Volodymyr Volodymyrovych Parchenko

Volodymyr Volodymyrovych Parchenko
Zaporozhye State Medical University | ZSMU · Inorganic Chemistry

Doctor of Pharmacy
Implementation of new veterinary drugs and plant protection products: fortis-combi, trifuzol-neo, vetmikoderm

About

212
Publications
18,012
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258
Citations
Citations since 2016
203 Research Items
256 Citations
20162017201820192020202120220102030405060
20162017201820192020202120220102030405060
20162017201820192020202120220102030405060
20162017201820192020202120220102030405060
Introduction
Volodymyr Volodymyrovych Parchenko currently works at the Inorganic Chemistry, Zaporozhye State Medical University.
Additional affiliations
January 2018 - present
Zaporozhye State Medical University
Position
  • Professor
Description
  • Search for biologically active compounds among 1,2,4-triazole derivatives. Author of the creation of the veterinary drug Trifuzol-Neo, a plant growth stimulant Fortis Сombi
Education
October 2002 - April 2020
Zaporozhye State Medical University
Field of study
  • Inorganic Chemistry

Publications

Publications (212)
Article
Full-text available
Today, 1,2,4-triazole derivatives are a promising class of organic compounds. This is caused, first of all, by the possibility of various chemical modifications of the 1,2,4-triazole fragment due to the addition of typical pharmacophores, which contributes to the expansion of the new molecules’ arsenal. A significant number of the 1,2,4-triazole de...
Article
Full-text available
Makale, izoniazid ve N'-(2-(5-((teofilin-7-il)metil)-4-etil-1,2,4-triazol-3-iltio)asetil)izonikotinohidrazit. Deri altı uygulama için hesaplanan N'-(2-(5-((teofilin-7-il)metil)-4-etil-1,2,4-triazol-3-iltiyo)asetil)izonikotinohidrazid dozu, etkili ve güvenli bir tüberkülosidal ilaç olarak veterinerlik uygulamaları için beklentiler.
Article
Full-text available
The aim of this work was to determine the angle of rotation of the polarization plane of solutions of some S-derivatives of 4-R-5-((((3- (pyridin-4-yl)-1H-1,2,4-triazole-5-yl)thio)methyl))-4H-1,2,4-triazole-3-thiols and the establishment of regularities between the structure of the studied molecules and their optical activity
Article
Full-text available
1,2,4-Triazole and its derivatives are a promising class of organic compounds. For a long time, they remain in the spotlight due to a number of unique properties: high ability to chemical transformations, the presence of various types of biological activity and, of course, low toxicity. Also, a number of 1,2,4-triazole derivatives are currently wel...
Article
The modern market of medicines in Ukraine has the dynamics of constant development. At the same time, the dynamics of the pharmaceutical market depend entirely on the welfare of the population. Current features of quarantine restrictions have caused a number of distortions in drug consumption. Thus, after the introduction of quarantine in March 202...
Article
Full-text available
1,2,4-triazoles belong to a well-known сlass of heterocyclic compounds that are of both theoretical and practical interest. This class has been known for about 100 years, and in recent decades 1,2,4-triazoles have become one of the most attractive objects of research in the chemistry of heterocyclic compounds due to their unique properties. Recentl...
Article
1,2,4-triazoles belong to a well-known сlass of heterocyclic compounds that are of both theoretical and practical interest. This class has been known for about 100 years, and in recent decades 1,2,4-triazoles have become one of the most attractive objects of research in the chemistry of heterocyclic compounds due to their unique properties. Recentl...
Article
Full-text available
The relevance of our study is due to the constant need to obtain new promising molecules that can have high pharmacological activity and low toxicity. That is why synthetic chemists around the world are actively searching for new methods for the synthesis of biologically active compounds and modifying already known molecules. Among heterocyclic sys...
Article
Full-text available
The formation of the parasite fauna of wild ungulates and control of diseases caused by them is an essential veterinary measure in the breeding of deer. The study aimed to conduct monitoring studies on the infestation of red deer parasites (Cervus elaphus) during commercial cultivation during acclimatization in the Western Polissya of Ukraine. Faec...
