Vikram Sinai Talaulikar

Vikram Sinai Talaulikar
University College London Hospitals NHS Foundation Trust | uclh · Institute of Women's Health

MD, FRCOG, PhD

About

141
Publications
95,822
Reads
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721
Citations
Introduction
Additional affiliations
October 2013 - October 2015
University College London Hospitals NHS Foundation Trust
Position
  • Clinical Fellow in Reproductive Endocrinology and Assisted Reproduction
January 2011 - December 2012
St George's, University of London
April 2009 - September 2013
St George's Hospital and University of London
Position
  • Researcher

Publications

Publications (141)
Article
Objective: Induction of puberty with exogenous oestrogen results in considerable variability in final uterine and breast volumes. We set out to quantify the variability of these two outcome measures with a view to establishing monitoring methods that could be used to individualise treatment protocols. Design: A prospective observational study....
Article
With life expectancy for women on the rise, most women will experience menopausal transition and will spend a significant number of years of their life in the menopausal phase. Menopausal transition involves a myriad of physical, endocrine, and psychological changes which are influenced by ethnic, psychological, and socio-cultural factors. Every wo...
Article
Full-text available
Plain language summary This paper deals with the use of hormone replacement therapy (HRT) after the removal of fallopian tubes and ovaries to prevent ovarian cancer in premenopausal high risk women. Some women have an alteration in their genetic code, which makes them more likely to develop ovarian cancer. Two well‐known genes which can carry an al...
Article
Full-text available
Breast cancer is the commonest cancer among women in the western world, accounting for up to 30% of all cancers in women. There is a long-standing controversy about the potential link to hormone replacement therapy (HRT), with large observational studies suggesting that HRT increases the risk, while the Women's Health Initiative (WHI), a prospectiv...
Article
Study question What is the role of endocrine stimulation therapy prior to mTESE in men with hypogonadism and non obstructive azoospermia (NOA)? Summary answer In hypogonadal men there is a positive correlation between change of serum Testosterone (ΔT) before and after stimulation, and a successful mTESE. What is known already NOA is the most comm...
Article
Study question Is there a difference in treatment outcome between gonadotrophin releasing hormone (GnRH) pump or hMG for women with Type 1 anovulation undergoing ovulation induction? Summary answer Treatment with GnRH was more efficient compared to hMG, with fewer number of cycles to pregnancy, fewer days of stimulation and fewer cycle cancellatio...
Article
Full-text available
Context Clinical practice guidelines (CPGs) are key instruments to implement the practice of evidence-based medicine. We aimed to evaluate the methodological quality and variations in CPGs recommendations on the diagnosis and management of polycystic ovary syndrome (PCOS). Evidence Acquisition We searched MEDLINE, EMBASE, and CENTRAL until Decembe...
Research
Background: Although induced abortion is one of the most commonly performed gynecological procedures in Great Britain and medical termination of pregnancy is being used more frequently, very little is known about the role of ambulation during the procedure. We sought to compare ambulatory and non-ambulatory groups of patients undergoing medical ter...
Article
Full-text available
Ulipristal acetate (UPA) was introduced as a novel progesterone receptor modulator as effective therapy for symptomatic fibroids. Randomised clinical trials established its effectiveness in the management of heavy menstrual bleeding due to uterine leiomyomas. The trials did not find any significant evidence of clinical harm to the participants. Rec...
Article
The apparent gender differences in favor of women in the risk of contracting and dying from coronavirus disease 2019 (COVID-19), and the fact that such trends have also been observed in recent epidemics including severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), have prompted the obvious question: Are the reasons...
Article
Objective Age at first date and sexual intercourse have been observed to be delayed in women with Turner syndrome (TS), with delayed puberty being the main factor. We sought to assess relationship and sexual experiences comparing women with TS and premature ovarian insufficiency (POI). Design Cross‐sectional observational study. Patients 302 wome...
