Vladimir Saenko

Vladimir Saenko
Nagasaki University · Atomic Bomb Disease Institute

PhD

About

202
Publications
38,272
Reads
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5,748
Citations
Citations since 2017
46 Research Items
2107 Citations
20172018201920202021202220230100200300400
20172018201920202021202220230100200300400
20172018201920202021202220230100200300400
20172018201920202021202220230100200300400
Additional affiliations
November 2013 - present
Nagasaki University
Position
  • Professor (Associate)
January 1995 - October 1996
Albert Einstein College of Medicine
Position
  • PostDoc Position

Publications

Publications (202)
Article
Full-text available
The potential overtreatment of patients with papillary thyroid microcarcinoma (MPTC) has been an important clinical problem in endocrine oncology over the past decade. At the same time, current clinical guidelines tend to consider prior radiation exposure as a contraindication to less extensive surgery, even for low-risk thyroid carcinomas, which p...
Article
Full-text available
With time after the Chernobyl accident, the number of papillary thyroid carcinomas (PTCs) driven by the BRAFV600E oncoprotein is growing in patients exposed to radiation at a young age. Clinicopathological associations of BRAFV600E in PTCs from patients with internal radiation history have not been sufficiently studied so far. This work analyzes th...
Article
Full-text available
Histopathological changes in the fusion oncogene-driven papillary thyroid carcinomas (PTCs) from children and adolescents exposed to Chernobyl fallout have been extensively studied. However, characteristics of the radiogenic BRAFV600E-positive PTCs, whose proportion is growing with time, are not well described yet. We analyzed the relationship betw...
Article
Full-text available
Marginal screening (MS) is the computationally simple and commonly used for the dimension reduction procedures. In it, a linear model is constructed for several top predictors, chosen according to the absolute value of marginal correlations with the dependent variable. Importantly, when kpredictors out of mprimary covariates are selected, the stand...
Article
Full-text available
The Chernobyl accident on 26 April 1986 led to a sharp increase in thyroid cancer (TC) incidence in the individuals exposed to radiation in childhood. The major risk factor for TC was exposure to Iodine-131 (131I). Here, we estimated the thyroid doses due to 131I intake for 2041 participants of the genome-wide association study of TC in Belarusian...
Article
Full-text available
Найпоширенішою точковою мутацією в папілярній тиреоїдній карциномі (ПТК) є BRAFV600E, яку пов’язують із більш агресивною поведінкою пухлини. Тим часом дані про частоту цієї мутації в різних вікових групах пацієнтів при наявності або відсутності радіаційного впливу в анамнезі вельми суперечливі. У більшості зазначених досліджень не використовувалися...
Article
Full-text available
Childhood papillary thyroid carcinoma (PTC) diagnosed after the Chernobyl accident in Belarus displayed a high frequency of gene rearrangements and low frequency of point mutations. Since 2001, only sporadic thyroid cancer occurs in children aged up to 14 years but its molecular characteristics have not been reported. Here, we determine the major o...
Article
Objective Telomerase reverse transcriptase promoter (TERT-p) mutations are strongly associated with tumour aggressiveness and worse prognosis in papillary thyroid carcinomas (PTCs). Since the TERT-p mutations have been reported to be subclonal, it is unclear how accurately they can be detected by preoperative fine-needle aspiration (FNA). The objec...
Article
Full-text available
There has been little understanding of the molecular pathogenesis of pediatric thyroid cancers. Most of them are histologically classified as papillary thyroid carcinoma (PTC). Ionizing radiation is the most important environmental factor to induce PTC, especially in children. Particularly, radiation-related pediatric PTCs after the Chernobyl accid...
Article
Full-text available
The microenvironment of an early-stage tumor, in which a small number of cancer cells is surrounded by a normal counterpart milieu, plays a crucial role in determining the fate of initiated cells. Here, we examined cell competition between anaplastic thyroid cancer cells and normal thyroid follicular cells using co-culture method. Cancer cells were...
Article
Full-text available
The incidence of differentiated thyroid cancer (DTC) is steadily increasing globally. Epidemiologists usually explain this global upsurge as the result of new diagnostic modalities, screening and overdiagnosis as well as results of lifestyle changes including obesity and comorbidity. However, there is evidence that there is a real increase of DTC i...
Preprint
Full-text available
Telomerase reverse transcriptase promoter ( TERT -p) mutations are strongly associated with tumor aggressiveness and worse prognosis in papillary thyroid carcinomas (PTCs). Since the TERT -p promoter mutations have been reported to be subclonal, it is unclear how accurately they can be detected by preoperative fine needle aspiration (FNA). The obje...
Article
Full-text available
Objective Risk for developing papillary thyroid carcinoma (PTC), the most common endocrine malignancy, is thought to be mediated by lifestyle, environmental exposures and genetic factors. Recent progress in the genome-wide association studies of thyroid cancer leads to the identification of several genetic variants conferring risk to this malignanc...
