Vito Di Maio

Vito Di Maio
Italian National Research Council | CNR · Institute of Applied Sciences and Intelligent Systems

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About

87
Publications
15,601
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465
Citations
Introduction
Study of information transfer and elaboration by synaptic transmission. The study is essentially carried by using computer simulation and modelling. The diffusion of neurotransmitter is simulated in the femtoseconds time scale while the postsynaptic response in the microseconds time scale. The main attention is actually on the glutamatergic synapse and the dendritic integration of the synaptic activity in the posts synaptic spike generation. The attempt is to identify, if exist, a synaptic code corresponding to the presynaptic neuronal code and to study how this code contributes to the generation of the postsynaptic neural code.
Additional affiliations
May 2015 - present
Italian National Research Council
Position
  • Researcher
November 2001 - June 2002
Università degli Studi della Basilicata
Position
  • Contract Professor
Description
  • Teaching "Probability and Mathematical Statistics"
December 1986 - May 2015
Italian National Research Council
Position
  • Researcher
Education
November 1975 - June 1982

Publications

Publications (87)
Book
Full-text available
The book gives a large view on the Covid-19 pandemic. Then the analysis is focused on Italy and a basic evaluation of Italian resilience is discussed.
Book
https://www.ilsileno.it/edizioni/ebooks/ This work adopts the concept of resilience and its attributes (safety, robustness, adaptive capacity, sustainability, governance, and anamnesis) developed in a previous work (Indirli, 2019) to analyze the COVID-19 pandemic, with specific reference to Italy during the first phase, from January to June 2020. T...
Article
Full-text available
Being the most abundant synaptic type, the glutamatergic synapse is responsible for the larger part of the brain’s information processing. Despite the conceptual simplicity of the basic mechanism of synaptic transmission, the glutamatergic synapse shows a large variation in the response to the presynaptic release of the neurotransmitter. This varia...
Article
Full-text available
Synaptic transmission is the key system for the information transfer and elaboration among neurons. Nevertheless, a synapse is not a standing alone structure but it is a part of a population of synapses inputting the information from several neurons on a specific area of the dendritic tree of a single neuron. This population consists of excitatory...
Preprint
Full-text available
The brain is a very powerful information processing machine, and synaptic transmission is the elementary mean by which neurons communicate and hence the way they exchange and process information contributing, at different levels, to the brain activity. Synapses are not only the foundation of brain information management; they also have the ability...
Chapter
Full-text available
The brain is probably the most complex machinery for information processing we can imagine. The amount of data it manages is extremely huge. Any conscious or unconscious event both internal and coming from the environment needs to be perceived, elaborated, and responded with an appropriate action. Moreover, the high-level activities of mind require...
Article
Full-text available
The brain is the most powerful computational machine composed of a huge set of processors (neurons), each connected with many others (networks), which is able to perform, in real time, a real multitasking job by billions of operations. The transmission of information which need elaboration and computation is operated mostly by the synapses which ar...
Book
This book is the collection of the research topic made for Computational Neuroscience and having the same title
Article
Full-text available
The main function of the brain is to process and integrate information coming from the environment and from other parts of the body and produce appropriate responses.This information processing capability is mimicked in neurons in which dendritic arborization integrates information from thousands of synapses, both excitatory and inhibitory. The mai...
Article
For 50 days freely available at : https://authors.elsevier.com/a/1XGOW1aPVQggz The activity of thousands of excitatory synapse in the dendritic tree produces variations of membrane potential which, while can produce the spike generation at soma (hillock), can also influence the output of a single glutamatergic synapse. We used a model of synaptic...
Article
The activity of the single synapse is the base of information processing and transmission in the brain as well as of important phenomena as the Long Term Potentiation which is the main mechanism for learning and memory. Although usually considered as independent events, the single quantum release gives variable postsynaptic responses which not only...
Poster
Full-text available
TB cells are a human neuroectodermal cell line able to morphologically differentiate towards a neuronal-like phenotype if cultured in presence of retinoic acid (RA) 10 µM. These cells were isolated from the cerebrospinal fluid (CSF) specimen of a patient with clinical diagnosis of primary leptomeningeal melanomatosis and characterized by immunologi...