Article
Full-text available
The global increase in life expectancy to 74 years for women, while the median age of the menopause remains at 51 years, means that an increasing number of women will live a significant portion of their adult lives in the menopause. The WHI publications in 2003/4 reported on the dangers of hormone replacement therapy, in particular with respect to...
Book
Isaac Manyonda and Vikram Sinai Talaulikar. MRCOG Part 3: 50 Clinical Tasks. Publisher: Jaypee UK; 1st edition
Article
Vikram Talaulikar, Sabaratnam Arulkumaran. Folic Acid and Reproductive Health. J Jaffna Sci.Association,2019, 1(1),1-11.
Chapter
Vikram Sinai Talaulikar, Sabaratnam Arulkumaran. Chapter 21 Birth Asphyxia in Arias' Practical Guide to High-Risk Pregnancy and Delivery. A South Asian Perspective. Editors: Fernando Arias, Amarnath Bhide, Arulkumaran S, Kaizad Damania, Shirish Daftary. 4th Edition. Pages 359-72. Elsevier India, 2020.
Article
The World Health Organization (WHO) type 1 anovulatory disorders include hypogonadotrophic hypogonadism, hypothalamic amenorrhoea and hypopituitarism. These conditions are encountered primarily in endocrine, gynaecology and reproductive medicine clinics, and can result in amenorrhoea/oligomenorrhoea, subfertility or pregnancy loss. These conditions...
Chapter
The process of labour and delivery can be a hazardous journey for the fetus. The principal aim of monitoring a fetus during labour is to detect changes in the fetal heart rate that suggest a possibility of fetal hypoxia and metabolic acidosis so that timely action can be taken to prevent adverse outcomes. For the last four decades, intrapartum moni...
Chapter
Complications of early pregnancy, including pregnancy loss and threatened miscarriage, are common. Miscarriage affects almost one in five pregnancies and accounts for utilization of a significant proportion of healthcare resources. Women presenting with miscarriage should ideally be assessed, diagnosed, and managed in early pregnancy assessment uni...
Chapter
As the epidemic of obesity spreads, increasing numbers of overweight or obese women are seeking fertility treatments as high body mass index (BMI) appears to be associated with delayed conception. Weight loss is recommended for women with high BMI before attempting natural conception or starting infertility treatment to improve fertility outcomes....
Article
Full-text available
Combined (estrogen and a progestogen) hormone replacement therapy (cHRT) is associated with an increased risk of breast cancer, while estrogen replacement therapy is not. Whatever the underlying mechanism, it is the progestogen in cHRT that seems to increase the risk. Fear of breast cancer is a major limiting factor in the use of hormone replacemen...
Article
Vikram Talaulikar. See your GP about the menopause. The Menopause Exchange, Issue 82, Page 4, Autumn 2019.
Article
Objective: Women with early-onset oestrogen deficiency are at risk of reduced bone mineral density (BMD). We sought to assess fracture history and BMD in women with Turner syndrome (TS) and premature ovarian insufficiency (POI). Design: A cross-sectional observational study. Patients: 267 women with TS (median age 34.3 years) and 67 women with...
Article
Objective: Adequate uterine growth is an essential component of pubertal induction with exogenous oestradiol in those with hypogonadism. Poor uterine development will render the individual vulnerable in the context of fertility. We assessed uterine size using ultrasound in those who had undergone pubertal induction treatment compared to a referenc...
Article
Objective: Although spontaneous fertility and successful pregnancies have been reported in well-chelated and transfused women with beta thalassaemia major (BTM), majority of women are subfertile due to hypogonadotropic hypogonadism (HH). Little is known about the effect of iron overload on ovarian follicles and whether ovarian reserve is affected...
Article
Full-text available
Context Turner Syndrome (TS) is often associated with delayed puberty. To induce puberty, estrogen is administered in incremental doses at an age determined by age of presentation. After puberty, various types of maintenance Estrogen Replacement Therapy (ERT) are used. Objective We sought associations between age of induction of puberty and type o...
