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Introduction
Dr Kodoth is a local investigator for Reveal IFR multi centric study. Moreover he is actively involved with recruitment for renal denervation studies. Please visit https://dr.kodoth.co.uk for his publications
Skills and Expertise
Publications
Publications (30)
Background: Rotational atherectomy (RA) and intravascular lithotripsy (IVL) are well-established technologies for modification of coronary calcification. Given their contrasting mechanisms of action, there has been interest in whether the use of these devices in conjunction could potentially be synergistic and offer improved procedural results. The...
Background:
Excimer laser atherectomy (ELCA) is an established adjunctive technique to facilitate acute success in percutaneous coronary intervention (PCI). Despite this there are a lack of contemporary outcome data, particulary longer-term, forpatients treated with ELCA PCI.
Aims:
To evaluate the contemporary use ofELCA in PCI, the frequency of...
Introduction:
Stent under-expansion due to calcification is associated with a less durable result. The development of intravascular lithotripsy (IVL) has provided clinicians with a readily available, simple-to-use treatment option for coronary calcification, but the use of IVL within a previously stented segment is currently off-license. There are...
Background/purpose
Calcified coronary artery stenosis remains a challenge for Percutaneous Coronary Intervention (PCI). Calcium modification is facilitated by rotablation and is used in 1–3% of cases. Data on rotablation in patients ≥80 years is limited and perceived to be high risk.
We compared PCI with rotablation and outcomes between patients ≥8...
Background
Impaired microcirculatory reperfusion worsens prognosis following acute ST ‐segment–elevation myocardial infarction. In the T‐ TIME (A Trial of Low‐Dose Adjunctive Alteplase During Primary PCI) trial, microvascular obstruction on cardiovascular magnetic resonance imaging did not differ with adjunctive, low‐dose, intracoronary alteplase (...
Background
Impaired microcirculatory reperfusion worsens prognosis post-primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI). Intracoronary (IC) alteplase targets persisting thrombus post-reperfusion & distal embolisation. In the T-TIME trial microvascular obstruction on cardiac magnetic resonance (CMR) di...
Background:
Remote ischaemic conditioning with transient ischaemia and reperfusion applied to the arm has been shown to reduce myocardial infarct size in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). We investigated whether remote ischaemic conditioning could reduce the incid...
This work presents a novel approach to ECG R-peak detection based on the Discrete Wavelet Transform. 18,647 beats were analysed from thirty AF patients who underwent DC cardioversion at Royal Victoria Hospital, Belfast. The efficacy of the R-peak detection algorithm for both normal sinus rhythm and atrial fibrillation beats was assessed using three...
A wireless powered implantable atrial defibrillator consisting of a battery driven hand-held radio frequency (RF) power transmitter (ex vivo) and a passive (battery free) implantable power receiver (in vivo) that enables measurement of the intracardiacimpedance (ICI) during internal atrial defibrillation is reported. The architecture is designed to...
The objective of this study is to assess the efficacy of Discrete Wavelet Transform (DWT) in the removal of power line (50Hz) interference (PLI). Eighteen mains noise corrupted ECG signals were denoised using thirty two different DWT mother wavelets in order to assess which are the top performing for power line interference cancellation. For compar...
Intra-cardiac impedance (ICI) is one of the major determinants of success during internal cardioversion of atrial fibrillation(AF) and is consequently of significant importance in the development of more effective cardioversion therapies. In this study, the voltage and current waveform delivered during internal cardioversion of patients with persis...
Background
Insulation defects resulting in conductor externalization (CE) have been reported in the Riata family of implantable cardioverter defibrillator (ICD) leads (St. Jude Medical, Sylmar, CA, USA). The aim of this study was to identify, prospectively, the rate of CE and outcomes following this, within a group of patients with a Riata ICD lead...
The objective of this study was to assess the efficacy of a novel wavelet based dominant atrial fibril/atory frequency (DAFF) estimation technique on twenty patients who underwent internal cardioversion at Royal Victoria Hospital, Belfast, The results acquired using the wavelet technique were compared against results achieved using a conventional a...
Intracardiac resistance (ICR) is an important determinant of treatment success during internal cardioversion of atrial fibrillation (AF). However, there is limited data on dynamic changes in ICR as a predictor of cardioversion outcome. In this retrospective study, thirty patients with persistent AF were randomised to treatment with a biphasic or mo...
In non-invasive atrial fibrillation (AF) ECG analysis, it is common to remove the QRST complex components by a time-aligned average over several ECG cycles. This paper proposes another alternative using zero-padding of the QRST segments which introduces less illusive high frequency content into the residual signal. The framework of this study follo...
Predicting non-invasively the effectiveness of a shock on Internal Electrical Cardio version (IECV) is clinically relevant to enhance step-up voltage protocols in the treatment of Persistent Atrial Fibrillation (PAF). The present study assess the ability of a non-linear index, such as sample entropy (SampEn), to follow-up noninvasively AF organizat...
In non-invasive analysis of atrial fibrillation (AF), the QRST cancellation is commonly applied by using a time-aligned average over several ECG cycles. This paper proposes another technique with less illusive high frequency content into the residual signal. Firstly the QRS complexes and T-end were detected by Pan-Tompkins's technique and Zhang's a...
Introduction:
Insulation defects with externalized conductors have been reported in the St. Jude Riata(®) family of defibrillation leads (St. Jude Medical, Sylmar, CA, USA). The objective of the Northern Ireland Riata(®) lead screening program was to identify insulation defects and externalized conductors by systematic fluoroscopic and electrical...
Percutaneous coronary interventions for bifurcation lesions were historically associated with reduced procedural success and a higher rate of restenosis. The Cappella Sideguard stent (Cappella Medical Devices Limited, Galway, Ireland) was developed to improve side-branch ostial patency.1 We report a case of Cappella Sideguard stent deformation and...
With the introduction of transcatheter aortic valve implantation (TAVI), the precise role of balloon aortic valvuloplasty (BAV) remains to be established.
Between August 2008 and November 2010, consecutive patients undergoing BAV for severe aortic stenosis (AS) in our center were enrolled. The primary endpoint was survival to hospital discharge. Se...
The major determinants of success during internal cardioversion of atrial fibrillation (AF) are voltage, duration and intracardiac impedance (ICI). However, there is a paucity of published data regarding evidence of ICI dynamics during internal cardioversion of AF using very-low-tilt rectilinear (VLTR) waveforms with stepped energy protocols. In th...
Introduction:
A novel atrial defibrillator was developed at the Royal Victoria Hospital in collaboration with the Nanotechnology and Integrated Bio-Engineering Centre, University of Ulster. This device is powered by an external pulse of radiofrequency energy and designed to cardiovert using low-tilt monophasic waveform (LTMW) and low-tilt biphasic...
To address concerns of late and very late stent thrombosis associated with first generation drug-eluting stent technology, novel approaches are being tested including stents with bioabsorbable polymers (including Biomatrix Flex™, Nobori™ and Synergy™), polymer-free drug delivery systems (including Biofreedom™ and Yukon®) and drug-eluting balloons (...
