Virgile Baudrot

Virgile Baudrot
Qonfluens

PhD

About

33
Publications
5,251
Reads
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227
Citations
Additional affiliations
November 2018 - present
French National Institute for Agriculture, Food, and Environment (INRAE)
Position
  • PostDoc Position
Description
  • Spatio-temporal exposure-hazard model for Ecological Risk Assessment: Bt-toxin and Non-TargetLepidoptera
September 2017 - September 2018
French National Centre for Scientific Research
Position
  • PostDoc Position
Description
  • Implementation of Bayesian inference models of survival models
March 2017 - August 2017
Claude Bernard University Lyon 1
Position
  • PostDoc Position
Description
  • Bayesian inference of survival models under time variable chemical exposure

Publications

Publications (33)
Article
Full-text available
The R-package rbioacc allows to analyse experimental data from bioaccumulation tests where organisms are exposed to a chemical (exposure) then put into clean media (depuration). Internal concentrations are measured over time during the experiment. rbioacc provides turnkey functions to visualise and analyse such data. Under a Bayesian framework, rbi...
Preprint
Full-text available
Figure Increase the confidence in using in vitro and in silico data to aid the chemical risk assessment process is one, if not the most, important challenge currently facing regulatory authorities. A particularly crucial concern is to fully take advantage of scientifically valid physiologically-based kinetic (PBK) models. Nevertheless, risk assesso...
Article
In the European Union, more than 100,000 man-made chemical substances are awaiting an environmental risk assessment (ERA). Simultaneously, ERA of chemicals has now entered a new era. Indeed, recent recommendations from regulatory bodies underline a crucial need for the use of mechanistic effect models, allowing assessments that are not only ecologi...
Article
Models that can predict the dynamics of larger scale ecological processes are increasingly important in a rapidly changing world. The Julia language gives a unique opportunity to produce new, generic tools to develop spatial mechanistic models, and to simultaneously increase their performance, resolution and predictive power. Here, we describe two...
Preprint
Full-text available
The R package `rbioacc` is dedicated to the analysis of experimental data collected from bioaccumulation tests. It provides ready-to-use functions to visualise a data set and to estimate bioaccumulation metrics to be further used in support of environmental risk assessment, in full compliance with regulatory requirements. Such metrics are classical...
Article
Full-text available
In the European Union, more than 100,000 man-made chemical substances are awaiting an environmental risk assessment (ERA). Simultaneously, ERA of these chemicals has now entered a new era requiring determination of risks for physiologically diverse species exposed to several chemicals, often in mixtures. Additionally, recent recommendations from re...
Preprint
Full-text available
Toxicokinetics-Toxicodynamics (TKTD) models are increasingly used for inference of toxicity indices of interest in Environmental Risk Assessment (ERA) thanks to their clear description of numerous mechanisms , from the kinetics of compounds inside organisms (Toxicokinetics, TK) to their related damages and effect dynamics at the individual level (T...
Preprint
Full-text available
Package morse is devoted to the analysis of experimental data collected from standard toxicity tests. It provides ready-to-use functions to visualize a data set and to estimate several toxicity indices to be further used in support of environmental risk assessment in full compliance with regulatory requirements. Such toxicity indices are indeed cla...
Preprint
Full-text available
In the European Union, more than 100,000 man-made chemical substances are awaiting an environmental risk assessment (ERA). Simultaneously, ERA of chemicals has now entered a new era. Indeed, recent recommendations from regulatory bodies underline a crucial need for the use of mechanistic effect models, allowing assessments that are not only ecologi...
Preprint
Full-text available
In the European Union, more than 100,000 man-made chemical substances are awaiting an environmental risk assessment (ERA). Simultaneously, ERA of chemicals has now entered a new era. Indeed, recent recommendations from regulatory bodies underline a crucial need for the use of mechanistic effect models, allowing assessments that are not only ecologi...
Preprint
Full-text available
Predictive environmental risk scenarios are today of major interest for environmental risk assessment as they provide plausible and consistent descriptions of possible effects of chemical in natura. In particular, they can be used for predictions of the future as consistent descriptions of pathways towards desired targets to protect. One single sce...
Article
Full-text available
Raw data on the number of deaths at a country level generally indicate a spatially variable distribution of COVID-19 incidence. An important issue is whether this pattern is a consequence of environmental heterogeneities, such as the climatic conditions, during the course of the outbreak. Another fundamental issue is to understand the spatial sprea...
Article
Full-text available
Discrepancies in population structures, decision making, health systems and numerous other factors result in various COVID-19-mortality dynamics at country scale, and make the forecast of deaths in a country under focus challenging. However, mortality dynamics of countries that are ahead of time implicitly include these factors and can be used as r...
Preprint
