Vincenzo Denaro

• Campus Bio-Medico University

Purpose The goal of this study was to assess the annual incidence of tibiotarsal arthrodesis in Italy and the epidemiological characteristics of patients requiring surgery. A secondary aim was to assess the economic impact of this type of surgery on the healthcare system. Methods The analysis was conducted by using the National Hospital Discharge...

Background Low back pain (LBP) is a leading cause of disability worldwide, often associated with intervertebral disc degeneration (IDD). Mesenchymal stromal cells (MSCs) have emerged as a promising regenerative therapy for IDD due to their ability to promote tissue repair. This phase IIB randomized controlled trial aimed to evaluate the safety and...

Lumbar spine fusion (LSF) surgeries have increased due to the rising prevalence of degenerative spine disorders and advancements in surgical techniques. However, the success of these procedures should be evaluated from the patient's perspective, emphasizing the need for effective patient-reported outcome measures (PROMs). Existing PROMs often focus...

Purpose In this experimental study, the Minimally Invasive Configuration (MIC), the Bunnell, Kessler and modified Bunnell–Kessler techniques for tendon rupture repair were compared in terms of the following biomechanical parameters: maximum load, mode of failure, failure elongation, tension/construct elongation and stiffness (Young's modulus). The...

Purpose Image-guided navigation and robotic systems have been introduced in spinal surgery to increase the accuracy of pedicle screws placement and reduce the rate of complications. The objective of this study is to evaluate the different final screw deviation from pre-operative planning and the associated pedicle screw accuracy in spinal fusion su...

Background The Shoulder Pain and Disability Index (SPADI) is one of the most widely used Patient Reported Outcome Measures designed to assess the severity of pain and disability in patients with shoulder conditions. Objective The aim of the study is to define the clinically significant outcomes of the Minimum Clinically Important Difference (MCID)...

Purpose This study aimed to evaluate the demographic features of patients undergoing wrist arthroscopy in Italy. A secondary aim was to perform an economic analysis of this type of surgery. Methods The National Hospital Discharge Records database was employed to conduct the analysis. Wrist arthroscopy surgical procedures were defined by the primar...

Purpose The rate of lumbar spine surgeries has increased and the postoperative course is influenced not only by physical but also psychological factors. Patients with pre-existing psychological disorders appear to be more likely to develop anxiety and depression, these factors could negatively affect pain perception, disability, and quality of life...

Purpose This study intended to estimate the annual number of hallux valgus surgical procedures in Italy and the patients' epidemiological features. A secondary goal was to compare the demographic differences in access to hallux valgus surgery amongst three Italian macroregions. Methods The analysis was conducted by using the National Hospital Disc...

Background Low back pain is the leading cause of disability worldwide with a significant socioeconomic burden; artificial intelligence (AI) has proved to have a great potential in supporting clinical decisions at each stage of the healthcare process. In this article, we have systematically reviewed the available literature on the applications of AI...

Purpose: Rotator cuff tear (RCT) is a common injury in adults over 50, causing significant pain and functional impairment. This review compares the cost-effectiveness of various surgical and non-surgical RCT treatment options. Methods: A systematic review was conducted, including cost analyses, randomized controlled trials, and feasibility studies...

Low back pain is the main cause of disability worldwide and is primarily caused by intervertebral disc degeneration. To date, several cell-based therapies have been proposed to replenish the disc cell population and promote tissue regeneration. However, as most anabolic effects exerted by transplanted cells derive from their secretome, direct utili...

Purpose Hip arthroscopy has gained popularity among orthopaedic procedures over the last decade. The present study aims to evaluate the trends of hip arthroscopy procedures in Italy analysing data recorded by the Italian Ministry of Health, reporting demographics, length of hospitalisation (LOS), diagnosis and the economic impact of the procedure....

Non-contact anterior cruciate ligament injuries (NC-ACLs) represent a significant concern in sports medicine, particularly among athletes and physically active individuals. These injuries not only result in immediate functional impairment but also predispose individuals to long-term issues such as recurrent instability and early-onset osteoarthriti...