Article
Full-text available
Synaptic transmission is the basic mechanism of information transfer between neurons not only in the brain, but along all the nervous system. In this review we will briefly summarize some of the main parameters that produce stochastic variability in the synaptic response. This variability produces different effects on important brain phenomena, lik...
Poster
Introduction We report the basic electrophysiological features of a novel human cell line, designated as TB, derived from the cerebrospinal fluid (CSF) of a patient with clinical diagnosis of primary leptomeningeal melanomatosis. These cells were previously isolated and characterized with an immunological and ultrastructural analysis [1]. TB cells...
Poster
Full-text available
Introduction We report the basic electrophysiological features of a novel human cell line, designated as TB, derived from the cerebrospinal fluid (CSF) of a patient with clinical diagnosis of primary leptomeningeal melanomatosis. These cells were previously isolated and characterized with an immunological and ultrastructural analysis [1]. TB cells...
Poster
Full-text available
We report the basic electrophysiological features of a novel human cell line, designated as TB, derived from the cerebrospinal fluid (CSF) of a patient with clinical diagnosis of primary leptomeningeal melanomatosis. These cells were previously isolated and characterized with an immunological and ultrastructural analysis [1]. TB cells have neuroect...
Article
Full-text available
Coexistence of AMPA and NMDA receptors in glutamatergic synapses leads to a cooperative effect that can be very complex. This effect is dependent on many param- eters including the relative and absolute number of the two types of receptors and biophysical parameters that can vary among synapses of the same cell. Herein we simulate the AMPA/NMDA coo...
Article
Full-text available
Glutamatergic synapses play a pivotal role in brain excitation. The synaptic response is mediated by the activity of two receptor types (AMPA and NMDA). In the present paper we propose a model of glutamatergic synaptic activity where the fast current generated by the AMPA conductance produces a local depolarization which activates the voltage- and...
Technical Report
Full-text available
Basic electrophysiological properties of a novel human neuroectodermal cell line have been established by using the whole cell patch clamp technique. The resting potential and the responses to different protocol stimuli have been recorded both in voltage and current clamp configuration. The functional changes induced by retinoic acid have been anal...
Article
Spiny neurons of striatum receive glutamatergic synapses on dendritic spines on the neck of which project dopaminergic synapses. Dopamine modulates, by D1 type receptors, the glutamatergic synapses by inducing the phosphorylation of AMPA and NMDA receptors which produces an increased amplitude response. Herein we present a model where, in addition...
Conference Paper
Full-text available
The single synaptic event has been analyzed considering two possible source of stochastic noise. The single event has been added with a sinusoid noise which resembles the invasion of retrograde spike into the dendritic domain where the excitatory synapse is located. A Gaussian noise has been used to reproduce the stochastic effect of all other syna...
Article
The Dopamine neurotransmitter regulates important neural pathways and its action in the brain is very complex. When dopaminergic neurons make synapses on spiny neurons of the striatum nucleus, they tune the responsiveness of glutamatergic synapses by means of the dopamine D1 and D2 receptors. We studied the effect of dopamine D1 receptors on gluta...
Article
The Dopamine neurotransmitter regulates important neural pathways and its action in the brain is very complex. When dopaminergic neurons make synapses on spiny neurons of the striatum nucleus, they tune the responsiveness of glutamatergic synapses by means of the dopamine D1 and D2 receptors. We studied the effect of dopamine D1 receptors on glutam...
Article
Full-text available
The basic electrophysiological properties of SH-SY5Y tumour cells have been studied by whole cell patch-clamp in voltage clamp configuration. The results shown the existence of a large variability of the response among individual cells in the same experimental conditions. Experiments conducted by using different ionic concentrations of the recordin...
Article
full text for limited time (31st/01/2014) at http://elsarticle.com/18AC0uW Over the last several years we have investigated the excitatory synaptic response by means of a mathematical model based on a detailed description of the synapse geometry, the Brownian motion of Glutamate molecules and their binding to postsynaptic receptors. Recently, the b...
