into flowing crystals when driven by external pressure. Via theory and numerics, we find that particle-particle hydrodynamic interactions drive self-organization under suitable conditions of particle morphology and geometric confinement. Small clusters...

Recent advances in microfluidic technologies have created a demand for techniques to control the motion of flowing microparticles. Here we consider how the shape and geometric confinement of a rigid microparticle can be tailored for 'self-steering' under external flow. We find that an asymmetric particle, weakly confined in one direction and strong...

Spatially ordered equilibrium states – crystals – and their excitations – phonons – are the mainstay of condensed matter physics. Flowing, nonequilibrium crystalline states of microparticles and droplets are desirable for microfluidic logic, assembly, and control, and have been achieved in recent work via exploitation of viscous hydrodynamic intera...

Proper timing of gene expression requires that transcription factors (TFs) efficiently locate and bind their target sites within a genome. Theoretical studies have long proposed that one-dimensional sliding along DNA while simultaneously reading its sequence can accelerate TF's location of target sites. Sliding by prokaryotic and eukaryotic TFs wer...

We model a pair of hydrodynamically interacting particles confined in a channel with thin rectangular cross section. We find that the particles have a finite region of attraction, which arises from the screening of dipolar hydrodynamic interactions by the side walls. Outside this region, the two particles break apart and scatter; inside, they oscil...

We use a coarse-grained numerical simulation to design a synthetic membrane with stable pores that can be controllably opened and closed. Specifically, we use dissipative particle dynamics to probe the interactions between lipid bilayer membranes and nanoparticles. The particles are nanoscopic Janus beads that comprise both hydrophobic and hydrophi...

Phospholipid membranes, which separate the cytoplasm from the extracellular environment in biological cells, embed a large diversity of proteins. Some proteins form pores for the free transport of small molecules and ions across the membrane. Here, we use coarse grained numerical simulations to design a synthetic membrane, where pores can be formed...

The authors study the response of a multicomponent budded vesicle to an imposed shear flow using dissipative particle dynamics. Under certain circumstances, phase separation in the vesicle membrane leads to the formation of a minority domain which deforms into a nearly spherical bud in order to reduce its interfacial energy. The authors show that a...