Vittorio Sansalone

Université Paris-Est Créteil Val de Marne - Université Paris 12 | UPEC · Modélisation et Simulation Multi-Echelle (MSME) - UMR 8208 CNRS

The mechanical quality of trabecular bone is influenced by its mineral content and spatial distribution, which is controlled by bone remodelling and mineralisation. Mineralisation kinetics occur in two phases: a fast primary mineralisation and a secondary mineralisation that can last from several months to years. Variations in bone turnover and min...

We present a computational framework for the study of cardiac motion. The bio-mechanical model captures the passive and active properties of the cardiac tissue as well as the fiber architecture. We focus on the analysis of deformations of a beating left ventricle (LV), comparing numerical simulations with real data acquired by echocardiography. The...

Numerical simulation of long-term orthodontic tooth movement based on Finite Element Analysis (FEA) could help clinicians to plan more efficient and mechanically sound treatments. However, most of FEA studies assume idealized loading conditions and lack experimental calibration or validation. The goal of this paper is to propose a novel clinical pr...

In recent years the interest in the realization of green wood plastic composites (GWPC) materials has increased due to the necessity of reducing the proliferation of synthetic plastics. In this work, we study a specific class of GWPCs from its synthesis to the characterization of its mechanical properties. These properties are related to the underl...

In the past few decades, numerous studies have attempted to address the various phenomena that take place simultaneously during bone remodeling. Drawing from Frost’s “mechanostat theory,” multiple phenomenological models of varying complexity have been developed to describe bone remodeling in terms of evolution of bone porosity, tissue properties,...

Numerical simulation of long term orthodontic tooth movement could help clinicians to plan more efficient and mechanically sound treatments (Burstone 2015). It remains a challenge and no prospective model exists yet. Finite element analysis (FEA) has been used by several authors to perform such simulations, but these studies usually lack of experim...

Introduction: Simulation of long-term orthodontic tooth movement could help clinicians to plan more efficient and mechanically sound treatments. Finite element modeling (FEM) has been used by several authors to perform such numeric simulations, but these studies usually lack of proper experimental calibration or validation. Objectives: The objectiv...

Osteoporosis (OP) is considered as a major health burden worldwide. OP drug treatments aim at reducing the augmented risk of bone fracture caused by OP-induced loss of bone mass and increased bone matrix brittleness. The development of bone biomarkers over the past decades improved the understanding of the pathophysiology of OP, providing indicator...

Bone remodeling is a highly complex biological process allowing bone tissue to evolve throughout life. While this continuous change involves various events at the microscopic scale, macroscopic observations show a correlation between bone architecture and in vivo loading conditions. In particular, the orientation of bone microstructure, also referr...

This paper introduces a theoretical framework for the study of the efficacy of romosozumab, a humanized monoclonal antibody targeting sclerostin for the treatment of osteoporosis. We developed a comprehensive mechanistic pharmacokinetic-pharmacodynamic (PK-PD) model of the effect of drug treatment on bone remodeling in postmenopausal osteoporosis (...

Significant progress has been made to identify the cells and signaling molecules involved in the mechanobiological regulation of bone remodeling. It is now well accepted that osteocytes act as mechanosensory cells in bone expressing several signaling molecules such as nitric oxide (NO) and sclerostin (Scl) which are able to control bone remodeling...

The controversy between passive and active ventricular filling has been debated for decades and the question about the existence of an active diastole remains open. In this work, we advocate the model of active diastole by considering the heart as a suction pump and we add some more clues to support this point of view by the analysis of the pressur...

This paper aims at assessing the influence of the bone ornamentation and, specifically, the associated loss of bone mass on the mechanical response of the crocodylomorph osteoderms. To this end, we have performed three-dimensional (3D) modeling and a finite element analysis on a sample that includes both extant dry bones and well-preserved fossils...

In this paper, we present and discuss a model of bone remodeling set up in the framework of the theory of generalized continuum mechanics which was first introduced by DiCarlo et al. [Sur le remodelage des tissus osseux anisotropes, Comptes Rendus Mécanique 334(11):651–661, 2006]. Bone is described as an orthotropic body experiencing remodeling as...

In this paper, green biocomposites based on poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBHV) and Miscanthus giganteus fibers (MIS) were prepared in the presence of dicumyl peroxide (DCP) via reactive extrusion. The objective of this study was to optimize the interfacial adhesion between the reinforcement and the matrix, improving the mechanical...

