Vinodkumar MugadaVignan Institute of Pharmaceutical Technology · Department of Pharmacy Practice
Vinodkumar Mugada
M.Pharm (Ph.D)
About
50
Publications
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Introduction
My research interests are clinical pharmacy, pharmacy practice, pharmacoepidemiology, and pharmacoeconomics. I am a PUBLONS certified academic peer reviewer. I like to review articles related to my field to improve my peer reviewing and manuscript writing skills. I am very happy to give feedback on the manuscripts of other authors if they are interested. I am also interested in helping other authors or young researchers in publishing their manuscript.
Publications
Publications (50)
Underreporting of adverse drug reactions (ADRs) due to time constraints, limited awareness, reluctance, and legal fears demands integrating pharmacists with physicians and implementing an extensive continuing education module on pharmacovigilance for application-based learning. Our study aimed to integrate a pharmacist with a treating physician to...
It is essential to assess the drug utilization evaluation patterns of antimicrobials in the ICU to safeguard rational use of antibiotics. We aimed to evaluate the drug utilization patterns of antibiotics using World Health Organization (WHO) methodologies, namely Defined Daily Dose (DDD)/100 patient days and DU 90% in the ICU. We conducted a drug u...
Kikuchi-Fujimoto disease (KFD) is a rare form of lymphadenitis that primarily affects young women in Japan and other parts of Asia. It is caused by unknown agents, possibly viruses that trigger an autoimmune response in genetically susceptible individuals. KFD is often misdiagnosed due to its resemblance to other benign and malignant conditions, in...
Diabetes Mellitus is recognized for its increased vulnerability to infections, notably cellulitis. This report presents a case of a 35-year-old male
with a history of type 2 diabetes for three years. Following a minor bike accident, the patient's wound ended in cellulitis due to unmanaged diabetes
and possible medical oversight. Initially, the woun...
IgG4-related disease (IgG4-RD) is an intricate autoimmune disorder that have an effect on multiple organs in the body, including the lachrymal and salivary glands, liver, biliary duct, thyroid, pancreas, gastrointestinal tract, kidney, aorta, prostate and retroperitoneum. Mikulicz disease, a subtype of IgG4-RD, specifically targets the lachrymal an...
The purpose of the present review is to proffer a comprehensive overview of Dercum's disease (DD), a rare medical condition typified by the presence of excruciating subcutaneous adipose tissue deposits. The ambit of this exposition encompasses the delineation of the clinical features, diagnostic criteria, and treatment options for DD. DD is a compl...
Rett syndrome is a neurodevelopmental disorder primarily affecting females, characterised by slowed growth, developmental regression, loss of fine motor skills, communication difficulties, and stereotypical hand movements. It is strongly associated with mutations in the MECP2 gene, while other variations have been linked to FOXG1 and CDKL5 mutation...
Wolfram syndrome is a rare neurological disorder characterised by four main symptoms: diabetes mellitus, optic atrophy, deafness, and diabetes insipidus. It is caused by alterations in the CISD2 and WFS1 genes, which encode important proteins involved in cellular processes. Wolfram syndrome type 1 (WS1) has an earlier onset of diabetes and more sev...
Coats disease is an attenuate ocular vasculopathy illustrated by the accumulation of fluid in the intra-retinal along subretinal space, primarily affecting young males. Although the underlying cause of the disease remains unknown, research has made significant progress in understanding its prevalence, morphology, patient variables, and history. Dia...
Kallmann syndrome (KS) is an uncommon disorder that was first defined in 1856 and designed by Kallmann in 1944. It is also referred to as olfactogenital dysplasia and is characterized by hypogonadism and the agenesis of the olfactory bulb. The prevalence of KS is not well understood, with the incidence in males ranging from 1 in 8000 to 1 in 10,000...
PDB is a long-standing pathological state illustrated by aberrant bone remodeling and metabolism arising in structural anomalies of the bone tissue. While this disease may remain asymptomatic, mild symptoms such as joint and bone discomfort may be present. However, an early warning sign is intense nocturnal bone pain. Moreover, PDB may result in co...