Article
Full-text available
The study aimed to establish the parameters of chronic toxicity of the newly developed drug based on phosphodiesterase-3 inhibitor and ethylmethylhydroxypyridine succinate in experiments on laboratory animals. The analysis was performed on white sexually mature young male Wistar rats weighing 170–185 g. Four groups of white rats were formed. The fi...
Article
Full-text available
Due to the study of the toxicity of 1,2,4-triazole derivatives by non-experimental methods using GUSAR and TEST models, it was found that the test compounds could be classified as low-toxic substances. The compound is an organic salt that exists in the crystal as a solvate with one molecule of methanol and two molecules of water. When studying the...
Poster
Full-text available
The original veterinary drug "Vetmicoderm" is registered in Ukraine
Article
Full-text available
In the latest conditions of development and formation of the pharmaceutical industry, the introduction of new synthetic medicines requires continuous monitoring of the quality and safety of their use. For many years, synthetic drugs have remained an essential tool in the prevention and control of diseases of various etiologies. Among the synthetic...
Patent
Full-text available
The active ingredient of the veterinary drug "Vetmikoderm"
Article
Full-text available
Citation: Karpun Ye, Parchenko V, Fotina T, Demianenko D, Fotin A, Nahornyi V, Nahorna N (2021) The investigation of antimicro-bial activity of some s-substituted bis-1,2,4-triazole-3-thiones. Pharmacia 68(4): 797-804. https://doi. Abstract New S-substituted 4-alkyl-5-((3-(pyridin-4-yl)-1H-1,2,4-triazole-5-yl)thio)methyl)-4H-1,2,4-triazole-3-thiol...
Article
Full-text available
New S-substituted 4-alkyl-5-((3-(pyridin-4-yl)-1H-1,2,4-triazole-5-yl)thio)methyl)-4H-1,2,4-triazole-3-thiol derivatives have been designed, synthesized and studied their antimicrobial activity on 11 standard Gram-positive and Gram-negative microorganism strains. Their spectral and physicochemical parameters were established using modern comprehens...
Article
Full-text available
The genus Salvia L. has more than 900 species distributed throughout the globe. 21 species are growing in Ukraine. All species of this genus have essential oils. Salvia officinalis and Salvia sclarea have been used in the culture and are widely used in medical practice. The chemical composition of other species of sage and the possibility of their...
Article
The derivatives of 1,2,4-triazole are of the great scientific interest in the fields of pharmaceutics, agricultural chemistry, and construction The production of Trifuzol-Neo has already been launched, and it is now commercially available. Compounds based on 1,2,4-triazole may also be useful in veterinary practice due to their antiviral activity. T...
Article
Full-text available
In this study, the antibacterial activity of 11 preparations of drugs was determined by disc diffusion method in agar. Suspensions (0.5×10 8 CFU) were prepared from the daily cultures of Enterobacteriaceae, Pseudomonadaceae, Staphylococcaceae, Bacillaceae, Listeriaceae, Campylobacteraceae, Nocardiaceae, and Saccharomycetaceae family. The resulting...
Article
Full-text available
The derivatives of 1,2,4-triazole are of the great scientific interest in the fields of pharmaceutics, agricultural chemistry, and construction The production of Trifuzol-Neo has already been launched, and it is now commercially available. Compounds based on 1,2,4-triazole may also be useful in veterinary practice due to their antiviral activity. T...
Article
Full-text available
Current trends in the search for new biologically active compounds among synthetic molecules have arguably proved a priority in studies of the heterocyclic 1,2,4-triazole system. For many years, 1,2,4-triazole derivatives remain the object of close attention of scientists of various scientific fields. The unique properties of 1,2,4-triazole derivat...
Article
Full-text available
Heterocyclic compounds are one of the most important branches of modern organic chemistry and are widely used in medicine, pharmacy, agriculture, and in the production of new materials. One of these compounds is 1,2,4-triazole, which has attracted the attention of scientists around the world for many years. The aim of the work is to synthesize new...