Article
Full-text available
RATIONALE : Insufficient world–wide clinical experience in radioiodine therapy (RIT) for Graves’ disease (GD) in children and adolescents, and limited knowledge of the predictors of RIT efficacy. AIMS : Analysis and identification of the most significant predictors of the efficacy of RIT in children and adolescents with Graves’ disease. MATERIALS A...
Article
Full-text available
Background: A significant increase in the incidence of papillary thyroid carcinoma (PTC) in subjects exposed to radiation at a young age is a well-documented health consequence of the Chernobyl accident. The ongoing Thyroid Ultrasound Examination (TUE) program in children and adolescents of Fukushima Prefecture in Japan also indicated a high preval...
Article
Full-text available
This population-based ecological study analyzes the prevalence of childhood leukemia in Ukraine before and after the Chornobyl nuclear power plant accident, based on the contamination status of the territory, time period, gender, and age. Three regions—Zhytomyr, Kyiv (except Kyiv city), and Chernihiv were included as areas contaminated by radioacti...
Article
Full-text available
Enormous amounts of childhood thyroid cancers, mostly childhood papillary thyroid carcinomas (PTCs), after the Chernobyl nuclear power plant accident have revealed a mutual relationship between the radiation exposure and thyroid cancer development. While the internal exposure to radioactive 131I is involved in the childhood thyroid cancers after th...
Article
Full-text available
Background: Telomerase reverse transcriptase (TERT) promoter mutations have been found in a subset of papillary thyroid carcinomas (PTCs) and are associated with tumor aggressiveness and worse prognosis. However, little is known about the status of TERT mRNA expression and its relationship between TERT promoter mutations and clinicopathological fea...
Chapter
Full-text available
This chapter analyzes histopathological characteristics of papillary thyroid carcinoma (PTC) in subjects of Ukraine who were children and adolescents at the time of the Chernobyl accident. Tumor architecture and invasive properties significantly changed with patients’ age at surgery increasing from 4 to 48 years and with the time elapsed after the...
Article
Genetic mutations play important roles in not only development of papillary thyroid carcinoma (PTC) but also determination of its properties. The radioactive iodine refractory (RAIR) state is a harbinger of poor outcomes for PTC. We used various statistical models to investigate the significance of TERT promoter, BRAF, and RAS mutations in distingu...
Article
Background: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive and refractory cancers, and a therapy with a new concept needs to be developed. Recently, research on cancer stem cells (CSCs) has progressed, and CSCs have been suggested to be responsible for metastasis, recurrence, and therapy resistance. In ATC-CSCs, aldehyde dehydroge...
Article
Full-text available
Mutation BRAFV600E is highly specific for papillary thyroid carcinoma. It’s detected in 40-70% of all papillary thyroid carcinoma cases. Moreover this mutation is noticed in anaplastic carcinoma in 40-50%.This fact gives a chance to select patients and provide targeted therapy with multi-kinase inhibitors in cases of unresectable anaplastic carcino...
Article
Full-text available
Thyroid ultrasound screening of young residents in Fukushima prefecture of Japan demonstrated high detection rate of papillary thyroid carcinoma (PTC). Detailed morphological analysis of these tumors was not presented to date. This study sets out to evaluate changes in histopathological and invasive characteristics of Fukushima PTC with time after...
Article
Full-text available
Objective: to analyze TP53, NOTCH1 and SF3B1 mutations in chronic lymphocytic leukemia (CLL) patients, sufferersof Chornobyl NPP accident to clarify the possible relationship between ionizing radiation (IR) and CLL. Methods: Mutations of TP53, NOTCH1, and SF3B1 genes were studied by direct sequencing in the main group of 106 CLLpatients exposed...
Article
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Background: The issue of whether radiation-induced thyroid cancer is pathologically different from sporadic remains not fully answered. This study compared structural characteristics and invasive features of papillary thyroid carcinoma (PTC) in two age-matched groups: patients who were children (≤4 years old) at the time of the Chernobyl accident...
Article
Full-text available
Thyroid cancer has one of the highest hereditary component among human malignancies as seen in medical epidemiology investigations, suggesting the potential meaningfulness of genetic studies. Here we review researches into genetic variations that influence the chance of developing non-familial differentiated thyroid cancer (DTC), focusing on the ma...
Article
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A growing body of evidence suggests a role of the von Hippel–Lindau (VHL) tumor suppressor gene in the progression of papillary thyroid carcinoma (PTC). Our previous study of VHL in PTCs showed that lower VHL expression was associated with aggressive tumor features, but we found no evidence for VHL downregulation through common genetic or epigeneti...
