Vikram Gharge

• Ph.D
• Principal Investigator at Emcure Pharmaceuticals ( Zuventus Healthcare )

Comparative analysis of the quality control tests for in-process and finished oral solid dosage form specifically tablets and capsules across the recent editions of the Indian Pharmacopoeia (IP), British Pharmacopoeia (BP) United States Pharmacopoeia (USP). This study provides a detailed examination of the in-process quality control (IPQC) tests as...

The stability-indicating method for Deflazacort Suspension was developed using the Analytical Quality by Design (AQbD) approach, focusing on process control and understanding. A multilevel factorial design was used to optimize the gradient mode's time and mobile phase ratio. Sophisticated software like Design Expert and Minitab aided in chromatogra...

Background: The fixed-dose combination (FDC) syrup of Paracetamol (PCM), chlorpheniramine Maleate (CPM), and Phenylephrine Hydrochloride (PPH) is widely used as an antipyretic and analgesic medication to manage pain and common cold symptoms. Objective: the study aims to develop a sugar-free syrup formulation of PCM, CPM, and PPH using a Quality...

This study focuses on novel high-performance liquid chromatography (HPLC) method to simultaneously identify and quantify degradation products of esomeprazole and levosulpiride in capsule dosage form, enhancing analytical precision and reliability. The gradient was thoroughly optimized for proper separation of all the peaks in the chromatogram. Chro...

Background: Esomeprazole (ESO) gastro-resistant tablets (40 mg) are sold under the brand name, Zosa, which effectively manages conditions associated with the overproduction of gastric acid, including peptic ulcer disease and Zollinger-Ellison syndrome. The present study quantifies impurities in esomeprazole using advanced analytical techniques know...

This study employs computational techniques to predict the performance of a modified-release matrix formulation of chirally pure S (-) Metoprolol Succinate, using a Quality by Design (QbD) approach. The research defines the Quality Target Product Profile (QTPP) and Critical Quality Attributes (CQAs) of the S (-) Metoprolol Succinate matrix formulat...

The balance of gut microbiota significantly impacts host health. Disruption of the natural gut flora, often caused by infections or the use of broad-spectrum antimicrobial drugs, can lead to dysbiosis, causing gastrointestinal disorders, such as diarrhea. Probiotics show promising outcomes in restoring gut health, but concerns remain about their in...

A easy, expeditious and accurate method for the analysis of bulk s(-) Metoprolol succinate and solid tablet dosage form is reversed-phase chromatographic technuique. This technuique has been designed, developed and validated. The method was accomplished with the help of ODS Inertsil-3, 4.600 mm x 250.000 mm, column having pore size of 5 μm or equiv...

Solubility, the phenomenon of dissolution of solute in solvent to give a homogenous system, is one of the important parameters to achieve desired concentration of drug in systemic circulation for desired pharmacological response. Low aqueous solubility is the major problem encountered with formulation development of new chemical entities as well as...

Orally disintegrating tablet (ODT) has number of advantages like faster onset of action, ease of administration, rapid disintegration and dissolution etc. A novel attempt has been made to develop orally disintegrating tablets of Ondansetron by using two approaches, one is soluble hydrophilic matrix by superdisintegrant and other is effect of sweete...

Cilnidipine is poorly water soluble antihypertensive drug (BCS class II). This study was conducted to increase solubility of drug. An attempt was made to formulate fast dissolving tablet of Cilnidipine by solid dispersion using melting method with Pluronic F-68. The API: carrier was taken as 1:1, 1:2 and 1:3. Effect of several variables such as con...

The objective of this investigation was to develop an oral sustained release formulation of linezolid that would maximize the duration of active drug concentration in the extracellular fluid, thus assuring the therapeutic efficacy. This rationale was based on the observation that the an efficacy of linezolid depends mainly on the length of time tha...

Solubility is an essential factor for drug effectiveness, independent of the route of administration. Poorly soluble drugs are often a challenging task for formulators in the industry. Conventional approaches for enhancement of solubility have limited applicability, especially when the drugs are poorly soluble simultaneously in aqueous and in non-a...

Solubility is an essential factor for drug effectiveness, independent of the route of administration. Poorly soluble drugs are often a challenging task for formulators in the industry. Conventional approaches for enhancement of solubility have limited applicability, especially when the drugs are poorly soluble simultaneously in aqueous and in non-a...

Modified release dosage forms are designed by altering drug absorption or the site of drug release in order to accomplish predetermined clinical objectives. Possible therapeutic benefits of a modified release product include improved efficacy and reduced adverse effects, increased convenience and patient compliance, optimized performance, a greater...

The objective of this present investigation was to develop and formulate floating sustained release matrix tablets of s (-) atenolol, by using different polymer combinations and filler, to optimize by using surface response methodology for different drug release variables and to evaluate the drug release pattern of the optimized product. Floating s...

The aim of this research was to develop a multiparticulate floating drug delivery system using porous calcium silicate and sodium alginate, for site specific drug release of ranolazine. Ranolazine is an anti-anginal drug with extensive and highly variable hepatic first pass metabolism following oral administration, with systemic bio-availability of...

Objective: The objective of this study was to compare and evaluate in vitro ex vivo transdermal potential of the diclofenac sodium (DS) gel by different permeation enhancers using Franz-type diffusion cells.

Evolution of an existing drug molecule from a conventional form to a novel delivery system can significantly improve its performance in terms of patient compliance, safety, and efficacy. Objective: The present investigation was undertaken to fabricate modified release tablet of metoprolol succinate using multiple unite pellets systems with Wruster...

Now day's formulation research is breaking barriers of conventional methods. Today, active ingredients can be delivered with a level of convenience, performance and bioavailability never seen in the market place. Fast disintegrating or Mouth dissolving tablet (MDTs) is one such novel approach to increase consumer acceptance by virtue of rapid disin...

Evolution of existing drug molecules from a conventional form to novel delivery system can significantly improve its performances in term of patient compliance, safety, and efficacy. These days drug delivery companies are engaged in the development of multiple platform technologies to get competitive advantage extend patent life and increase market...

Ziprasidone Hydrochloride, a Class II drug is an atypical antipsychotic agent, which is poorly water soluble with only 60% bioavailability. In present study attempt has been made to prepare Ziprasidone Hydrochloride fast disintegrating/ dissolving tablets. For enhancing solubility of drug, inclusion complexes of drug were prepared using ȕCD and HPβ...