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Vincent Schlageter

Vincent Schlageter

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64
Publications
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1,279
Citations

Publications

Publications (64)
Article
Full-text available
Background/Objectives: Chronic nausea and vomiting (N/V) disorders are common in clinical practice. Our primary aim was to compare total and segmental gastrointestinal transit times as well as gastric contraction patterns in patients with chronic N/V syndrome to those of healthy volunteers (HVs). In the patient group, our secondary aim was to explo...
Article
Full-text available
Characteristics of electrograms depend on the electrode design and distance to the electric source. Our aim was to assess the impact of electrode design and distance from the myocardial electric source on the unipolar and bipolar electrograms to deduce a far-field cut-off. We retrospectively analyzed left atrial electroanatomical maps of 25 patient...
Conference Paper
Introduction Cardiac autonomic dysfunction has been linked to an increased risk of mortality (1), stroke and silent brain lesions (2) and cognitive impairment (3) in patients with atrial fibrillation (AF). However, the impact of AF on cardiac autonomic function is poorly understood. Purpose We aimed to explore the impact of AF on cardiac autonomic...
Conference Paper
Background Sex-specific differences in cardiac autonomic tone have not been thoroughly investigated in patients with atrial fibrillation (AF) but may play a relevant role. Purpose We aimed to investigate cardiac autonomic function of female compared to male AF patients by means of short-term heart rate variability (HRV) analysis. Methods In this...
Article
Background Outcome prediction after catheter ablation for atrial fibrillation (AF) based on electronic health records (EHR) using machine learning (ML) is not yet established. Purpose The aim of the study was to assess the value of ML methods to predict the risk of AF recurrence after catheter ablation based on easily accessible EHR. Methods We a...
Article
Background The characteristics of intracardiac unipolar and bipolar voltage electrograms (EGM) acquired by electrophysiological catheters depend on the electrical source and on the electrode design and configuration. Purpose The aim of the study was to assess the impact of the electrode configuration and their distance from the myocardial tissue (...
Conference Paper
Background Cardiac autonomic dysfunction after brain infarcts is a strong predictor of adverse outcome. Purpose The aim of this study was to investigate the association of large cortical or non-cortical brain infarcts (LNCCI) with multiscale (MSE) and sample entropy (SE), which characterize the complexity of RR interval time series in atrial fibri...
Preprint
Full-text available
Background The characteristics of intracardiac unipolar and bipolar voltage electrograms (EGM) acquired by electrophysiological catheters depend on the electrode design and configuration. The aim of the study was to assess the impact of electrode design and distance from the myocardial electric source on the unipolar and bipolar intracardiac electr...
Article
Full-text available
Funding Acknowledgements Type of funding sources: Private company. Main funding source(s): The study was supported by an investigator sponsored grant (Boston Scientific). Background Bipolar voltage electrograms (BVE) for left atrial (LA) substrate characterization strongly depend on the catheter design and electrode configuration. Purpose The aim...
Conference Paper
Full-text available
Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): Swiss National Science Foundation, Swiss Heart Foundation Background Emerging evidence indicates that a high atrial fibrillation (AF) burden is associated with adverse outcome. However, AF burden is not routinely measured in clinical practice. An artificial intel...
Article
Full-text available
Background: Bipolar voltage (BV) electrograms for left atrial (LA) substrate characterization depend on catheter design and electrode configuration. Aims: The aim of the study was to investigate the relationship between the BV amplitude (BVA) using four catheters with different electrode design and to identify their specific LA cutoffs for scar...
Article
Full-text available
Background Superimposition of farfield (FF) and nearfield (NF) bipolar voltage electrograms (BVE) complicates the confirmation of pulmonary vein (PV) isolation after catheter ablation of atrial fibrillation. Our aim was to develop an automatic algorithm based on a single-beat analysis to discriminate PV NF from atrial FF BVE from a circular mapping...
Article
Background: Emerging evidence indicates that a high atrial fibrillation (AF) burden is associated with adverse outcome. However, AF burden is not routinely measured in clinical practice. An artificial intelligence (AI)-based tool could facilitate the assessment of AF burden. Objective: We aimed to compare the assessment of AF burden performed ma...
