Volker von Baehr

Volker von Baehr
Institut für Medizinische Diagnostik Berlin-Potsdam · Department of Immunology

About

77
Publications
25,536
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
1,826
Citations

Publications

Publications (77)
Article
Full-text available
Background: Vitamin D is a fat-soluble steroid that influences cardiovascular health by affecting lipid metabolism. Since dyslipidemia is a key risk factor for cardiovascular disease (CVD), our study aimed to explore the relationship between vitamin D levels and lipid parameters, considering the effects of age and gender. Methods: In this cross-sec...
Article
Full-text available
Introduction: Osteoimmunology recognizes the relationship between bone cells and immune cells. Chronic osteoimmune dysregulation is present in bone marrow defects of the jaw (BMDJ) as fatty-degenerative osteonecrosis (FDOJ). In comparison to samples from healthy jaw bone, the cytokine analysis of samples of BMDJ/FDOJ from 128 patients showed downr...
Article
Full-text available
Objective Bone marrow defects of the jaw (BMDJ) surrounding dental implants, in combination with impaired bone-to-implant contact (BIC), are difficult to detect in X-rays. This study evaluated BMDJ surrounding titanium (Ti-Impl) and ceramic (Cer-Impl) dental implants and incomplete BIC using a new trans-alveolar ultrasonography device (TAU) with nu...
Article
Full-text available
Due to rare but major adverse reactions to the AstraZeneca adenoviral ChAdOx1-S-nCoV-19 vaccine (ChAd), German health authorities recommended adults under 60 who received one dose of ChAd, to receive a second dose of the BioNTech mRNA BNT162b2 vaccine (BNT) as a booster. Studies in the general population suggest an enhanced efficacy of the heterolo...
Article
Full-text available
Vaccination against the SARS-CoV-2 virus or infection with SARS-CoV-2 will lead to the development of IgG antibodies against the S1 protein of the SARS-CoV-2 virus. However, even despite having high levels of IgG antibodies against the S1 protein of the SARS-CoV-2 virus, (re-)infection may occur. We thus examined 2994 consecutive blood samples of o...
Article
Full-text available
It was shown that hypertension delays SARS CoV-2 viral clearance and exacerbates airway hyperinflammation in the respiratory tract. However, it is unknown whether hypertension determines the long-term cellular and humoral response to SARS Cov2. Health care workers (HCWs) after an outbreak of SARS Cov-2 infections were analyzed. Infected HCWs were n...
Article
Both infection with and vaccination against SARS-CoV-2 trigger a complex B-cell and T-cell response. Methods for the analysis of the B-cell response are now well established. However, reliable methods for measuring the T-cell response are less well established and their usefulness in clinical settings still needs to be proven. Here, we have develop...
Article
In vitro studies indicate that 25-hydroxyvitamin D3 (25(OH)D3) and 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) inhibits the synthesis of parathyroid hormone (PTH). The degree of PTH inhibition in humans by circulating 25(OH)D and 1,25(OH)2D may be different. Moreover, age and sex as well as confounding factors like calcium and phosphate may likewise aff...
Article
Full-text available
Background: The role played by signaling pathways in the cell-cell communication associated with multiple sclerosis (MS) progression has become a critical area in research. Chemokine RANTES (regulated upon activation, normal T-cell expressed and secreted), also named chemokine C-C motif ligand 5 (CCL5; R/C), is a protein that has been investigated...
Article
Full-text available
Background Cytokines, especially chemokines, are of increasing interest in immunology. This study characterizes the little-known phenomenon of “bone marrow defects of the jawbone” (BMDJ) with known overexpression of the chemokine RANTES/CCL5 (R/C). Purpose Our investigation clarifies why BMDJ and the intensity of local R/C overexpression are chall...
Article
Full-text available
Background The role of signaling pathways as part of the cell-cell communication within cancer progression becomes a crucial area. Chemokine RANTES (regulated upon activation, normal T-cell expressed and secreted), also known as the chemokine C-C motif ligand 5 (CCL5) (R/C), is a protein on which cancer research focus due to its link with aggressiv...
Article
Background Animal studies suggested that vitamin D might decrease insulin resistance. Estrogen increased insulin sensitivity and glucose tolerance in rodents. However, sex-specific association of vitamin D with insulin resistance in humans remains unclear. Objectives To investigate the sex-dependency of the association of insulin resistance and 25...
