Vladimir Voeikov

• Ph. D., Dr. Sci., Professor
• CEO at Lomonosov Moscow State University

Previous research has demonstrated that a combined magnetic field (CMF) plays a critical role in modifying the properties of aqueous solutions, leading to an increase in the luminol-enhanced chemiluminescence of neutrophils. Using this model, the distant interaction between aqueous solutions was demonstrated, and the role of a CMF in the regulation...

The dynamics of sedimentation of whole blood cells, as well as erythrocyte mass, has been studied during sequential dilution with dextran solutions in vitro. Nonmonotonic changes in the optical density of the boundary between erythrocytes sedimenting both in their own plasma and in model systems were revealed. The oscillations of both the average r...

Water vapor absorbs well in the infra-red region of the electromagnetic spectrum. Absorption of radiant energy by water or water droplets leads to formation of exclusion zone water that possesses peculiar physico-chemical properties. In the course of this study, normally functioning and damaged alkaline phosphatase, horseradish peroxidase and catal...

Water vapor absorbs well in the infrared (IR) region of the spectra. On the other hand, it was recently demonstrated that IR radiation promotes formation of the so-called exclusion zones (EZ) at the interfaces between hydrophilic surfaces and water. EZ-water properties differ significantly from that of bulk water. It was studied for the first time...

Hydrated fullerene C60 (HyFn) is a supramolecular object in which the nanosized fullerene molecule is enclosed in a multilayer shell of water molecules. Despite the fact that fullerene C60 is chemically rather inert, aqueous solutions of HyFn exhibit a wide spectrum of biological activity in particular in low and ultra-low concentrations. Thus, phy...

Regulatory peptides are one of the main signaling molecules that provide intercellular interactions in biological systems. Thus, regulatory peptides are known as morphogens - biologically active substances involved in the regulation of the morphogenesis of animals and plants. Until now, the interaction of plant and animal peptides and, in particula...

Background: Hydrated Fullerene C60 is a 60 carbon atoms symmetrical molecule that can be found in nature. Being transferred into aqueous solution, a hydrophobic C60 establishes Hydrated Fullerene C60 (HyFnC60) water solutions that possess oxidation balancing properties in a wide range of concentrations (2.5×10-6 - 2.5×10-19 M). Nano-particles of si...

It is shown for the first time using a complex of physicochemical methods (dynamic and electrophoretic light scattering, conductometry, pH-metry) that below a threshold concentration of 1.0•10–7 mol L–1 the disperse phase of the aqueous systems based on moss peptide PpCLE2 undergoes the domain—nanoassociate rearrangement, which affects the nonmonot...

A pilot study of the effect of the antioxidant drug ethylmethylhydroxypyridine malate on indicators of oxidative stress in patients with chronic cerebral ischemia. At 6 day course administration investigated the antioxidant in these patients significantly accelerates the process of generation of superoxide anion radical, established by lucigenin-de...

Hydrated fullerene (HyFnC60) is a highly hydrophilic supra-molecular complex consisting of unmodified С60 fullerene molecule enclosed into a hydrated shell. It has been shown in numerous experiments that aqueous solutions of HyFnC60 manifest a wide range of biological activities both in vivo and in vitro even at very low concentrations of HyFnC60....

According to quantum electrodynamics (QED) liquid water is a two-phase system in which one of the phases is in a coherent state where all molecules are phase correlated, whereas the other is made up of uncorrelated molecules in a gas-like state. Recent data demonstrate that interfacial water adjacent to hydrophilic surfaces exhibits peculiar anomal...

The fundamental property of aqueous bicarbonate solutions (ABS) is that they reside in a stable non-equilibrium (excited) state. Due to this they represent the simplest model of an aqueous matrix of living organisms. Their non-equilibrium state is maintained by continuous proceeding in them of Red/Ox processes with reactive oxygen species (ROS) par...

It is the scope of this paper to propose an additional charging mechanism of water-fall generated aerosols. The observations leading to this approach arose from a field study at five waterfalls in the Austrian Alps. Thereby, size distributions of ion clusters, their mobility and their intermediate progenies near waterfalls have been measured with a...

Abstract. Quantum Electrodynamics (QED) predicts the occurrence of a number of coherent dynamical phenomena in liquid water. In the present paper we focus our attention on the joint coherent oscillation of the almost free electrons produced by the coherent oscillation of the electron clouds of water molecules, which has been described in previous p...

