Vivek Kumar Morya

Hallym University Medical Center · Department of Orthopedic Surgery

Cauliflower (Brassica oleracea var. botrytis) is a crucial cash crop predominantly consumed as a vegetable. High-yielding varieties are favored to maximize productivity and income, but they require substantial nutrients, leading to heavy reliance on chemical fertilizers and pesticides. This practice poses health risks and causes environmental pollu...

Degenerative tendinopathy results from the accumulation of minor injuries following unsuccessful tendon repair during acute tendon injuries. The process of tendon repair is prolonged and varies between individuals, making it susceptible to reinjury. Moreover, treating chronic tendinopathy often requires expensive and extensive rehabilitation, along...

Artificial intelligence (AI) has rapidly transformed various aspects of life, and the launch of the chatbot “ChatGPT” by OpenAI in November 2022 has garnered significant attention and user appreciation. ChatGPT utilizes natural language processing based on a ”generative pre-trained transfer” (GPT) model, specifically the transformer architecture, t...

A study was conducted to discover a novel microorganism capable of producing multiple enzymes with industrial applications. Bacterial isolates were screened from a soil sample collected from a wood-decaying area, and their ability to produce various enzymes of industrial significance was evaluated. Among the 100 screened bacterial isolates, the str...

A study was conducted to discover a novel microorganism capable of producing multiple enzymes with industrial applications. Bacterial isolates were screened from a soil sample collected from a wood-decaying area, and their ability to produce various enzymes of industrial significance was evaluated. Among the 100 screened bacterial isolates, the str...

Hypoxia-inducible factor-1α (HIF-1α) is a major transcriptional factor, which plays an important role in cellular reprogramming processes under hypoxic conditions, which facilitate solid tumors’ progression. HIF-1α is directly involved in the regulation of the angiogenesis, metabolic reprogramming, and extracellular matrix remodeling of the tumor m...

Tendinopathy is a debilitating condition marked by degenerative changes in the tendons. Its complex pathophysiology involves intrinsic, extrinsic, and physiological factors. While its intrinsic and extrinsic factors have been extensively studied, the role of physiological factors, such as hypoxia and oxidative stress, remains largely unexplored. Th...

Background Degenerative tendinopathy, a condition causing movement restriction due to high pain, highly impacts productivity and quality of life. The healing process is a complex phenomenon and involves a series of intra-cellular and inter-cellular processes. Proliferation and differentiation of the tenocyte is a major and essential process to heal...

Many ethnic plants are used as a source of traditional medicine to cure a variety of illnesses in both humans and animals. Developing secondary metabo-lites in plants with antifungal characteristics, offer alternative medications for reasonably priced and safe treatments. In the present study, methanolic, etha-nolic, hexane and ethyl acetate leaves...

Our plant biodiversity and conservation are greatly enhanced by the usage of medicinal herbs in traditional community practices. Natural products are essential components of traditional knowledge systems in nutraceuticals, food supplements, pharmacological bioactive metabolites of novel chemical entities, and complementary and alternative medicine....

In the quest for a novel microbe capable of producing multiple enzymes significant in industrial applications, bacterial isolates from soil samples collected from the wood-decaying area were screened. With this aim, the isolates were screened for the capability of producing various enzymes of industrial importance. Among the 100 screened isolates o...

Polybrominated diphenyl ethers (PBDEs) are a class of persistent organic pollutants (POPs) used as flame retardants in the products utilized in day-to-day life. Their bioaccumulation, low volatility, and high persistence in the environment have led to their global spread even to remote and distant regions. The present study identifies gaps in the i...

Linen fabrics used in healthcare facilities need proper disinfection and sterilization to ensure hygiene. Due to several side effects from the recommended chemical disinfectants, there is always a need for appropriate and affordable technology to disinfect and sterilize the linen. Here, we propose a device for dry sterilization of linen using micro...

The L-lysine is one of the most important essential amino acid used in food and pharmaceutical industries. The present investigation was conducted to optimize the L-lysine production by Corynebacterium glutamicum (NCIM 2168). The production parameters such as the temperature, pH and glucose concentration (g/l) were optimised and evaluated by simula...

Prunus spp. and locally available plants (used as folkloric medicine) were screened to find a novel and natural anti-melanogenic agent. Based on p-protein promoter reporter assay (PPRA) the candidate plants were screened in the quest for p-protein inhibitor. Expression profiling of key proteins revealed the molecular mechanism of the melanin inhibi...

Synthesis of caffeic acid ester essentially requires an efficient esterification process to produce various kinds of medicinally important ester derivatives. In the present study, a comprehensive and comparative analysis of whole-cell catalyzed caffeic acid esters production in ionic liquids (ILs) media was performed. Olive oil induced mycelial mas...

WD is a mobile application for personal health and disease management. ▪ Easy to use and useful in wellbeing management. ▪ WD is to enable sustained behavior change and learning through self-observations and feedback. ▪ Evidence-based clinical guidelines, developed specifically for self-management of health or chronic illnesses. ▪ Personalization,...

A total of 129 proteases sequences comprising 43 serine proteases, 36 aspartic proteases, 24 cysteine protease, 21 metalloproteases, and 05 neutral proteases from different Aspergillus species were analyzed for the catalytically active site residues using MEROPS database and various bioinformatics tools. Different proteases have predominance of var...

The ionic liquids dubbed as green solvents have been demonstrated to be very effective in pre-treatment of various kinds of biomass for better saccharification. Present study describes ionic liquid stability of thermophilic . Sporotrichum thermophile xylanase. It was active and stable in 1-ethyl-3-methylimidazolium acetate [EMIM][OAc] up to 50% con...