Otogenic brain abscess, precipitated by acute mastoiditis, is a rare but potentially fatal condition. It constitutes an intracranial complication that can further develop due to meningitis and sigmoid sinus thrombosis. This case underscores the critical importance of early detection and therapeutic intervention, which often pose substantial clinica...
Objectives:
The iatrogenic triad is a significant global health problem in the elderly population. This study aimed to evaluate the iatrogenic triad in the elderly and identify potential preventive measures to mitigate its occurrence.
Materials and methods:
A preliminary observational study was conducted on 150 ambulatory elderly patients to ass...
Abstract
Background: One in five women in India suffers from polycystic ovarian syndrome (PCOS). In this study, we aimed to evaluate the quality of life of pharmacy students suffering from PCOS and provide awareness through counseling.
Methods: A cross-sectional study was conducted on 103 students with PCOS for 6 months. The Polycystic Ovarian Syn...
Objective:
To evaluate potentially inappropriate medications, potential drug-drug interactions, and prescribing practices in elderly ambulatory patients.
Methods:
We carried out a cross-sectional study on 275 elderly patients attending different outpatient departments. We used the Screening Tool for Older Person's Prescriptions criteria version...
The aim of the present study was to evaluate the effectiveness of oral nano formulation of vitamin-D in pain management of some neurospinal and musculoskeletal disorders. The study was conducted for duration of two years on patients suffering from neurospinal disorders like generalised back pain, myofascial syndrome, osteopenia and osteoporosis. Nu...
Tubercular mastitis is a rare form of extrapulmonary tuberculosis commonly seen in multiparous and lactating women in developing countries. It is a diagnostic challenge and commonly misdiagnosed as breast carcinoma. Tubercular mastitis is paucibacillary, and fine-needle aspiration cytology provides an accurate diagnosis-the presence of granulomas w...
Knee osteoarthritis causes physical, functional limitations and difficulty in performing activities of daily living and mobility. The study aimed to assess patient-relevant outcomes in knee osteoarthritis patients using the Knee Injury and Osteoarthritis Outcome Score (KOOS) scale. A descriptive cross-sectional study was conducted on 120 patients....
Background: The presence of risk factors have a high risk of developing breast cancer. Our study aimed to find an association between sociodemographic factors and the risk of estrogen receptor (ER)-positive, progesterone receptor (PR)-positive breast cancer among women.
Methods: A cross-sectional study was conducted on 200 women with breast cancer...
Almotriptan belongs to second-generation triptans, which were discovered and developed by Almirall for the treatment of severe migraine headaches. Piperine (N-acyl piperidine) is a plant alkaloid and a natural bioenhancer, which was found to reinforce the bioavailability of structurally and therapeutically different drugs. The study developed a val...
Objectives:
Antibiotic resistance poses a significant threat to the world, and irrational use of antibiotics is a major contributing factor. Evaluation of antimicrobial use is underway with the help of indicators and the World Health Organization (WHO) classification of antibiotics into Access, Watch, and Reserve (AWaRe) categories. We aimed to ev...
Background: Low birth weight is an alarming problem in developing countries and has severe future complications. Aim of the study: Our study aimed to compare the risk factors among mothers with low and normal birth weight babies. Materials and Methods: A cross-sectional study was carried out on 1000 mothers with normal and low birth weight babies (...
The present study aimed to assess the rational use of drug use using World Health Organization (WHO) prescribing and patient care indicators in a tertiary care hospital. 180 prescriptions were analyzed. 636 drugs were prescribed in total. The mean age group of patients was 37.14±19.54 years. 93.3 % of prescriptions contain less than or equal to fiv...
Anxiety and depression were interlinked with the severity of liver diseases. Patients should know the true severity of the disease and patient counselling helps them. This was a cross-sectional study carried out on 100 patients suffering from chronic liver disease. Child Turcotte Pugh score was used to calculate the severity of the disease. Hospita...
Background: Rhinocerebral mucormycosis is the most common form of mucormycosis in patients with diabetes mellitus; it is linked to poor prognosis, presenting most commonly in an acute setting, mimicking symptoms of sinusitis or periorbital cellulitis. The general survival rate in chronic cases is 83%, compared to 10-35% in acute. Aim of the study:...