Article
Full-text available
The somatic mutation in BRAFT1799A (BRAFV600E), the data on the prognostic role of which are contradictory, is one of the most common molecular genetic abnormalities in the cells of papillary thyroid carcinoma (PTC). Objective: To investigate the association of the immunoexpression of mutant BRAF in PTC with different morphological characteristic...
Chapter
This chapter presents results of the thyroid cancer epidemiological survey carried out in the areas of Russia most heavily contaminated by radiation from the Chernobyl accident from 1991 to 2013. The average radiation dose to the thyroid was 174 mGy in children and adolescents and 36 mGy in adults. Those in the younger group had a higher radiation...
Chapter
The dramatic increase in the incidence of thyroid cancer in young residents of regions contaminated with radiative fallout is a well-known health consequence of the Chernobyl accident. The residents of four regions of Russia located around Chernobyl form a prospective cohort that receives regular health checkups including thyroid ultrasound. Aside...
Chapter
Full-text available
This chapter presents the results of studies on pediatric papillary thyroid carcinoma (PTC) in Belarus after the Chernobyl accident. Our investigations are based on a scrupulous histopathological review of all cases by a group of experienced pathologists with special skills in thyroid neoplasia, who confirmed the diagnosis, and determined the exten...
Chapter
Full-text available
Early diagnosis of thyroid cancer in children exposed to radionuclides is clinically important for good outcome. Ultrasound examination commonly detects thyroid cancer as a hypoechoic nodule with inhomogeneous structure and irregular outline, or less frequently as a diffuse formation; regional lymph nodes are often enlarged. Post-Chernobyl thyroid...
Article
Full-text available
Background The symposium entitled “Chernobyl +30, Fukushima +5: Lessons and Solutions for Fukushima’s Thyroid Question” was held in September, 2016 in Fukushima. The aim of the Symposium was to revisit and recapitulate evidence from the studies in Chernobyl in order to share multidisciplinary opinions and views on the likely reason for the high rat...
Article
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This study set out to compare structural and invasive characteristics of sporadic papillary thyroid carcinoma (PTC) in age-matched groups of children and adolescents of Japan and Ukraine to provide detailed histopathological analysis of tumors from different geographical areas with different iodine intake. A total of 348 (160 Japanese and 188 Ukrai...
Article
Full-text available
This study set out to investigate chromosomal damage in peripheral blood lymphocytes of thyroid cancer patients receiving (131)I for thyroid remnant ablation or treatment of metastatic disease. The observed chromosomal damage was further converted to the estimates of whole-body dose to project the adverse side effects. Chromosomal aberration analys...
Chapter
Full-text available
The incidence and pathological characteristics of thyroid cancer in subjects from Ukraine who were children and adolescents at the time of the Chernobyl accident, but reached adulthood at the time of surgery, were analyzed. A significant increase in thyroid cancer incidence in this age group persists up to 2014, and the incidence rate in the six mo...
Article
Background: The BRAFV600E mutation is the most frequent genetic abnormality in adult papillary thyroid carcinomas (PTCs). On the other hand, various chromosomal rearrangements are more prevalent in childhood and adolescent PTCs. The aim of the present study was to identify novel rearrangements in PTCs from young patients. Methods: Among 63 posto...
Article
Objectives: To analyze the distribution of single nucleotide polymorphisms (SNPs) in the TP53 gene in chronic lymphocytic leukemia (CLL) patients and to evaluate their associations with clinical behavior of the disease. Methods: SNPs in exons and parts of adjacent introns of the TP53 gene were analyzed in 235 CLL patients observed during 2005-20...
Article
Full-text available
Although most papillary thyroid carcinomas (PTCs) have a good prognosis, a small but certain fraction shows aggressive behavior. Therefore, a novel and well-performing molecular marker is needed. In the present study, we assessed the impact of the combination of the TERT promoter/BRAF mutations and Ki-67 labeling index (LI) as a prognostic marker i...
Article
Full-text available
One of the major health consequences of the Chernobyl Nuclear Power Plant accident in 1986 was a dramatic increase in incidence of thyroid cancer among those who were aged less than 18 years at the time of the accident. This increase has been directly linked in several analytic epidemiological studies to iodine-131 (I-131) thyroid doses received fr...
Article
Full-text available
Background: Several functional SNPs at the FOXE1 locus on chromosome 9q22.33 have been associated with the risk for papillary thyroid carcinoma (PTC). This study set out to elucidate whether their effects are independent, using genotyping results in populations of Asian and European descent. Methods: Single-nucleotide polymorphisms (SNPs) rs9655...
Article
Full-text available
Introduction: This work is the first genetic association study of a potential relationship of single nucleotide polymorphisms rs8193036 and rs2275913 located in the IL17A promoter on chromosome 6p12 to chronic viral hepatitis and its progression in Kazakh population. Purpose: Evaluation of the effect of IL17A polymorphism on predisposition for c...