Preprint
Full-text available
Background Bipolar voltage (BV) electrograms for left atrial (LA) substrate characterization depend on catheter design and electrode configuration. The aim of the study was to investigate the relationship between the BV amplitude (BVA) using four different catheters and to identify their specific LA cutoffs for scar and healthy tissue. Methods Cons...
Conference Paper
Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Swiss National Science Foundation Introduction Despite the broad use of oral anticoagulants, stroke remains one of the most serious complications in atrial fibrillation (AF) patients. Stroke has been linked to disturbances of the auton...
Article
Funding Acknowledgements Type of funding sources: None. Introduction Magnetic interference of portable electronic devices (PEDs), such as state-of-the-art mobile phones, with cardiovascular implantable electronic devices (CIEDs) has been reported. Purpose The aim of the study was to quantify the magnetic fields of latest generation Smartwatches a...
Article
Funding Acknowledgements Type of funding sources: Public hospital(s). Main funding source(s): “Stiftung für Herzschrittmacher und Elektrophysiologie” Basel, Switzerland Background Confirmation of pulmonary vein (PV) isolation (PVI) during ablation of atrial fibrillation can be challenging due to superimposition of nearfield (NF) PV and farfield (F...
Article
Background The effect of the ventricular repolarization heterogeneity has not been systematically assessed in patients with atrial fibrillation (AF). Aim of this study is to assess ventricular repolarization heterogeneity as predictor of cardiovascular (CV) death and/or other CV events in patients with AF. Methods From the multicenter prospective...
Article
Full-text available
Background/aims: Patients with diabetes mellitus (DM) often suffer from gastrointestinal (GI) symptoms, but these correlate poorly to established objective GI motility measures. Our aim is to perform a detailed evaluation of potential measures of gastric and small intestinal motility in patients with DM type 1 and severe GI symptoms. Methods: Tw...
Article
Objective: To evaluate the safety and use of the 3D-Transit system (Motilis SA, Lausanne, Switzerland) and to describe regional gastrointestinal transit times, segmental colonic transit times and colonic movement patterns in healthy children. Methods: 21 healthy children (11 girls, median age 10.5 years, range 7-15 years) were included. For eval...
Article
Full-text available
Purpose: Silent brain infarcts (SBI) are frequently detected in patients with atrial fibrillation (AF), but it is unknown whether SBI are linked to autonomic dysfunction. We aimed to explore the association of autonomic dysfunction with SBI in AF patients. Methods: 1,358 AF patients without prior stroke or TIA underwent brain MRI and 5-min resting...
Conference Paper
Full-text available
Precise landslide monitoring with differential global navigation satellite system (GNSS) is well known, but technical or economic reasons limit its application by geotechnical companies. This study demonstrates the reliability and the usefulness of Geomon (Infrasurvey Sàrl, Switzerland), a stand-alone and cost-effective rover network. The system pe...
Article
Full-text available
Background Impaired heart rate variability (HRV) is associated with increased mortality in sinus rhythm. However, HRV has not been systematically assessed in patients with atrial fibrillation (AF). We hypothesized that parameters of HRV may be predictive of cardiovascular death in patients with AF. Methods and Results From the multicenter prospect...
Article
Full-text available
Background Gastrointestinal (GI) symptoms are common in patients with diabetes mellitus (DM). The electromagnetic 3D‐Transit system allows assessment of regional transit times and motility patterns throughout the GI tract. We aimed to compare GI transit times and detailed motility patterns of the colon in patients with DM and GI symptoms to those o...
Article
Full-text available
Background The Motilis 3D‐Transit system allows ambulatory description of transit patterns throughout the gastrointestinal tract and offers an alternative method for studying gastric motility. We aimed to establish normative values for gastric motility assessed with the method. Method A total of 132 healthy volunteers ingested the 3D‐Transit capsu...
Article
Full-text available
Background Opioid treatment often causes debilitating constipation. However, it is not well described how opioids affect colonic motility and whether opioid‐induced constipation is due to either a decrease of powerful peristaltic contractions or “uncoordinated” peristalsis. The present study aims to investigate the effect of oxycodone on parameters...
