Vivianne Chappuis

Universität Bern | UniBe

Purpose: This in vitro study aimed at comparing the accuracy of freehand implant placement with static computer-assisted implant surgery (sCAIS), utilizing a keyless and a drill-key implant system and two guide-hole designs. Methods: A total of 108 implants were placed in 18 partially edentulous maxillary models simulating two different alveolar...

Objectives The primary aim of this in vitro study was to evaluate the influence of alveolar ridge morphologies on the accuracy of static Computer-Assisted Implant Surgery (sCAIS). The secondary aims were to evaluate the influence of guide-hole design and implant macro-design on the accuracy of the final implant position. Methods Eighteen standardi...

The preservation of osseointegration is fundamental for the long-term success of dental implants. Breakdown of osseointegration may occur in cases of aseptic implant loosening, a poorly understood process leading to sudden implant failure. So far, no evidence-based therapy concept exists for implants with aseptic loosening. The present case report...

There is widespread knowledge that the mental foramen or incisive foramen can be projected onto tooth roots in conventional radiographs, thus simulating apical lesions. In contrast, the anatomical structure of the canalis sinuosus and its branching canals in the anterior maxilla are less known. Sometimes these bone canals mimic a dentino- or osteol...

Introduction The objective of this retrospective study was to assess the outcome of periapical surgery in a large number of molars in order to identify possible variables that might affect the outcome. Methods The healing outcome of patients undergoing periapical surgery of molars from October 1999 to October 2019 was retrospectively evaluated. Ou...

Objectives To evaluate the long-term effectiveness of 6 mm implants in various indications with a micro-rough surface after 4.6-18.2 years in function and to assess key factors associated with implant survival, success and biological/technical complications. Materials and Methods Fifty-five patients with seventy-four 6 mm implants placed from 2000...

Objectives The aim of the study was to investigate whether the osteoinductive properties of bone-conditioned medium (BCM) harvested from cortical bone chips within a clinically relevant short-term period can enhance the biologic characteristics of deproteinized bovine bone mineral (DBBM) in vitro.Materials and methodsTo assess the biofunctionalizat...

Objectives: The aim of the study was to investigate the impact of two hyaluronan (HA) formulations on the osteogenic potential of osteoblast precursors. Materials and methods: Proliferation rates of HA-treated mesenchymal stromal ST2 and pre-osteoblastic MC3T3-E1 cells were determined by 5-bromo-20-deoxyuridine (BrdU) assay. Expression of genes...

Abstract Purpose: The hydrophilic implant surface (INICELL) is a chemical alteration of a sandblasted and thermally acid-etched surface that should lead to long-term osseointegration. This study investigated 3-year results after early loading of implants with a hydrophilic, moderately rough surface in occlusal contact. Materials and methods: This...

Objective The aim of the present study was to assess the effects of alendronate (ALN) on bone remodeling following tooth extraction in a dog model. Material and methods For the study, fifteen male Beagles dogs of approximately 12 months of age were used. Mesial roots of four mandibular premolars were endodontically treated, and the distal roots we...

A short inflammatory phase and fast ingrowth of blood vessels and mesenchymal cells are essential for tissue integration of a biomaterial. Macrophages play a key role in this process. We investigated invasion of macrophages, blood vessels, and proliferating cells into a highly porous and volume-stable collagen matrix (VCMX) used for soft tissue aug...

Purpose: There is a lack of knowledge concerning the critical buccal bone thickness required for securing favorable functional and esthetic outcomes, conditioned to the dimensional changes after implant placement. A preclinical study was therefore carried out to identify the critical buccal bone wall thickness for minimizing bone resorption during...

Objectives: To evaluate the patient population over a three-year period and to compare it to observations of the population at the same clinic over a period of 15 years. Material and methods: Records of patients receiving dental implants in the Department of Oral Surgery and Stomatology, University of Bern, between January 2014 and December 2016...

Frequently, dentists raise questions about the risks and benefits of antibiotic administration for prophylactic or therapeutic purposes in children and adolescents. This chapter highlights the risks of antibiotic resistance, misuse and adverse drug events. It furthermore offers guidelines for the correct indication for antibiotic therapy and for pr...

Implant placement post single tooth extraction in the esthetic zone is an important and frequent indication for implant therapy. Today, the clinician can choose from four different treatment approaches for the timing of implant placement. The decision for the most appropriate treatment plan should be based on a thorough clinical and radiographic ex...

