
Viktor DreminAston University
Viktor Dremin
PhD, MSCA Alumni, FHEA
About
191
Publications
38,262
Reads
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1,735
Citations
Introduction
Additional affiliations
September 2021 - present
Orel State University
Position
- Senior Researcher
February 2018 - April 2020
September 2011 - January 2018
SPE “Astron Electronics”
Position
- Engineer
Education
September 2013 - November 2017
Orel State University
Field of study
- Biomedical Engineering
September 2008 - June 2013
Orel State University
Field of study
- Biomedical Engineering
Publications
Publications (191)
We developed a compact, hand-held hyperspectral imaging system for 2D neural network-based visualization of skin chromophores and blood oxygenation. State-of-the-art micro-optic multichannel matrix sensor combined with the tunable Fabry-Perot micro interferometer enables a portable diagnostic device sensitive to the changes of the oxygen saturation...
Recent advances in the development of ultra-compact semiconductor lasers and technology of printed flexible hybrid electronics have opened broad perspectives for the design of new pulse oximetry and photoplethysmography devices. Conceptual design of optical diagnostic devices requires careful selection of various technical parameters, including spe...
The prevalence of diabetes complications is a significant public health problem with a considerable economic cost. Thus, the timely diagnosis of complications and prevention of their development will contribute to increasing the length and quality of patient life, and reducing the economic costs of their treatment. This article aims to review the c...
This paper presents the results of the experiments which were performed using the optical biopsy system specially developed for in vivo tissue classification during the percutaneous needle biopsy (PNB) of the liver. The proposed system includes an optical probe of small diameter acceptable for use in the PNB of the liver. The results of the feasibi...
Aging and diabetes lead to protein glycation and cause dysfunction of collagen-containing tissues. The accompanying structural and functional changes of collagen significantly contribute to the development of various pathological malformations affecting the skin, blood vessels, and nerves, causing a number of complications, increasing disability ri...
Studies on laboratory animals are a crucial step in a wide range of fundamental and applied scientific investigations. In addition to ensuring that research methods are chosen correctly, it is also necessary to use them properly in order to obtain the maximum amount of reliable information. In this study, we analyze and compare laser speckle contra...
The publications devoted to studying the diagnostic capabilities of fluorescence spectroscopy, confocal microscopy and optical coherence tomography in urological patients are analyzed in this part of the review.
The analysis of data from relevant domestic and foreign literature on the intraoperative determination of intestinal viability using modern diagnostic methods in various diseases of the abdominal cavity accompanied by impaired blood supply to the intestinal wall is presented in this work. The analysis is based on the concept of mesenteric ischemia...
Although there is currently sufficient information on various parameters of capillary blood flow, including the average values of blood velocity, there is no data on the dynamics of velocity and the mechanisms of its modulation in various parts of the capillary.
The main idea of this work is to develop a tool and image data processing to study the...
This study explored the effects of 1267 nm laser irradiation on changes in blood flow parameters and activation of the regulatory mechanisms of the microcirculatory bed (MCB). Using laser Doppler flowmetry (LDF) technique and time-frequency analysis of perfusion signals, changes in the MCB of 16 healthy volunteers, targeting the distal phalanx of t...
Objectives
One of the widely used optical biopsy methods for monitoring cellular and tissue metabolism is time-resolved fluorescence. The use of this method in optical liver biopsy has a high potential for studying the shift in energy-type production from oxidative phosphorylation to glycolysis and changes in the antioxidant defense of malignant ce...
The work presents the results of the use of the convolutional neural network ResNet-50 in digital diaphanoscopy for the diagnosis of maxillary sinus conditions. The analysis of registered diaphanograms of patients with sinusitis, cystic fluid and conditionally healthy volunteers was carried out. It is shown that applying the proposed classification...
The effects of the interaction of optical radiation and biological
tissues underlie various optical diagnostics technologies, including laser Doppler flowmetry, diffuse reflection spectroscopy, fluorescent spectroscopy, photodynamic diagnostics (fluorescent cystoscopy), confocal microscopy, optical coherence tomography, etc. The efficiency of these...
The 3D structure of native human skin is fundamental for studying skin health, diseases, wound healing, and for testing the safety of skin care products, as well as personalized treatments for skin conditions. Tissue regeneration, driven by tissue engineering, often involves creating full-thickness skin equivalents (FSE), which are widely used for...
Microscopic images of cells often contain multiple objects with similar properties. In this study, we collected videos of blood microcirculation in nailfold capillaries to identify correlations between video data and indicators of complete blood count tests. The specific features of these videos include a high number of capillaries and a high varia...