The effect of an aqueous solution of hydrated C60-fullerene (HyFn) on the growth and “stationary phase aging” (accumulation of “age-related” changes in cultured cells during the slowing down of their proliferation within a single passage and the subsequent “aging” in the stationary phase of growth) of transformed B11-dii FAF28 Chinese hamster cells...

Dependence of dynamics of blood sedimentation upon successive dilution of blood with saline solution in vitro was studied basing on the application of the principles of the system of technical vision. Oscillatory nature of the process of sedimentation of boundary between blood cells and plasma dependent on the degree of blood dilution with saline w...

Data obtained by electron paramagnetic resonance (EPR) and chemiluminescence analysis indicate that in aqueous solutions of bicarbonates, superoxide radical and other reactive oxygen species (ROS) are constantly produced. The stationary level of the superoxide radical is found to increase when a solution is illuminated. Reactions involving ROS are...

Chronic obstructive pulmonary disease (COPD) is an inflammatory disease associated with reactive oxygen species (ROS) production. The aim of this study was to evaluate the effect of Hypoxen treatment and the effect of HyFnC₆₀ on ROS production in patients' blood. ROS production in blood was estimated using chemiluminescence (CL) measurement with CL...

An automatic device for the resolution of red-blood sedimentation at a high temporal level was designed. Using the principles of a technical vision system, a detailed analysis of red-blood sedimentation kinetics revealed the non-linear, macrokinetic behavior of whole-blood sedimentation, including several periods of the observed process. Dynamic ch...

The general problems of information deriving from the oscillation kinetics of Belousov-Zhabotinsky reactions were discussed. The discussion was organized around a particular example of the complex fluctuation dynamics of the Maillard reaction, i.e., a multistage reaction between a carbonylcontaining compound and the nucleophilic amino group of an a...

Stable nonequilibrium (excited) state of living matter is supported by an energy flux which is gained mostly from one-electron oxygen reduction (genuine burning). Water hydrating biopolymers and supramolecular complexes (interfacial water) account for a significant part of living matter by weight. This polarized water may cause transformation of lo...

The Belousov-Zhabotinsky phenomenon is analyzed in a framework where the dynamics of dissipative structures outlined by Prigogine is implemented through the collective dynamics produced in liquid water by Quantum Electrodynamics, which has received recently some experimental support. A mechanism allowing the appearance of self-produced oscillations...

Addition of H2O2 in sub-millimolar concentrations to 1-5 mM Na/K-bicarbonate solutions initiates in them a process accompanied with low-level photon emission amplified with luminol. Photon emission lasts without decay for many months in samples isolated from air and ambient light. Photon emission intensity reveals monthly and circadian rhythms. Amp...

Unique properties of oxygen and of the reactions with reactive oxygen species (ROS) participation are considered, the multiple ways of ROS generation and utilization are discussed in view of evidence for the absolute necessity of ROS for the normal vital activity. Many difficulties in the realization of the real role of ROS in vital activity are ca...

“Real” liquid aqueous systems general- ly represent complex systems where the phase of polarized water, as recently pro- pounded by Pollack in his description of “exclusion zone” water, contrasts with the coexisting, but much less well organized, bulk water. Polarized water is a potential electron donor (i.e., reducer). Under con- ditions where ele...

One of the unresolved questions related to the mechanism of action of light negative air ions (reactive oxygen species) produced by air ionizers upon humans and animals is transmission of these short-living chemical species upon long distances from the place of their origin. We discovered the phenomenon which may probably resolve this problem. When...

Phenomena of long-term 'memory of water' imply that aqueous systems possessing it remain for a long period after the initial perturbation in an out-of equilibrium state without a constant supply of energy from the environment. It is argued here that various initial perturbations initiate development of a set of chain reactions of active oxygen spec...

Water actively participates in bioenergetics and bioregulation. It is essential for purposeful production of reactive oxygen species (ROS) in cells and extracellular matrix. Due to specific structuring of water it itself may serve the source of free radicals and initiate reactions with their participation. On the other hand water structuring provid...