Objective Polyetheretherketone (PEEK) is a popular synthetic thermoplastic polymer for medical applications, but its clinical use suffers from several limitations. Therefore, the aim was to compare the soft tissue response to dental implant closure caps made of PEEK or titanium as evaluated by the occurrence of multinucleated giant cells (MNGCs)....

Aim To assess the effectiveness and clinical performance of early implant placement, 4‐8 (Type 2) or 12‐16 weeks (Type 3) after extraction, in single anterior sites. Methods Studies reporting on Type 2 and 3 implant placement were identified. Findings were summarized in evidence tables. Main outcome was implant survival. Peri‐implant soft and hard...

In aesthetic sites, the integrity of the facial bone wall dimension in the anterior maxilla is jeopardized by physiologic and structural changes postextraction. An effective regenerative protocol is key to reestablish and maintain the hard and soft tissue dimensions over time. The present prospective case series study examined the effectiveness of...

Objectives: The aim of Working Group 1 was to address the influence of different local (implant length, diameter, and design) and systemic (medications) factors on clinical, radiographic, and patient-reported outcomes in implant dentistry. Focused questions on (a) short posterior dental implants (≤6 mm), (b) narrow diameter implants, (c) implant d...

Objectives The aim of this systematic review was to investigate the association between the intake of systemic medications that may affect bone metabolism and their subsequent impact on implant failures. Material and methods Electronic and manual literature searches were conducted. Implant failure (IF) was the primary outcome, while biological/mec...

Advances in biomaterials science and implant surface technology have made dental implants more predictable and implant therapy more attractive to patients. Surgical interventions are becoming less invasive, and patients heal faster and suffer less morbidity. In this preclinical in vivo study, we compared a new ultra-fine grained titanium (ufgTi) im...

The purpose of this case series was to assess safety and feasibility of a novel resorbable collagen matrix (CMX) to enhance tissue thickness simultaneous with implant placement and guided bone regeneration (GBR) in esthetic sites over an 8-week healing period. Soft tissue thickness at implant sites and adjacent teeth was monitored with an ultrasoni...

‘Bone-conditioned medium’ could improve oral bone regeneration therapy by promoting the proliferation and maturation of bone-forming cells. Building on recent research demonstrating the benefits of using cell culture medium prepared with bone chips (BCM) in such treatments, researchers led by Maria Asparuhova of the University of Bern, Switzerland,...

Background: Due to its advantageous physical, biological, and esthetic proper-ties as well as its resistance to corrosion, zirconia as a biomaterial to replace missing tooth roots has been the focus of great interest and may become a reli-able alternative to titanium implants.Aim: To present and discuss the preclini- cal data available on osseointe...

Objectives: To evaluate the effect of a resorbable collagen membrane and autogenous bone chips combined with deproteinized bovine bone mineral (DBBM) on the healing of buccal dehiscence-type defects. Material and methods: The second incisors and the first premolars were extracted in the maxilla of eight mongrels. Reduced diameter, bone-level imp...

Background Although many studies have been published on single implants, long‐term data remain scarce. Purpose To evaluate immediately restored single implants after at least 8 years of follow‐up in terms of buccal bone, soft tissue alterations, aesthetic ratings, and patient‐reported outcomes. Materials and Methods This prospective cohort study...

Background The use of platelet rich plasma (PRP, GLO) has been used as an adjunct to various regenerative dental procedures. The aim of the present study was to characterize the influence of PRP on human gingival fibroblasts, periodontal ligament (PDL) cells and osteoblast cell behavior in vitro. Methods Human gingival fibroblasts, PDL cells and o...

This lecture covers a variety of innovations that have the potential to provide patients with predictable esthetics, stable peri-implant bone levels, and a functional prosthesis from a long-term perspective. Current research that focuses on a better understanding of the biological processes that underlie alveolar bone healing, osseointegration, and...

Progess and developments in implant design, surgical techniques, and materials, abutment design and restorative materials, as well as patient evaluation add up to make this a timely moment to revisit single-tooth replacements in the esthetic zone. From the first consultation to follow-up and maintenance. This volume focuses on the treatment modalit...

When a tooth is extracted, the alveolar bone that supports the tooth resorbs over time. This resorption results in a reduction in alveolar bone volume, as shown in this clinical example of a missing upper right central incisor. The bone has diminished significantly in orofacial width, and this is in conflict with the fundamental requirement in impl...