Animal models mimicking human transient ischemic attack (TIA) and cerebral microinfarcts are essential tools for studying their pathogenetic mechanisms and finding methods of their treatment. Despite its advantages, the model of single arteriole photothrombosis requires complex experimental equipment and highly invasive surgery, which may affect th...
The paper presents the results of the study of the effect of singlet oxygen induced by 1267 nm laser irradiation without the use of photosensitizers on the bioenergetics of rat RINm5F insulinoma cells.
This paper demonstrates the results of the application of singlet oxygen in β-amyloid induced neurotoxicity. The experimental results of the use of 1267 nm laser for generating singlet oxygen in primary co-culture of cortical cells addition β-amyloid peptide fragment 25-35 (5 μM) are described.
This paper presents a microscopic diagnostic system that combines hyperspectral and frequency domain fluorescence lifetime imaging to record the content of chromophores and highspeed changes in cell and tissue metabolism. The efficiency of the system was tested on liver tumor slices of a laboratory mouse.
This paper presents the results of investigating the blood flow dynamics using the laser speckle contrast imaging method in rats with blood loss and without it. The results indicate that under such conditions, there was no significant decrease in speckle perfusion values.
Numerous studies have been published that discuss the triggering of apoptosis and the enhancement of mitochondrial respiration through laser illumination and singlet oxygen production in different cells and tissues. However, a significant gap in understanding remains, and it is crucial to pinpoint the precise mechanisms of laser irradiation effects...
This work reports a machine-learning-based approach to
interpret time-resolved fluorescence spectroscopy data acquired
during optical biopsy of the liver. The approach allowed to
differentiate between liver parenchyma and tumor with sensitivity
and specificity above 0.91 and 0.79, respectively, providing
differential diagnosis of liver cancer (prim...
A characteristic feature of diabetes mellitus is an increase in blood glucose levels and the development of hyperglycemia, which provokes the development of metabolic changes at the level of cells and tissues of the body. The dysfunction of pancreatic beta cells with impaired insulin secretion and a decrease in their mass is the main sign of the de...
Significance
The study of the effect of aging on the optical properties of biological tissues, in particular polarization, is important in the development of new diagnostic approaches.
Aim
This work aims to provide a comprehensive analysis of the factors and mechanisms that contribute to the alteration of skin polarization properties caused by agi...
The work considers a theranostic system that implements a multimodal approach allowing the simultaneous generation of singlet oxygen and visualization of the various parameters of the vascular bed. The system, together with the developed data processing algorithm, has the ability to assess architectural changes in the vascular network and its blood...
Profound changes in the metabolism of cancer cells have been known for almost 100 years, and many aspects of these changes have continued to be actively studied and discussed. Differences in the results of various studies can be explained by the diversity of tumours, which have differing processes of energy metabolism, and by limitations in the met...
Background. Acute intestinal ischemia is a disease characterized by a violation of blood supply, which leads to hypoxia of intestinal
wall tissues and secondary pathological changes. One of the main factors determining the urgency of the problem of acute intestinal ischemia is the intraoperative determination of the viability of the intestinal wall...
In the article by E.O. Bryanskaya et al. (doi: 10.1002/jbio.202300138), published in J. Biophotonics 16 (9), e202300138 (2023), an error occurred in the Figure 5B. This erratum corrects the Figure 5B
The aim of this work was to study the regulation of insulin production by synucleins. In addition, we aimed to evaluate the possible efect of 1267 nm light irradiation, which leads to singlet oxygen production, on insulin production in the animal organism. the present work showed that knockout of genes encoding synuclein proteins is associated with...
The use of the digital diaphanoscopy method, based on the transmission of maxillary sinus tissues by low-intensity radiation, and subsequent registration of diaphanograms, is currently characterized by the absence of classification models to exclude the subjectivity of diagnosis. Thus, the purpose of this study is to use machine learning methods to...
This study presents a hyperspectral optical imaging system for the diagnosis of infantile hemangiomas. Pilot studies were conducted in the clinic on infants. As the main results, the parameters of blood flow and saturation of the areas with hemangiomas were calculated using a previously developed neural network approach. The results indicate the po...
The work is devoted to the study of the effect of complete hyper- and hypoventilation breathing on the parameters of the blood flow microcirculation. Volunteers achieved hypo- and hyperventilation modes by performing full breathing. The correlations found between parameters of gas analysis and blood microcirculation may indicate
the peculiarities o...
