Vincent Lacoste

Vincent Lacoste
Institut Pasteur · Department of Virology

PhD

About

348
Publications
23,019
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1,907
Citations
Additional affiliations
September 2005 - November 2015
Institut Pasteur de la Guyane
Position
  • Principal Investigator

Publications

Publications (348)
Article
Henipaviruses include highly pathogenic emerging zoonotic viruses, derived from bat, rodent, and shrew reservoirs. Bat-borne Hendra (HeV) and Nipah (NiV) are the most well-known henipaviruses, for which no effective antivirals or vaccines for humans have been described.
Article
Full-text available
The first documented chikungunya virus (CHIKV) outbreak in Lao People’s Democratic Republic (Lao PDR) occurred in 2012–2013. Since then, several imported and a few autochthonous cases were identified by the national arbovirus surveillance network. The present study aimed to summarize the main genetic features of the CHIKV strains detected in Lao PD...
Preprint
The genus Henipavirus (family Paramyxoviridae ) is currently comprised of seven viruses, four of which have demonstrated prior evidence of zoonotic capacity. These include the biosafety level 4 agents Hendra (HeV) and Nipah (NiV) viruses, which circulate naturally in pteropodid fruit bats. Here, we describe and characterize Angavokely virus (AngV),...
Poster
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This study provides a new insight from the literature, and unpublished data on field and laboratory work with the aims to help explain observed patterns of Ae. albopictus distribution, biology and its vector role in arbovirus transmission in Madagascar
Article
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The animal reservoir of SARS-CoV-2 is unknown despite reports of various SARS-CoV-2-related viruses in Asian Rhinolophus bats1–4, including the closest virus from R. affinis, RaTG135,6 and in pangolins7–9. SARS-CoV-2 presents a mosaic genome, to which different progenitors contribute. The spike sequence determines the binding affinity and accessibi...
Article
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Since its first detection in 1979, dengue fever has been considered a major public health issue in the Lao People's Democratic Republic (PDR). Dengue virus (DENV) serotype 1 was the cause of an epidemic in 2010-2011. Between 2012 and 2020, major outbreaks due successively to DENV-3, DENV-4 and recently DENV-2 have been recorded. However, DENV-1 sti...
Article
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Members of the family Herpesviridae have enveloped, spherical virions with characteristic complex structures consisting of symmetrical and non-symmetrical components. The linear, double-stranded DNA genomes of 125–241 kbp contain 70–170 genes, of which 43 have been inherited from an ancestral herpesvirus. In general, herpesviruses have coevolved wi...
Preprint
Full-text available
The animal reservoir of SARS-CoV-2 is unknown despite reports of various SARS-CoV-2-related viruses in Asian Rhinolophus bats, including the closest virus from R. affinis, RaTG13. Several studies have suggested the involvement of pangolin coronaviruses in SARS-CoV-2 emergence. SARS-CoV-2 presents a mosaic genome, to which different progenitors cont...
Article
Full-text available
Rodents are important reservoirs of numerous viruses, some of which have significant impacts on public health. Ecosystem disturbances and decreased host species richness have been associated with the emergence of zoonotic diseases. In this study, we aimed at (a) characterizing the viral diversity in seven neotropical rodent species living in four t...
Article
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Background In 2020 Lao PDR had low reported COVID-19 cases but it was unclear whether this masked silent transmission. A seroprevalence study was done August - September 2020 to determine SARS-CoV-2 exposure. Methods Participants were from the general community (n=2433) or healthcare workers (n=666) in five provinces and bat/wildlife contacts (n=7...
Article
Bats are recognized as reservoirs of numerous viruses. Among them, paramyxoviruses, for example, Hendra and Nipah viruses, are highly pathogenic to humans. Nothing is known regarding the circulation of this viral family in bats from French Guiana. To search for the presence of paramyxoviruses in this territory, 103 bats of seven different species w...
Article
Objective: To understand the transmission dynamics of the HIV-1 subtype B epidemic in French Guiana and the factors that shaped the expansion of major phylogenetic transmission clusters. Design: HIV-1 subtype B pol sequences with associated epidemiological data obtained from 703 treatment-naïve patients living in French Guiana between 2006 and 2...
Preprint
Full-text available
Background: In 2020 Lao PDR had low reported COVID-19 cases but it was unclear whether this masked silent transmission. A seroprevalence study was done August - September 2020 to determine SARS-CoV-2 exposure. Methods: Participants were from the general community (n=2433) or healthcare workers (n=666) in five provinces and bat/wildlife contacts...
Article
Full-text available
Amerindian and Maroon populations of French Guiana have been living in isolation for generations and sexual networks remained mostly endogamous. The present study aimed to describe the phylogeny of E6 and E7 sequences of the most common high-risk HPV genotypes in these regions, to ascertain the diversity of intra-type variants and describe evolutio...
Article
