Vytautas Cėpla

Vytautas Cėpla
Center for Physical Sciences and Technology | CPST · Nanoengineering

PhD

About

14
Publications
3,042
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156
Citations
Citations since 2017
8 Research Items
135 Citations
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2017201820192020202120222023010203040
2017201820192020202120222023010203040

Publications

Publications (14)
Article
Full-text available
Neuronal-glial cell cultures are usually grown attached to or encapsulated in an adhesive environment as evenly distributed networks lacking tissue-like cell density, organization and morphology. In such cultures, microglia have activated amoeboid morphology and do not display extended and intensively branched processes characteristic of the ramifi...
Article
Full-text available
Dilated cardiomyopathy (DCM) is the most common type of nonischemic cardiomyopathy characterized by left ventricular or biventricular dilation and impaired contraction leading to heart failure and even patients’ death. Therefore, it is important to search for new cardiac tissue regenerating tools. Human mesenchymal stem/stromal cells (hmMSCs) were...
Article
Full-text available
Purpose To determine feasibility of plant-derived recombinant human collagen type I (RHCI) for use in corneal regenerative implants Methods RHCI was crosslinked with 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide (EDC) and N-hydroxysuccinimide (NHS) to form hydrogels. Application of shear force to liquid crystalline RHCI aligned the collagen fibr...
Article
Full-text available
There is a growing need for novel in vitro corneal models to replace animal-based ex vivo tests in drug permeability studies. In this study, we demonstrated a corneal mimetic that models the stromal and epithelial compartments of the human cornea. Human corneal epithelial cells (HCE-T) were grown on top of a self-supporting porcine collagen-based h...
Preprint
There is a growing need for novel in vitro corneal models to replace animal-based ex vivo test in drug permeability studies. In this study we demonstrate a corneal mimetic that models the stromal and epithelial compartments of human cornea. Human corneal epithelial cells (HCE-T) were grown on top of a self-supporting porcine collagen-based hydrogel...
Article
An efficient procedure for chemical initiator-free, in situ synthesis of functional polyethylene glycol methacrylate (PEG MA) hydrogel on regular glass substrates is reported. It is demonstrated that self-initiated photografting and photopolymerization (SIPGP) driven by UV irradiation can yield tens of nanometers-thick coatings of carboxy- function...
Article
Full-text available
Hydrogel-supported neural cell cultures are more in vivo-relevant compared to monolayers formed on glass or plastic substrates. However, there is a lack of synthetic microenvironment available for obtaining standardized and easily reproducible cultures characterized by tissue-mimicking cell composition, cell–cell interactions, and functional networ...
Article
Full-text available
Purpose: To investigate the efficacy of recombinant human collagen type I (RHC I) and collagen-like peptide (CLP) hydrogels as alternative carrier substrates for the cultivation of limbal epithelial stem cells (LESC) under xeno-free culture conditions. Methods: Human LESC were cultivated on seven different collagen-derived hydrogels: (1) unmodif...
Article
INTRODUCTION: Limbal Epithelial Stem Cell (LESC) deficiency is an orphan disease leading to corneal blindness. Tissue engineering has become a treatment modality for this condition, as cultivated limbal epithelial transplantation (CLET) can successfully regenerate the anterior cornea [1]. In CLET, a limbal biopsy is cultivated and transplanted with...
Article
The implant-host interface is a critical element in guiding tissue or organ regeneration. We previously developed hydrogels comprising interpenetrating networks of recombinant human collagen type III and 2-methacryloyloxyethyl phosphorylcholine (RHCIII-MPC) as substitutes of the corneal extracellular matrix that promote endogenous regeneration of c...
Article
6-Methyl-2-methylthio-4-oxopyrimidin-3(4H)-yl)acetohydrazide on heating in benzylamine undergo cyclization to 8-methyl-2H-pyrimido[2,1-c][1,2,4]triazine-3, 6(1H, 4H)-dione, which under treatment with bromine in glacial acetic acid was converted to 7-bromo substituted derivative and at reflux with Lawesson's reagent yielded 3-thioxo compound. The la...

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