Viol Dhea Kharisma

Airlangga University | UNAIR · Department of Biology

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a novel coronavirus and the primary causative agent of coronavirus disease 2019 (COVID-19), first occurred in China and rapidly spread worldwide. The government of the Republic of Indonesia confirmed its first two cases of COVID-19 in March 2020. COVID-19 is a serious illness with no eff...

Coronavirus disease 2019 (COVID-19) is a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 has spread quickly across the world and has been declared a pandemic. Indonesia has many COVID-19 cases, with a high mortality rate. This study aimed to describe the distribution of COVID-19 in Indonesia and constructed...

Sudden emergence and a rapid outbreak of SARS-CoV-2 accompanied by a devastating impact on the economy and public health has driven extensive scientific mobilization to study and elucidate the various associated concerns about SARS-CoV-2. Bioinformatics plays a crucial role in addressing and providing solutions to questions about SARS-CoV-2. It hel...

Background: An immunoinformatic approach may be useful to investigate the conserved region in the spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Indonesia isolates. The aim of this study was to investigate Indonesian SARS-CoV-2 isolates based on B cell epitopes by targeting the conserved regions in the spike glyc...

COVID-19 pandemic has no immediate ending in sight, and any significant increasing cases were observed worldwide. Currently, there are only two main strategies for developing COVID-19 drugs that predominantly use a proteomics-based approach, which are drug repurposing and herbal medicine strategies. However, a third strategy has existed, called sma...

This research focuses on an innovative approach utilizing in silico methods to design small interfering RNA (siRNA) targeting the HER2 splice variant mRNA in Homo sapiens. HER2 is known to be overexpressed in certain types of breast cancer, contributing to tumor progression and poor prognosis. By designing siRNA molecules that can specifically bind...

Background: Plasmodium falciparum is a malaria-causing unicellular parasite with strain 3D7 (Pf3D7) being the most lethal. Currently, antimalarial resistance has been reported which necessitates the development of novel antimalarial drugs to combat the spread of malaria. Garcinia atroviridis Griff. ex T. Anders contains phytochemical compounds that...

Ferulic acid (4-hydroxy-3-methoxycinnamic acid) is a phytochemical compound that is commonly found in conjugated forms within mono-, di-, polysaccharides and other organic compounds in cell walls of grain, fruits, and vegetables. This compound is highly abundant in the palm oil waste. The aim of the study was to predict the anticancer activity of f...

The emergence of antimicrobial resistance has led to an urgent need for novel antimicrobial drugs. This study aimed to determine the antioxidant and antimicrobial potentials in silico and in vitro of Pandanus amaryllifolius Roxb. ethanolic extract. The extracts were subjected to gas chromatography-mass spectrometry (GC-MS) analysis to identify the...

The most common gram-negative, Escherichia coli, and gram-positive bacteria, Bacillus spp., have evolved different mechanisms that have caused the emergence of multi-drug resistance. As a result, drugs that block the bacterial growth cycle are needed. Here, in silico and in vitro studies were performed to assess compounds in the Pluchea indica leaf...

A BST R ACT Alizarin is a polycyclic compound isolated from roots of Rubia tinctorum that has potential as a breast anticancer candidate. Increasing anticancer activity can be done through structural modification to produce derivatives in the form of group substitution in the meta position using acyl. The purpose of this work is to forecast the ant...

Background Cymbopogon is a member of the family Poaceae and has been explored for its phytochemicals and bioactivities. Although the antimicrobial activities of Cymbopogon spp. extracts have been extensively studied, comprehensive analyses are required to identify promising compounds for the treatment of antimicrobial resistance. Therefore, this st...

Combining beta-tricalcium phosphate (β-TCP) with other materials may be promising to expand its therapeutic applications, especially in bone regeneration. Dicalcium phosphate dihydrate (DCPD), which has the highest solubility among calcium phosphates at physiological conditions, may escalate β-TCP osteoinductivity.

Bone remodeling begins with bone resorption and culminates with the formation of new bone. Several variables influence bone remodeling, including oxidative stress, which results from an imbalance of oxidants, reactive oxygen species (ROS), and antioxidants. Herbal supplements may enhance interactions between antioxidants, growth factors, osteoclast...

