Viktor Lukacs

Viktor Lukacs
University of Leeds · Leeds Institute of Biomedical and Clinical Sciences

M.D., Ph.D.

About

23
Publications
5,014
Reads
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1,659
Citations
Citations since 2016
6 Research Items
1249 Citations
2016201720182019202020212022050100150200250
2016201720182019202020212022050100150200250
2016201720182019202020212022050100150200250
2016201720182019202020212022050100150200250
Additional affiliations
January 2019 - June 2020
University of Leeds
Position
  • Professor (Assistant)
July 2018 - December 2018
Sanford Burnham Prebys Medical Discovery Institute
Position
  • PostDoc Position
Description
  • Novel Technology Development team
September 2013 - June 2018
The Scripps Research Institute
Position
  • PostDoc Position
Description
  • Physiologcial function and regulation of Mechano-sensitive ion channels
Education
September 2007 - April 2013
UMDNJ / Rutgers School of Biomedical and Health Sciences
Field of study
  • Pharmacology and Physiology
September 2000 - June 2007
Semmelweis University
Field of study
  • Medicine

Publications

Publications (23)
Article
Full-text available
Piezo1 ion channels are mediators of mechanotransduction in several cell types including the vascular endothelium, renal tubular cells and erythrocytes. Gain-of-function mutations in PIEZO1 cause an autosomal dominant haemolytic anaemia in humans called dehydrated hereditary stomatocytosis. However, the phenotypic consequence of PIEZO1 loss of func...
Article
Full-text available
Transient Receptor Potential Vanilloid 1 (TRPV1) is a polymodal, Ca(2+)-permeable cation channel crucial to regulation of nociceptor responsiveness. Sensitization of TRPV1 by G-protein coupled receptor (GPCR) agonists to its endogenous activators, such as low pH and noxious heat, is a key factor in hyperalgesia during tissue injury as well as patho...
Article
Full-text available
The membrane phospholipid phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2 or PIP2] regulates many ion channels. There are conflicting reports on the effect of PtdIns(4,5)P2 on transient receptor potential vanilloid 1 (TRPV1) channels. We show that in excised patches PtdIns(4,5)P2 and other phosphoinositides activate and the PIP2 scavenger poly...
Article
ANO1 (TMEM16A) is a Ca²⁺-activated Cl¯ channel (CaCC) expressed in peripheral somatosensory neurons that are activated by painful (noxious) stimuli. These neurons also express the Ca²⁺ -permeable channel and noxious heat sensor TRPV1, which can activate ANO1. Here, we revealed an intricate mechanism of TRPV1-ANO1 channel coupling in rat dorsal root...
Article
Full-text available
Significance PIEZOs are mechanically activated cation channels. Recently, loss-of-function mutations of human PIEZO1 were found among patients with familial lymphedema, suggesting a requirement of PIEZO1 in the lymphatic system. In this paper, utilizing mouse models lacking PIEZO1 in endothelial cells, we show that this ion channel is required for...
Article
Mechanotransduction plays a crucial role in vascular biology. One example of this is local regulation of vascular resistance via flow-mediated vasodilation (FMD). Impairment of this process is a hallmark of endothelial dysfunction, and a precursor to a wide array of vascular diseases such as hypertension and atherosclerosis. And yet, the molecules...
Article
Mechanotransduction plays a crucial role in vascular biology. One example of this is the local regulation of vascular resistance via flow-mediated dilation (FMD). Impairment of this process is a hallmark of endothelial dysfunction and a precursor to a wide array of vascular diseases, such as hypertension and atherosclerosis. Yet the molecules respo...
Article
Hereditary xerocytosis is thought to be a rare genetic condition characterized by red blood cell (RBC) dehydration with mild hemolysis. RBC dehydration is linked to reduced Plasmodium infection in vitro; however, the role of RBC dehydration in protection against malaria in vivo is unknown. Most cases of hereditary xerocytosis are associated with ga...
Preprint
Full-text available
Hereditary xerocytosis (HX) is thought to be a rare genetic condition characterized by red blood cell (RBC) dehydration with mild hemolysis. Gain-of-function (GOF) mutations in mechanosensitive Piezo1 ion channels are identified in HX patients. RBC dehydration is linked to reduced Plasmodium infection rates in vitro. We engineered a Piezo1 mouse mo...
Article
Full-text available
Proprioception, the perception of body and limb position, is mediated by proprioceptors, specialized mechanosensory neurons that convey information about the stretch and tension experienced by muscles, tendons, skin and joints. In mammals, the molecular identity of the stretch-sensitive channel that mediates proprioception is unknown. We found that...
Article
Full-text available
The regulation of the heat- and capsaicin-activated transient receptor potential vanilloid 1 (TRPV1) channels by phosphoinositides is controversial. Data in cellular systems support the dependence of TRPV1 activity on phosphoinositides. The purified TRPV1, however, was recently shown to be fully functional in artificial liposomes in the absence of...
Article
Transient Receptor Potential Vanilloid 1 (TRPV1) ion channels are regulated in a complex manner. Activation of G-protein coupled receptors (GPCR) by inflammatory mediators sensitizes the channels to moderate stimuli, whereas prolonged pharmacological activation of TRPV1 leads to diminished activity over time (desensitization). Paradoxically, both c...
Article
Full-text available
TRPV1 is a nonselective calcium permeable cation channel present in polymodal nociceptors that plays a crucial role in the development of inflammatory pain and thermal hypersensitivity. Plasmamembrane phosphoinositides are recognized as important regulators of TRPV1; the precise nature of their effect is, however, controversial. We and others have...
Article
Full-text available
The activity of the cold- and menthol-activated transient receptor potential melastatin 8 (TRPM8) channels diminishes over time in the presence of extracellular Ca(2+), a phenomenon referred to as desensitization or adaptation. Here we show that activation of TRPM8 by cold or menthol evokes a decrease in cellular phosphatidylinositol 4,5-bisphospha...
Article
Full-text available
TRPV6 is a member of the transient receptor potential superfamily of ion channels that facilitates Ca2+ absorption in the intestines, especially the duodenum. TRPV6 channels have been shown to be inactivated by increased cytoplasmic Ca2+ concentrations. We studied the mechanism of this Ca2+-induced inactivation. Monovalent currents through TRPV6 su...
Article
Full-text available
The transient receptor potential vanilloid type 1 (TRPV1) channels are involved in both thermosensation and nociception. They are activated by heat, protons, and capsaicin and modulated by a plethora of other agents. This review will focus on the consequences of phospholipase C (PLC) activation, with special emphasis on the effects of phosphatidyli...
Article
Full-text available
TRPV6 is a member of the transient receptor potential superfamily of ion channels that facilitates Ca(2+) absorption in the intestines. These channels display high selectivity for Ca(2+), but in the absence of divalent cations they also conduct monovalent ions. TRPV6 channels have been shown to be inactivated by increased cytoplasmic Ca(2+) concent...

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