Facial peri-implant mucosal recessions represent an increasing complication in implant dentistry and may negatively affect the esthetic outcome and patient satisfaction. The aim of the present paper is to provide a review on the potential causes of facial peri-implant mucosal recessions and to provide a rationale for treatment along with possible t...

Implant placement in post-extraction sites of single teeth in the esthetic zone has been a topic of great interest in the field of implant dentistry since 1990. Triggered by the development of guided bone regeneration, the concept of immediate implant placement became quite popular in the 1990s. In the past 12 years, however, the dental community h...

The key to achieving pleasing esthetics in implant dentistry is a thorough understanding of the biological processes driving dimensional bone and soft tissue alterations post-extraction. The aim of the present report is first to characterize the extent of bone and soft tissue changes post-extraction and second to identify potential factors influenc...

Bone healing around dental implants follows the pattern and sequence of intramembraneous osteogenesis with formation of woven bone first of all followed later by formation of parallel-fibered and lamellar bone. Bone apposition onto the implant surface starts earlier in trabecular bone than in compact bone. While the first new bone may be found on t...

Patients’ esthetic expectations are increasing, and the options of the prosthetic pathways are currently evolving. The objective of this randomized multicenter clinical trial was to assess and compare the esthetic outcome and clinical performance of anterior maxillary all-ceramic implant crowns (ICs) based either on prefabricated zirconia abutments...

This e-learning module includes eight videos illustrating the PRI procedure in different clinical situations. After completing this ITI Online Academy Module, you should be able to… - outline the indications for performing a PRI - list the anatomical considerations when planning and performing a PRI - outline the steps in performing a PRI - list th...

Background: The use of autogenous block grafts harvested from intraoral donor sites has proven to be effective for the reconstruction of horizontal bone defects.

Objectives: In patients with implant placement and simultaneous sinus floor elevation (SFE), healing periods of 6 months have been the standard of care for more than 25 years. The primary objective of this prospective case series study was to determine what percentage of implants placed with SFE reach a threshold Implant Stability Quotient (ISQ) o...

The understanding of the facial anatomy with its associated osseous and neurovascular structures is essential to the implant surgeon. During treatment planning and implant surgery certain critical landmarks and boundaries must be respected. The surgeon should also keep in mind that many variations exist between individuals. Anatomy of the upper and...

Objectives: The aim of the present observational medical device performance study was to test whether implants with an intra-operatively conditioned hydrophilic surface can be safely reconstructed when applying an early loading protocol after 21 days in partially edentulous posterior mandibles. Material and methods: Partially edentulous patients...

Background: Current strategies to reduce medical device-associated infections propose zirconia as a potential implant material which may limit bacterial adhesion. Because multinucleated giant cells (MNGCs) have been detected on these implant surfaces, concerns have been raised regarding tissue integration. Purpose: The present study examined the...

AimTo examine the influence of two different neck designs on facial bone crest dimensions in esthetic single implant sites after a 5-to-9-year follow-up analyzed by cone beam computed tomography (CBCT).Materials and methodsSixty-one patients with an implant-borne single crown following early implant placement in the esthetic zone were enrolled. The...

Purpose: To analyze the indications and frequency for three-dimensional (3D) imaging for implant treatment planning in a pool of patients referred to a specialty clinic over a 3-year period. Materials and methods: All patients who received dental implants between 2008 and 2010 at the Department of Oral Surgery and Stomatology at the University o...

Dimensional alterations of the facial soft and bone tissues following tooth extraction in the esthetic zone play an essential role to achieve successful outcomes in implant therapy. This prospective study is the first to investigate the interplay between the soft tissue dimensions and the underlying bone anatomy during an 8-wk healing period. The a...

To associate the dimension of the facial bone wall with clinical, radiological, and patient-centered outcomes at least 10 years after immediate implant placement with simultaneous guided bone regeneration in a retrospective study. Primary endpoint was the distance from the implant shoulder (IS) to the first bone-to-implant contact (IS-BIC10y ). Sec...

Purpose: The aim of this study was to analyze the patient pool referred to a specialty clinic for implant surgery over a 3-year period. Materials and methods: All patients receiving dental implants between 2008 and 2010 at the Department of Oral Surgery and Stomatology were included in the study. As primary outcome parameters, the patients were...

These are the first true success rates of dental implants with a TPS surface in partially edentulous patients over a 20-year followup period. Even though these implants revealed a rather rough and microporous surface, the analysis demonstrated that 92% showed peri-implant bone loss of less than 1 mm over the 20-year observation period. The 20-year...