Traditional herbal remedies have an important role in human health. Empirically, Blumea balsamifera is often used as a traditional beverage to alleviate fever symptoms, lower cholesterol levels, and maintain body immunity. The purpose of this study was to discover the phytoconstituent profile that contributes to the anti-diabetic properties of B. b...

HIV-2 infection is a unique concern with fewer cases than HIV-1, but it poses a high mortality rate due to its resistance to all HIV-1 antiretroviral treatments. This study focuses on one type of antiretroviral, reverse transcriptase (RT) inhibitors, as they play an important role in HIV-2 replication. The screening of potential HIV-2 antiretrovira...

Viral replication inhibition strategies are needed to prevent pandemics through the latest therapeutic agent designs. A viral infection occurring over a wide area is called a pandemic. The strategy of inhibiting virus replication is used to tackle the pandemic Viruses can trigger negative regulation of apoptosis in host cells for viral survival. Ap...

T cell immunity, like responses of CD4 + and CD8 + T-cell, plays an important role to fight against viral infections and pathological harm. Several previous studies have shown the results that rabies virus (RABV) protein can act as an ideal receptor for rabies neuroseptic vaccine by inducing a response of T-cell. In this research, we evaluated poss...

Background: Dental peri-implantitis is an inflammation that occurs in the peri-implant soft tissue and is accompanied by bone resorption, decreased osseointegration, and pockets. Graptophyllum pictum L. Griff extract may act as complementary therapy for peri-implantitis. Objectives: To investigate the effectiveness of G. pictum L. Griff extract as...

Human immunodeficiency virus (HIV) is a genus of Lentivirus that triggers opportunistic diseases in the human body. HIV-1 has been a major problem for the world community for a long time and triggered a pandemic. HIV-1 antiviral drugs with the mechanism of inhibiting specific proteins have been found but have some harmful side effects for patients....

Breast cancer is a chronic health problem that causes 690,000 deaths worldwide. The development of secondary metabolite compounds from natural preparations through an in silico approach is needed as a predictive tool to prevent breast cancer, one of them is cladosporol from Cladosporium spp. This study aims to utilize an in silico approach to predi...

Rabies remains a pervasive zoonotic disease in Indonesia, necessitating innovative strategies for vaccine development. This manuscript presents an in silico study focused on the construction of a novel plasmid-based DNA vaccine targeting the Indonesian rabies virus (RBV) glycoprotein, augmented with myeloid differentiation factor 88 (MyD88) as a ge...

Nowadays, dengue virus (DENV) is still become a global problem, even though the virus infection issues have reached half of the population in some countries each year. DENV belongs to the enveloped virus with positive-sense single-stranded RNA (+ssRNA) genus Flavivirus and belongs to the Flaviviridae family. DENV has structural proteins which consi...

Context: Stem cell research has become popular in Indonesia for more than a decade. The scope of research involves in vitro to animal studies as well as human trials. However, no evidence proved its trend. Aims: To analyze the trends and patterns of stem cell research in Indonesia from 2003 to 2022 using a bibliometric analysis of the Scopus databa...

Cancer-related hypercalcemia is a common metabolic complication seen in patients with advanced malignancies, affecting 10-30% of all cancer patients. It is associated with significant morbidity and mortality, highlighting the need for a comprehensive understanding of its pathophysiology and effective treatment strategies. The pathophysiology of can...

Infection with a DNA virus called monkeypox virus (MPXV) in humans has been identified in the Congo since 1970. Antiviral drugs are not effective for preventing MPXV infection. MPXV infection cases in Indonesia are very low but MPXV has the potential to become a global pandemic so it is very important to do prevention such as vaccine development. T...

Klebsiella pneumoniae is a gram-negative of bacteria that are known to cause a variety of nosocomial respiratory tract infections including pneumonia. K. pneumoniae is also included in the ESKAPE bacteria group which has high resistance to antibiotics. Therefore, alternative treatment for K. pneumoniae infection is needed, one of which is by develo...