Background With life expectancy on the rise, there has been an increase in patients with concomitant degenerative hip and spine pathology, defined as hip-spine syndrome (HSS). Patients affected by HSS may require both total hip arthroplasty (THA) and lumbar spinal fusion (LSF), although there is a paucity of data regarding how the sequential timing...

Purpose Implanted devices used in metastatic spine tumor surgery (MSTS) include pedicle screws, fixation plates, fixation rods, and interbody devices. A material to be used to fabricate any of these devices should possess an array of properties, which include biocompatibility, no toxicity, bioactivity, low wear rate, low to moderate incidence of ar...

Bone fragility is a recognized complication of type 2 diabetes mellitus (T2DM), increasing patient morbidity. Thus, the development of an effective intervention to prevent diabetic bone fragility is urgently needed. As lifestyle intervention represents an effective option for diabetes management, it may have an impact on bone health. While studies...

Simple Summary Bone metastases represent a serious and common challenge in advanced cancer patients, making early detection crucial. The growing implementation of artificial intelligence (AI) in various medical fields is revolutionizing healthcare by enhancing diagnostic accuracy. This systematic review includes 59 articles and sought to assess the...

Study Design Systematic review and meta-analysis. Objective This study aims to compare pedicle screw accuracy, clinical outcomes, and complications between navigated and conventional techniques. Summary of Background Data In the last decades, intraoperative navigation has been introduced in spinal surgery to prevent risks and complications. Meth...

The intervertebral disc (IVD) is the largest avascular organ of the human body and plays a fundamental role in providing the spine with its unique structural and biomechanical functions. The inner part of the IVD contains the nucleus pulposus (NP), a gel-like tissue characterized by a high content of type II collagen and proteoglycans, which is cru...

Aims Proximal humeral fractures are the third most common fracture among the elderly. Complications associated with fixation include screw perforation, varus collapse, and avascular necrosis of the humeral head. To address these challenges, various augmentation techniques to increase medial column support have been developed. There are currently no...

Chronic low back pain (LBP) represents a leading cause of absenteeism from work. An accurate knowledge of complex interactions is essential in understanding the difficulties of return to work (RTW) experienced by workers affected by chronic LBP. This study aims to identify factors related to chronic LBP, the worker, and the psycho-social environmen...

Background Several studies have compared the pros and cons of simultaneous bilateral versus staged bilateral hip and knee replacement but the outcomes of these two surgical options remains a matter of controversy. This study aimed to evaluate demographic features, incidence and hospitalization rates of bilateral one stage total hip and knee arthrop...

Background Chronic discogenic low back pain (LBP) poses a significant global burden, yet effective therapeutic interventions directly targeting the underlying degenerative process remain elusive. After demonstrating promising results in preclinical studies, intradiscal injection of cell‐based treatments has been increasingly investigated in the cli...

Background: Knee osteoarthritis is the most prevalent type of osteoarthritis. Patients frequently encounter pain triggered by movement that evolves into impaired joint function. Needing persistent rest or having night-time pain signifies advanced disease. Qualitative research is considered the most effective method for comprehending patients’ needs...

Introduction: With life expectancy on the rise, there has been an increase in patients with concomitant degenerative hip and spine pathology, namely hip-spine syndrome (HSS). Patients with HSS may require both total hip arthroplasty (THA) and lumbar spinal fusion (LSF), but there is a paucity of data regarding how the sequential timing of these pro...

Introduction Intraoperative navigation systems for lumbar spine surgery allow to perform preoperative planning and visualize the real-time trajectory of pedicle screws. The aim of this study was to evaluate the deviation from preoperative planning and the correlations between screw deviation and accuracy. Method Patients affected by degenerative s...

Background: The etiopathogenesis of ACL rupture is not clarified. The aim of this study is to identify genomic regions and genetic variants relevant to anterior cruciate ligament injury susceptibility that could be involved in non-contact anterior cruciate ligament ruptures. Methods: A systematic review of the literature was performed according to...