Bone graft incorporation depends on the orchestrated activation of numerous growth factors and cytokines in both the host and the graft. Prominent in this signaling cascade is BMP2. Although BMP2 is dispensable for bone formation, it is required for the initiation of bone repair (2); thus understanding the cellular mechanisms underlying bone regene...

In this prospective case series study, 20 patients with an implant-borne single crown following early implant placement with simultaneous contour augmentation were followed for 6 years. Clinical, radiologic, and esthetic parameters were assessed. In addition, cone beam computed tomog-raphy (CBCT) was used at 6 years to examine the facial bone wall....

In this prospective case series study, 20 patients with an implant-borne single crown following early implant placement with simultaneous contour augmentation were followed for 6 years. Clinical, radiologic, and esthetic parameters were assessed. In addition, cone beam computed tomography (CBCT) was used at 6 years to examine the facial bone wall....

Dimensional alterations of the facial bone wall following tooth extractions in the esthetic zone have a profound effect on treatment outcomes. This prospective study in 39 patients is the first to investigate three-dimensional (3D) alterations of facial bone in the esthetic zone during the initial 8 wks following flapless tooth extraction. A novel...

Background Long-term studies of 10 years are important milestones to get a better understanding of potential factors causing implant failures or complications. PurposeThe present study investigated the long-term outcomes of titanium dental implants with a rough, microporous surface (titanium plasma sprayed [TPS]) and the associated biologic and tec...

Background: Early implant placement with simultaneous contour augmentation is documented with short- and medium-term studies. The long-term stability of contour augmentation is uncertain. Methods: In this prospective, cross-sectional study, 41 patients with an implant-borne single crown were examined twice, in 2006 and 2010. Clinical, radiologic...

Early implant placement is one of the treatment options after tooth extraction. Implant surgery is performed after a healing period of 4 to 8 weeks and combined with a simultaneous contour augmentation using the guided bone regeneration technique to rebuild stable esthetic facial hard- and soft-tissue contours. In this prospective study, 20 patient...

To evaluate the treatment outcome of avulsed and replanted permanent incisors. 42 avulsed and replanted permanent incisors in 37 individuals were followed over a median observation period of 2.8 years (range: one year to five years). The mean age was 16.3 years at the time of replantation, with 81% of patients being younger than 20 years. The tooth...

While new roles for the adult skeleton as an endocrine organ continue to emerge, our understanding of how bone homeostasis is maintained is also changing. Here we focus on BMP2, a molecule identified by its ability to induce bone formation at extraskeletal sites. We detail specific roles for BMP2 in the adult skeleton, where it acts to regulate the...

Grafting of the maxillary sinus in both one- and two-stage protocols has become a highly predictable surgical technique for site development and for the placement of implants to support dentures. However, despite the predictability and high success rates reported for dental implants placed either simultaneously with or after a sinus floor elevation...

Early implant placement is one of the treatment options in postextraction sites in the anterior maxilla. Implant placement is performed after a soft tissue healing period of 4 to 8 weeks. Implant placement is combined with a simultaneous guided bone regeneration (GBR) procedure to rebuild esthetic facial hard and soft tissue contours. In this prosp...

The aim of this prospective study was to evaluate the 5-year performance and success rate of titanium screw-type implants with the titanium plasma spray (TPS) or the sand-blasted, large grit, acid-etched (SLA) surface inserted in a two-stage sinus floor elevation (SFE) procedure in the posterior maxilla. A total of 59 delayed SFEs were performed in...

To evaluate the pulp sensitivity and vitality of mandibular incisors and canines before and after bone harvesting in the symphysis. In 20 patients requiring bone grafts from the symphysis, pulp sensitivity (carbon dioxide [CO2]) and pulpal blood flow (laser Doppler flowmetry [LDF]) of mandibular incisors and canines were evaluated preoperatively, p...

Diagnostic and therapeutic interventions following dental injuries are not part of the routine practice in the dental office. Quite often, these patients are emergency cases who seek treatment after normal office hours. The objective of this and the future papers is to present the current treatment concepts in dental traumatology at the School of D...

Thirty-four patients with 45 avulsed and replanted permanent teeth were followed for 1 year. All teeth were soaked in tetracycline before replantation. In addition, enamel matrix derivative was used in teeth with dry storage times exceeding 30 min. Splinting was carried out with a non-rigid titanium splint and was limited to 7-10 days. Within that...