Reliability of multiscale models of bone is related to the accuracy of the experimental information available on bone microstructure. X-ray-based imaging techniques allow to inspect bone structure and mineralization in vitro at the micrometre scale. However, spatial resolution achievable in vivo is much coarser and can produce blurry, uncertain inf...

In previous work, we proposed a stochastic model to describe the elasticity of bone matrix (so-called ultrastructure, US) based on basic statistical information on the tissue mineral density (TMD). This information was obtained by analyzing high-resolution images of a human femoral neck realized by means of synchrotron radiation micro-computed tomo...

We propose an extension of Biot’s poroelasticity that allows for absorption of the permeating fluid from the channeling pores into the solid skeleton.We frame our theory in a non-conventional virtual power format, where a key role is played by compatibility of test velocities with mass balance, no matter whether mass exchanges between interstitial...

In order to assess the implication of the crocodylomorph ornamented osteoderms on the skin conduction during basking, we have performed three dimensional modeling and finite element analyses on a sample which includes both extant dry bones and well-preserved fossils tracing back to the Early Jurassic. In purpose to reveal the possible implication o...

The aim of this work was to model tooth movement in a more clinically-exact fashion, thanks to the use of new IT tools and imaging systems (cone-beam). Image segmentation and 3D reconstruction now enable us to model the anatomy realistically, while finite element (FE) analysis makes it possible to evaluate stresses and their distribution on the lev...

Résumé L’objectif de cette étude est de développer un modèle de déplacement dentaire, plus fidèle à la clinique, à partir des nouveaux outils radiologiques (Cone Beam) et informatiques. La segmentation d’image et la reconstruction tridimensionnelle nous permettent de modéliser l’anatomie réelle, l’analyse par éléments finis (EF) d’évaluer les contr...

We have developed two techniques for chemical modification of plant fibers: a method using the esterification reactions between the hydroxyl functions of cellulose and the acid chloride functions of oligoesters, or transesterification reaction. This process has been optimized to provide solvent-free and catalyst-free reactions. The second technique...

Stem cell “mechanomics” refers to the effect of mechanical cues on stem cell and matrix biology, where cell shape and fate are intrinsic manifestations of form and function. Before specialization, the stem cell itself serves as a sensor and actuator; its structure emerges from its local mechanical milieu as the cell adapts over time. Coupling of no...

The fast thiol-ene reaction between the unsaturated groups of the Miscanthus fibers, MIS, and poly(mercaptopropyl)methylsiloxane, PMMS, was activated in the presence of a photoinitiator. The evidence of the grafting was studied by energy-dispersive X-ray (EDX), X-ray photoelectron spectrometry (XPS), and FTIR-ATR spectroscopy. Then, grafting of pol...

Bone tissue can adapt its properties and geometry to its physical environment. This ability is a key point in the osteointegration of bone implants since it controls the tissue remodeling in the vicinity of the treated site. Since interstitial fluid and ionic transport taking place in the fluid compartments of bone plays a major role in the mechano...

Accurate and reliable assessment of bone quality requires predictive methods which could probe bone microstructure and provide information on bone mechanical properties. Multiscale modelling and simulation represent a fast and powerful way to predict bone mechanical properties based on experimental information on bone microstructure as obtained thr...

We present a mechanical model— a growing spherical shell—suitable for predicting the evolution of a Saccular Cerebral Artery Aneurysms (SCAA). It relies basically on the Kröner-Lee decomposition, used to describe the interplay between the current and the relaxed configuration of body elements. Rupture or stabilization of a SCAA are the end effect o...

Les propriétés mécaniques du tissu osseux dépendent de sa structure hiérarchisée, de l'échelle de l'organe à celle de ses constituants élémentaires (nano-échelle). En se basant sur la connaissance de la morphologie, de l'organisation et des propriétés mécaniques de ces derniers, des modèles multi-échelles permettent d'estimer les propriétés mécaniq...

Interstitial fluid within bone tissue is known to govern the remodelling signals' expression. Bone fluid flow is generated by skeleton deformation during the daily activities. Due to the presence of charged surfaces in the bone porous matrix, the electrochemical phenomena occurring in the vicinity of mechanosensitive bone cells, the osteocytes, are...

Assessing bone quality is crucial to to assist physicians in diagnostics and decision making processes, and to predict the outcome of orthopedic treatments. Bone quality is related to bone mineralization and micro-architecture. The aim of this study was to investigate the spatial variations of the tissue mineral density (TMD) and of the Haversian p...