Objective: To evaluate the global practice pattern of wound dressing use after lumbar fusion for degenerative conditions.Methods: A survey issued by AO Spine Knowledge Forums Deformity and Degenerative was sent out to AO Spine members. The type of postoperative dressing employed, timing of initial dressing removal, and type of subsequent dressing a...

Objective: Several studies have advocated for the higher accuracy of transpedicular screw placement under cone-beam computed tomography (CBCT) compared to conventional 2-dimensional (2D) fluoroscopy. The superiority of navigation systems in perioperative and postoperative outcomes remains a topic of debate. This study aimed to compare operative ti...

Study design: Epidemiological study. Objective: This study aimed to evaluate the annual incidence of spondylolisthesis requiring surgery in Italy and the epidemiological characteristics of the patients. Background: The health care system continues to incur considerable costs as a result of low-back pain. Segmental instability of the lumbar spi...

Purpose To investigate the therapeutic potential of extracellular vesicles (EVs) derived from human nucleus pulposus cells (NPCs), with a specific emphasis on Tie2-enhanced NPCs, compared to EVs derived from human bone marrow-derived mesenchymal stromal cells (BM-MSCs) in a coccygeal intervertebral disc degeneration (IDD) rat model. Methods EVs we...

Purpose This systematic review aimed to report the current evidence in the literature about the efficacy of interventional treatments in the management of low back pain (LBP) due to sacroiliac joint dysfunction. Methods A systematic review was performed using the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guideline...

INTRODUCTION: Despite promising results in attempting intervertebral disc regeneration, intradiscal cell transplantation is affected by several drawbacks, including poor viability in the harsh disc environment, low cost-effectiveness, and immunogenic/tumorigenic concerns1. Recently, the development of cell- free approaches is gaining momentum in th...

Study Design Systematic review and meta-analysis. Objective To compare clinical and radiographic outcomes as well as complications of unplated vs plated anterior cervical discectomy and fusion (ACDF) surgery considering the role of osteobiologics in single- and multi-level procedures. Methods A systematic search of PubMed/MEDLINE, Scopus, CINAHL,...

The 36-Item Short-Form Health Survey questionnaire (SF-36) is a reliable tool to assess the health-related quality of life of patients. If a mean difference between pre-operative evaluation and final follow-up is found to be statistically significant, then the change in score is not random. However, a statistically significant mean change may not c...

Patient-Reported Outcome Measures (PROMs) are standardized questionnaires that gather information on health-related quality of life directly from patients. Since a significant statistical mean change may not correspond to a clinical improvement, there is a need to calculate a considerable change in scores. This is done by the Minimum Clinically Imp...

Background This study examines the relationship between functional disability and work ability in workers affected by low back pain (LBP) through an analysis of correlations between the Oswestry Disability Index (ODI) and Work Ability Index (WAI). The role of personal and work factors on functional disability/work ability levels has also been studi...

Background Intradiscal transplantation of mesenchymal stromal cells (MSCs) has emerged as a promising therapy for intervertebral disc degeneration (IDD). However, the hostile microenvironment of the intervertebral disc (IVD) may compromise the survival of implanted cells. Interestingly, studies reported that paracrine factors, such as extracellular...

Patients with rheumatic disease may present with a myriad of symptoms, but the most common is undoubtedly chronic or intermittent joint pain. Rheumatic disorders typically affect the musculoskeletal system determining, especially if left untreated, long-term functional damage and deformity. Rheumatisms can be distinguished into two main types on th...

Cervical spondylotic myelopathy (CSM) is a disorder with an increasing prevalence. CSM is an impaired function of the spinal cord caused by degenerative changes in the cervical spine that results in compression of the spinal cord. Symptoms of CSM are the instability of gait, loss of fine motor control of the upper limbs, numbness in the hands, weak...

Neurological pathologies could affect the musculoskeletal system leading to progressive joint destruction. The common characteristic is a deficit in nociceptive sensitivity. This deficit exposes the joint to repeated microtrauma, resulting in microfractures, subluxations, and dislocations. The most common neurological pathologies related to musculo...

