Vusala Ibrahimova

University of Bordeaux · Department of Science and Technology

In response to variations in osmotic stress, in particular to hypertonicity associated with biological dysregulations, cells have developed complex mechanisms to release their excess water, thus avoiding their bursting and death. When water is expelled, cells shrink and concentrate their internal bio(macro)molecular content, inducing the formation...

Design of reversible organelle-like microcompartments formed by liquid–liquid phase separation in cell-mimicking entities has significantly advanced the bottom-up construction of artificial eukaryotic cells. However, organizing the formation of artificial organelle architectures in a spatiotemporal manner within complex primitive compartments remai...

Temperature-sensitive lipo-proteinosomes were engineered by grafting lipids onto temperature-responsive elastin-like polypeptides (ELPs). Maintained at 37 °C, folded ELP loops on the internal/external surface of the biohybrid membrane prevent the leaching of encapsulated molecules, while cooling of the dispersion induces a burst release, in correla...

Elastin‐like polypeptides (ELPs) have been proposed as a simple model of intrinsically disordered proteins (IDPs) which can form membraneless organelles by liquid–liquid phase separation (LLPS) in cells. Herein, the behavior of fluorescently labeled ELP is studied in cytomimetic aqueous two‐phase system (ATPS) encapsulated protocells that are forme...

Elastin‐like polypeptides (ELPs) have been proposed as a simple model of intrinsically disordered proteins (IDPs) which can form membrane‐less organelles via liquid‐liquid phase separation (LLPS) in cellular milieu. Herein, fluorescently labeled ELP is studied in cytomimetic aqueous two‐phase system (ATPS). Droplet‐based protocells are obtained in...

Localization of the photosensitizer conjugation site in amphiphilic block copolymers is shown to have a great impact on photodynamic therapy efficiency. To this end, an asymmetric multifunctional derivative of the azadipyrromethene boron difluoride chelate (Aza-BODIPY) was synthesized and inserted at specific locations in polypeptide-based rod-coil...

Nanocomposites of colloidal quantum dots (QDs) integrated into conjugated polymers (CPs) are key to hybrid optoelectronics, where engineering the excitonic interactions at the nanoscale is crucial. For such excitonic operation, it was believed that exciton diffusion is essential to realize nonradiative energy transfer from the CPs into the QDs. In...

Conjugated polymer nanoparticles (CPNs), prepared in aqueous dispersion from poly[(9,9-bis{3-bromopropyl}fluorenyl-2,7-diyl)-co-(1,4-benzo-{2,1,3}-thiodiazole)] (PFBT-Br), are incorporated into a nanopillar architecture of InGaN/GaN multiple quantum wells (MQWs) to demonstrate a new organic/inorganic class of nanostructured excitonic model system....

A hybrid platform of colloidal quantum dots integrated into conjugated polymers is reported for excitonically driven light-emitting diodes having pure quantum dot emission in the electroluminescence spectrum with substantially enhanced efficiency.

A series of novel, fluorene-based conjugated copolymers, poly[(9,9-bis{propenyl}-9H-fluorene)-co-(9,9-dihexyl-9H-fluorene)] (P1), poly[(9,9-bis{carboxymethylsulfonyl-propyl}fluorenyl-2,7-diyl)-co-(9,9-dihexyl-9H-fluorene)] (P2) and poly[(9,9-dihexylfluorene)-co-alt-(9,9-bis-(6-azidohexyl)fluorene)] (P3), are synthesized by Suzuki coupling reactions...

Here, we report a novel method to synthesize multifunctional nanoparticles that can be used in biological studies, such as in cell imaging and as a carrier for biomolecules/drugs. The nanoparticles were prepared either via Cu-catalyzed or cucurbit[6]uril (CB6)-catalyzed click reactions between azidegroups containing hydrophobic blue, green and yell...

We report on the synthesis and characterization of water-dispersible, mechanically stable conjugated polymer nanoparticles (CPNs) in shelled architecture with tunable emission and controllable photometric properties via cross-linking. Using a reprecipitation method, white-emitting polymer nanoparticles are prepared in different sizes by varying the...

Vertically aligned multi-walled carbon nanotubes (MWCNTs) synthesized by the alcohol catalytic CVD (ACCVD) technique are dispersed in water with the aid of water-dispersible conjugated polymer nanoparticles (CPNs). The interactions between CPNs and CNTs are studied with spectroscopy (UV-Vis, fluorescence and Raman) and electron microscopy technique...