Article
Full-text available
Recent genome-wide association studies have identified several single nucleotide polymorphisms in the FOXE1 locus, which are strongly associated with the risk for thyroid cancer. In addition, our recent work has demonstrated FOXE1 overexpression in papillary thyroid carcinomas. To assess possible contribution of Foxe1 to thyroid carcinogenesis, tra...
Article
Oncocytic follicular adenomas (FAs) of the thyroid are neoplasms of follicular cell origin that are predominantly composed of large polygonal cells with eosinophilic and granular cytoplasm. However, the pathological characteristics of these tumors are largely unexplored. Both the initiation and progression of cancer can be caused by an accumulation...
Article
Estimating radiation risks of thyroid cancer in the range of middle an low doses and prediction of the incidence with account of screening effect is a complex problem. The present article considers the problem of radiation risks estimation and screening effect on detection of thyroid cancer. Development of methodology and risk assessment were based...
Conference Paper
Abstract 0034-P Background Obesity and diabetes mellitus are associated with increased incidence of several cancers. More data are known to be associated with breast, colon/rectum cancers, less – with thyroid cancer. The aim of the study was to analyze the frequency of thyroid nodular disease, both benign and malignant in Belarusian patients with p...
Article
Full-text available
After the accident at the Fukushima Daiichi Nuclear Power Plant, the thyroid ultrasound screening program for children aged 0-18 at the time of the accident was started from October 2011. The prevalence of thyroid carcinomas in that population has appeared to be very high (84 cases per 296,253). To clarify the pathogenesis, we investigated the pres...
Conference Paper
Thyroid cancer is a cancer recommended for early detection. Ultrasound screening play important role in the epidemiological studies aimed early diagnosis of thyroid diseases in high-risk groups of people exposed to radiation during the Chernobyl accident. The aim of our study was to evaluate thyroid nodular diseases and thyroid cancer among exposed...
Conference Paper
Full-text available
The incidence of thyroid cancer increased markedly in the past 20 years in countries exposed to radiation after Chernobyl accident. This increase has been directly linked to iodine-131 (131I) thyroid doses. However, there remains limited understanding of factors that modify the 131I-related risk such as endocrine disruptors. The aim of the study wa...
Article
Full-text available
One of the major health consequences of the Chernobyl Nuclear Power Plant accident in 1986 was a dramatic increase in incidence of thyroid cancer among those who were aged less than 18 years at the time of the accident. This increase has been directly linked in several analytic epidemiological studies to iodine-131 (131I) thyroid doses received fro...
Article
Full-text available
The G allele of the rs6983267 single nucleotide polymorphism, located on chromosome 8q24, has been associated with increased risk of several cancer types. The association between rs6983267G and thyroid cancer has been tested in different populations, mostly of European ancestry, and has led to inconclusive results. While significant associations ha...
Article
The G allele of the rs6983267 single-nucleotide polymorphism, located on chromosome 8q24, has been associated with increased risk of several cancer types. The association between rs6983267G and thyroid cancer (TC) has been tested in different populations, mostly of European ancestry, and has led to inconclusive results. While significant associatio...
Article
Full-text available
Background: Several single nucleotide polymorphisms (SNP) have been identified to be associated with the risk for differentiated thyroid cancer in populations of distinct ethnic background. The relationship of these genetic markers to a benign tumor of the thyroid, follicular adenoma (FA), is not well established. Methods: In a multicenter retro...
Article
Full-text available
Abstract Alterations of the von Hippel–Lindau (VHL) tumor suppressor gene can cause different hereditary tumors associated with VHL syndrome, but the potential role of the VHL gene in papillary thyroid carcinoma (PTC) has not been characterized. This study set out to investigate the relationship of VHL expression level with clinicopathological fea...
Article
Full-text available
After the Tokyo electric power company (TEPCO) Fukushima Daiichi nuclear power plant accident, cancer risk from low-dose radiation exposure has been deeply concerned. While the linear no-threshold (LNT) model is applied for the purpose of radiation protection, it is a model based upon the concept, in which ionizing radiation induces stochastic onco...
Article
Full-text available
Long-term management of patients with differentiated thyroid cancer (DTC) commonly includes TSH-suppressive therapy with L-T4 and, in case of postsurgical hypoparathyroidism, Calcium-D3 supplementation, both of which may affect skeletal health. Experience with female patients treated for DTC at a young age and who were then receiving long-term ther...
Article
Full-text available
Geographic differences have been reported to affect the morphological and molecular features of papillary thyroid carcinomas (PTCs). The area around Chernobyl is well-known to be iodine-deficient in contrast to Japan, an iodine-rich country. We reviewed histological differences in adult PTC between Ukraine and Japan. In total, 112 PTCs from age- an...