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The Caribbean and South American French Overseas Territories (CSAFOT) are the region most heavily affected by the Human Immunodeficiency Virus type 1 (HIV-1) epidemic in France. Although dominated by HIV-1 subtype B, the detection of non-B subtypes and the great proportion of HIV-positive persons born abroad demonstrated the potential for local spr...
Article
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Since 2005, we have recorded annual episodes of alphaherpesvirus outbreaks in chicks of magnificent frigatebird Fregata magnificens on the Ile du Grand Connétable Nature Reserve in French Guiana. In 2009, we found sooty terns, Onychoprion fuscatus, that live sympatrically with frigatebirds, with visible clinical signs of a potential viral infection...
Article
In the past decade, a large number of studies have detected herpesvirus sequences from many bat species around the world. Nevertheless, the discovery of bat herpesviruses is geographically uneven. Of the various bat species tested to date, only a few were from the New World. Seeking to investigate the distribution and diversity of herpesviruses cir...
Article
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The human immunodeficiency virus-type 1 (HIV-1) subtype B has probably been circulating on the island of Hispaniola since the 1960s, but information about the early viral history on this Caribbean island is scarce. In this study, we reconstruct the dissemination dynamics of early divergent non-pandemic subtype B lineages (designated BCAR) on Hispan...
Article
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We report viral RNA loads and antibody responses in 6 severe human cases of Maripa virus infection (2 favorable outcomes) and monitored both measures during the 6-week course of disease in 1 nonfatal case. Further research is needed to determine prevalence of this virus and its effect on other hantaviruses.
Article
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High-throughput sequencing (HTS) along with bioinformatics tools that handles the huge amount of data produced, have enabled the access to viral diversity studies. In the context of emerging infectious diseases from wildlife, viromes studies are a tool of choice. However, viromes studies remain challenging. As a multistep process, parameters such a...
Article
Full-text available
The HIV-1 subtype B epidemic in French Guiana and Suriname is characterized by the co-circulation of the globally disseminated “BPANDEMIC” lineage and of non-pandemic subtype B lineages of Caribbean origin (BCAR). To reconstruct the spatiotemporal pattern of spread of those viral lineages circulating in these two countries, a total of 361 HIV-1 sub...
Article
Full-text available
The HIV-1 subtype B epidemic in French Guiana and Suriname is characterized by the co-circulation of the globally disseminated “BPANDEMIC” clade and of non-pandemic subtype B clades of Caribbean origin (BCAR). To reconstruct the spatiotemporal pattern of spread of those viral clades circulating in these two countries, a total of 361 HIV-1 subtype B...
Article
Investigating evolutionary processes between viruses and nonhuman primates has led to the discovery of a large number of herpesviruses. No study published so far on primate cytomegaloviruses has extensively studied New World monkeys (NWMs) at the subspecies, species, genus, and family levels. The present study sought to identify cytomegalovirus hom...
Article
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Background: Cervical cancer prevention using cervical cytology is insufficiently sensitive, a significant proportion of HPV-infected women having normal cytology. The objective of the present study was to try to identify factors associated with abnormal cytology in HPV-infected women living in remote areas of French Guiana. Methods: A study was...
Article
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Genome sequences are available for a sizeable number of herpesviruses that need to be classified. The Herpesvirales Study Group plans to approach this in a staged fashion. This year, we focus on the family Herpesviridae and propose the classification of 18 new species in existing genera and the placement of one existing species, which was not assig...
Article
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Social systems are major drivers of population structure and gene flow, with important effects on dynamics and dispersal of associated populations of parasites. Among bats, the common vampire bat (Desmodus rotundus) has likely one of the most complex social structure. Using autosomal and mitochondrial markers on vampires from Mexico, French Guiana...
Article
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Environmental disturbances in the Neotropics (e.g., deforestation, agriculture intensification, urbanization) contribute to an increasing risk of cross-species transmission of microorganisms and to disease outbreaks due to changing ecosystems of reservoir hosts. Although Amazonia encompasses the greatest diversity of reservoir species, the outsized...
Data
Read and contig processing of D. rotundus and M. molossus samples. Read data reduction steps and de novo assembly of processed reads. Contig and sequential BLAST comparisons, with the total number of contigs and viral families identified in D. rotundus and M. molossus samples. (DOCX)
Data
Predicted genome organization of the putative papillomavirus sequence directly recovered from the metagenomic data of M. molossus bat feces. The open-reading frames encoding the putative late (L1 and L2) and early (E1, E2, E6 and E7) proteins are shown in green boxes. The genome organization was determined with Geneious R9. (TIF)
Data