Sophorolipids are a kind of glycolipid-based bio-surfactant, and some known yeasts can produce them by utilizing plant oil at elevated glucose. In spite of a high production yield, sophorolipids have a limited industrial application, due to their narrow range of HLB (hydrophile - lipophile balance) value. These molecules have regained the attention...

The pink-eyed dilution protein (P-protein) plays a critical role in melanin synthesis in melanocytes and retinal pigment epithelium cells. Mutation in this protein may cause complete or partial albinism. Role of the P-protein ranges in melanin synthesis to maturation and trafficking of the melanosomes. The aim of the present study was to evaluate t...

Peanut (Arachis hypogaea L.) is a major species of the family, Leguminosae, and economically important not only for vegetable oil but as a source of proteins, minerals and vitamins. It is widely grown in the semi-arid tropics and plays a role in the world agricultural economy. Peanut production and productivity is constrained by several biotic (ins...

Sugar fatty acid esters are bio-surfactants known for their non-toxic, non-ionic and high biodegradable properties. With great emulsifying and conditioning effects, sugar fatty acids are widely used in food, pharmaceutical and cosmetic industries. Biosynthesis of sugar fatty acid esters has attracted growing attention during the past decades. In th...

Recombination is one of the keys factor in evolutionary processes, involved in shaping the architecture of genomes and consequent phenotype. Understanding the recombination phenomenon especially among viruses will help in disease management. The present study aimed for in-silico analysis of recombination phenomenon among Begomoviruses, particularly...

An adequate knowledge on molecular mechanism of melanogenesis provides an opportunity to find the novel molecular targets for the discovery and development of new cosmetics. Among various genes the OCA2 is being essential for proper melanin synthesis and, mutation or deletion of this gene leads to Oculocutaneous albinism type 2. Thus, for this stud...

Recently, the interest in mimicking functions of chalcogen-based catalytic antioxidants like selenoenzymes, has been increased. Various attempts had been done with selenium, but very few attempts were carried out with tellurium. Bio-complex formation and characterization of tellurium was not tried earlier by using any organism. The present study wa...

Sophorolipids, a kind of glycolipids, regarded as the most promising bio-surfactant, are synthesized by a selected number of yeast species. Instead of offering, as an environmental friendly alternative to the petrochemical based surfactants, it also exhibits various bioactivities. Sophorolipids in particular are on the brink of being incorporated i...

Melanin synthesis is a complex phenomenon which involves about 192 known gene products. Among them, MITF is a key transcription factor for tyrosinase, Trp1 and Trp2 proteins, which are essential for melanin biosynthesis. Thus, intervening inhibitor for the MITF-E-box complex formation can downregulate melanin synthesis. The focus of the present stu...

The microbial intervention for sustainable management of aquaculture, especially use of probiotics, is one of the most popular and practical approaches towards controlling pathogens. Vibrio harveyi is a well-known pathogenic bacterium, which is associated to a huge economic loss in the aquaculture system by causing vibriosis. The present study is c...

The present study was designed for the production and optimization of the C12-C14 sophorolipid, using the yeast Candida bombicola ATCC-22214. The fermentation was carried under fed-batch culture conditions i.e., maintaining 15% coconut oil and 10% glucose as hydrophobic and hydrophilic carbon sources, respectively. A maximum yield 54.0g/L (in 234h)...

Sophorolipids, a kind of glycolipids, regarded as the most promising bio-surfactant, are synthesized by a selected number of yeast species. Instead of offering, as an environmental friendly alternative to the petrochemical based surfactants, it also exhibits various bioactivities. Sophorolipids in particular are on the brink of being incorporated i...

Staphylococcus aureus, a Gram-positive bacterium, can cause a range of illnesses from minor skin infections to life-threatening diseases, such as bacteraemia, endocarditis, meningitis, osteomyelitis, pneumonia, toxic shock syndrome and sepsis. Due to the emergence of antibiotic resistance strains, there is a need to develop of new class of antibiot...

Aspergillus is a leading causative agent for fungal morbidity and mortality in immuno-compromised patients. To identify a putative target to design or identify new antifungal drug, against Aspergillus is required. In our previous work, we have analyzed the various biochemical pathways, and we found Ketol Acid Reducto-Isomerase (KARI) an enzyme invo...

Fucoidan is a complex-sulfated polysaccharide distributed in various marine organisms, and the brown algae are reported as the major producer. The fucoidan is important for their high bioactive properties, like antibacterial, anticoagulant, antiviral, anti-tumor, etc., and many more to be explored. There is a strong archival support for the bioacti...

A total of 49 protein sequences of alkaline proteases retrieved from GenBank representing different species of Aspergillus have been characterized for various physiochemical properties, homology search, multiple sequence alignment, motif, and super family search and phylogenetic tree construction. The sequence level homology was obtained among diff...

An indigenously isolated strain of Aspergillus tubingensisNIICC-08155 from soil of teak dominated vegetation of kusmi forest at Gorakhpur was subjected to neutral protease production and its partial characterization. The maximum production of neutral protease i.e. 68.50 U/ml was attained after 96h of incubation. The crude preparation of protease sh...

Staphylococcus aureus is one of the most important and studied gram positive bacterial strains, which have a greatpotential to infect human beings as well as other mammals. The hospital-acquired methicillin-resistant, vancomycinsusceptiblegram–positive bacteria strain is responsible for much life threatening diseases like Toxic-shock syndrome,staph...