Article
Measurements of total 25-hydroxyvitamin D (t25(OH)D) are currently primarily used to assess the vitamin D status. The lipophilic cell membrane can only be passed by the un-bound form of 25-hydroxyvitamin D: free 25-hydroxyvitamin D (f25(OH)D). It is thought that f25(OH)D does reflect its biological actions better than t25(OH)D. However, as of today...
Article
Full-text available
Introduction Bisphosphonate (BP)-related osteonecrosis of the jaw (BRONJ) is a complication of intravenous (IV) BP therapy. BP therapy locally affects the dentoalveolar area, while systemic effects are associated with parenteral/IV BP use. Despite numerous publications, the pathogenesis of BRONJ is not fully understood, as only some patients receiv...
Article
Full-text available
Introduction The presently used impulse echo ultrasound examination is not suitable to provide relevant and reliable information about the jawbone, because ultrasound (US) almost completely reflects from the hard cortical jawbone. At the same time, “focal osteoporotic bone marrow defects” (BoneMarrowDefects = BMD) in jawbone are the subject of scie...
Article
Full-text available
Background Fatty degenerative osteonecrosis in the medullary spaces of the jawbone (FDOJ) may be identified as a lesser known source of RANTES/CCL5 (R/C) overexpression. The chemokine R/C also interferes with bone metabolism leading to osteolysis in areas affected by FDOJ. Many dental surgeries require functioning repair mechanisms and these may be...
Article
Full-text available
Background The immune and bone systems are closely linked via cytokine cross-talk. This interdisciplinary field of research is referred to as osteoimmunology and pertains to inflammatory and osteoarticular diseases that feature the primary expression of tumor necrosis factor-alpha (TNF-α) and IL-6. Objective Are there bone resorptive processes whe...
Article
Zusammenfassung Eine intakte Darmschleimhaut ist Voraussetzung für die effiziente Mineralstoffresorption. Toxische Metalle aus Luft, Nahrung, Wasser und Zahnersatz hemmen die Resorption ebenso wie eine exzessive Zufuhr essenzieller Mineralstoffe. Auch bei normwertigen Mineralstoffspiegeln kann ein funktioneller Mangel vorliegen, weil toxische Metal...
Article
Full-text available
Background and introduction It is a well-known fact that titanium particles deriving from dental titanium implants (DTI) dissolve into the surrounding bone. Although titanium (TI) is regarded as a compatible implant material, increasing concern is coming up that the dissolved titanium particles induce inflammatory reactions around the implant. Spec...
Article
Hintergrund: Diese Studie behandelt die Frage, ob allgemeine und weit verbreitete zahnärztliche Eingriffe, wie Zahnextraktionen und operative Entfernung von Weisheitszähnen, zu chronischer Kieferknochenentzündung führen. Eine mangelhafte Wundheilung im Kieferknochen kann über Entzündungsmediatoren eine versteckte Ursache chronischer Erkrankungen se...
Article
Full-text available
Background: This study compares the radiographic distribution of apical periodontitis (AP) in rootfilled and endodontically treated teeth among healthy controls and patients with systemic diseases; the incidence of AP was almost twice as high in the latter group.Objective: The question arises as to whether the biogenic amines (mercaptan/thioether/h...
Article
Full-text available
Of the definitions listed in the International Statistical Classification of Diseases and Related Health Problems, tenth revision (ICD-10), two disease descriptions can be found together: “idiopathic aseptic bone necrosis” and “avascular bone necrosis.” The relevant literature on both the conditions abbreviates both as “aseptic ischemic osteonecros...
Article
Full-text available
This study elucidates the question of whether chronic inflammation in the jawbone contributes to the development of Chronic Fatigue Syndrome (CFS). Fatty degenerative osteonecrosis in jawbone (FDOJ) may contribute to CFS by induction of inflammatory mediators. We examined seven cytokines by multiplex analysis in jawbone samples from two groups of p...