Article
Mathematical models of the excitatory synapse are providing valuable information about the synaptic response. The effects of several synaptic components on EPSC variability have been tested by computer simulation. Our model, based on Brownian diffusion of glutamate in the synaptic cleft, is basically the same we have used in previous papers but par...
Article
Full-text available
The interaction among synapses on dendritic tree of pyramidal neurons, combined with the variability of dendritic passive membrane properties, produces a complex system which regulates both the transfer of information among neurons and between different dendritic areas of the same neuron. A non linear mechanism, based on the excitatory reversal pot...
Article
Full-text available
The largest part of information passed among neurons in the brain occurs by the means of chemical synapses connecting the axons of presynaptic neurons to the dendritic tree of the postsynaptic ones. In the present paper, the most relevant open problems related to the mechanisms of control of the information passing among neurons by synaptic transmi...
Conference Paper
Full-text available
A neuron in the Central Nervous System receives thousands of synaptic inputs arriving both from close and long distance neurons. Synaptic activity modulates the electrical potential of the neuronal membrane producing an output which is regulated by a threshold mechanism. The crossing of the threshold produces a sequence of spikes which, very likely...
Article
The highly irregular firing of mammalian cortical pyramidal neurons is one of the most striking observation of the brain activity. This result affects greatly the discussion on the neural code, i.e. how the brain codes information transmitted along the different cortical stages. In fact it seems to be in favor of one of the two main hypotheses abou...
Conference Paper
Full-text available
The problem of the code used by brain to transmit information along the different cortical stages is yet unsolved. Two main hypotheses named the rate code and the temporal code have had more attention, even though the highly irregular firing of the cortical pyramidal neurons seems to be more consistent with the first hypothesis. In the present arti...
Article
Previous investigations have shown that presubicular commissural fibers traveling in the caudal part of the dorsal hippocampal commissure (PSD) selectively activated the dorsalmost portion of the entorhinal cortex (EC), where they discharged perforant path neurons to the dorsal dentate gyrus. The dentate activation was followed by that of the dorsa...
Book
Full-text available
Preface The 1st International Symposium on “Brain, Vision & Artificial intelligence” (BVAI, Naples, Italy, October 19–21, 2005) was a multidisciplinary symposium aimed at gathering scientists involved in study of the Brain, Vision and Intelli- gence, from both the natural and artificial points of view. The underlying idea was that to advance in eac...
Article
Full-text available
Different variants of stochastic leaky integrate-and-fire model for the membrane depolarisation of neurons are investigated. The model is driven by a constant input and equidistant pulses of fixed amplitude. These two types of signal are considered under the influence of three types of noise: white noise, jitter on interpulse distance, and noise in...
Article
The postsynaptic response in glutamatergic synapses of hippocampus, produced by the release of a single presynaptic vesicle, shows a large variability in amplitude not only among the synapses, but also for a single synapse. A mathematical modelling based on a Brownian motion for the diffusion of glutamate molecules and receptor binding was applied...
Article
Full-text available
A neural network with mutual excitatory connections and external stimulation is investigated. The units of the network are Morris–Lecar neurons. The synaptic transmission is described at the vesicular level. Random number of activated vesicles at synaptic contacts and random quanta of released transmitter are considered. These fluctuations are appl...
Article
Full-text available
The rising phase of fast, AMPA-mediated Excitatory Post Synaptic Currents (EPSCs) has a primary role in the computational ability of neurons. The structure and radial expansion velocity of the fusion pore between the vesicle and the presynaptic membrane could be important factors in determining the time course of the EPSC. We have used a Brownian s...
Article
Full-text available
Electrophysiological recordings of extracellular neuronal activity often produce complex patterns caused both by the simultaneous firing of many neurons in the proximity of the recording electrode and by the superimposition of biological and instrumental noise onto the neuronal signals. This pattern complexity requires a fast evaluation of the clas...
Article
The peak amplitudes of the quantal Excitatory Post Synaptic Currents in single hippocampal synapses show a large variability. Here, we present the results of a mathematical, computational investigation on the main sources of this variability. A detailed description of the synaptic cleft, rigorously based on empirically-derived parameters, was used....