This work shows the application of LSCI for mapping the cerebral vessels of a laboratory animal, and also presents the time-frequency processing of the registered signal. Thus, we expand the capabilities of the existing LSCI approach and demonstrate spatial mapping of blood flow fluctuations.
The fabrication of artificial tissue and organ models is one of the important directions of the development of modern biomedicine. Assessment of the morphology, maturation, and viability is an important part of such developments. Here, we report on the validation of our custom-build fluorescence spectroscopy (FS) system with optical coherence tomog...
This study contains analysis of existing approaches for detecting photosensitizer-free laser-induced singlet oxygen, including their ability to quantitatively measure the relationship between a dose of laser radiation and the amount of singlet oxygen produced.
Current medicine might be greatly enhanced by the ability to in vivo control and monitor neurons using opsins/phytochromes expressed in neural cells. The fundamental challenge with non-invasive neural cell activity regulation is a high absorption of visible light into biological tissues. This drawback could be mitigated by the photoconversion of ph...
This work investigates the influence of laser irradiation parameters (wavelength, power density and exposure time) on singlet oxygen (1O2) generation efficiency. Chemical trap (L-histidine) and fluorescent probe (Singlet Oxygen Sensor Green, SOSG) detection methods were used. Studies have been conducted for 1267, 1244, 1122 and 1064 nm laser wavele...
Bulk tissue polarimetry is a promising method for label-free imaging of biological samples utilizing naturally accrued polarization contrast of structural tissue composition exploiting vector nature of the light. Besides, the hyperspectral imaging is an emerging diagnostic modality widely used for functional tissue characterization. We develop an a...
Modern preclinical and clinical studies show that the use of diagnostic methods based on the registration of fluorescent radiation can improve the early diagnosis of cancer and other destructive processes of various organs. Currently, many studies are being conducted aimed at studying the processes of oxidative metabolism using methods that registe...
The process and results of numerical Monte Carlo simulation of optical radiation propagation in laser Doppler flowmetry and fluorescence spectroscopy channels of a wearable diagnostic multimodal device are described in this paper. To achieve the goal, a multilayer skin model with different parameters of blood and melanin content and different dista...
Maxillary sinus pathologies remain among the most common ENT diseases requiring timely diagnosis for successful treatment. Standard ENT inspection approaches indicate low sensitivity in detecting maxillary sinus pathologies. In this paper, we report on capabilities of digital diaphanoscopy combined with machine learning tools in the detection of su...
Editorial of the Special Issue: Lesion Detection and Analysis Using Optical Imaging (https://www.mdpi.com/journal/diagnostics/special_issues/Lesion_Optical_Imaging).
Improving noninvasive approaches to monitoring blood microcirculation is an urgent topic in modern biomedical engineering. One of the actively developing methods is laser speckle contrast imaging (LSCI), which allows not only the visualization of microvessels but also the quantitative measurements of microcirculatory blood flow. This work shows the...
Optogenetic control of neuronal activity requires efficient light energy transmission through head tissues and bone. Here we evaluate the efficiency of ultrashort pulsed and continuous-wave light transmittance through the mouse scalp, skull, and brain tissues in near-IR optical windows. The outcomes of the experiments and computer modelling show th...
Our healthy lifestyle requires a personalized healthy diet and balanced physical activities. All of these will in principle be possible with personal trainers and dietologists. Why the development of continuous monitoring of human health and activity wireless wearable devices will be one of the key technologies in the ubiquitous sensor network soci...
In recent years, there has been increasing interest in the singlet form of oxygen as a regulator of the physiological functions of cells. The use of photosensitisers is a classical mechanism for the excitation of the main triplet form of oxygen and the generation of its singlet form. At the same time, it has been shown that there is a possibility o...
In this work, we demonstrate the results of measuring the optical properties of rat liver tissue slices after the liver itself underwent the perfusion procedure with an isotonic solution. The approach is suggested as a means to attenuate the influence of blood absorption on recorded characteristics and demonstrates its effectiveness in changing the...
The theory of rheology of non-Newtonian fluids is based on the generalized Newtonian hypothesis of viscosity. The viscometers for non-Newtonian fluids should implement fluid flows with the known stress and strain state parameters distributions. Ideally, the distributions should be homogeneous in the flow domain. The idea of the proposed method is b...
We present a prototype and verification of a multichannel laser system applicable to optogenetic research.
In vivo
photostimulation of neural cells expressing photoconvertible phytochromes or opsins requires enough light irradiation delivery to the brain that cannot be supported by continues-wave (CW) light sources. The use of ultra-short pulsed...
