Vladimir Baulin

Vladimir Baulin
Universitat Rovira i Virgili | URV · Department of Physical and Inorganic Chemistry

PhD

About

111
Publications
20,057
Reads
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4,233
Citations
Introduction
Theory and computer simulation of soft matter, including polymer and colloid physics, biophysics, nanostructured surfaces and theoretical design of nanomaterials. Web site: https://vbaulin.softmat.net/ Coordinator of Initial Training Network SNAL http://itn-snal.net/ Biomaterials and lipid bilayers group in Facebook: http://www.facebook.com/groups/softmat/ Softmat web site: http://softmat.net/
Additional affiliations
March 2008 - March 2013
Catalan Institution for Research and Advanced Studies
Position
  • ICREA Junior
March 2006 - February 2020
Universitat Rovira i Virgili
Position
  • Researcher
Description
  • Theory and simulation of soft matter: polymers, surfactants, colloids, liquid crystals. Modelling of interaction of phospholipid bilayers with nano-objects: carbon nanotubes, polymers, nanoparticles.
October 2004 - December 2005
Institut Charles Sadron
Position
  • PostDoc Position
Description
  • Theory of sliding polymers and topological materials Effects of gravity on microtubule self-assembly
Education
October 2000 - October 2003
Université Grenoble Alpes
Field of study
  • Soft matter physics
September 1994 - January 2000
Lomonosov Moscow State University
Field of study
  • Polymer physics

Publications

Publications (111)
Article
Cholesterol is a crucial component of mammalian cell membranes that takes part in many vital processes. It is generally accepted that cholesterol stabilizes the membrane and induces transitions into ordered states. In contrast to expectations, we demonstrate that cholesterol can destabilize the membrane by creating a nanodomain around a perpendicul...
Article
Antibiotic resistance is a global human health threat, causing routine treatments of bacterial infections to become increasingly difficult. The problem is exacerbated by biofilm formation by bacterial pathogens on the surfaces of indwelling medical and dental devices that facilitate high levels of tolerance to antibiotics. The development of new an...
Article
Full-text available
The impact of protein corona on the interactions of nanoparticles (NPs) with cells remains an open question. This question is particularly relevant to NPs which sizes, ranging from tens to hundreds nanometers, are comparable to the sizes of most abundant proteins in plasma. Protein sizes match with typical thickness of various coatings and ligands...
Article
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Estimated millions of tons of plastic are dumped annually into oceans. Plastic has been produced only for 70 y, but the exponential rise of mass production leads to its widespread proliferation in all environments. As a consequence of their large abundance globally, microplastics are also found in many living organisms including humans. While the h...
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The mechano-bactericidal activity of nanostructured surfaces has become the focus of intensive research toward the development of a new generation of antibacterial surfaces, particularly in the current era of emerging antibiotic resistance. This work demonstrates the effects of an incremental increase of nanopillar height on nanostructure-induced b...
Article
Ultrasmall metal nanoclusters (NCs) are employed in an array of diagnostic and therapeutic applications due to their tunable photoluminescence, high biocompatibility, polyvalent effect, ease of modification, and photothermal stability. However, gold nanoclusters' (AuNCs') intrinsically antimicrobial properties remain poorly explored and are not wel...
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A detailed description of photophysical properties of NIR-II emitting probe and their use for pseudo-3D views of vascular blood vessels.
Article
The influence of solvent polarity and surface ligand rigidification on the SWIR emission profile of gold nanoclusters with an anistropic surface was investigated. A strong enhancement of the SWIR emis- sion band at 1200 nm was observed when measuring in different local environments: in solution, in polymer composites, and in solids. SWIR in vivo im...
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The micellization and morphology of spherical telechelic micelles formed by triblock copolymers with short solvophobic end blocks at low concentrations are discussed within scaling arguments and Single Chain Mean Field Theory (SCMFT). In an ultradilute regime, individual telechelic polymer chains can exist in solution in two distinct states: an ope...
