Vina Dewi Lestari PutraChildren's Cancer Institute Australia · Histone modifications
Vina Dewi Lestari Putra
Tissue Engineering and Regenerative Medicine
PhD in Materials Science and Engineering
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Citations since 2017
5 Research Items
I am a research assistant at the Histone modifications, Children's Cancer Institute Australia. My current research focuses on the role of histone methylation and its potential as a target for neuroblastoma therapy. My research interests are: - cancer and stem cells therapy - investigation of cellular emergent response - development of drug delivery modes and tissue engineered constructs
September 2015 - August 2017
Approximately 25% of human neuroblastoma is caused by amplification of the MYCN oncogene, which leads to over‐expression of N‐Myc oncoprotein. The survival rate for this patient subtype is less than 50%. Here we show that N‐Myc protein bound to the DEAD‐box RNA helicase DDX21 gene promoter and upregulated DDX21 mRNA and protein expression. Genome‐w...
Mechanomics, the mechanics equivalent of genomics, is a burgeoning field studying mechanical modulation of stem cell behavior and lineage commitment. Analogous to mechanical testing of a living material as it adapts and evolves, mapping of the mechanome necessitates the development of new protocols to assess changes in structure and function in liv...
Mechanomics represents the natural progression of knowledge at the intersection of mechanics and biology with the aim to codify the role of mechanical environment on biological adaptation. Compared to the mapping of the human genome, the challenge of mapping the mechanome remains unsolved. Solving this grand challenge will require both top down and...
Across complex, multi-time and -length scale biological systems, redundancy confers robustness and resilience, enabling adaptation and increasing survival under dynamic environmental conditions; this review addresses ubiquitous effects of cytoskeletal remodelling, triggered by biomechanical, biophysical and biochemical cues, on stem cell mechanoada...
This study conducted biomechanical and biocompatibility tests of textiles and textile composites, created using recursive logic to emulate the properties of natural tissue weaves and their intrinsic mechanical stiffness gradients. Two sets of samples were created, first to test feasibility on textile samples designed as periosteum substitutes with...