Raw data on the cumulative number of deaths at a country level generally indicate a spatially variable distribution of the incidence of COVID-19 disease. An important issue is to determine whether this spatial pattern is a consequence of environmental heterogeneities, such as the climatic conditions, during the course of the outbreak. Another funda...
Preprint
Full-text available
Objective. Countries presently apply different strategies to control the COVID-19 outbreak. Differences in population structures, decision making, health systems and numerous other factors result in various trajectories in terms of mortality at country scale. Our objective in this manuscript is to disentangle the future of second-line European coun...
Article
1. Understanding pesticide impacts on populations of target/non‐target species and communities is a challenge to applied ecology. When predators that otherwise regulate pest densities ingest prey contaminated with pesticides, this can suppress predator populations by secondary poisoning. It is, however, unknown how species relationships and protoco...
Article
Full-text available
Providing reliable environmental quality standards (EQSs) is a challenging issue in environmental risk assessment (ERA). These EQSs are derived from toxicity endpoints estimated from dose-response models to identify and characterize the environmental hazard of chemical compounds released by human activities. These toxicity endpoints include the cla...
Article
Once released into the environment antibiotics can kill or inhibit the growth of bacteria, and in turn potentially have effects on bacterial community structure and ecosystem function. Environmental risk assessment (ERA) seeks to establish protection limits to minimise chemical impacts on the environment, but recent evidence suggests that the curre...
Preprint
Full-text available
Providing reliable environmental quality standards (EQS) is a challenging issue for environmental risk assessment (ERA). These EQS are derived from toxicity endpoints estimated from dose-response models to identify and characterize the environmental hazard of chemical compounds as those released by human activities. The classical toxicity endpoints...
Article
Full-text available
Mechanistic modelling approaches, as the toxicokinetic‐toxicodynamic (TKTD) framework, are promoted by international institutions as EFSA and OECD to assess the environmental risk of chemical products generated by human activities. TKTD models can encompass a large set of mechanisms describing the kinetics of compounds inside organisms (e.g. uptake...
Code
morse: Modelling Tools for Reproduction and Survival Data in Ecotoxicology. Tools for ecotoxicologists and regulators dedicated to the mathematical and statistical modelling of toxicity test data. They use advanced and innovative methods for a valuable quantitative environmental risk assessment.
Article
Toxicokinetic-toxicodynamic (TKTD) models, as the General Unified Threshold model of Survival (GUTS), provide a consistent process-based framework compared to classical dose-response models to analyze both time and concentration-dependent data sets. However, the extent to which GUTS models (Stochastic Death (SD) and Individual Tolerance (IT)) lead...
Article
Full-text available
In response to anthropogenic eutrophication and global warming, deep-water oxygen depletion is expected to have large effects on freshwater lake biogeochemistry and resident communities. In particular, it has been observed that deep-water hypoxia may potentially lead to regime shifts of lake benthic communities. We explored such community shifts by...
Thesis
Full-text available
La structure et l’intensité des interactions ressources-consommateurs qui forment les réseaux trophiques régulent une très grande partie des transferts de biomasse mais aussi de contaminants biologiques et chimiques dans les écosystèmes. L’objectif de la thèse est de développer des modèles permettant d’étudier les mécanismes de transport des contam...
Article
The ability for a generalist consumer to adapt its foraging strategy (the multi-species functional response, MSFR) is a milestone in ecology as it contributes to the structure of food webs. The trophic interaction between a generalist predator, as the red fox or the barn owl, and its prey community, mainly composed of small mammals, has been em...

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Projects

Projects (3)
Project
MOSAIC is a turnkey decision-making tool for ecotoxicologists and regulators. Without wasting time on extensive mathematical and statistical technicalities, users are given advanced and innovative methods for a valuable quantitative environmental risk assessment.
Project
Human beings modify ecosystems to maximise benefits from natural resources and as a result wildlife adapts ecological relationships. For instance, voles show multiannual population cycles and predators respond numerically, possibly limiting vole populations. Voles also damage crops and reduce food available for livestock. Subsequently, farmers respond using anticoagulant rodenticides to control voles. That means indirect control of predators by secondary exposure or by reduction of food sources. Therefore, anticoagulant rodenticides will be acting analogously as a superpredator, impeding the natural autoregulation of vole populations. In this project our international team want to study this system by combining multidisciplinary and intersectoral knowledge. We will try to understand the effects of anticoagulant rodenticides and predation as tools for pest control. We combine academic and non-academic partners to promote research and dissemination of results to the public. We will also work hand-in-hand with farmers, stakeholders, etc. about vole populations in western Europe.