Monoclonal antibodies composed entirely of human immunoglobulin G4 that specifically target programmed death-1 (PD-1) are referred to as Nivolumab and Pembrolizumab. Monoclonal antibody of anti-PD-1 type for glioblastoma was found to be beneficial and harmless in preclinical research. Monoclonal antibody of anti-PD-1 (Pembrolizumab, Nivolumab) vers...

HIV has a host cell, T‑cell lymphocytes with CD4+ receptors. HIV drugs have the inhibitory activity on HIV‑1 protease by producing chemical bonding interactions such as hydrogen and hydrophobic. However, some cases show long-term side effects that may be harmful from the use of synthetic antiretrovirals. This requires new innovations to make drugs...

Rabies remains a pervasive zoonotic disease in Indonesia, necessitating innovative strategies for vaccine development. This manuscript presents an in silico study focused on the construction of a novel plasmid-based DNA vaccine targeting the Indonesian rabies virus (RBV) glycoprotein, augmented with myeloid differentiation factor 88 (MyD88) as a ge...

Dengue fever, caused by the dengue virus, is a significant global health concern, with millions of cases reported annually. The absence of specific antiviral treatments or effective preventive measures has fuelled the urgent need for a dengue vaccine. This provides a comprehensive review of the development of a dengue vaccine, summarizing the major...

SARS-CoV-2 has caused a prolonged COVID-19 pandemic since the end of December 2019 and is still ongoing now. Bioactive compounds can be used as drugs to treat infectious diseases. This study aims to determine C. alata as a drug candidate for COVID-19 through its inhibitory activity to M pro SARS-CoV-2 in silico. Cassia alata bioactive compounds hav...

The use of medicinal plants to treat the symptoms of COVID-19 is essential to increase immunity. Our research aimed to determine the therapeutic potential of Indonesian medicinal plants and the herb concoction used by the Osing Tribe in Kemiren and Glagah Village, Glagah District, Banyuwangi Regency, East Java, Indonesia, for treating the symptoms...

Dengue virus (DENV) is still global problem and infecting millions of people a year. This virus belongs to Flavivirus and consists of the structural and non-structural proteins including envelop (E), capsid (C), NS2B/NS3, and NS5. Garcinia atroviridis Griff. ex T. Anders is traditional plant that has broad potential as antioxidant, antibacterial, a...

African Swine Fever Virus (ASFV) is an infectious agent that triggers acute and lethal hemorrhagic disease. ASFV is a virus with a type of genetic material that is double-stranded (dsDNA), this virus is a member of the Asfarviridae genus Asfivirus family which is able to infect Suidae (pig family). The first case of ASFV infection in Indonesia was...

The global health landscape has seen an upsurge in viral diseases, underlining the urgency for novel antiviral therapies. This mini-review illuminates the potential antiviral capabilities of gamma-mangostin, a xanthone derivative derived from the pericarp of the Garcinia mangostana fruit. Gamma-mangostin's mechanisms of action are multifaceted, dis...

Coronavirus disease 2019, also known as COVID-19, is a respiratory disease. Symptoms of COVID-19 include fever, dry cough, inflammation of the throat area, loss of smell, and even breathing difficulty. COVID-19 is caused by SARS-CoV-2 infection, a virus that is a member of the coronavirus family. The SARS-CoV-2 structure consists of S (spike), M (m...

The Chikungunya virus (CHIKV), a zoonotic virus transmitted through mosquito bites, can cause dengue-like fever in humans. Despite the lack of specific clinical treatments and vaccines, there has been limited attention given to CHIKV in recent decades. This study utilized an immunoinformatics approach to design a potential multi-epitope vaccine for...

This mini review aims to explore the potential of alpha-mangostin as an antiviral candidate. Alpha-mangostin is a natural compound found in the fruit of the Garcinia mangostana tree. Over the years, it has attracted considerable attention due to its diverse pharmacological properties, including antiviral activity. This review provides an overview o...

Temu ireng (C. aeruginosa Roxb.) is a rhizome plant that is well known among Indonesians as a type of herbal plant due to the presence of bioactive compounds with numerous benefits. One of them is to act as an anti-bacterial agent. Tuberculosis is a symptomatic chronic condition triggered by a bacterial infection of the lungs in humans. The goal of...