Diabetes leads to protein glycation and causes dysfunction of collagen-containing tissues. The accompanying structural and functional changes of collagen significantly contribute to the development of various pathological malformations affecting the skin, blood vessels, and nerves, causing a number of complications, increasing disability risks and...
Assessment of biological tissues’ intrinsic fluorescence provides unique perspectives for the development of new methods of optical noninvasive diagnostics for application in many fields of medicine. Fluorescence techniques alone or together with other biophotonics methods have found their application in oncology, surgery, dermatology, etc. This ch...
Purpose of research . Development of theoretical premises for the new inertial viscometer, as well as the development of an approximate model of the viscosity fluid flow using convolutional neural networks and laser speckle contrast imaging data. Methods . The study consists of two parts. The first is devoted to a theoretical study of viscosity flu...
Singlet oxygen (1O2) is an electronically excited state of triplet oxygen which is less stable than molecular oxygen in the electronic ground state and produced by photochemical, thermal, chemical, or enzymatic activation of O2. Although the role of singlet oxygen in biology and medicine was intensively studied with photosensitisers, using of these...
In recent years, there has been a growing interest in the singlet form of oxygen as a regulator of the physiological functions of cells. One of the ways to generate singlet oxygen is direct optical excitation of the triplet oxygen form. Since molecular oxygen weakly absorbs light, high power is required to obtain sufficient concentrations of single...
Nowadays, photonics-based techniques are used extensively in various applications, including functional clinical diagnosis, progress monitoring in treatment, and provision of metrological control. In fact, in the frame of practical implementation of optical methods, such as laser Doppler flowmetry (LDF), the qualitative interpretation and quantitat...
Optogenetic research has opened up the possibility to control neurons that will help detect and treat neurological diseases in the early stage. Treatment of dysfunctions requires exposure to a partial neural network accessible through the absorption of opsins or phytochromes expressed in the brain matter. The use of II-NIR USP lasers makes it possi...
At the moment, percutaneous needle biopsy (PNB) remains the gold standard for diagnosing liver cancer. However, the relatively high probability of false-negative results can still be an issue with the method. The introduction of real-time feedback for the precise navigation of the biopsy tool is an up-and-coming technology to immensely reduce the m...
An approach to visualization of the vascular bed with the possibility of assessing changes in blood filling and identifying diagnostically significant periodic changes in the signal by analyzing speckle images is proposed. The effect of singlet oxygen by direct excitation of an oxygen molecule by 1267 nm laser radiation on changes in the vascular b...
The paper presents the results of a study of conditionally healthy volunteers and patients with various maxillary sinuses diseases by digital diaphanoscopy with a comparison of the results obtained with CT studies. The results of the classification of pathological changes based on a quantitative assessment of the registered scattering patterns of l...
Advances in the development of ultra-compact semiconductor lasers have opened up new possibilities for the development of wearable devices implementing biophotonic technologies, such as laser Doppler flowmetry (LDF) and fluorescence spectroscopy (FS). This work is aimed to evaluate the correlation between diagnostic parameters simultaneously regist...
This article presents a liquid phantom technology that simulates the fluorescent properties of protoporphyrin IX (PPIX). A technology was developed for the isolation of PPIX from dark egg shells with a final concentration close to the real values in human tissues. A comparative analysis of the transmittance coefficient of the manufactured phantom a...
The paper deals with processing data obtained using nailfold high-speed videocapillaroscopy. To detect the red blood cells velocity two approaches are used. The deterministic approach is based on pixel intensities analysis for object detection and calculation of the displacement and velocity of red blood cells in a capillary. The obtained data form...
The aim of this work is to develop practical tools to recognize the average flow rate of physiological fluids in capillaries. This tool is represented by classification models in an artificial neural networks form. The flow rate data were obtained experimentally. Intralipid was used as the test liquid. Laser speckle contrast imaging was used to obt...
The interaction of laser radiation of wavelengths of direct optical generation of singlet oxygen with cell culture media was simulated. Using the COMSOL Multiphysics software, the distribution of the thermal field over the culture media volume was obtained depending on the wavelength, power and exposure time. The results demonstrate the importance...
In this work, we propose the results of pilot studies on using the modulated CMOS camera for the imaging of autofluorescence in murine hepatocellular carcinoma cells with excitation in UV light. Here, we assess the capabilities of the imaging system to detect changes in the NAD(P)H fractions produced and utilised in the glycolysis, pentose phosphat...