Article
Full-text available
The aim of the work. 1,2,4-triazole derivatives possess a wide range of pharmacological activity, so they are used for the development of drugs and active pharmaceutical ingredients. Due to the reactivity of 1,2,4-triazoles there are many options for their further structural modification on different reaction centers. Therefore, the aim of the work...
Article
Full-text available
The theoretical description of prodigiosin pigment electrochemical determination, assisted by novel triazolic derivatives, reinforced by cobalt and nickel oxyhydroxides, has been described. It was noticed that both cobalt and nickel oxyhydroxides may serve as efficient electrode modifiers of prodigiosin electrochemical determination in neutral and...
Article
Today there is a large number of scientific publications in which the heterocyclic systems of 1,2,4-triazole and their derivatives are studied. Many of the medications, which contain compounds with the 1,2,4-triazole ring, were discovered and applied in practice. For many years, 1,2,4-triazole derivatives remain the object of close attention of sci...
Article
Full-text available
Today there is a large number of scientific publications in which the heterocyclic systems of 1,2,4-triazole and their derivatives are studied. Many of the medications, which contain compounds with the 1,2,4-triazole ring, were discovered and applied in practice. For many years, 1,2,4-triazole derivatives remain the object of close attention of sci...
Article
Full-text available
The results of morpho-biochemical studies of tuberculosis inflammation in rabbits in an experimental model with comparative isoniazid treatment and N'-(2-(5-((theophylline-7-yl)methyl)-4-ethyl-1,2,4-triazole-3-ylthio)acetyl)isonicotinohydrazide. It was found that subcutaneous administration of N'-(2-(5-((theophylline-7-yl)methyl)-4-ethyl-1,2,4-tria...
Article
Full-text available
2-(4-аміно-5-(фуран-2-іл)-1,2,4-триазол-3-ілтіо)ацетату Актуальність. Пошуку нових біологічно активних сполук серед фуранпохідних 1,2,4-триазолів присвяче-но багато публікацій. Кожен учений аргументовано доводить перспективність використання саме цього класу синтетичних похідних в якості потенційних фармакологічно активних речовин. Таким чином, на...
Article
Full-text available
The aim of our study was known and accessible synthesis of literary material for studying the pharmacological activity of new S-derivatives of 1,2,4-triazoles, which may be promising for the implementation of the veterinary practice and development of a new national veterinary medicinal product.
Article
Full-text available
The achievements of the world organic chemistry are most clearly represented by scientific publications that prove the promising nature of heterocyclic substances. The possibility of combining various pharmacophore fragments and 1,2,4-triazole in one molecule is quite popular. In 2018, the drug Trifuzol-NEO appeared on the veterinary market of U...
Article
Full-text available
The most practical methods of detoxication of mycotoxins in animals and poultry are based on damaged feed sorbents. The search aims to study the influence of HamecoTox on the morphological and biochemical indices of the blood of laying hens in spontaneous fumonisin toxicosis. Laying hens (ferrets, aged 78 weeks) of cross Highsex White, with an aver...
Article
Full-text available
Introdução: Pela primeira vez, o processo eletroanalítico da detecção da ergina (LSA) sobre um elétrodo, modificado por um derivado triazólico, dopado pelo íon amavadina, tem sido descrito teoricamente. Métodos: O modelo matemático, correspondente ao desempenho do sensor, tem sido desenvolvido e analisado do ponto de vista da teoria de estabilidad...
Article
Full-text available
Anaproxen-sensitive potentiometric sensor with a plasticized PVC membrane was designed. The sensor contains an ion associate of naproxen with rhodamine 6G dye and exhibits a linear response to naproxen anion in the range from 8 × 10–5 to 1 × 10–1 M with an electrode function slope characteristic of singly charged ions. The minimum determined concen...
Patent
Full-text available
Eye drops for animals
Patent
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Fertilizer Fortis Combi has the properties of a growth stimulator, rooting agent, adaptogen
Article
Full-text available
The problem of tuberculosis infection caused by multidrug-resistant strains is becoming increasingly important in the world. This infectious disease poses a global health risk with an incidence rate of 8.8 million cases and a fatal outcome of 1.4 million. Coinfection with human immunodeficiency virus (HIV) increases the number of cases of tuberculo...