Article
Full-text available
Background The 3D‐Transit electromagnet tracking system (Motilis Medica, SA, Lausanne, Switzerland) is an emerging tool for the ambulatory assessment of gastrointestinal (GI) transit and motility. Using this tool, we aimed to derive normative values for region‐specific colonic and GI transit times and to assess the influence of age, gender, and bod...
Article
Full-text available
Background The Motilis 3D‐Transit system tracks electromagnetic capsules as they traverse the gastrointestinal tract. The method is minimally invasive and ambulatory. Analysis has previously been limited to regional gut transit times, but new methods may allow detailed analysis of colonic motility. Methods Parameters of colonic motility were analy...
Article
Full-text available
Aim: We aimed to determine colorectal length with the 3D-Transit system by describing a 'centerline' of capsule movement and compare it to known anatomy, as determined by magnetic resonance imaging (MRI). Further, we aimed to test the day-to-day variation of colorectal length assessed with the system. Method: The 3D-Transit system consists of el...
Article
Background: Gastrointestinal (GI) dysmotility may present secondary to inflammatory bowel disease. The main aim of this study was to investigate GI motility in ulcerative colitis (UC) patients during severe disease activity. Methods: Twenty patients with severe UC were studied with a novel telemetric capsule system (3D-Transit) designed for mini...
Article
Full-text available
Studies of gastrointestinal function during sleep are hampered by lack of applicable techniques. Recent development of a novel ambulatory telemetric capsule system, which can be used in conjunction with polysomnography, offers a solution to this problem. The 3D-Transit system consists of ingestible electromagnetic capsules traceable through a porta...
Article
Full-text available
The paucity of knowledge regarding gastrointestinal motility in patients with neuroendocrine tumors and carcinoid diarrhea re-stricts targeted treatment. 3D-Transit is a novel, minimally invasive, ambulatory method for description of gastrointestinal motility. The system has not yet been evaluated in any group of patients. We aimed to test the perf...
Article
Background Gastrointestinal (GI) motor disorders often involve several regions of the GI tract. Therefore, easy and safe assessment of whole gut and regional motility is valuable for more precise diagnosis. 3D-Transit is a novel method for ambulatory evaluation of total and regional gastrointestinal transit times (GITT) based on the anatomical loca...
Article
Introduction Due to the inaccessibility of the gastrointestinal (GI) tract and lack of proper measurement techniques clinical studies describing gastrointestinal function during sleep are sparse. In the present pilot study we aimed at introducing a novel ambulatory telemetric capsule system (3D-Transit) in conjunction with polysomnography (PSG). M...
Article
Full-text available
Data on small intestinal transit time in healthy children are lacking, and normal values for gastric emptying and colonic transit time are sparse. Conventional methods, including radiopaque markers, scintigraphy, and PillCam™ involve radiation or require the child to swallow a large pill. The minimally invasive, radiation-free Motility Tracking Sys...
Article
Aim: Sacral nerve stimulation (SNS) reduces symptoms in up to 80% of patients with faecal incontinence (FI). Its effects are not limited to the distal colon and the pelvic floor. Accordingly, spinal or supraspinal neuromodulation have been suggested as part of the mode of action. The effect of SNS on gastric and small-intestinal motility was studi...
Article
Full-text available
Tracking an ingested magnet by the Magnet Tracking System MTS-1 (Motilis, Lausanne, Switzerland) is an easy and minimally-invasive method to assess gastrointestinal transit. The aim was to test the validity of MTS-1 for assessment of gastric transit time and small intestinal transit time, and to illustrate transit patterns detected by the system. A...
Article
Full-text available
Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis and collagen deposits. Gastrointestinal symptoms of SSc, including abdominal pain, bloating and discomfort, are common but diffuse and their pathophysiology remains obscure. To investigate the pathophysiology of abdominal pain and discomfort in individuals with SSc. A total...
Article
Full-text available
Diarrhea is part of the carcinoid syndrome and a significant clinical problem in neuroendocrine tumor (NET) patients. Somatostatin analog (SA) treatment usually alleviates carcinoid diarrhea, but little is known about the objective effects of SA on gastrointestinal transport. To compare gastrointestinal motility in healthy subjects and NET patients...