Preprint
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Micellization and morphology of spherical telechelic micelles formed by tri-block copolymers with short solvophobic end blocks at low concentrations is discussed within scaling arguments and Single Chain Mean Field Theory (SCMFT). In ultra-dilute regime, individual telechelic polymer chains can exist in solution in two distinct states: open linear...
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Deep learning methods provide a fast approach to move noninvasive infrared in vivo imaging to high resolution imaging techniques with full analyses of the vascular network.
Article
Hypothesis: The ability exhibited by insect wings to resist microbial infestation is a unique feature developed over 400 million years of evolution in response to lifestyle and environmental pressures. The self-cleaning and antimicrobial properties of insect wings may be attributed to the unique combination of nanoscale structures found on the wing...
Preprint
Full-text available
The impact of protein corona on the interactions of nanoparticles (NPs) with cells remains an open question. This question is particularly relevant to NPs which sizes, ranging from tens to hundreds nanometers, are comparable to the sizes of most abundant proteins in plasma. Protein sizes match with typical thickness of various coatings and ligands...
Article
Full-text available
Shortwave infrared window (SWIR: 1000‐1700 nm) represents a major improvement compared to the NIR‐I region (700‐900 nm) in terms of temporal and spatial resolutions in depths down to 4 mm. SWIR is a fast and cheap alternative to more precise methods such as X‐ray and opto‐acoustic imaging. Main obstacles in SWIR imaging are the noise and scattering...
Preprint
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In vivo optical imaging is a fast growing field that offers great perspectives for biomedical applications. In particular, imaging in the shortwave infrared window (SWIR: 1000-1700 nm) represents major improvement compared to the NIR-I region (700-900 nm) in terms of temporal and spatial resolutions in depths down to 4 mm. SWIR is a fast and cheap...
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It is commonly accepted that nanoparticles (NPs) can kill bacteria; however, the mechanism of antimicrobial action remains obscure for large NPs that cannot translocate the bacterial cell wall. It is demonstrated that the increase in membrane tension caused by the adsorption of NPs is responsible for mechanical deformation, leading to cell rupture...
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The antibacterial action of large (>10 nm) spherical gold nanoparticles is demonstrated by Elena P. Ivanova and co‐workers in article number 2005679 to be attributed to the combined stretching and rupture of the bacterial cell membrane. The newly discovered mechanical modes of antibacterial action pose varied implications for the use and applicatio...
Preprint
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Recent developments in computer processing power lead to new paradigms of how problems in many-body physics and especially polymer physics can be addressed. Parallel processors can be exploited to generate millions of molecular configurations in complex environments at a second, and concomitant free-energy landscapes can be estimated. Databases tha...
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Full-text available
Recent developments in computer processing power lead to new paradigms of how problems in many-body physics and especially polymer physics can be addressed. Parallel processors can be exploited to generate millions of molecular configurations in complex environments at a second, and concomitant free-energy landscapes can be estimated. Databases tha...
Article
Interaction of single-chain nanoparticles (SCNPs) with lipid membranes is studied theoretically based on Monte Carlo simulations using the bond fluctuation model. SCNPs with a tunable elasticity represent an intermediate between rigid nanoparticles and flexible polymers. The degree of cross-linking between monomers of the precursor polymer is the k...
Article
Abstract Hypothesis Titanium and titanium alloys are often the most popular choice of material for the manufacture of medical implants; however, they remain susceptible to the risk of device-related infection caused by the presence of pathogenic bacteria. Hydrothermal etching of titanium surfaces, to produce random nanosheet topologies, has shown r...
Article
Nanostructured mechano-bactericidal surfaces represent a promising technology to prevent the incidence of microbial contamination on a variety of surfaces and to avoid bacterial infection, particularly with antibiotic resistant strains. In this work, a regular array of silicon nanopillars of 380 nm height and 35 nm diameter was used to study the re...