Multiple myeloma (MM) is a hematologic neoplasm due to malignant proliferation of plasma cells derived from a single clone. Plasma cell proliferation induced bone resorption causing diffused lytic lesions. The treatment of MM needs a multidisciplinary approach, including also radio- and chemotherapy. Sickle cell anaemia is an inherited haemoglobino...

Lumbar spinal stenosis (LSS) describes a broad spectrum of anatomical, clinical, and radiographic findings. The clinical manifestation of this disease is claudication, lower back and extremity pain, and reduced functionality. The use of a corset is indicated. The surgery aims to decompress the spinal canal and neural foramina, reducing the pressure...

Several endocrine disorders may affect the musculoskeletal system altering bone metabolism and growth. The pituitary gland produces growth hormone (GH): it increases longitudinal height during childhood, promotes mineralization of bone and determines muscle mass hypertrophy. An oversecretion of GH leads to acromegaly and gigantism. GH deficiency le...

The surgical treatment of bone metastases aims to reduce pain, improve function, prevent tumour progression and decrease complications. Surgery is indicated only for patients with an expected survival of 3–6 months. In other cases, palliative treatment is preferred. Wide or marginal excision is always associated with osteosynthesis or prosthetic re...

Advancement in technology, radiotherapy, surgical approaches (anterior, posterior and combined) and technique improved the quality of cervical spine tumour management. Biopsy is necessary to establish the histological diagnosis. There are no precise guidelines concerning cervical spine tumour surgical management; therefore, this surgery needs to be...

Despite promising results in attempting intervertebral disc regeneration, intradiscal cell transplantation is affected by several drawbacks, including poor viability in the harsh disc environment, low cost-effectiveness, and immunogenic/tumorigenic concerns. Recently, the development of cell-free approaches is gaining increasing interest in the fie...

Purpose Rotator Cuff (RC) lesions are classified in full-thickness and partial-thickness tears (PTRCTs). To our knowledge, no studies investigated the mean size of shoulder tendons in healthy and PTRCT patients using MRI scans. The aim of the study was to provide data to obtain and compare the mean value of tendon sizes in healthy and PTRCTs groups...

The aim of this review is to determine the safety and efficacy of pre-operative spinal metastases embolization procedures. Two reviewers independently conducted the literature search (on MEDLINE databases), including in the review of all the studies that used pre-operative TAE to treat spinal metastases. Twelve articles on pre-operative spinal meta...

This review aims to evaluate the usefulness of preoperative education in the orthopedic patient undergoing knee and total hip replacement. The systematic review was conducted by searching the PubMed, Cochrane, CINAHL, and Embase databases from inception to April 2021. Keywords and combinations of keywords were organized according to the PICOs appro...

The anterior cruciate ligament (ACL) is the most injured ligament of the knee, and the treatment of choice is usually ACL reconstruction. Kinesiophobia refers to an irrational and paralyzing fear of movement caused by the feeling of being prone to injury or reinjury. The aim of the present study is to evaluate the relationship between preoperative...

The rehabilitation of those who have undergone anterior cruciate ligament reconstruction (ACL-R) is a complex process that involves many factors. Physical ability recovery is not the only factor in the return to sport; psychosocial factors such as anxiety, pain response, self-esteem, locus of control, and fear of re-injury also play an important ro...

Objective: To assess the effect of transitioning to remote working during the coronavirus disease 2019 pandemic in a population of adults affected by chronic low back pain (cLBP). Methods: An online questionnaire was sent by email to teleworkers affected by cLBP. Demographic data, remote working features and tasks, and LBP burden were analyzed....

The foot is a complex organ which controls the kinematic chain of the lower limb. The kinematic chain is characterized by different phases of stability and instability, made possible by the finely anatomical structures of feet. Several pathological conditions can alter this complex circuit. Among these, Charcot-Marie-Tooth (CMT) disease and Morton’...

The foot and the ankle work synchronically in a complex system made of 26 bones and joints. They help the feet to adapt to uneven surfaces while the other parts of the body rest standing. The ankle plays an essential role in the execution of plantar flexion and dorsiflexion movements. During gait, when the heel hits the surface, the ankle movement...