Article
Many patients with spinal cord injury (SCI) suffer from constipation, abdominal pain, nausea, or bloating, and colonic transit times are prolonged in most. Gastric and small intestinal dysfunction could contribute to symptoms but remain to be described in detail. Also, it is obscure whether the level of SCI affects gastric and small intestinal func...
Article
Full-text available
Although other methods exist for monitoring gastrointestinal motility and contractility, this study exclusively provides direct and quantitative measurements of the forces experienced by an orally ingested pill. We report motive forces and torques calculated from real-time, in vivo measurements of the movement of a magnetic pill in the stomachs of...
Article
Direct electrical stimulation of the colon offers a promising approach for the induction of propulsive colonic contractions by using an implantable device. The objective of this study was to assess the feasibility to induce colonic contractions using a commercially available battery-operated stimulator (maximum pulse width of 1 ms and maximum ampli...
Article
The Magnet Tracking System (MTS) is a minimally-invasive technique of continuous evaluation of gastrointestinal motility. In this study, MTS was used to analyse colonic propulsive dynamics and compare the transit of a magnetic pill with that of standard radio-opaque markers. MTS monitors the progress in real time of a magnetic pill through the gut....
Article
Direct colonic electrical stimulation may prove to be a treatment option for specific motility disorders such as chronic constipation. The aim of this study was to provoke colonic contractions using electrical stimulation delivered from a battery-operated device. Electrodes were inserted into the caecal seromuscular layer of eight anaesthetized pig...
Article
Digestive motility was studied in the rat using a miniaturized version of the Magnet Tracking system which monitored the progression of a small magnetic pill through the entire digestive tract. The dynamics of movement was followed and three-dimensional (3-D) images of digestive tract were generated. After a retention period in the stomach and rapi...
Article
Full-text available
Fluoroscopic verification of nasogastric (NG) feeding tube placement is inconvenient and involves radiation exposure. We tested whether the position of an NG tube can be assessed reliably by a recently introduced magnet-tracking system. A small permanent magnet was attached at the end of an NG tube and its position was monitored using an external s...
Article
A new minimally invasive technique allowing for anatomical mapping and motility studies along the entire human digestive system is presented. The technique is based on continuous tracking of a small magnet progressing through the digestive tract. The coordinates of the magnet are calculated from signals recorded by 16 magnetic field sensors located...
Conference Paper
We present a new graphical tool to investigate the time evolution of phase-synchronization clusters and apply it to a computer model of the intestine consisting of coupled oscillators. The method estimates the synchronized zones using a covariance analysis of the electrical activity to detect any linear relationship between segments of the intestin...
Article
These Ecole polytechnique federale de Lausanne EPFL, n° 2872 (2003)Section de microtechniqueFaculte des sciences et techniques de l'ingenieurInstitut de microelectronique et microsystemesJury: Patrick J. French, Jean-Jaques Gonvers, Max-Olivier Hongler, Jean-Marc Vesin Public defense: 2003-11-26 Reference doi:10.5075/epfl-thesis-2872Print copy in l...
Article
A tracking system with five degrees of freedom based on a 2D-array of 16 Hall sensors and a permanent magnet is presented in this paper. The sensitivity of the Hall sensors is increased by integrated micro- and external macro-flux-concentrators. Detection distance larger than 20cm (during one hour without calibration) is achieved using a magnet of...
Article
Based on a 2D-array of 16 cylindrical Hall sensors and a permanent magnet, a tracking system with five degrees of freedom is analysed in this paper. The system accuracy is studied, including offset drifts, sensitivity mismatches and the number of sensors. A detection distance as large as 14 cm (during 1 h without calibration) is achieved using a ma...
Chapter
We have studied the sensitivity of Hall devices using planar magnetic flux concentrators of various lengths. By placing magneto-concentrators (MCs) on Hall device, we obtained sensitivity up to 100 V/T for a bias current of 1 mA and for a length of the MCs of 50 mm. This value is about 1000 times better then that of a conventional silicon Hall devi...

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