Article
Macromolecules of amphiphilic invertible polymers (AIPs) are capable of self-assembly into micellar assemblies of various morphologies in solvents of different polarities. The micellar assemblies in aqueous media are capable of encapsulating poorly aqueous soluble cargo and can undergo inverse conformational change and cargo release in contact with...
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Recent technological advances have allowed the development of a new generation of nanostructured materials, such as those displaying both mechano-bactericidal activity and substrata that favor the growth of mammalian cells. Nanomaterials that come into contact with biological media such as blood first interact with proteins, hence understanding the...
Article
The waxy epicuticle of dragonfly wings contains a unique nanostructured pattern that exhibits bactericidal properties. In light of emerging concerns of antibiotic resistance, these mechano-bactericidal surfaces represent a particularly novel solution by which bacterial colonization and the formation of biofilms on biomedical devices can be prevente...
Article
Blood circulation is the main distribution route for systemic delivery and the possibility to manipulate red blood cells by attaching nanoparticles to their surface provides a great opportunity for cargo delivery into tissues. Nanocarriers attached to red blood cells can be delivered to specific organs by orders of magnitude faster than if diluted...
Article
Standard chemotherapies that interfere with microtubule dynamics are a chemotherapeutic option used for the patients with advanced malignancies that invariably relapse after targeted therapies. However, major efforts are needed to reduce their toxicity, optimize their efficacy, and reduce cancer chemoresistance to these agents. We previously identi...
Article
Increasing awareness of bioeffects and toxicity of nanomaterials interacting with cells puts in focus the mechanisms by which nanomaterials can cross lipid membranes. Apart from well-discussed energy-dependent endocytosis for large objects and passive diffusion through membranes by solute molecules, there can exist other translocation mechanisms ba...
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The interface between water and a textured hydrophobic surface can exist in two regimes; either the Wenzel (surface-engulfed) or Cassie-Baxter (water-suspended) state. Better understanding of the influence of pattern geometry and spacing is crucial for the design of functional (super)hydrophobic surfaces, as inspired by nu-merous examples in nature...
Article
The Single Chain Mean Field theory is used to link coarse-grained models of amphiphilic molecules with analytical models for membrane elasticity, where phenomenological parameters are deduced from explicit molecular models and force fields. We estimate the elastic constants based on the free energy of the amphiphilic bilayer in planar and cylindric...
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Dragonfly wings are of great interest to researchers investigating biomimetic designs for antiwetting and antibacterial surfaces. The waxy epicuticular layer on the membrane of dragonfly wings possesses a unique surface nanoarchitecture that consists of irregular arrays of nanoscale pillars. This architecture confers superhydrophobic, self-cleaning...
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Growing interest in the bactericidal effect of graphene and graphene-derived nanomaterials has led to the investigation and effective publication of the bactericidal effects of the substratum, many of which present highly conflicting material. The nature of bacterial cell death on graphene bio-interfaces, therefore, remains poorly understood. Here,...
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One of the major challenges faced by the biomedical industry is the development of robust synthetic surfaces that can resist bacterial colonization. Much inspiration has been drawn recently from naturally occurring mechano-bactericidal surfaces such as the wings of cicada (Psaltoda claripennis) and dragonfly (Diplacodes bipunctata) species in fabri...
Article
The threat of a global rise in the number of untreatable infections caused by antibiotic resistant bacteria calls for the design and fabrication of a new generation of bactericidal materials. Here, we report a concept for the design of antibacterial surfaces, whereby cell death results from the ability of the nanofeatures to deflect when in contact...
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Insects represent the majority of known animal species and exploit a variety of fascinating nanotechnological concepts. We investigated the wings of the damselfly Calopteryx haemorrhoidalis, whose males have dark pigmented wings and females have slightly pigmented wings. We used scanning electron microscopy (SEM) and nanoscale synchrotron X-ray flu...
Article
Damselflies Calopteryx haemorrhoidalis exhibiting black wings are found in the western Mediterranean, Algeria, France, Italy, Spain and Monaco. Wing pigmentation is caused by the presence of melanin, which is involved in physiological processes including defence reactions, wound healing and sclerotization of the insect. Despite the important physio...