Poster
Full-text available
Veterinary medicinal product
Article
1,2,4-тріазолу як компоненти під час створення нових ліків, засобів захисту рослин, полімерних матеріалів, антикорозійних засобів тощо. Хімічне моделювання заміщених 1,2,4-тріазолу шляхом уведення у структуру різних фармакофорів викликає чималий інтерес у науковців різних напрямів. Відомо, що деякі S-похідні 5-(5-бромфуран-2-іл)-4R-1,2,4-тріазол-3-...
Article
Full-text available
1,2,4-тріазолу як компоненти під час створення нових ліків, засобів захисту рослин, полімерних матеріалів, антикорозійних засобів тощо. Хімічне моделювання заміщених 1,2,4-тріазолу шляхом уведення у структуру різних фармакофорів викликає чималий інтерес у науковців різних напрямів. Відомо, що деякі S-похідні 5-(5-бромфуран-2-іл)-4R-1,2,4-тріазол-3-...
Article
Full-text available
In this study, the antibacterial activity of 11 preparations of drugs was determined by disc diffusion method in agar. Suspensions (0.5×108 CFU) were prepared from the daily cultures of Enterobacteriaceae, Pseudomonadaceae, Staphylococcaceae, Bacillaceae, Listeriaceae, Campylobacteraceae, Nocardiaceae, and Saccharomycetaceae family. The resulting s...
Article
Full-text available
Artigo de pesquisa científica / http://dx. A descrição matemática da detecção eletroanalítica dos íons de zinco em formas farmacêuticas de uso oftálmico, baseada na complexação de zinco com algumas bases de Schiff Título curto: Detecção eletroanalítica dos íons de zinco em formas farmacêuticas de uso oftálmico Resumo Um processo eletroanalítico da...
Article
Full-text available
In this work, the electrochemical description for metformin electrochemical determination, assisted by Ag2O2 composite with squaraine dye, is evaluated from the theoretical point of view. Metformin oxidation is realized via assisted electrochemical 1,2,4-triazole formation, followed by its polymerization and N-oxidation. The correspondent mathemati...
Article
Full-text available
Hypoxia is a discrepancy between the required energy of the cell in the mitochondrial oxidative phosphorylation system. The immediate cause of the deficiency is a decrease in the oxygen concentration in the mitochondria. Today there is a huge demand for the development of new anti-hypoxic drugs. t is known that 1,2,4-triazole compounds can have ant...
Article
Full-text available
The alkylation of 5-(5-bromofuran-2-yl)-4-methyl-1,2,4-triazole-3-thiol with bromoalkanes was carried out. Synthesis was accomplished by addition of equivalent amounts of bromoalkanes (bromomethane, bromoethane, bromobutane-bromodecane) to 5-(5-bromofuran-2-yl)-4-methyl-1,2,4-triazole-3-thiol in a methanol medium in the presence of an equivalent am...
Patent
Full-text available
Pouczenie Jeżeli w chwili wydania decyzji rozpoczął się kolejny okres ochrony wynalazku (kolejne lata), a Zgłaszający chce przedłużyć ochronę na te okresy (te lata), powinien łącznie z opłatą za I okres ochrony, wymienioną wyżej, wnieść opłatę za następne okresy-art. 224 ust. 1 ustawy Prawo własności przemysłowej. Nasz znak: DP.P.430791.8.lnog Wasz...
Article
Full-text available
A descrição matemática da detecção eletroquímica dos alcaloides do grupo da insubosina, assistida pelos novos triazóis com e sem composto de ligação Resumo Pela primeira vez, foi feita uma abordagem teórica do desempenho dos novos deri-vados triazólicos durante a determinação química dos alcaloides acridínicos do grupo insubosina, na presença de um...
Article
Full-text available
The purpose of this work is to study the effect of excipients which are used in the technology of manufacturing veterinary suppositories (carrier bases and surface-active substances) on the emission of trifuzole, as the main biopharmaceutical characteristic of intrauterine veterinary dosage forms. An urgent problem of low reproductive ability are o...