Article
We simulated the diffusion of glutamate, following the release of a single vesicle from a pre-synaptic terminal, in the synaptic cleft by using a Brownian diffusion model based on Langevin equations. The synaptic concentration time course and the time course of quantal excitatory post-synaptic current have been analyzed. The results showed that the...
Article
Full-text available
To gain a better understanding of the elementary unit of synaptic communication between hippocampal neurons, we simulated the release of glutamate from a single pre-synaptic vesicle and its diffusion into the synaptic cleft. Diffusion of glutamate was simulated by a Brownian model based on Langevin equations. The model was implemented for parallel...
Article
Full-text available
The Müller-Lyer patterns formed by separate dots have been used as stimuli in an experiment on visual perception to assess the influence of the number of dots composing the figures on the magnitude of the illusion. As predicted by our model, based on the Image Function theory, an increase was noted in the magnitude of illusion when the number of do...
Article
Full-text available
Filtering of the input image has been shown to play a central role in several aspects of visual perception. In our experiments in visual perception of the area of geometrical figures the orientation in random dot patterns, and some visual illusions, we have shown that a threshold effect inferred from the filtering of the input image produces a perc...
Article
Full-text available
The visual perception of area of geometrical figures was compared for subjects of high and low hypnotizability in experiments with direct comparison of two different geometrical figures. The Stanford Hypnotic Susceptibility Scale (Form C) was used to assess subjects' hypnotizability. No differences between 17 highly hypnotizable and 10 low hypnotiz...
Article
The area perception of incomplete (interpolated) geometric figures is studied. The obtained data are discussed in order to compare them with the results of our previous experiments where complete figures were studied. The results of the present experiment support the validity of the model of area perception that is based on the concept of image fun...
Article
A computerized approach to study the visual perception of rectangles and squares is proposed. A program has been used for comparison of these two figures when one of them is fixed in size while the other is varied actively by a subject to match the area of the fixed one. The final errors on area and on perimeter made by the subject are computed for...
Article
A psychophysical experiment was performed to measure the ability of human observers to compare the areas of two geometrical figures (squares and rectangles). The results show a systematic overestimation of rectangle area with respect to that of the squares. A formal model of area perception and its consequent estimation is proposed, which is based...
Article
The perception of the orientation of random-dot patterns was studied using four different matching tasks. Homogeneous, elongated patterns and patterns containing Moiré effects were used. One of the tasks implied linear extrapolation and two others implied linear interpolation of the matching line. The fourth task was identical with those used in pr...
Article
Full-text available
The results of experiments on visual perception of area of circles and squares are reported. Pairs of geometrical figures were presented simultaneously on an oscilloscope screen. While one of them was fixed, the other one was controlled by an experimental subject. The task of the subject was to match the area of the variable figure to the area of t...
Article
Full-text available
To establish whether thyroid hormone modifies the heart rate directly or through an action on other neuroendocrine modulators, the authors have examined several animals models differing in the plasma levels of such compounds. Induction of the hypothyroid state in rats produced a slow onset of bradycardia, which may be removed by a prolonged triiodo...
Article
Full-text available
The aim of the present study is to ascertain whether transmembrane temperature gradients couple with transport of electric charge in living cells of Valonia utricularis and eventually measure the thermodynamic coupling coefficient (s). Simple experimental procedures are described that allow generation of temperature gradients of predetermined sense...
Article
Full-text available
The aim of the present study is to ascertain whether transmembrane temperature gradients couple with transport of electric charge in living cells ofValonia utricularis and eventually measure the thermodynamic coupling coefficient (s). Simple experimental procedures are described that allow generation of temperature gradients of predetermined sense...
Article
Full-text available
The effects of the thyroid hormone on the number and protein content of mitochondria were investigated in rat heart. The specific mitochondrial population, determined by direct counting, was estimated to be about 3.7 X 10(11) mitochondria per g wet weight in young hypothyroid male rats (T) and about 2.4 X 10(11) (65%) in euthyroid animals, sex- and...
Chapter
Hydra is photosensitive, although missing known organized photorece- ptive cellular structures. Its contraction-relaxation activity is periodic. Short or long wavelength visible light has opposite effects (respectively long/short main contraction-relaxation period during steady stimulation, low/ high efficiency in interrupting a contraction in prog...