Viorel Jinga

• Th Burghele Hospital

Acute bacterial prostatitis (ABP) is a clinical condition frequently encountered in clinical practice, but there is a lack of consensus for the diagnosis, investigations, and treatment for this pathology. We have enrolled patients diagnosed with acute prostatitis in three academic urological centres between 2019-2020 and followed-up prospectively t...

Objective To access the feasibility of palliative cystoprostatectomy/pelvic exenteration in patients with bladder/rectal invasion due to prostate cancer (PC). Patients and methods Twenty-five men with cT4 PC were retrospectively identified in the institutional databases of six tertiary referral centers in the last decade. Local invasion was docume...

There are unexplained geographical variations in the incidence of kidney cancer with the high rates reported in Baltic countries, as well as eastern and central Europe. Having access to a large and well-annotated collection of “tumor/non-tumor” pairs of kidney cancer patients from the Czech Republic, Romania, Serbia, UK, and Russia, we aimed to ana...

PurposeNephrolithiasis is a urological pathology that occurs at high rates and carries a great burden in terms of costs. The probability of recurrence is significant, necessitating improvements in prophylaxis and understanding of the disease mechanism. Despite the high heritability of this disease, only five genome-wide association studies (GWAS) o...

Background During the past decades, genetic research has reached new heights as next generation sequencing has rapidly taken over and genome-wide association studies (GWAS) have broug. The purpose of the research is to determin high-risk variants (Single-Nucleotide-Variants,SNVs) associated with hypertension (HTA) in the Romanian population. The cu...

Bladder cancer (BC) is one of the most frequent forms of cancer, particularly in Caucasian population. Many environmental factors are recognized as carcinogenic in humans for this form of neoplasia and some of them are related to occupation. In order to illustrate these effects, we have selected several relevant cases with smoking and occupational...

Introduction & Objectives: Xantogranulomatous pyelonephritis is a rare pathology that is characterized by inflammation and destruction of renal parenchyma secondary to chronic obstruction. Symptoms and laboratory data are not pathognomonic and diagnosis can often be mistaken for renal tumor. The imaging investigation of choice is CT, but the certai...

Background: Relative telomere length in peripheral blood leukocytes has been evaluated as a potential biomarker for renal cell carcinoma (RCC) risk in several studies, with conflicting findings. Objective: We performed an analysis of genetic variants associated with leukocyte telomere length to assess the relationship between telomere length and...

Background: Relative telomere length in peripheral blood leukocytes has been evaluated as a potential biomarker for renal cell carcinoma (RCC) risk in several studies, with conflicting findings. Objective: We performed an analysis of genetic variants associated with leukocyte telomere length to assess the relationship between telomere length and RC...

In the present study we investigated for the first time the profile of common prostate cancer risk variants in an unscreened Romanian population. The study population consisted of 990 unrelated histopathologically confirmed prostate cancer (PCa) cases and 1,034 male controls consisting of patients admitted for urological and surgical conditions, ex...

Introduction. Xantogranulomatous pyelonephritis is a rare pathology that is characterized by inflammation and destruction of renal parenchyma secondary to chronic obstruction. Symptoms and laboratory data are not pathognomonic and diagnosis can often be mistaken for renal tumor. The imaging investigation of choice is CT, but the certain diagostic i...

Introduction. Testicular cancer is relatively rare accounting for 1% of male neoplasm. Aproximately 95% of all testicular neoplasm are of germ cell origin. Testicular cancer show excellent cure rates based on their chemosensitivity and early diagnosis. Late diagnosis translates into a significant prognostic worsening. 20-30% of patients with GCT pr...

Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases an...

Case-only associations with age at onset and stage for SNPs selected for replication

Expression quantitative trail locus analysis (eQTL) results for genes located up to 3Mb around the newly identified risk markers (or highly-correlated proxies) using clear cell renal cell carcinoma and normal kidney tissue data from the Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma collection (KIRC; 481 tumor and 71 normal tissue samples] a...

Supplementary Figures, Supplementary Tables, Supplementary Notes and Supplementary References

Associations with renal cell carcinoma and selected histologic subtypes (clear cell, papillary, chromophobe) for SNPs selected for replication

Annotation of functional variation in newly identified susceptibility regions using ENCODE data

Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases an...

Recent genomic studies of sporadic clear cell renal cell carcinoma (ccRCC) have uncovered novel driver genes and pathways. Given the unequal incidence rates among men and women (male:female incidence ratio approaches 2:1), we compared the genome-wide distribution of the chromosomal abnormalities in both sexes. We observed a higher frequency for the...

Introduction and Objectives. Testicular cancer is one of the most curable malignancies due to the last advances in diagnosis and treatment, but late diagnosis remains a serious problem. Materials and Methods. We present a case of a 44-year-old man who presented in our clinic with a giant testicular tumor, measuring about 40 cm in diameter, extended...

Objective: To study the effects of intravitreal anti-Vascular Endothelial Growth Factor (VEGF) therapy with Avastin for wet Age-Related Macular Degeneration (AMD) on Benign Prostatic Hyperplasia (BPH)-related symptoms. Methods: An exploratory trial was conducted from August 1, 2013 to February 1, 2014, that included 14 male patients previously diag...

The aim of the study was to evaluate the efficacy of the combination for cutaneous application of piroxicam/lidocaine/cyclobenzaprine hydrochloride for the pain management during Extracorporeal Shock Wave Lithotripsy (ESWL). A number of 256 patients with renal and ureteral stones were randomly assigned to one of the 3 groups: group A (topical analg...

Introduction. Malignant prostate pathology is in most cases represented by adenocarcinoma. Leiomyosarcoma is discovered in less than 0.1% of prostate malignancies. Due to limited therapeutic possibilities and late diagnosis in many cases, the disease is rapidly leading to exitus. Material and method. We present a 84 year old patient, urgently admit...

Introduction: Pigmented clear cell epithelioid angiomyolipoma of the kidney is an extremely rare mesenchymal tumor from the PEComa family. In this paper, we present the case of a 28 years old female patient submitted to the hospital for a renal tumor detected three months earlier on routine ultrasound exam. The tumor was IRM confirmed and partial l...

Table S1 Characteristics of controls and cancer cases. Table S2 Association of the 34 SNPs with clinical TNM stage and Gleason score on biopsy. Table S3 Association of the 34 SNPs with PSA levels and disease aggressiveness. Table S4 Association of the 34 SNPs with PSA using linear regression.