An ultraweak photon emission (UWPE) of the living systems, while being registered in certain experimental situations and/or demonstrating some specific populations. To these situations and dynamic properties belong: a degradational UWPE, largely synchronized (rhythmic) UWPE patterns (especially if accompanied sample and its components. We describe...

the realization of biological functions. Its direct involvement in hydrolytic processes in which primary “fuels” are produced, in ATP synthesis and energy gain due to to be one of the major sources of high grade energy – energy of electronic excitation (EEE) generated in the reactions in which active oxygen participates. Due different kinds of chem...

This study explored the integral intensity, slopes, and dynamics of the spectral gels, dried collagen samples, and collagen fibrils extirpated from rat tails after UV emitted from dry collagen samples are more exponential, whereas water-

In Part 1 of the review of experimental data concerning reactive oxygen species (ROS) production and use, their indispensable role in regulation of multiple physiologic processes is examined. Part 2 considers the unique property of reactions in which ROS participates, the generation of energy of electronic excitation (EEE). Because of incessant ROS...

Free radicals and reactive oxygen species (ROS) are considered to be dangerous pathogens as they may damage key molecular constituents of cells. However this concept approach does not take into account vital functions of ROS in normal physiology. Information has emerged that a substantial share of oxygen consumed by aerobic organisms is used for RO...

From Mitogenetic Rays to Biophotons.- Photon Sucking as an Essential Principle of Biological Regulation.- Quantum Squeezed State Description of Spectral Decompositions of a Biophoton Signal and the Possibility of Remote Intervention.- Biological Structure as a Converter of Coherent Radiation.- The Oscillation Behavior of the Delayed Luminescence of...

After much research in the field of biological oxidation, two main concepts of the mechanism of energy gain were consecutively proposed--the concept of direct oxygen activation (analogous to combustion), and the concept of activation of hydrogen followed by gradual energy release (analogous to putrefaction). The latter concept currently dominates....

We studies correlations of parameters measured by several scattering and imaging techniques with normal subjects and patients suffering from CAD and showed high diagnostic value of the combined measurements.

Simultaneous temporal analysis of whole human or rat blood luminescence and erythrocytes sedimentation rate (ESR) in same blood using special computerized optoelectronic devices for single photon counting and for high temporal resolution of the rate of sedimentation of red blood/plasma boundary revealed correlation between both time series. Correla...

Monitoring of spontaneous and luminophore amplified photon emission (PE) from non-diluted human blood under resting conditions and artificially induced immune reaction revealed that blood is a continuous source of biophotons indicating that it persists in electronically excited state. This state is pumped through generation of electron excitation p...

We recorded the fluctuations of the dark current in two photomultipliers located 2000 km from each other in different time zones (in International Institute of Biophysics (Neuss, Germany) and in Moscow State University(Moscow, Russia)). We studied the fluctuations by distribution of their amplitudes (histograms of data). Comparison of the histogram...

Mitogenetic radiation (MGR), discovered by A. G. Gurwitsch, gave birth to the field of biophotonics that is now energetically developing. However, most facts of unique properties of MGR and of processes in which they originate, of the surprising discoveries made during several decades of intensive MGR research, are practically forgotten. Present-da...

The present work reveals the helio-geophysical factors HGF) influence on natural surroundings, human and society, health state and professional reliability of human functioning in technogenic and social systems of extreme risk. The interdisciplinary complex investigations were performed on the social-population, organismal, organ cell and molecular...

An automatic device for high-temporal resolution of the process of red blood sedimentation was designed. The position of the boundary between red blood and plasma may be registered each 30 sec in several pipettes simultaneously with +/- 10 mkm precision. Fractional rates of the boundary movement are deduced with high accuracy. Data are processed by...

Currently two types of theories of aging are generally recognized: the genetic and the free radical theories. Each of them allow to explain plasibly some particular features of the aging process and pathologies associated with it. However, there are some phenomena related to aging and longevity that are not easily interpreted in frames of both theo...

It was found that the bubbling of argon through NaCl/H2O2 aqueous solutions results in the development of intense sustained luminol-dependent chemiluminescence. Bubbling of nitrogen and air through similar solutions does not result in such effect. The relationship between argon-supported chemiluminescence and initial concentrations of NaCl and H2O2...

It was found that the bubbling of argon through NaCl/H2O2 aqueous solutions results in the development of intense sustained luminol-dependet chemiluminescence. Bubbling of nitrogen and air through similar solutions does not result in such effect. The relationship between argon-supported chemiluminescence and initial concentrations of NaCl and H2O2...