Post-menopausal women experience symptoms such as irregular periods, lower fertility, vaginal dryness, hot flashes and night sweats. Hormone replacement therapy (HRT) relieves menopausal symptoms. The aim of this review was to assess the benefits and risks of HRT in post-menopausal women. A scoping review was conducted for original peer-reviewed En...
The aim of the study was to assess the ototoxicity and nephrotoxicity in cancer patients receiving weekly cisplatin therapy. This prospective cross-sectional study was carried out in chemotherapy ward, department of radiotherapy, for the duration of six months. This was designed to implement a mixed methods approach. Patient's baseline Serum Creati...
Objective: The aim of the present study was to assess the factors affecting carotid artery intima-media thickness (CIMT) and 10-year risk of heart disease in diabetic patients classified according to CIMT. Methods: This was an analytical cross-sectional study conducted on 92 patients for 1 year. 10-year risk of heart disease was calculated using th...
This review evaluates the safety and efficacy of SGLT2 inhibitors in relative to other conventional anti-diabetic agents. SGLT2 inhibitors are a new class of anti-diabetic medication that acts on the kidney and increase the urinary glucose excretion by inhibiting sodium-glucose cotransporter 2 in the proximal tubule. They have been evaluated in typ...
The prevalence of childhood overweight and obesity has increased markedly in most countries during the past several decades. Obese individuals often have a reduced life expectancy and increased healthcare needs, mostly due to the increased risk of co-morbidities. Publications were identified through keywords in the databases like PubMed, Trip datab...
This study was aimed to evaluate the quality of life of head and neck cancer patients receiving treatment. This prospective cross-sectional study was carried out for the duration of 9 months. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 Items (EORTC QLQ-C30) including the H&N-35 module for ass...
Urinary tract infections (UTI) are among the most common bacterial infections in humans usually caused by Escherichia coli. In our body, estrogen and progesterone hormones play a very important role in the urinary tract. Cyclical variations in these levels during the menstrual cycle changes urodynamics and cause lower urinary tract symptoms. The ai...
Preeclampsia/eclampsia is a potentially fatal disorder in pregnant women and remains one of the leading causes of maternal mortality and morbidity maternal and fetal mortality. Pre-eclampsia is 2-10% of all pregnancies and this may be higher in low resource settings. The databases searched included Pub Med, Science direct, and Trip database. To con...
The purpose of the present study was to categorize, assess and report medication errors. The descriptive cross-sectional study was conducted on 377 patients in the department of general medicine for six months. Medication error reporting form (MERF) is used as study instrument. The higher prevalence rate is seen in prescribing errors. Mostly seen p...
Cardiovascular disease is the leading cause of morbidity and mortality in the world. Cardiotoxic effects can lead to heart failure, the inability of the heart to pump enough blood throughout the body which is due to cardiomyopathy. The present review is focusd on the plants that have been evaluated for cardioprotective activity against doxorubicin-...
The aim of the present study was to monitor adverse drug reactions in cancer patients receiving chemotherapy. The
present study was carried out on 135 patients for six months. The causality assessment was done by using Naranjo’s
scale. The severity of ADR’s was assessed using Hartwig’s severity scale. The mean age of patients in sample was
49.31± 1...
The purpose of the present study was to determine the mother's knowledge towards childhood immunization and examining the reasons for incomplete immunization. Information regarding socio demographic variables, gender disparity ratio, urban and rural inequality ratio and causes for incomplete immunization, knowledge of immunization was collected fro...
Objective: To assess the association of some risk factors on the effectiveness of palliative chemotherapy treatment in cancer patients. Methods: A prospective observational study was conducted in the department of radiotherapy for a period of 6 mo. Ages, Gender, Cancer type, Physical Functioning, Anxiety and Depression, Medical Social Support, Como...
5-Fluorouracil (5-FU) induced severe febrile neutropenia is a serious threat which, if unnoticed may lead to death. We present here a case of 46 years old female patient who suffered severe febrile neutropenia and finally death due to 5-FU. Naranjo's causality assessment revealed that 5-Fluorouracil was the probable cause of severe febrile neutrope...