Article
Objective: To study the safety and efficacy of ovarian stimulation and oocyte cryopreservation as a method of fertility preservation in women with Turner syndrome (TS). Design: Retrospective cohort study. Setting: Reproductive medicine clinic. Patient(s): Seven women with TS who attended the clinic between 2011 and 2017. Intervention(s): Ovarian st...
Article
HRT Myths in Menopause Exchange autumn issue
Chapter
Professional Development Skills for Obstetricians and Gynaecologists - edited by Tahir Mahmood September 2018
Article
Cambridge Core - Obstetrics and Gynecology, Reproductive Medicine - Professional Development Skills for Obstetricians and Gynaecologists - edited by Tahir Mahmood
Article
Objective: There is uncertainty whether treatment with dehydroepiandrosterone (DHEA) decreases menopausal symptoms for women in the peri- or postmenopausal phase. A previous systematic review considering this subject suggested that DHEA may slightly improve sexual function compared with placebo (CS. Scheffers, S. Armstrong, AEP. Cantineau, C. Farq...
Chapter
Obstetric malpractice claims and their escalating costs, together with the increase of medical malpractice insurance premiums, have become a major concern for maternity service providers across most of the developed world. Electronic fetal monitoring is the recommended method of intrapartum fetal surveillance in high-risk pregnancies and cardiotoco...
Article
Caesarean section (CS) rates continue to evoke worldwide concern because of their steady increase. The national caesarean section (CS) rate in the UK is almost 25%, having increased by 5.7% in the last 10 years. A rising primary CS rate is a significant contributor to this trend. The latest available data show that almost 1 in 5 women in the world...
Chapter
Chapter 23 - Medicolegal Considerations of CTG in Handbook of cardiotocography edited by Roza Olyai, pages165-76. CBS Publishers & Distributors, India 2018.
Article
Nearly 95% of fetuses at term present with the vertex and with such a presentation, the vast majority of women progress well in labour and have a spontaneous vaginal delivery. Any presentations other than vertex can lead to difficulties in labour and hence are called as malpresentations. Malpresentations of fetal head occur due to extension of the...
Article
Full-text available
The mucopolysaccharide diseases are a group of heterogeneous, inherited conditions that are characterized by the deficiency of specific lysosomal enzymes. These lysosomal enzymes are responsible for the breakdown of glycosaminoglycans (GAGs), which are a key component of connective tissue. When lysosomal enzymes are deficient, the resultant build-u...
Article
Talaulikar V. Continuous combined HRT in Menopause Exchange, Issue 74, Autumn, November 2017.
Article
Full-text available
Electronic fetal monitoring (EFM) is the recommended method of intrapartum fetal surveillance for high-risk pregnancies. The cardiotocogram (CTG) trace forms a central piece of documentary evidence in medico-legal cases related to intrapartum hypoxia and birth asphyxia. Cardiotocography was introduced in 1960s as a screening tool with the view to r...
Article
Uterine fibroids are the most common benign tumours in women of reproductive age group and are a cause of significant healthcare burden. Although surgical treatments have been the traditional gold standard for symptomatic uterine fibroids, several medical therapeutic approaches have been used to achieve symptom suppression in women who wish to pres...
Article
http://www.hospitalpharmacyeurope.com/featured-articles/medical-treatment-uterine-fibroids
Article
Going on HRT in Menopause Exchange by Dr. Vikram Talaulikar, UCLH, Issue 70, Page 3, autumn 2016
Poster
Full-text available
Poster presented on Outcome of ovarian stimulation for oocyte cryopreservation in women with Turner syndrome at the SfE BES 2016 7th November at Brighton Centre, Brighton, UK
Article
Full-text available
http://www.glowm.com/Critical_current_issue/page/38
Article
Importance: Metformin, an oral antihyperglycemic drug, acts as an insulin sensitizer in the treatment of type 2 diabetes mellitus. It has also been widely used in the treatment of polycystic ovary syndrome (PCOS) and gestational diabetes mellitus. Although randomized clinical trials have failed to establish its superiority over other forms of trea...