Article
Full-text available
The purpose of this research was to study the anti-inflammatory properties of morpholine 2-(5-(3-fluorophenyl)-4-amino-1,2,4-triazol-3-ylthio) acetate (BKP-115) in intramuscular and intragastric introduction on the model of experimental pancreatitis in rats. Determination of the anti-inflammatory activity of the substance morpholine 2-(5-(3-fluorop...
Article
Full-text available
Ukraine. Hunchak, V. M., Martynyshyn, V. P., Gutyj, B. V., Hunchak, A. V., Stefanyshyn, O. M., & Parchenko, V. V. (2020). Impact of 1,2,4-thio-triazole derivative-based liniment on morphological and immunological blood parameters of dogs suffering from der-matomycoses. The development of new preparations in soft medical form with antifungal effect...
Article
Full-text available
5-(ТІОФЕН-3-ІЛМЕТИЛ)-4-R 1-1,2,4-ТРИАЗОЛ-3-ТІОЛУ Ключові слова: актопротекторна дія , втомлюваність, тіофен-3-іл-, похідні 1,2,4-триазолу O. A. BIHDAN (https://orcid.org/0000-0002-2283-1695) Zaporizhzhia State Medical University ACTOPROTECTIVE ACTIVITY OF SOME 5-(THIOPHEN-3-YLMETHYL)-4-R 1-1,2,4-TRIAZOLE-3-THIOLS DERIVATIVES Наукові публікації оста...
Article
Full-text available
The theoretical description of a new sandwich-like rhenium-based polymer composite cathodic electrodeposition has been given. The cathodic process is realized by perrhenate-ion electrochemical reduction to rhenium (IV) oxide, acting as an in situ formed oxidant for 3,4-dimethoxypyrrole polymerization. It is shown that the polymer deposition in this...
Patent
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The method of synthesis of the substance of fertilizer Fortis Combi Fortis-combi.com
Patent
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A new method for the synthesis of the substance of the veterinary drug Trifuzol-neo
Patent
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54) СПОСІБ ОДЕРЖАННЯ МОНОЕТАНОЛАМОНІЮ 2-(5-(ПІРИДИН-4-ІЛ)-1,2,4-ТРИАЗОЛ-3-ІЛТІО)АЦЕТАТУ (57) Реферат: Винахід стосується фармацевтичної хімії і медицини, а саме способу одержання моноетаноламонію 2-(5-(піридин-4-іл)-1,2,4-триазол-3-ілтіо)ацетату-біологічно активної сполуки для створення нових оригінальних лікарських препаратів для стимуляції росту...
Patent
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57) Реферат: Використання: винахід належить до фармацевтичної хімії і медицини, а саме до способу одержання піперидинію 2-[5-(2-фурил)-4-феніл-1,2,4-тріазол-3-ілтіо]ацетату-біологічно активної сполуки для створення нових оригінальних лікарських препаратів антиоксидантної, гепатопротекторної та імуностимулюючої дії, які мають у своєму складі ядро 1,...
Conference Paper
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сurrent trends in the search for new biologically active compounds among synthetic molecules clearly prove the priority in studies of the heterocyclic system of 1,2,4-triazole. Scientists of different scientific fields have been studying 1,2,4-triazole derivatives for many years. The unique properties of 1,2,4-triazole derivatives include high reac...
Conference Paper
Full-text available
Збірник містить тези доповідей, у яких викладені результати наукових досліджень у галузях неорганічної та фізичної хімії, матеріалознавства та нанотехнологій, аналітичної хімії та хімії навколишнього середовища, хімії органічних та високомолекулярних сполук, теорії та методики навчання хімії. Дослідження виконані у навчальних закладах та наукових у...
Article
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X міжнародна науково-практична інтернет-конференція «Сучасний рух науки» присвячена головній місії Міжнародного електронного науково-практичного журналу «WayScience» – прокласти шлях розвитку сучасної науки від ідеї до результату
Article
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2020.-Т. 13, №1(32) Оригінальні дослідження Оriginal research Молекулярний докінг і біодоступність S-алкіл похідних 5-(3-флуорофеніл)-, 5-(5-бромофуран-2-іл)-та 5-(((3-(піридин-4-іл)-1H-1,2,4-тріазол-5-іл)тіо)метил)-4-метил-4H-1,2,4-тріазолів in silico методами Запорізький державний медичний університет, Україна A-концепція та дизайн дослідження; B...