Map of collecting sites of all samples/individuals used across French Guiana. The total number of collected samples per site is given in parentheses. Pie chart indicates the proportion of feces (orange) and saliva (orange dots) samples collected. Detailed characteristics of the different collecting sites are given in Table 1. (TIF)
Article
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Though the common vampire bat, Desmodus rotundus, is known as the main rabies virus reservoir in Latin America, no tools are available to investigate its antiviral innate immune system. To characterize the IFN-I pathway, we established an immortalized cell line from a D. rotundus fetal lung named FLuDero. Then we molecularly characterized some of t...
Article
We report 5 human cases of hantavirus pulmonary syndrome found during surveillance in French Guiana in 2008–2016; of the 5 patients, 4 died. This pathogen should continue to be monitored in humans and rodents in effort to reduce the occurrence of these lethal infections in humans stemming from ecosystem disturbances
Article
Full-text available
We report 5 human cases of hantavirus pulmonary syndrome found during surveillance in French Guiana in 2008–2016; of the 5 patients, 4 died. This pathogen should continue to be monitored in humans and rodents in effort to reduce the occurrence of these lethal infections in humans stemming from ecosystem disturbances.
Article
Full-text available
Introduction: Leishmania RNA virus type 1 (LRV1) is an endosymbiont of some Leishmania (Vianna) species in South America. Presence of LRV1 in parasites exacerbates disease severity in animal models and humans, related to a disproportioned innate immune response, and is correlated with drug treatment failures in humans. Although the virus was ident...
Data
Phylogenetic analysis of partial 5’UTR sequences (alignment of 219 nucleotides). The tree was inferred using the Bayesian method with the GTR + G model. Novel sequences generated in this study are shown in bold. Sequence identifiers include the strain ID and the NCBI accession number. The major clades representing the different LRV1 genotypes ident...
Data
Phylogenetic analysis of partial 5’UTR—capsid gene sequences (alignment of 719 nucleotides corresponding to LRV1s/LRV2as PCR products excluding primers). The tree was inferred using the Bayesian method with the GTR + G + I model. New LRV1 sequences generated in this study are in boldface. Sequence identifiers include the strain ID and the NCBI acce...
Data
Phylogenetic analysis of Leishmania RNA virus 1 isolates based on the almost complete genome sequences. The phylogenetic trees were inferred from the almost complete nucleotide sequences (nucleotides 60–5248 relative to the LRV1-1 sequence) using the Bayesian method with the GTR + G + I model. New LRV1 sequences generated in this study are in boldf...
Data
Phylogenetic analysis of partial RdRp gene sequences (alignment of 865 nucleotides corresponding to LRV3s/LRV4as PCR products excluding primers). The tree was inferred using the Bayesian method with the T92 +G + I model. New LRV1 sequences generated in this study are in boldface. Sequence identifiers include the strain ID and the NCBI accession num...
Presentation
Full-text available
Amazonia is a major biodiversity hotspot which encompasses a great diversity of bat species, as well as a wide variety of climates and vegetation formations. Landscape characteristics (e.g. climate, vegetation structure, anthropogenic disturbances) are relevant predictors of species richness and influence the host-pathogens relationships. However,...
Poster
Full-text available
Host-pathogen interactions—greatly influenced by environmental characteristics—are a major determinant of the extensive polymorphism of the major histocompatibility complex (MHC) genes that play an important role in both resistance and susceptibility to diseases. Amazonia encompasses the greatest bat richness, as well as great landscape diversity....
Article
Among mammals, rodents play a key role in the emergence of viral diseases. In French Guiana, with 36 rodent species recorded in various ecosystems (pristine forests, savannas, anthropized environments), some natural habitats today encounter anthropogenic perturbations that induce changes in community structure and population dynamics. These modific...
Article
Full-text available
Infectious diseases are one of the most common threats for both domestic and wild animals, but little is known about the effects on the physiological condition and survival of wild animals. Here, we have tested for the first time in a wild vertebrate facing a viral disease possibly due to herpesvirus (i) whether nestlings with either low levels of...
Article
Among mammals, rodents play a key role in the emergence of viral diseases. In French Guiana, with 36 rodent species recorded in various ecosystems (pristine forests, savannas, anthropized environments), some natural habitats today encounter anthropogenic perturbations that induce changes in community structure and population dynamics. These modific...
Article
Full-text available
Vaccinia virus (VACV) circulates in Brazil and other South America countries and is responsible for a zoonotic disease that usually affects dairy cattle and humans, causing economic losses and impacting animal and human health. Furthermore, it has been detected in wild areas in the Brazilian Amazon. To better understand the natural history of VACV,...
Article
Full-text available
Background In French Guiana, cervical cancer is the second most frequent cancer in females. The objective of the present study was to describe the prevalence of HPV infections in women with normal cervical cytology living in the remote villages of French Guiana. Methods Before the study, the study team communicated in the remote villages on the imp...