Article
Full-text available
Hintergrund Trotz erheblicher therapeutischer Fortschritte sind die meisten malignen Erkrankungen unheilbar geblieben. Gleichzeitig nimmt die Bedeutung der Mikroumgebung, die die Tumorzellen mit „Silent Inflammation“ umgibt, zu. Zielsetzung: Um den Verdacht auf tumorrelevante inflammatorischen Zytokin-Quellen in fettig-degenerativ veränderten Osteo...
Article
Full-text available
Abstract Fulltext References Tables & Figures Download PDF Background and Introduction: The transition from acute local inflammation following wisdom tooth surgery to a chronic stage of "Silent Inflammation" could be a neglected cause of unexplained medical conditions. Case Report: Here we will refer to an unusual case of recurrent syncope in a...
Article
Full-text available
Seit Jahrzehnten werden Phänomene wie „Kieferostitis“ und „NICO“ als sogenannte „Herde“ mit Allgemeinerkrankungen in kausale Verbindung gebracht. Auch Energieleitbahnen der chinesischen Akupunkturlehre dienten bislang als ganzheitliche Funktions- und Erklärungsmodelle. Die Forschungen der Autoren zeigen mit modernen Labormethoden, dass überaktivier...
Book
Full-text available
Abstract: Die Diskussion zeigt, dass eine Erweiterung von Band I „Kavitätenbildende Osteolysen des Kieferknochens - Systemisch-ganzheitliche Wirkungen der aseptischen Osteonekrosen „Kieferostitis“ und „NICO“ im Kiefer - Dokumentation und Einführung in eine immunbiologisch und kieferchirurgisch erweiterte Therapie chronischer Krankheiten“ aus 2011 n...
Research
Full-text available
Hollow dead spaces in the jawbone known popularly as “cavitations,” and as “NICO,” might serve as a fundamental cause of neuropathic pain, through the inflammatory cytokines that they produce. Opioid receptors mediate anti-pain responses in both the peripheral and central nervous systems, and RANTES is able to enhance the pain response. Data demons...
Article
Full-text available
Background This research elucidates the question of whether common and widespread dental procedures (DP) like root filling (RF) and the removal of wisdom teeth (WT) contribute to chronic inflammation in the jawbone. Dentists, in carrying out these DP, can set off defective wound healing in the jawbone in ignorance of its connection to inflammatory...
Book
Full-text available
Diese DEGUZ-Monografi e 02 ist die zweite in einer Reihe von wissenschaftlich abgesicherten DEGUZ-Publikationen. DEGU-Monografi en werden von in der DEGUZ organisierten Ärzten und Zahnärzten erstellt zur Dokumentation und inhaltlichen Bestimmung dessen, was Um-welt-ZahnMedizin für chronisch Kranke, aber auch gesunde Menschen im Vorfeld systemisch-i...
Article
Full-text available
Persistent microorganisms in endodontically treated teeth produce volatile sulfur compounds (VSC) such as methyl mercaptan, hydrogen sulfide, and thioether. In this retrospective study, we evaluated the ex vivo immune response of peripheral blood mononuclear cells to sulfur compounds in 354 patients with systemic diseases. These systemic findings a...
Article
Full-text available
Bacterial infections of the residual dentin or infected pulp tissue are responsible for most cases of endodontic treatment failures. Persisting microorganisms in necrotic pulp tissue produce sulphur components such as methyl mercaptan and hydrogen sulfide as well as thioether derivatives. Although there is emerging evidence that these sulphur compo...
Article
Full-text available
Background: Hollow spaces in the jawbone have been defined as fatty degenerative osteonecrosis of jawbone (FDOJ) and have been linked with a dysregulated immune system. Little is known about the underlying relationship. Objectives: Samples of FDOJ were analyzed to assess expression of cytokines which can play a role in the pathogenesis of breast...
Article
Full-text available
Epstein-Barr virus (EBV) has long been discussed as a possible cause or trigger of Chronic Fatigue Syndrome (CFS). In a subset of patients the disease starts with infectious mononucleosis and both enhanced and diminished EBV-specific antibody titers have been reported. In this study, we comprehensively analyzed the EBV-specific memory B- and T-cell...
Book
Full-text available
DEGUZ-Monografi e 01 ist die erste in einer Reihe von wissenschaftlich abgesicherten DE-GUZ-Publikationen. DEGU-Monografi en werden von in der DEGUZ organisierten Ärzten und Zahn-ärzten erstellt zur Dokumentation und inhaltlichen Bestimmung dessen, was Umwelt-ZahnMedi-zin für chronisch Kranke, aber auch gesunde Menschen im Vorfeld systemisch-immuno...
