Vishwanath Managuli

Manipal Academy of Higher Education | MAHE · Department of Mechanical and Industrial Engineering

AFM-based single cell force spectroscopy is increasingly being used to understand many biological health problems like malaria, cancer etc. A reliable diagnostics needs, accurate measurement and a clear understanding of the influencing factors, which may otherwise sour the measured biomechanics. Results from any successful experimentation should be...

One of the major sources of error in Atomic Force Microscopy based Force Spectroscopic studies is bottom substrate effect, which comes due to assumption of infinite sample thickness. In the present work, anew experimentally validated mathematical correction for finite thickness of thesample is incorporated into a dynamic indentation model. This mod...

Background Colon cancer cells can migrate and metastasize by undergoing epithelial-to-mesenchymal transition (EMT). Mesenchymal stem cells (MSCs) are non-cancerous, multipotent adult stem cells, which can also migrate. In this study, we wanted to compare the biological, physical, and functional properties of these migratory cells.Materials and meth...

This paper presents a study on corrugated design based 3D printed sandwich panels subjected to quasi-static compression. The study focuses on the investigation of unique corrugated triangular and trapezoidal core designs. Effects of core thickness, skins, height of core and the contact area between core and skins on the mechanical properties of the...

Hole drilling in Ti6Al4V titanium alloy is challenging due to its poor machinability resulting from high-temperature strength and low thermal conductivity. Therefore, an evaluation of the helical milling process is carried out by comparing the thrust force, surface roughness, machining temperature, burr size, and hole diametrical accuracy with the...

Importance of hospital environment in patient-care has been recognized widely in infection prevention and control. Inappropriate antibiotic use led to emergence of resistant strains that are difficult to treat with the available antibiotics. Progress in nanotechnology led to enhancement of nanoparticles with physicochemical characteristics and func...

Retrogradation is defined as the recrystallization or realignment of amylose and amylopectin chains upon cooling of gelatinization starch gels. The storage conditions such as the storage time and temperature are crucial factors that influence and govern the degree of retrogradation and in turn, affect the formation of resistant starch and alteratio...

The nanoindentation has proved to be a most promising technique in the investigation of the bone at the level of individual osteons and lamellae. It provides the nanomechanical properties of bone at submicron levels without being affected by its size, shape, and porosity. Its application in the study of bone requires the understanding of its functi...

A comparative study on the effect of nano seashell, multiwall carbon nanotubes and nano alumina on mechanical and impact properties of bidirectional Kevlar/epoxy composite To cite this article: Soumitra M Dodkey et al 2022 IOP Conf. Ser.: Mater. Sci. Eng. 1248 012085 View the article online for updates and enhancements. You may also like The effect...

There is an urgent requirement of replacing the environmentally hazardous petroleum‐based plastics with sustainable and efficient starch‐based bioplastics. Development and detailed characterization of the biodegradable bioplastics from plant‐based polysaccharides such as starch is essential to reduce plastic pollution in the environment. In this re...

Diatoms are microscopic photosynthetic algae with siliceous frustule usually bound to aquatic environments. Atomic force microscopy (AFM) is widely applied to study and comprehend the morphology, topography, and structure of diatoms. The most common application of AFM is to study the biomineral formation in diatoms. Further, AFM is very useful in v...

Nosocomial infections, termed hospital-acquired infections (HAIs), are acquired from a healthcare or hospital setting. HAI is mainly caused by bacteria, such as Acinetobacter baumannii, Klebsiella pneumoniae, Escherichia coli, Enterococci spp., Methicillin-resistant Staphylococcus aureus (MRSA), and many more. Due to growing antibacterial resistanc...

To reduce dependence on fossil fuels and boost sustainability, bioplastics offer an exceptional replacement for petroleum-based environmentally harmful plastics. The present work describes the preparation and characterization of starch-based bioplastic composites reinforced with 10%, 30%, and 50% citric acid for crosslinking. Comprehensive morpholo...

Importance of hospital environment in patient care has recently been recognized widely in infection prevention and control (IPC). Exploitation of antibiotic use has led to emergence of resistant strains of organisms that are difficult to treat with the available sources of antibiotics. Progress in nanotechnology has led to the enhancement of nanopa...

The Atomic Force Microscopy based micro-rheological studies on thin samples like biological cells gets influenced by hard substrate present below the sample. The classical dynamic contact models fails to address this problem due to the infinite thickness assumption [1]. In the present work, an experimentally validated mathematical correction for fi...

The bottom substrate effect is one of the major sources of error in force map studies of adherent cells and thin soft samples in an atomic force microscope (AFM)-based force spectroscopy. Because of this, samples appear stiffer than the natural. The popular Sneddon’s contact model, which assumes the sample as infinitely thick, fails to correct this...

A new asymptotically correct contact model has been developed for conical tip based AFM nanoindentation. This new model provides both elastic and non-specific adhesion properties of cells and soft gels by taking sample thickness at the point of indentation and its depth of indentation into consideration. The bottom substrate effect is the most comm...

Investigate the invasive nature of cancer cells on the bases of changes in mechanical properties, morphological phenotype and adhesive nature. The recent studies in cell Mechanics indicated that cell health and its mechanical properties are interrelated and can be correlated for better understanding of effects of those changes in its surrounding ti...