Palmar-Plantar Erythrodysesthesia (PPE) (or) Burgdorf's Reaction (BR) (or) Hand-Foot Syndrome (HFS) is the most common and dose limiting reversible dermatologic adverse reaction induced by anticancer chemotherapy. We report two cases of palmar-plantar erythrodysesthesia (or) hand-foot syndrome of varying degree of severity induced by capecitabine....
Objective: The objective of present study was to find out the difference in the effect of insight and medication benefits, internal and external barriers towards medication adherence among rural and urban psychiatric outpatients. Methods: An analytical observational study was conducted on 205 patients for duration of 6months in the outpatient depar...
Stevens Johnson syndrome is a life threatening IgE mediated hypersensitivity reaction affecting the skin and mucous
membranes and should be considered in any child who has been on antiepileptic medication. A case of Stevens
Johnson Syndrome and hepatitis following treatment with sodium valproate is presented. A 2 year old female
pediatric patient s...
Drug Utilization Evaluation (DUE) promotes rational use of drugs. The aim of present study was to conduct DUE of anticancer drugs. Newly diagnosed and/or known case of carcinoma which required treatment with chemotherapy, patients of both sex, and age >18 years were included in the study. Patients diagnosed as having carcinoma that also required su...
Venous thromboembolism is a global health concern with substantial morbidity and mortality. About 30 percent of patients with symptomatic venous thromboembolism manifest Pulmonary Embolism, others manifest Deep Vein Thrombosis. Despite a similar proportion of at risk hospitalized patients in India and other countries, there is major under utilizati...
Introduction: Drug Use Evaluation (DUE) is a system of ongoing, systematic, criteria-based evaluation of drug use that will help ensure that medicines are used appropriately (at the individual patient level).
Methodology: It was an Observational Descriptive Study. Drug Utilization data was obtained from the
prescriptions of the patients attending...
Questions
Questions (9)
I had 13 case histories of a disease, I am wondering whether to present them as a case series or as a small descriptive study of cases? Please can someone answer my question as early as possible?
How do you calculate adjusted odds ratio and unadjusted odds ratio in multivariate logistic regression analysis?
Hi. I am interested in doing meta-analysis. So I searched free software for it. Luckily I cam across Openmeta. This forest plot was from it. Can anyone please help me to interpret this forest plot. Please explain me this terms and forest plot result
Binary Random-Effects Model
Metric: Odds Ratio
Model Results
Estimate Lower bound Upper bound p-Value
0.770 0.485 1.222 0.267
Heterogeneity
tau^2 Q(df=18) Het. p-Value I^2
0.378 33.360 0.015 46.044
Results (log scale)
Estimate Lower bound Upper bound Std. error
-0.262 -0.724 0.200 0.236
We carried out a research study on quality of life of breast cancer patients. There are three groups (paired-baseline, cycle 1, cycle 2). We used EORTC QLQ C-30, BR-23 questionnaires. They have different domains like physical functioning, role functioning etc with their respective scores. We want to predict the effect of each independent variable on the various domains of the quality of life questionnaire. However, since there are three groups, can we do the average of each domain (baseline, cycle 1, cycle 2) and obtain a single value for each domain and use it to perform multiple linear regression analysis with other independent variables? After doing average, each domain will get one value
If the p-value was less the alpha, then the data do not follow poisson distribution
Neyman Bias is a selection bias where the very sick or very well (or both) are
erroneously excluded from a study. You may not know which (improved/died) you are excluding, making it impossible to adjust for any bias in your
results.
The bias (“error”) in your results can be skewed in two directions:
Excluding patients who have died will make conditions look less severe.
Excluding patients who have recovered will make conditions look more severe
Recently i read an article about medication antidote signals and the prediction of ADRs with help of them. By using positive predictive values they found association between drug and antidote
JADAD score was used to assess the quality of randomized controlled trial using a predefined criteria. Randomization scheme and its appropriateness is one of the parameter used to assess the quality of the RCT.
I read that Kappa statistic was used to measure the agreement between two categorical variables. If we use two scales which measure the same property for example say medication adherence, can we use Kappa statistic to measure the agreement between the two scales?