This review discusses the antimicrobial potential of Curcuma longa, a plant traditionally recognized for its medicinal properties. The emerging concern over antimicrobial resistance, coupled with the adverse effects of synthetic drugs, necessitates an exploration of plant-based natural antimicrobials. Curcuma longa, commonly known as turmeric, prov...

Oscillatoxins (OTXs) are cytotoxins produced by some marine cyanobacteria. Their unique structures show a great potency as an anticancer agent. The limited availability of OTX derivatives in nature provides little information about their biological activity. Some of OTX activities have been tested in the in vitro or in vivo studies toward cancer ce...

Clitoria ternatea may possess antimicrobial, antioxidant, and anti-inflammatory activities that are expected to provide benefits for dental peri-implantitis treatment. Objective to investigate C. ternatea ethanolic extract (CTEE) antibacterial activity toward periimplantitis bacteria in vitro and C. ternatea’s anthocyanin anti-inflammatory, antimic...

Marumoside, Rutin and Quercetin are Moringa oleifera (MO) bioactive compounds which may act as anti-oxidant, anti-bacterial, anti-bone resorption, anti-inflammatory agent, pro-osteogenic and pro-growth factor that beneficial during bone remodeling. Aim: to analyze the Marumoside, Rutin and Quercetin of MO to Tartate Resistant Acid Phosphatase (TRAP...

The natural curcumin (Curcuminoid) is an anticancer compound. DFT and molecular docking curcuminoid to Tribolium castaneum telomerase were performed for curcumin (C), demethoxycurcumin (DC), and bisdemethoxycurcumin (BDC) in two structures, diketone (dk) and keto-enol (ke). Curcuminoid as inhibitor have optimized in gas phase used DFT/B3LYP. Optimi...

Nipah virus (NiV) is an RNA virus, a pathogenic paramyxovirus that causes nonlethal respiratory illness in pigs. It was originally reported in Malaysia in 1998. NiV is considered a potential outbreak threat because it is zoonotic. However, no vaccines or antiviral drugs have been found against NiV. Therefore, the main objective is to develop effect...

The aim of this research was to study the capability of gliserol in improving the characteristics of edible film made from chitosan. Three various a concentration of gliserol was used, namely 1%, 3% and 5%. The results of edible film characterization from the three concentrations of glyserol showed that the concentration of 1% was the best concentr...

CRISPR-Cas9 has emerged as a revolutionary tool that enables precise and efficient modifications of the genetic material. This review provides a comprehensive overview of CRISPR-Cas9 technology and its applications in genome editing. We begin by describing the fundamental principles of CRISPR-Cas9 technology, explaining how the system utilizes a si...

This article explores the potential of the salicylate compound (Syzygium Aromaticum) as a stimulant for Carbonic Anhydrase I in gastric acid secretion, using a computational approach. The research methods include molecular modeling with Pymol and Pyrex, determination of compound structure and interactions with Protein Plus, and examination of physi...

his study aims to investigate the potential of Emodin, a compound found in Aloe vera, as a stimulator of Protein Kinase PIM1 in the central nervous system using an in-silico approach. The research method involves the use of software such as Pymol, Pyrex, Protein Plus, and Lepinski Rule. Firstly, the protein structure of the target Protein Kinase PI...

Context: Mangosteen (Garcinia mangostana L.) is used in traditional medicine as an antibacterial, antioxidant, and anti-inflammatory. Aims: To determine the molecular mechanism and potential of garciniaxanthone derivate compounds from G. mangostana as SARS-CoV-2 antiviral and prevent cytokine storm through in silico approach. Methods: Ligand and...

This study aims to analyze the potential of Rhamnocitrin, a compound found in clove extract (Syzygium aromaticum), as an inhibitor of Adenylate Cyclase through an in-silico approach. The research method involves the use of software such as Pymol, PyRx, Protein Plus, and Lipinski Rule for molecular interaction analysis and physicochemical characteri...

This study explores the potential of Guaiacol, a green tea extract from Camellia sinensis, as a stimulant in renal tubular acidosis through in-silico investigation on the Carbanoic Anhydrase II enzyme. Utilizing comprehensive computational tools including PyMOL, PyRx, Protein Plus, and the Lipinski's Rule of Five, a detailed examination of the mole...