Article
Antral follicle count (AFC) variation was examined across the menstural cycle and its effect on clinical management assessed. In 79 women, AFC was documented in early (iAFC) and late follicular phase (sAFC). Absolute agreement between iAFC and sAFC and agreement for classification into categories of risk of extremes of ovarian response were examine...
Article
Postpartum hemorrhage (PPH) continues to be one of the leading causes of maternal deathsworldwide [1]. Several treatment procedures used in the management of severe PPH are based on the principle of uterine or pelvic vessel compression [2]. PPH compression belts are a novel uterine compression device aimed at reducing uterine blood flow to prevent...
Article
Full-text available
Caesarean section (CS) has evolved from a procedure with considerable morbidity and mortality risks into one that is safe enough to be considered as a matter of maternal choice in high resource countries. Improvements in operative techniques, anaesthesia, intensive care, blood transfusion services and availability of antibiotics have all contribute...
Article
Nearly 95% of fetuses at term present with the vertex (an area subtended by the two parietal eminences and the anterior and posterior fontanelles). With vertex presentation, the vast majority of women progress well in labour and have spontaneous vaginal delivery. Any presentations other than vertex can lead to difficulties in labour and hence are c...
Chapter
Chapters entitled Infections and vaccinations in pregnancy, Jaundice, Convulsions, Intrauterine death, Unstable lie, Poor progress in labour, Abnormal fetal heart rate in labour, Prolonged second stage, Postpartum psychosis, Leg pain and swelling in pregnancy and puerperium, Maternal collapse, Postoperative care after a caesarian section and Emerge...
Article
Although it has been known for a long time that uterine fibroids respond to changes in sex steroid concentrations, it is the availability of selective progesterone receptor modulators such as ulipristal acetete that has provided the gynecologist with a novel option for medical management of uterine fibroids. Ulipristal acetate is presently licensed...
Article
Uterine fibroids, the most common benign gynaecological tumours in women of reproductive age, impact negatively on women’s health and quality of life and have significant cost implications for their management. The current mainstay treatments are surgical or radiological but none of these are ideal for every woman. Ulipristal acetate is a selective...
Article
Talaulikar VS. Ulipristal acetate: a novel medical therapy for uterine fibroids. Glob. libr. women’s med., (ISSN: 1756-2228) 2014; DOI 10.3843/GLOWM.10472.
Chapter
Full-text available
Sinai Talaulikar V, Arulkumaran S. Global and Historical Perspective of Safe Motherhood Initiative: A Small Beginning and a Long Journey. Chapter 1 in Safe Motherhood Initiative A Silent Revolution edited by S Gupta, pg 3-30. First edition. Jaypee Brothers Medical Publishers P Ltd. 2014.
Article
Full-text available
Electronic fetal monitoring (EFM) is the recommended method of intrapartum fetal surveillance for high risk pregnancies. Despite the questions about its efficacy and controversy regarding increased rates of operative delivery associated with its use, continuous cardiotocography (CTG) remains the predominant method of intrapartum fetal monitoring. T...
Article
Full-text available
Sinai Talaulikar V, Arulkumaran S. Medico-Legal Issues with CTG Interpretation. Current Women’s Health Reviews 2013; 9: 145-57.
Article
Uterine-sparing surgical interventions have long been practiced as an alternative to hysterectomy in the management of severe postpartum haemorrhage (PPH); however, the risks of impairment of subsequent fertility from such procedures are unclear. To evaluate the menstrual and fertility outcomes following radiological or conservative surgical interv...
Article
The last two decades have witnessed tremendous advances in the field of reproductive medicine, especially assisted reproductive technology and stem cell research. As research continues in future, it is vital to ensure that individuals from all ethnic backgrounds are represented in the study populations so that the findings of the research can be ge...
Chapter
1. The goal of antepartum fetal surveillance is to ascertain fetal well-being and detect fetuses which may be at r