Article
Full-text available
Background: Jawbone cavitations (JC) are hollow dead spaces in jaw bone with dying or dead bone marrow. These areas are defined as fatty degenerative osteonecrosis of jawbone or „Neuralgia Inducing Cavitational Osteonecrosis/NICO“ and may produce facial pain. They have been linked with the immune system and chronic illnesses. Little is known about...
Article
Full-text available
Jawbone cavitations (JC) are hollow dead spaces in jawbones with dying or dead bone marrow. These areas are defined as fatty degenerative osteonecrosis of the jawbone or neuralgia-inducing cavitational osteonecrosis and may produce facial pain. These afflictions have been linked to the immune system and chronic illnesses. Surgical debridement of JC...
Article
Background: Laboratory diagnosis of Lyme borreliosis follows a two-step algorithm, starting with a screening assay with maximum sensitivity followed by a confirmatory assay of positive results with respect to specificity. Line immunoassays with single recombinant antigen lines are the established confirmatory test method, although result interpret...
Article
Full-text available
Borrelia-specific antibodies are not detectable until several weeks after infection and even if they are present, they are no proof of an active infection. Since the sensitivity of culture and PCR for the diagnosis or exclusion of borreliosis is too low, a method is required that detects an active Borrelia infection as early as possible. For this p...
Article
Synovial tissues in joints with prostheses display characteristic morphological changes in cases with aseptic failure, particularly macrophage infiltration. Since proliferation of the synovial lining cell layer represents a feature characteristic of autoimmune joint diseases, the possibility of morphological changes of the synovial lining cell laye...
Article
Mannose-binding lectin (MBL) mediates important functions within the innate immune system, and its deficiency was associated with infectious complications. However, in adults without concomitant immunodeficiency the clinical relevance of MBL deficiency remains controversial. We analyzed the distribution of MBL deficiency and its association with co...
Article
Nutrition is known to influence the immune system and can thereby modulate resistance to infection. The objective of this clinical trial was to assess the influence of a cascade-fermented food consisting of fruits, nuts, and vegetables rich in polyphenols (Regulat) on the immune system in healthy volunteers. The clinical trial was double-blinded an...
Article
I cannot share the view that immunological tests have no relevance in the differential diagnosis of environmental-medical patients. Diagnostic tests to demonstrate allergic reactions to environmental agents that rely on the patient's history, do, however, prevent subsequent doctor hopping and save substantial costs. The authors note that the lymph...
Article
The sequence of the human leukocyte antigen (HLA)-DRB1*1475 differs from the closest aligned sequence HLA-DRB1*140102 by a single-nucleotide substitution at codon 81 (CAC-->TAC) resulting in an amino acid change from Leu to Gln.
Article
Full-text available
Borrelia-specific antibodies are not detectable until several weeks after infection and their presence alone is not proof of an active infection. The sensitivity of culture methods and PCR for the confirmation or exclusion of Lyme borreliosis is too low. Therefore, a method is required that detects an active Borrelia infection as early as possible....
Article
Full-text available
Drug toxicity and viral resistance limit the long-term efficacy of antiviral drug treatment for human immunodeficiency virus (HIV) infection. Thus, alternative therapies need to be explored. We tested the infusion of T lymphocytes transduced with a retroviral vector (M87o) that expresses an HIV entry-inhibitory peptide (maC46). Gene-modified autolo...
Article
Full-text available
Drug toxicity and viral resistance limit the long-term efficacy of antiviral drug treatment for human immunodeficiency virus (HIV) infection. Thus, alternative therapies need to be explored. We tested the infusion of T lymphocytes trans-duced with a retroviral vector (M87o) that expresses an HIV entry–inhibitory peptide (maC46). Gene-modified autol...
Article
Full-text available
Even though mistletoe extracts have been in clinical use for centuries their exact mode of action is still unknown. Currently, the application scheme for registered preparations is a dose-escalating scheme to thus reduce side effects. In this study, healthy controls and patients were evaluated for their immunologic response to treatment with a stan...