Article
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QUANTITATIVE DETERMINATION OF TRIFUZOL IN THE 2.5% INJECTION SOLUTION BY SPECTROPHOTOMETRIC METHOD
Patent
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71) STACHOWSKI MICHAŁ, Gdańsk (72) STACHOWSKI MICHAŁ (54) Kompozycje farmaceutyczne i/lub kosmetyczne pielęgnacji skóry wrażliwej i/lub atopowej na bazie naturalnych składników bez konserwantów oraz sposób ich wytwarzania (57) Przedmiotem zgłoszenia są kompozycje farmaceutyczne i/lub kosmetyczne pielęgnacji skóry wrażliwej i/lub atopowej na bazie n...
Article
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The effectiveness of the treatment of common diseases of the respiratory system, hematopoietic system, digestive system of livestock and domestic animals with the help of existing drugs is not always sufficient, and there is an urgent need to expand the arsenal of domestic veterinary medicinal products that would exhibit antiviral, anti-inflammator...
Article
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The development of new preparations in soft medical form with antifungal effect and the ability to exert an antimicrobial effect on the secondary microflora accompanying the infection with accompanying desensitizing action is extremely relevant, as well as introduction of such drugs into veterinary medicine. The compound and compounding of the prep...
Article
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Objective: The aim of the research is the histological study of the corrective effect of the compound potassium 2((4-amino-5-(morpholinomethyl)-4H-1,2,4-triazol-3yl)thio)acetate (PKR-173) with different antibiotics on the state of chicken's liver under infection by Pseudomonas aeruginosa.
Article
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The aim of the research is the histological study of the corrective effect of the compound potassium 2((4-amino-5-(morpholinomethyl)-4H-1,2,4-triazol-3yl)thio)acetate (PKR-173) with different antibiotics on the state of chicken's liver under infection by Pseudomonas aeruginosa. Material and Method: The histological study was carried out on the leve...
Book
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Ще на світанку відродження української хімічної мови один із її творців – видатний вчений і реформатор науки А.М.Голуб (1918-1977) писав: «Як у коморі хорошого господаря різні речі розташовані по певних полицях і скриньках, так в арсеналі фактів,що ними оперує хімія,неодмінною умовою є раціональна система».....
Book
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Ще на світанку відродження української хімічної мови один із її творців – видатний вчений і реформатор науки А.М.Голуб (1918-1977) писав: «Як у коморі хорошого господаря різні речі розташовані по певних полицях і скриньках, так в арсеналі фактів,що ними оперує хімія,неодмінною умовою є раціональна система». Отже, вивчення природи та успішне викорис...
Patent
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Veterinary antiviral drug
Article
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In this work, the gebcitabine electrochemical determination, assisted by amavadin-doped triazolic derivatives, has been described. The analysis of the correspondent mathematical model shows that amavadin may serve as an efficient electrode modifier for gebcitabine electrochemical determination, while introduced into the triazole matrix. The steady-...
Article
Full-text available
The electrosynthesis of squaraine-dye doped triazolic conducting polymer for electroanalytical, electrocatalytical and enery conversion purposes has been described theoretically. The correspondent mathematical model has been developed and analyzed by means of linear stability theory and bifurcation analysis. It has been shown that the steady-state...
Article
Full-text available
The possibility of erythromycin electrochemical determination, assisted by CoO(OH)-Poly (Triazole) hybrid material has been evaluated. The correspondent mathematical model has been developed and analyzed by means of linear stability theory and bifurcation analysis. It was shown that the hybrid material may be applied as an efficient electrode modif...
Article
Full-text available
The possibility of Dobutamine electrochemical determination, assisted by CoO(OH)-Poly(1,2,4-triazoles) hybrid material has been evaluated. The correspondent mathematical model has been developed and analyzed by means of linear stability theory and bifurcation analysis. It was shown that the hybrid material may be applied as an efficient electrode m...