An automatic device for high-temporal resolution of the process of erythrocytes sedimentation in blood was designed. The position of the boundary between red blood and plasma is registered each 30 sec in several pipettes simultaneously with +/- 10 mkm precision. Data are processed by a PC and presented as velocity-time curves (ESR-grams) and the cu...

The fine structures of distributions of photomultiplier dark current fluctuations measured in two laboratories 2000 km distant from other: in the international Institute of Biophysics (Neuss, Germany) and in the Moscow State University (Moscow, Russia) were compared. It is shown that similar forms of appropriate histograms are apparently more often...

The Maillard reaction between carbonyl and amino compounds in aqueous solutions at room temperature was shown to be accompanied by long-duration periodic and aperiodic photon emission oscillations. Ascorbate and transition metal ions in micromolar concentrations had substantial influence on the kinetics of chemiluminescence, which was evidence of t...

The dynamics of the erythrocyte sedimentation rate (ESR) in patients with ischemic disease shows a significantly different pattern in the days of raised geomagnetic activity as compared to quiet days. This is revealed by a greater intensity of ESR variations during geomagnetic storms as compared to the days of when there was little or no sun activi...

Frequency-correlated oscillations of chemiluminescence and the redox potential are observed during the amino-carbonyl reaction, which occurs in aqueous solutions of methylglyoxal and various amino-containing compounds (ethanolamine, glycine, and -alanine) at room temperature. The duration and amplitude of oscillations depend on the composition and...

An automatic device for high-temporal resolution of the process of erythrocytes sedimentation in blood was designed. The position of the boundary between red blood and plasma is registered each 30 sec in several pipettes simultaneously with ±10 mkm precision. Data are processed by a PC and presented as velocity-time curves (ESR-grams) and the curve...

The sedimentation properties of blood of 13 ischemic heart disease patients and 2 healthy volunteers have been analyzed using a special computerized optical device for high temporal resolution tracing of red blood/plasma boundary movement rate (ESR-graphy). The kinetic curves of red blood sedimentation are substantially nonmonotonic and exhibit mul...

An automatic device for high-temporal resolution of the process of red blood sedimentation was designed. The position of the boundary between red blood and plasma may be registered each 30 sec in several pipettes simultaneously with +/- 10 mkm precision. Fractional rates of the boundary movement are deduced with high accuracy. Data are processed by...

Lucigenin- and luminol-dependent chemiluminescence [(LC-CL) and (LM-CL)] in nondiluted human blood was studied. LM-CL was low in fresh blood and disappeared after its storage for 3 h, though the respiratory burst (RB) stimulation in blood was followed by high intensity and long-lasting LM-CL. LC-CL was high in fresh blood and was steadily increasin...

We have demonstrated recently that luminol- or lucigenin- dependent chemiluminescence (LM-CL and LC-CL, respectively) registered from whole non-diluted blood may reach rather high intensities. Here we demonstrate, that parameters of both LM-CL and LC-CL in non-diluted human blood during RB development is influenced by a reflective screen of aluminu...

Despite frequent use and long history of the measurement of the erythrocyte sedimentation rate (ESR) in clinical practice the coherent theory of this process is still lacking. Analysis of the "aggregation theory" of red blood sedimentation in tubes is performed. This theory claims that erythrocytes in resting blood aggregate due to adhesion provide...

Is shown, that the process of red blood sedimentation under the conditions of standard measurement of a clinical parameter ESR (erythrocyte sedimentation rate) is multistage and non-monotonous. Red blood sedimentation is preceded by the "latent" period lasting up to tens of minutes. When sedimentation begins, multiple accelerations and deceleration...

Three sessions of intravenous He−Ne laser therapy markedly decreased the intensity of luminol-dependent chemiluminescence of undiluted blood in most patients with ischemic heart disease. After seven sessions, the chemiluminescence parameters in most patients were similar to those in healthy donors. However, in some patients a 10-session course of l...

Nonenzymatic glycation of free or peptide bound amino acids (Maillard reaction, MR) plays an important role in aging, diabetic complications and atherosclerosis. MR taking place at high temperatures is accompanied by chemiluminescence (CL). Here kinetics of CL development in MR proceeding in model systems at room temperature has been analyzed for t...