Article
A 54-year-old woman presented with myalgia and arthralgia predominantly in the knees and small joints of the hands and feet with morning stiffness lasting for at least 2 h. The patient had received a wrought titanium 6-aluminium 4-vanadium alloy C cage implant 1.5 years previously, following a severe disc prolapse. No signs of rheumatic disease wer...
Article
Full-text available
Lyme disease (LD) is caused by Borrelia burgdorferi and displays different stages, including localized, early disseminated, and persistent infection, all of which are associated with profound inflammatory reactions in the host. Induction of proinflammatory cytokines by B. burgdorferi is mainly mediated by outer surface proteins interacting with TLR...
Article
Full-text available
Specific immunotherapy (SIT) is believed to modulate CD4+ T-helper cells. In order to improve safety, SIT vaccines are often formulated with allergoids (chemically modified allergens). Interaction between T-cells and allergoids is necessary to influence cellular cytokine expression. There have been few reports on identification the early cellular e...
Article
The chronic fatigue syndrom (CFS) is a multifactorial disease. Metal sensitization has been, at least partly, implicated as a causal or symptom aggravating factor. In a pilot study, 32 patients with CFS have been investigated for the existence of sensitization toward 15 different metals by means of a standardized and optimized lymphocyte proliferat...
Article
The measurement of the proliferative response of primed T cells to an antigenic stimulus (lymphocyte transformation assay: LTT) is commonly used for determining T cell immune responsiveness. However, the ratio between the spontaneous and the antigen-triggered response (stimulation index) is frequently quite low (<3-5) making the interpretation diff...
Article
Full-text available
In patients with alcoholic liver cirrhosis, endotoxaemia is a frequent finding. Unknown mechanisms, however, prevent typical clinical symptoms of endotoxaemia in many patients. We determined plasma levels of pro- and anti-inflammatory mediators, ex vivo cytokine secretion capacity, and expression of tumour necrosis factor (TNF) receptors on phagocy...
Article
Full-text available
Endotoxin tolerance (ET) has been described as a temporary alteration in the lipopolysaccharide (LPS) response of monocytic cells after an initial LPS exposure with respect to the production of soluble immunomodulators. Apart from the LPS response, monocytic cells play an important role in initiation of the specific immune response as antigen-prese...
Article
Endotoxin tolerance (ET) has been described as a temporary alteration in the lipopolysaccharide (LPS) response of monocytic cells after an initial LPS exposure with respect to the production of soluble immunomodulators. Apart from the LPS response, monocytic cells play an important role in initiation of the specific immune response as antigen-prese...
Article
A large number of compounds are known to reduce the ATP-dependent efflux pump activity of multidrug resistant (mdr) tumor cells. Here we report that an infection of cancer cells with T. gondii reduced the multidrug resistance of the tumour cells against cytostatic drugs. Two mouse lymphoma cell lines (Mdr L 5718 and Par 5718) were infected with Tox...
Article
Immunoparalysis is an acquired immunodeficiency which may occur in patients after major surgery, burns, polytrauma and sepsis. It is associated with a modified state of monocytes marked by their altered capacity to induce antigen-specific T cell stimulation and to release various cytokines. However, the pathogenesis of immunoparalysis may differ in...
Article
The function of small GTPases is fine-tuned by a complex network of regulatory proteins such as GTPase-activating proteins. The C1 gene at Xq28 encodes a protein assumed to function as a Rho GTPase-activating protein (rhoGAP). Characterization of the molecular defect causing X-linked nephrogenic diabetes insipidus (NDI) in a patient revealed a subm...
Article
Immunoparalysis is an acquired immunodeficiency which may occur in patients after major surgery, burns, polytrauma and sepsis. It is associated with a modified state of monocytes marked by their altered capacity to induce antigen-specific T cell stimulation and to release various cytokines. However, the pathogenesis of immunoparalysis may differ in...
Chapter
Mit der endovaskulären Implantation eines Stentprothesensystems (EA) steht eine gegenüber der konventionellen Ausschaltung (CA) alternative Methode zur Behandlung des Aortenaneurysmas zur Verfügung, deren kurz- und mittelfristige Ergebnisse bei entsprechender Indikationsstellung überzeugend erscheinen [1]. Obwohl die EA gegenüber der CA als minimal...

Network

Cited By