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Titanium is a biocompatible material that is frequently used for making implantable medical devices. Nanoengineering of the surface is the common method for increasing material biocompatibility, and while the nanostructured materials are well-known to represent attractive substrata for eukaryotic cells, very little information has been documented a...
Article
Synthetic polymers, nanoparticles, and carbon-based materials have great potential in applications including drug delivery, gene transfection, in vitro and in vivo imaging, and the alteration of biological function. Nature and humans use different design strategies to create nanomaterials: biological objects have emerged from billions of years of e...
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Cellular attachment plays a vital role in the differentiation of pheochromocytoma (PC12) cells. PC12 cells are noradrenergic clonal cells isolated from the adrenal medulla of Rattus norvegicus and studied extensively as they have the ability to differentiate into sympathetic neuron-like cells. The effect of several experimental parameters including...
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The effect of red blood cells (RBC) exposed to an 18 GHz electromagnetic field (EMF) was studied. The results of this study demonstrated for the first time that exposure of RBCs to 18 GHz EMF has the capacity to induce nanospheres uptake in RBCs. The uptake of nanospheres (loading efficiency 96% and 46% for 23.5 and 46.3 nm nanospheres respectively...
Article
Statement of significance: Nanostructured cicada and dragonfly wing surfaces have been discovered to be able physically kill bacterial cells. Here, we report on the successful fabrication of bactericidal three-dimensional structures of two main lipid components of insect wings epicuticule, palmitic (C16) and stearic (C18) fatty acids. Both palmiti...
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Nanostructured insect wing surfaces have been reported to possess the ability to resist bacterial colonization through the mechanical rupture of bacterial cells coming into contact with the surface. In this work, the susceptibility of physiologically young, mature and old Staphylococcus aureus CIP 65.8 and Pseudomonas aeruginosa ATCC 9721 bacterial...
Article
Cryopreservation of red blood cells (RBC) is an important method for maintaining an inventory of rare RBC units and managing special transfusion circumstances. Currently, in a clinical setting, glycerol is used as cryoprotectant against freezing damage. After thawing and before transfusion, glycerol must however be removed to avoid intravascular he...
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Deeper understanding of the molecular interactions between polymeric materials and the lipid membrane is important across a range of applications from permeation for drug delivery to encapsulation for immuno-evasion. Using highly fluidic microcavity supported lipid bilayers, we studied the interactions between amphiphilic polymer PP50 and a DOPC li...
Article
We present parallel version of Rosenbluth Self-Avoiding Walk generation method implemented on Graphics Processing Units (GPUs) using CUDA libraries. The method scales almost linearly with the number of CUDA cores and the method efficiency has only hardware limitations. The method is introduced in two realizations: on a cubic lattice and in real spa...
Article
Deeper understanding of the molecular interactions between polymeric materials and the lipid membrane is important across a range of applications from permeation for drug delivery to encapsulation for immuno-evasion. Using highly fluidic microcavity supported lipid bilayers, we studied the interactions between amphiphilic polymer PP50 and a DOPC li...
Article
We propose a theory to predict the passive translocation of flexible polymers through amphiphilic membranes. By using a generic model for the potential felt by a monomer across the membrane we calculate the free energy profile for homopolymers as a function of their hydrophobicity. Our model explains the translocation window and the translocation r...
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Hydrophobic nanoparticles introduced into living systems may lead to increased toxicity, can activate immune cells, or can be used as nanocarriers for drug or gene delivery. It is generally accepted that small hydrophobic nanoparticles are blocked by lipid bilayers and accumulate in the bilayer core, whereas big nanoparticles can only penetrate cel...
Article
The protein adsorption of two human plasma proteins-albumin (Alb) and fibronectin (Fn)-onto synthetic nanostructured bactericidal material-black silicon (bSi) surfaces (that contain an array of nanopillars) and silicon wafer (nonstructured) surfaces-was investigated. The adsorption behavior of Alb and Fn onto two types of substrata was studied usin...