This study aims to investigate the potential of sinensetin, a compound found in the Cat's Whiskers plant (Orthosiphon aristatus), as an inhibitor in inhibiting uric acid through its interaction with ATP Binding Cassette Sub-Family G Member 2 (ABCG2). The in-silico approach was employed using software tools such as Pymol, PyRx, Protein Plus, and Lep...

This study aims to evaluate the potential of Rosmarinic Acid as an inhibitor against Hepatitis E by interacting with the active site of the Tyrosine FYN protein. Computational approaches were employed to predict the molecular interactions between Rosmarinic Acid and Tyrosine FYN. The research methodology involved the use of software such as Pymol,...

This research discusses an in-silico study of sitogluside found in the clove plant (Syzygium aromaticum) as a potential inhibitor of B and T cell proliferation through interaction with Interleukin-2. This study utilizes methods such as Swiss Target Prediction, Pymol, Pyrex, Protein Plus, and Lipinski's Rule to predict the biological activity and ph...

This research aims to investigate the interaction between cynaroside, a natural compound found in Orthosiphon aristatus plant extract, with TNF Alpha as a stimulant in the context of malaria and asthma. The research method involved an in-silico approach using software such as Pymol, PyRx, Protein Plus, and the Lepinski Rule. The results of the stud...

This study aims to analyze the potential of Thaflavine, a compound found in green tea (Camellia sinensis), as an inhibitor in inhibiting B-cell lymphoma through its interaction with the BCl2 apoptosis regulator using an in-silico approach. The research methodology involved the use of software tools such as PyMOL, PyRx, Protein Plus, and the Lepinsk...

Quercetin, a natural compound present in various fruits and vegetables, shows promise as a potential inhibitor for glioblastoma multiforme (GBM) development. This study aims to examine the anti-GBM potential of Quercetin. The protein target of Quercetin is identified and analyzed using databases such as NCBI, SEA, CTD, and STRING. Protein-protein i...

Adipose-derived stem cells (ADSCs) have been developed as substi-tute cells for tissue engineering. However, in order to get a high number of cells,over-repassage leads the cells to become big in spread size indicating that senes-cence occurred. This study aimed to evaluate the potency of ascorbic acid toinduce the proliferation and angiogenic pote...

Context: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread, causing a global pandemic with diverse symptoms and increased risk of mortality. Various symptoms and comorbidities contribute to a higher likelihood of death in patients. Additionally, existing antiviral drugs have shown incomplete efficacy. Rafflesia sp. and...

There are no specific drugs or vaccines for Nipah virus (NiV), which is a new Paramyxovirus that infects swine and humans. This study was conducted to investigate B-cell epitope mapping of the NiV attachment glycoprotein and to construct peptide-based vaccine candidates using the reverse vaccinology approach. To generate the linear B-cell epitope,...

Ebola virus (EBOV) is a type of RNA virus from the family of Filoviridae. The 2014-2016 Ebola outbreak in African countries Guinea, Liberia and Sierra Leone has a total of 28,616 cases and 11,310 deaths. People suffering from Ebola disease reported to have symptoms such as fever, body aches, diarrhea and internal and external bleeding. Death from E...

Diabetes is caused by many factors such as hyperglycemia conditions, it triggers type 1 and 2 diabetes. Hyperglycemia was triggered by the inhibition of glucose absorption of cells and triggers an increase in ROS, insulin signaling can be disrupted due to high ROS levels, the cycle will repeat and then trigger fat accumulation, increase in proinfla...

The Chinese believe consuming edible bird's nests (EBN) can increase immunity to various diseases, including Covid-19. This study attempts to identify SARS COV-2-specific anti-viral and anti-inflammatory agents of EBN. We gathered samples from PubChem and Protein Data Bank (PDB). Afterwards, drug likeness was examined using the Lipinski model from...

Ebola virus (EBOV) is a type of RNA virus from the family of Filoviridae. The 2014-2016 Ebola outbreak in African countries Guinea, Liberia and Sierra Leone has a total of 28,616 cases and 11,310 deaths. People suffering from Ebola disease reported to have symptoms such as fever, body aches, diarrhea and internal and external bleeding. Death from E...