Vishwanath Tantry

KMC Hospital · Department of Gastroenterology

Context: Radiology and pathology are pivotal tools in the investigational artillery for management of wide spectrum of hepatic lesions and early detection is of a paramount importance. Aims: The study aimed at analyzing the efficacy, comparative yield and validity of image-guided aspiration cytology (FNA)/core biopsy (CB) in focal hepatic lesion...

Background Azathioprine (AZA) is most commonly used drug worldwide for maintenance therapy in moderately severe ulcerative colitis (UC) patients even in today’s biologicals era. We aimed to investigate mucosal healing (MH) and deep remission rate in patients with UC on long-term AZA therapy. Methods The study included UC patients presenting to KMC...

Background Cultural, local dietary and social factors, the frequency of malignancy in the population studied are known to affect the epedimiology of dyspepsia. Clinical features are highly unreliable in determining the aetiology of dyspepsia. Alarm features are known to help in identifying underlying malignancy in patients with dyspepsia. However,...

Background: Loss of heterozygosity of p53 along with aneuploidy is deemed to be the early molecular steps in Barrett metaplasia-dysplasia-adenocarcinoma sequence. Objective biomarkers need to be used along with microscopy for risk stratification to predict the progression of Barrett esophagus (BE) to carcinoma. Aim: This study aims to study p53...

Background The incidence of and mortality from colorectal cancers (CRC) can be reduced by early detection. Currently there is a lack of established markers to detect early neoplastic changes. We aimed to identify the copy number variations (CNVs) and the associated genes which could be potential markers for the detection of neoplasia in both ulcera...

Penicillamine-induced lung injury has been sparsely reported in the literature. We report one such case with its wide-ranging ramifications. We present an unusual case of drug induced-interstitial lung disease (DI-ILD) caused by penicillamine, resulting in acute lung injury in a young patient with Wilson’s liver disease. Patient had a interstial lu...

Hepatic epithelioid hemangioendothelioma, is a rare vascular tumor of undetermined malignant potential. Clinical symptoms and signs are nonspecific, and the diagnosis may be easily missed. We report a case of 23 - year - old female who presented with right upper quadrant abdominal pain. Ultrasonography of the abdomen showed multiple discrete nodule...

Acute cholangitis is inflammation of biliary ductal system from infection with an associated biliary obstruction. This retrospective study was done to determine the factors responsible for cholangitis and the microbiological profile of the bile in patients with cholangitis. In the study involving 348 patients, 36.4% had associated malignancy. A tot...

Crohn's disease (CD) can often present initially with extraintestinal manifestations and/or perianal disease. Cytology of such a lesion helps arrive at the diagnosis. A 27-year-old woman presented with recurrent, painful, discharging perianal lesions. On examination, multiple perianal abscesses, sinuses, skin tags and healed scars were noted. Fine...

Pseudomembranous colitis in association with pregnancy has not been well described in English literature. Recent studies show a drastic increase in the incidence and severity of Pseudomembranous colitis in pregnant women, who were once thought to be at low risk. We report here a case of Pseudomembranous colitis in a young healthy immunocompetent pr...

Solitary rectal ulcer syndrome is a rare disorder of childhood and usually goes unrecognised or misdiagnosed because it can mimic various other rectal entities. Here a 9-year old boy presented with bleeding per rectum and altered bowel habits. Colonoscopy revealed multiple ulcers which on histopathological examination showed features of SRUS with s...

Though emotional factors are known to influence gut functions, studies evaluating the role of anxiety and personality in non-ulcer dyspepsia (NUD) are few and have not yielded consistent results. To find out whether anxiety and abnormal personality pattern are specifically associated with NUD. 33 patients with NUD and 30 patients with duodenal ulce...

Systematic studies of psychiatric disorders in non -ulcer dyspepsia are rare. The aim of the present study was to find out the nature and prevalence of psychiatric morbidity in non-ulcer dyspepsia. Thirty three patients with non-ulcer dyspepsia and thirty with duodenal ulcer were assessed for psychiatric morbidity with the help of the regular versi...

Pneumatic dilatation was effective in relieving dysphagia in 16/17 subjects with achalasia cardia. It was also effective and safe in those with sigmoid oesophagus, although dilatation persisted in them. Recurrences were noted in one quarter of cases which were managed satisfactorily with subsequent dilatations. There were no complications. Pneumati...

The reported incidence of post sclerotherapy esophageal ulcers has shown marked variation, possibly due to lack of uniform criteria for their diagnosis. Using fixed criteria (size greater than or equal to 5 mm, duration greater than or equal to 2 weeks), we prospectively studied 82 patients with portal hypertension, who underwent four or more sessi...

Seven patients with uncomplicated hepatic hydatid cysts (Echinococcus granulosus) were treated with albendazole 10 mg/kg/day for 2-6 months (mean 4 months). Serial sonographic evaluation showed reduction in cyst size in only 1 patient (the anteroposterior diameter decreased from 16.5 cm to 4.9 cm). Therapy in this patient was discontinued after 4 m...

Summary Among 3,501 individuals receiving endoscopic examination for the upper digestive tract, 41 were found to have esophageal candidiasis including 17 malignancies, 14 immunological disorders, 4 diabetes mellitus, 7 other underlying diseases and 7 apparently healthy sujbects. The diagnosis was made either by brushing of the esophagus or by histo...

Leukocyte adherence inhibition (LAI) has been demonstrated to be a simple, rapid, and reliable technique in the diagnosis of various malignancies including hepatocellular carcinoma. The LAI test was carried out employing modified tube LAI technique in patients with primary hepatocellular carcinoma (HCC) and secondary carcinomas of liver. Positive L...