Vitor C M Neves

King's College London | KCL · Centre for Craniofacial and Regenerative Biology

Este livro descreve os conceitos e técnicas mais utilizados no âmbito da Odontologia Regenerativa. Ele foi delineado pensando-se em, didaticamente, separar as principais especialidades da Odontologia em capítulos, dando-se ênfase ao uso da terapia celular em cada uma delas. O livro é rico em esquemas ilustrativos que facilitam o entendimento do le...

Oral diseases such as dental caries (DC) and periodontitis are widely prevalent, and existing approaches to managing these conditions have only a limited effect. Accordingly, there is growing interest in the development of novel biological interventions (including, among others, CRISPR-Cas9) that might, in the future, be used to prevent the develop...

Innovation has always been part of dentistry and with that comes thinking outside the box to produce guidelines for implementation of new approaches. Regenerative dentistry (RD) is a young specialty within the profession, which gathers knowledge from stem cells, molecular biology, and tissue and material engineering to produce and apply novel biolo...

The interaction between immune cells and stem cells is important during tissue repair. Macrophages have been described as being crucial for limb regeneration and in certain circumstances have been shown to affect stem cell differentiation in vivo. Dentine is susceptible to damage as a result of caries, pulp infection and inflammation all of which a...

Understanding cell types and mechanisms of dental growth is essential for reconstruction and engineering of teeth. Therefore, we investigated cellular composition of growing and non-growing mouse and human teeth. As a result, we report an unappreciated cellular complexity of the continuously-growing mouse incisor, which suggests a coherent model of...

Despite the major improvements in clinical dentistry, resulting from dental science efforts to shape current clinical dentistry, it has been almost forty years since a new therapy has reached dental practice. The focused scientific effort on evolving dental materials and equipment to facilitate their use has overshadowed the most important aim for...

Purpose of Review Current dental treatments are based on conservative approaches, using inorganic materials and appliances. This report explores and discusses the newest achievements in the field of “regenerative dentistry,” based on the concept of biological repair as an alternative to the current conservative approach. Recent Findings The review...

During the treatment of dental caries that has not penetrated the tooth pulp, maintenance of as much unaffected dentine as possible is a major goal during the physical removal of decayed mineral. Damage to dentine leads to release of fossilized factors (transforming growth factor–β [TGF-β] and bone morphogenic protein [BMP]) in the dentine that are...

In non-growing teeth, such as mouse and human molars, primary odontoblasts are long-lived post-mitotic cells that secrete dentine throughout the life of the tooth. New odontoblast-like cells are only produced in response to a damage or trauma. Little is known about the molecular events that initiate mesenchymal stem cells to proliferate and differe...

The restoration of dentine lost in deep caries lesions in teeth is a routine and common treatment that involves the use of inorganic cements based on calcium or silicon-based mineral aggregates. Such cements remain in the tooth and fail to degrade and thus normal mineral volume is never completely restored. Here we describe a novel, biological appr...