Canalicular fluid flow is acknowledged to play a major role in bone functioning, allowing bone cells' metabolism and activity and providing an efficient way for cell-to-cell communication. Bone canaliculi are small canals running through the bone solid matrix, hosting osteocyte's dendrites and saturated by an interstitial fluid rich in ions. Becaus...

This paper investigates the effects of the heterogeneous distribution of the Haversian Porosity (HP) and Tissue Mineral Density (TMD) on the elastic coefficients of bone in the human femoral neck. A bone specimen from the inferior femoral neck was obtained from a patient undergoing standard hemiarthroplasty. The specimen was imaged using 3-D synchr...

Canalicular fluid flow is acknowledged to play a major role in bone functioning, allowing bone cells' metabolism and activity and providing an efficient way for cell-to-cell communication. Bone canaliculi are small canals running through the bone solid matrix, hosting osteocyte's dendrites, and saturated by an interstitial fluid rich in ions. Becau...

Mechanical properties of bone tissue result from its hierarchical structure. At the scale of several micrometers, the relevant structure is the bone fibril. Bone fibril is mainly composed of collagen, mineral, and water. Exact composition and arrangement of these constituents are hardly available through nowadays experimental techniques. In this pa...

Bone reacts to local mechanical environment by adapting its structure. Bone is also a key source of calcium for the body homeostasis. Osteocytes, cells located within the bone tissue, are thought to play a major role in sensing mechanical signals and regulating bone remodeling. Interestingly, osteocytes were also shown to directly participate in th...

Osteoporotic hip fractures represent a major public health problem associated with high human and economic costs. The anatomical variation of the tissue mineral density (TMD) and of the elastic constants in femoral neck cortical bone specimens is an important determinant of bone fragility. The purpose of this study was to show that a Synchrotron ra...

Cortical bone, constituting the outer shell of long bones, is continuously renewed by bone cells in response to daily stimuli. This process, known as bone remodelling, is essential for proper bone functioning in both physiological and pathological conditions. Classical bone remodelling models do not, or only implicitly do, take into account physico...

This paper presents a theoretical investigation of the multiphysical phenomena that govern cortical bone behaviour. Taking into account the piezoelectricity of the collagen-apatite matrix and the electrokinetics governing the interstitial fluid movement, we adopt a multiscale approach to derive a coupled poroelastic model of cortical tissue. Follow...

Les propriétés mécaniques du tissu osseux sont dues à sa structure hiérarchique. À l’échelle de quelques micromètres, la structure que l’on peut observer est la fibrille de collagène minéralisée. Dans ce travail, nous présentons un modèle mécanique multi-échelle de la fibrille basé sur une technique d’homogénéisation variationnelle. Des simulations...

In this study, a multiscale model of interstitial fluid transport within bone tissues is proposed. Based on an asymptotic homogenization procedure, it takes into account the possible ionic exchanges at the pore level. Since these chemical reactions directly change the physico-chemical properties of the tissues, the macroscopically observed flow is...

This paper presents a one-dimensional model describing the ultrasonic wave propagation in a poroelastic medium immersed in fluid. Motivation of this study arises from simulating the in vitro transverse transmission test on cancellous bone. Biot’s theory is used for modeling the porous bone tissue. The solution is obtained by using the Laplace trans...

Cortical bone is a multiscale composite material. Its elastic properties are anisotropic and heterogeneous across its cross-section, due to endosteal bone resorption which might affect bone strength. The aim of this paper was to describe a homogenization method leading to the estimation of the variation of the elastic coefficients across the bone c...

Cancellous bone at the macroscopic level is known as being a two-phase anisotropic material composed of a solid rod-like or plate-like skeleton filled with viscous fluid. Quantifying the mechanical properties of cancellous bones by using ultrasound techniques should take into account these complexities. This paper proposes a model to investigate th...

In this study, a multiphysical description of fluid transport through osteo-articular porous media is presented. Adapted from the model of Moyne and Murad, which is intended to describe clayey materials behaviour, this multiscale modelling allows for the derivation of the macroscopic response of the tissue from microscopical information. First the...

The importance of a multiscale modeling to describe the behavior of materials with microstructure is commonly recognized. In general, at the different scales the material may be described by means of different models. In this paper we focus on a specific class of materials for which it is possible to identify (at the least) two relevant scales a ma...

A two-step orthodontic treatment of an included canine is presented. Tooth movement is induced by orthodontic appliances through the stress induced remodeling of the alveolar bone. Finite element method was used to analyze the stress patterns within the different tissues, thus allowing a better understanding of the mechanisms responsible for bone r...