Scapular dyskinesis (SD) is a condition of loss of normal mobility or function of the scapula. SD is frequently observed in patients with other shoulder disorders, such as rotator cuff (RC) tears. This study evaluates the different presentations in clinical outcomes and range of motions (ROMs) in patients suffering from RC tears with and without SD...

The Shoulder Disability Questionnaire (SDQ) is a Patient-Reported Outcome Measure (PROM) applied to evaluate shoulder surgery outcomes. The purpose of this study is to identify the accurate Minimal Clinically Important Difference (MCID), Substantial Clinical Benefit (SCB) and Patient Acceptable Symptom State (PASS) values for the SDQ score. A total...

This study intended to estimate the annual number of hallux valgus surgical procedures in Italy and the patients’ epidemiological features. A secondary goal was to compare the demographic differences in access to hallux valgus surgery amongst three Italian macroregions. The analysis was conducted by using the National Hospital Discharge Records (NH...

Tendinopathy is one of the most common musculoskeletal disorders, with significant repercussions on quality of life and sport activities. Physical exercise (PE) is considered the first-line approach to treat tendinopathy due renowned mechanobiological effects on tenocytes. Irisin, a recently identified myokine released during PE, has been recognize...

Background context: Low back pain (LBP) is the leading cause of disability worldwide, with a tremendous socioeconomic burden. It is mainly caused by intervertebral disc degeneration (IDD), a progressive and age-related process. Due to its ability to accurately characterize intervertebral disc morphology, magnetic resonance imaging (MRI) has been e...

Anxiety and depressive symptoms adversely affect surgical outcomes in patients with rotator cuff tear (RCT) undergoing surgical repair. Patients without a diagnosis of mood disorders, such as anxiety and depression, before rotator cuff repair (RCR) can be considered an optimal candidate for surgery. The objective of this prospective observational s...

Oxidative stress, a key mediator of cardiovascular disease, metabolic alterations, and cancer, is independently associated with menopause and obesity. Yet, among postmenopausal women, the correlation between obesity and oxidative stress is poorly examined. Thus, in this study, we compared oxidative stress states in postmenopausal women with or with...

Osteoarthritis negatively impacts the patient’s quality of life. Qualitative research is an effective tool in detecting the various emotions experienced by patients with osteoarthritis. Such studies play a crucial role in promoting comprehension of the patient’s experiences of health and illness among healthcare professionals, including nurses. The...

Background Rotator Cuff Related Shoulder Pain (RCRSP) is the most common type of shoulder pain and the most disabling common symptom in people with Rotator Cuff Tear (RCT). The patient’s point of view concerning health status has become important in decision-making procedures and has therefore been considered a possible criterion standard for asses...

Osteoarthritis (OA) is one of the main causes of disability worldwide and is caused by the progressive degeneration of joint tissues, ultimately leading to chronic pain and loss of function. Intraarticular delivery of mesenchymal stromal cells, such as adipose-derived stromal cells (ASCs), is being actively investigated due to their trophic propert...

Introduction: Intradiscal mesenchymal stromal cell (MSC) therapies for intervertebral disc degeneration (IDD) have been gaining increasing interest due to their capacity to ameliorate intervertebral disc metabolism and relieve low back pain (LBP). Recently, novel investigations have demonstrated that most of MSC anabolic effects are exerted by secr...

Sarcopenia is a progressive and generalized skeletal muscle disorder associated with poor outcomes and complications, including falls, fractures, physical disability, and death. The aim of this review is to assess the possible influence of sarcopenia on outcomes of sarcopenia in patients who underwent knee or hip replacement. A systematic review wa...

The present study aimed to evaluate the yearly number of Colles’ fractures in Italy from 2001 to 2016, based on official information found in hospitalization records. A secondary aim was to estimate the average length of hospitalization for patients with a Colles’ fracture. A tertiary aim was to investigate the distribution of the procedures genera...

This study describes the trends of elbow arthroscopy in Italy and other countries in order to evaluate the yearly rates of EA. Its purpose is for future epidemiological studies to be able to compare their data between countries in order to understand the reasons for the increasing and decreasing trends. Data for this study were obtained from Nation...