Measurement of erythrocyte sedimentation rate (ESR) is one of the most widely used diagnosis techniques. It is believed that high ESR testifies to inflammatory conditions or decay in body tissues. However, standard ESR test data do not allow definitive determination of such conditions. ESR is currently determined manually. The ambiguity of standard...

An automatic device for high-temporal resolution of the process of erythrocytes sedimentation in blood was designed. The position of the boundary between red blood and plasma is registered each 30 sec in several pipettes simultaneously with ±10 mkm precision. Data are processed by a PC and presented as velocity-time curves (ESR-grams) and the curve...

Comparison of lucigenin- and luminol-dependent chemiluminescence (LC-CL and LM-CL, respectively) in nondiluted healthy donors' blood revealed significant differences in their patterns. LM-CL was low in fresh blood and disappeared after it storage for 3 hours. LC-CL was already high in fresh blood and was steadily increasing with blood storage. Seri...

Ability of many living systems to emit extra-weak UV-light capable to induce cell divisions (“mitogenetic radiation,” MGR) was discovered by A.G. Gurwitsch (1923). In 1920s–1930s the existence of MGR was confirmed by a large number of workers in laboratories throughout the world. There are also reports in recent literature on the ability of living...

Addition of Luminol to nondiluted blood of healthy donors results in a short and weak increase of chemiluminescence (CL) from it. Contrary to that in 25 cases of stable angina pectoris the intensity of CL from blood of patients sharply increased upon addition of luminol exceeding that form healthy donors' blood 10-100-fold. 24 hours after the 3D in...

To study a possibility of interaction of two optically, but not chemically coupled samples of whole human blood the following experimental setup was used. A quartz cuvette with either nondiluted blood or saline was placed inside a glass vial. Saline diluted whole blood was poured into the vial and respiratory burst (RB) was initiated in it with pho...

Parameters of chemiluminescence (CL) from nondiluted human blood were studied. Kinetics and intensity of CL depended upon donor's state of health, time after blood extravasion, conditions of its storage, conditions of its counting. Peculiar dependence of Luminol-enhanced CL on sample volume changes during respiratory burst (RB) was revealed. When 0...

Addition of Luminol to nondiluted blood of healthy donors results in a short and weak increase of chemiluminescence (CL) from it. Contrary to that in 25 cases of stable angina pectoris the intensity of CL from blood of patients sharply increased upon addition of luminol exceeding that form healthy donors' blood 10-100-fold. 24 hours after the 3D in...

Possibility of interaction between the two optically coupled samples of whole human blood as studied. A quartz cuvette was placed inside a vial for a liquid scintillation counter. Saline diluted whole blood was poured into the vial and either undiluted blood or saline was poured into the cuvette. Respiratory burst (RB) was initiated in blood placed...

Oxidative processes are major sources of energy accumulated in macroergic bonds of ATP in living cells. A part of the energy produced in redox reactions is transformed into the energy of electron excitation of the corresponding reaction products. Recently, much experimental evidence has been obtained that confirms that the energy of electron excita...

By chromatography on hydroxylapatite and CM-Toyopearl, it was shown that, after short irradiation of aqueous solutions of a mixture of amino acids (glycine, L-arginine, and L-leucine or glycine, L-lysine, and L-leucine) by ultraweak UV light, products with the adsorption characteristics of polymers are formed. Similar irradiation of the aqueous sol...

Short irradiation of an aqueous solution of glycine by an ultraweak source of UV photons initiates a process accompanied by the accumulation of ammonium ions. More intense deamination occurs in an aqueous solution of glycine in the presence of H2O2. The kinetics of the ammonia formation coincides with the kinetics of enhancement of luminescence, wh...

By chromatography on hydroxylapatite and CM-Toyopearl, it was shown that, after short irradiation of aqueous solutions of a mixture of amino acids (glycine, L-arginine, and L-leucine or glycine, L-lysine, and L-leucine) by ultraweak UV light, products with the adsorption characteristics of polymers are formed. Similar irradiation of the aqueous sol...

In recent years, quite a few structures of the genes coding membrane-bound hormonal receptors, have been revealed, and the recombinant receptors were cloned in heterogeneous systems. The role of the specific sites of a receptor molecule in the latter's functions is reviewed on example of the beta-adrenergic receptor. These functions involve ligand...